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Enzymatic Basis Of Detoxication Volume 1


Enzymatic Basis Of Detoxication Volume 1
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Enzymatic Basis Of Detoxication Volume 1


Enzymatic Basis Of Detoxication Volume 1
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Author : William B. Jakoby
language : en
Publisher: Elsevier
Release Date : 2012-12-02

Enzymatic Basis Of Detoxication Volume 1 written by William B. Jakoby and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Science categories.


Enzymatic Basis of Detoxication, Volume I focuses on the catalytic mechanisms and physiological expression of the enzymes that are involved in the detoxication of foreign compounds. The book explores foreign compound metabolism at the level of what specific enzymes can do. This book is organized into three sections and comprised of 17 chapters. The discussion begins with an overview of detoxication and covers both catalytic and non-catalytic removal of foreign substances, along with the general properties of the enzymes that are active in detoxication. The reader is then introduced to the physiological aspects of detoxication, paying particular attention to the kinetic aspects of metabolism and elimination of foreign compounds in animals, human genetic variation in detoxication enzymes, and how such enzymes are induced. The next section focuses on mixed function oxygenase systems and includes chapters on cytochrome P-450 and the detoxication reactions it catalyzes. The book also considers other oxidation-reduction systems, with reference to alcohol dehydrogenase, aldehyde reductase, aldehyde oxidizing enzymes, ketone reductases, xanthine oxidase and aldehyde oxidase, glutathione peroxidase, and superoxide dismutases. The final chapter is devoted to monoamine oxidase, its properties, substrate specificity, inhibitors, kinetics and mechanism, and multiple forms. Pharmacologists, toxicologists, and biochemists will find this book extremely helpful.



Enzymatic Basis Of Detoxication Volume 1


Enzymatic Basis Of Detoxication Volume 1
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Author : William B. Jakoby
language : en
Publisher: Academic Press
Release Date : 1980-10-28

Enzymatic Basis Of Detoxication Volume 1 written by William B. Jakoby and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1980-10-28 with Medical categories.


Enzymatic Basis of Detoxication, Volume I focuses on the catalytic mechanisms and physiological expression of the enzymes that are involved in the detoxication of foreign compounds. The book explores foreign compound metabolism at the level of what specific enzymes can do. This book is organized into three sections and comprised of 17 chapters. The discussion begins with an overview of detoxication and covers both catalytic and non-catalytic removal of foreign substances, along with the general properties of the enzymes that are active in detoxication. The reader is then introduced to the physiological aspects of detoxication, paying particular attention to the kinetic aspects of metabolism and elimination of foreign compounds in animals, human genetic variation in detoxication enzymes, and how such enzymes are induced. The next section focuses on mixed function oxygenase systems and includes chapters on cytochrome P-450 and the detoxication reactions it catalyzes. The book also considers other oxidation-reduction systems, with reference to alcohol dehydrogenase, aldehyde reductase, aldehyde oxidizing enzymes, ketone reductases, xanthine oxidase and aldehyde oxidase, glutathione peroxidase, and superoxide dismutases. The final chapter is devoted to monoamine oxidase, its properties, substrate specificity, inhibitors, kinetics and mechanism, and multiple forms. Pharmacologists, toxicologists, and biochemists will find this book extremely helpful.



Enzymatic Basis Of Detoxication Volume 2


Enzymatic Basis Of Detoxication Volume 2
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Author : William B. Jakoby
language : en
Publisher: Elsevier
Release Date : 2012-12-02

Enzymatic Basis Of Detoxication Volume 2 written by William B. Jakoby and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Science categories.


Enzymatic Basis of Detoxication, Volume II, reviews the state of knowledge on foreign compound metabolism at the level of what specific enzymes can do. The book attempts to provide a holistic view of the information gleaned from work with specific, purified enzymes encompassing as many mammalian sources as have been studied. The book is organized into two parts. Part I on conjugation reactions and related systems includes studies on the properties of glucuronide formation; the physiological function, assay, and purificatgion of function of bilirubin-glucuronoside glucuronosyltransferase; the roles of N- and O-methylation reactions and glutathione transferases in detoxication; and amino acid conjugation. Part II presents studies on hydrolytic systems, covering the role of epoxide hydrolase, carboxylesterases, and amidases in detoxication and the regulatory effects of these enzymes. This book provides pharmacologists and toxicologists with the biochemical view of detoxication, and biochemists with the corresponding pharmacological and toxicological aspects.



Enzymatic Basis Detoxication 2 Vol Set


Enzymatic Basis Detoxication 2 Vol Set
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Author : Elsevier Science & Technology Books
language : en
Publisher:
Release Date : 1980-12-01

Enzymatic Basis Detoxication 2 Vol Set written by Elsevier Science & Technology Books and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1980-12-01 with categories.




Enzymatic Basis Of Detoxication Volume 2


Enzymatic Basis Of Detoxication Volume 2
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Author : William B. Jakoby
language : en
Publisher: Academic Press
Release Date : 1980-10-28

Enzymatic Basis Of Detoxication Volume 2 written by William B. Jakoby and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1980-10-28 with Medical categories.


Enzymatic Basis of Detoxication, Volume II, reviews the state of knowledge on foreign compound metabolism at the level of what specific enzymes can do. The book attempts to provide a holistic view of the information gleaned from work with specific, purified enzymes encompassing as many mammalian sources as have been studied. The book is organized into two parts. Part I on conjugation reactions and related systems includes studies on the properties of glucuronide formation; the physiological function, assay, and purificatgion of function of bilirubin-glucuronoside glucuronosyltransferase; the roles of N- and O-methylation reactions and glutathione transferases in detoxication; and amino acid conjugation. Part II presents studies on hydrolytic systems, covering the role of epoxide hydrolase, carboxylesterases, and amidases in detoxication and the regulatory effects of these enzymes. This book provides pharmacologists and toxicologists with the biochemical view of detoxication, and biochemists with the corresponding pharmacological and toxicological aspects.



Biological Basis Of Detoxication


Biological Basis Of Detoxication
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Author : John Caldwell
language : en
Publisher: Elsevier
Release Date : 2012-12-02

Biological Basis Of Detoxication written by John Caldwell and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Nature categories.


Biological Basis of Detoxication focuses on the biological processes involved in detoxication, with emphasis on the biochemistry of the removal of xenobiotics from an organism. Topics range from the formation of toxic metabolites and compounds that are not metabolized at all to the tissue distribution and nutritional considerations, the kinetics and mechanisms of the metabolic and excretory processes, and the integration of xenobiotic metabolism in the activation and detoxication of carcinogens. Organized into 14 chapters, this book begins with an overview of the enzymatic basis for the metabolic activation of foreign compounds in forming reactive chemical intermediates. The first few chapters discuss the identification of reactive electrophiles derived from xenobiotics, intratissue distribution of activating and detoxicating enzymes, enzymatic and non-enzymatic modes of xenobiotic metabolism, and unmetabolized compounds. The middle chapters explore the biological basis of detoxication of oxygen free radicals, physiologic and kinetic aspects of the fate of xenobiotics, excretion of xenobiotics, and effects of nutrition on detoxication. The remaining chapters look at the relationships between the enzymes of detoxication and host defense mechanisms, metabolic basis of target organ toxicity, the enzymatic factor in selective toxicity, and intraindividual and interindividual variations in rates of hepatic metabolism of exogenous chemicals. Pharmacologists, toxicologists, and biochemists will find this book highly informative.



Metabolic Basis Of Detoxication


Metabolic Basis Of Detoxication
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Author : William B. Jakoby
language : en
Publisher: Academic Press
Release Date : 1982

Metabolic Basis Of Detoxication written by William B. Jakoby and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1982 with Medical categories.


METABOLIC BASIS OF DETOXICATION ...



Patty S Toxicology 6 Volume Set


Patty S Toxicology 6 Volume Set
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Author : Eula Bingham
language : en
Publisher: John Wiley & Sons
Release Date : 2012-07-31

Patty S Toxicology 6 Volume Set written by Eula Bingham and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-07-31 with Science categories.


Featuring the improved format used in the 5th edition, this updated set presents, in logical groupings, comprehensive toxicological data for industrial compounds, including CAS numbers, physical and chemical properties, exposure limits, and biological tolerance values for occupational exposures, making it essential for toxicologists and industrial hygienists. This edition has about 40% new authors who have brought a new and international perspective to interpreting industrial toxicology, and discusses new subjects such as nanotechnology, flavorings and the food industry, reactive chemical control to comprehensive chemical policy, metalworking fluids, and pharmaceuticals.



The Alkaloids Chemistry And Pharmacology


The Alkaloids Chemistry And Pharmacology
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Author :
language : en
Publisher: Academic Press
Release Date : 1987-10-01

The Alkaloids Chemistry And Pharmacology written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1987-10-01 with Science categories.


The Alkaloids: Chemistry and Pharmacology



Chemical Sensitivity


Chemical Sensitivity
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Author : William J. Rea
language : en
Publisher: CRC Press
Release Date : 1992-09-23

Chemical Sensitivity written by William J. Rea and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992-09-23 with Science categories.


Chemical Sensitivity is the first major scientific book series on chemical sensitivity, an increasingly important worldwide health problem. This four-volume series features results from the study of more than 20,000 environmentally sensitive patients at the Environmental Health Center (EHC) in Dallas. Results from the study at EHC are supplemented by information accumulated from the treatment and study of an estimated 100,000 patients by other environmentally oriented physicians and scientists around the world.