Epigenetics And Dna Repair In Cancer
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Epigenetics And Dna Repair In Cancer
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Author : Elena Hern√°ndez-Caballero
language : en
Publisher:
Release Date : 2022
Epigenetics And Dna Repair In Cancer written by Elena Hern√°ndez-Caballero and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with Science categories.
Cells can use chemical modifications in chromatin to regulate accessibility to DNA to the repair complexes and to prevent transcription in case of damage. We analyzed the relationship between repair systems and epigenetic mechanisms in DNA and RNA. We searched the PubMed database for genes involved in DNA damage response (DDR) and methylation in mRNA and DNA repair, in cancer. Epigenetic modifications, particularly histone modifications and nucleosome remodeling, trigger a signaling cascade of kinases in DNA damage response (DDR) toward efficient repair. SWI/SNF remodelers promote the recruitment of repair factors in DNA, such as DNA double-strand breaks (DSBs) that activate kinases in DDR. RNA methylation via m6A has recently attracted attention as a possible alternative pathway for repairing DNA damage. m6A is a dynamic methylation mark on mRNA that accumulates after UV irradiation and regulates transcription to facilitate DNA repair. Currently, studies seek to understand how signaling pathways activate proteins in the early response to damage. The repair maintains DNA integrity, which is a challenge in cancer because this process also represents a potential barrier to anticancer agents. The impact that epigenetic regulation can have on DNA repair is beginning to be understood.
Epigenetics Territory And Cancer
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Author : Parvin Mehdipour
language : en
Publisher: Springer
Release Date : 2015-03-18
Epigenetics Territory And Cancer written by Parvin Mehdipour and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-03-18 with Medical categories.
This book explores epigenetic strategies, bridging fundamental cancer epigenetics, different paradigms in tumor genetics and translational understanding for both the clinic and improved lifestyles. The work provides target-based insights for treating different types of cancers and presents research on evolutionary epigenetics, introducing ‘Medical Epi- Anthropology’ and ‘Cancer Epi-Anthropology’. Translating multi-disciplinary research into therapeutic design is at the core of this book. Readers may explore how cancer management involves unmasking the involved networks and the interactive status of different genes to achieve the appropriate methylome based therapy. Early chapters explore fundamental aspects and brain tumours, whilst later chapters investigate breast cancer and various other cancers, and the final chapter presents an evolutionary insight in cancer epigenetics, considering that the epigene is beyond DNA methylation, RNA interference and histone modification in cancer development. This book will be of interest to researchers in different medical and scientific fields, including clinical management (diagnosis, prognosis, prediction, prevention, and guidelines), genetic education, nutrition and nutrigenomics, industrial chemistry, and drug innovation. Because of the unique bridging between science and medicine this book will also be useful as an educational and translational research package.
Epigenetics And Dna Damage
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Author : Miriam Galvonas Jasiulionis
language : en
Publisher: Academic Press
Release Date : 2022-08-14
Epigenetics And Dna Damage written by Miriam Galvonas Jasiulionis and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-14 with Medical categories.
Although scientists recognize the role of epigenetic mechanisms in DNA damage response, the complex, mechanistic interplay between chromatin regulation and DNA repair is still poorly understood. Comprehending how these processes are connected in time and space and play out in developmental processes may reveal novel directions for new research and disease treatment. Epigenetics and DNA Damage, a new volume in the Translational Epigenetics series, offers a thorough grounding in the relationship between DNA Damage, epigenetic modifications, and chromatin regulation. Early chapters address the basic science of DNA damage and its association with various epigenetic mechanisms, including DNA methylation, post-translational histone modifications, histone variants, chromatin remodeling, miRNAs, and lncRNAs. This is followed by a close discussion of DNA damage and epigenetics in metabolism, aging, cellular differentiation, immune function, stem cell biology, and cancer, tying recent research to translational application in disease understanding. Later chapters examine possible epigenetic therapies combining DNA damage induction and epigenetic alteration, as well as instructive chapters on how to analyze DNA damage and epigenetic alterations in new research. Offers a thorough foundation in epigenetics and DNA damage research, as well as informed discussion of evolving research trends, disease findings, and early therapeutics Features chapter contributions from leading international contributors Empowers scientists to apply protocols in DNA damage and epigenetic alteration analysis and experimatation in their own research
Epigenetics And Cancer Part A
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Author :
language : en
Publisher: Academic Press
Release Date : 2010-11-22
Epigenetics And Cancer Part A written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-11-22 with Science categories.
Genes interact with the environment, experience, and biology of the brain to shape an animal’s behavior. This latest volume in Advances in Genetics, organized according to the most widely used model organisms, describes the latest genetic discoveries in relation to neural circuit development and activity. Explores the latest topics in neural circuits and behavior research in zebrafish, drosophila, C.elegans, and mouse models Includes methods for testing with ethical, legal, and social implications Critically analyzes future prospects
Epigenetic Alterations In Oncogenesis
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Author : Adam R. Karpf
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-09-06
Epigenetic Alterations In Oncogenesis written by Adam R. Karpf and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-09-06 with Medical categories.
The purpose of this book is to provide an up to date review of the nature and consequences of epigenetic changes in cancer. Epigenetics literally means “above” genetics, and consists of heritable gene expression or other phenotypic states not accounted for by DNA base sequence. Epigenetic changes are now known to make a large contribution to various aspects of tumorigenesis. These changes include alterations in global and promoter specific DNA methylation, activating and repressive histone modifications, and changes in higher order chromatin structures. Each of these topics will be covered in this book.
Cancer Epigenetics
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Author : Antonio Giordano
language : en
Publisher: John Wiley & Sons
Release Date : 2011-10-07
Cancer Epigenetics written by Antonio Giordano and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-10-07 with Medical categories.
Cancer Epigenetics: Biomolecular Therapeutics in Human Cancer is the only resource to focus on biomolecular approaches to cancer therapy. Its presentation of the latest research in cancer biology reflects the interdisciplinary nature of the field and aims to facilitate collaboration between the basic, translational, and clinical sciences.
Epigenetic Regulation Of Cancer Part B
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Author :
language : en
Publisher: Elsevier
Release Date : 2024-04
Epigenetic Regulation Of Cancer Part B written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-04 with Science categories.
Epigenetic Regulation of Cancer, Part B, Volume 383 in the International Review of Cell and Molecular Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of hot topics, including Epigenetic control of cell signaling in cancer stem cells, Genetic and epigenetic features of neuroendocrine prostate cancer and their emerging applications, Epigenetic regulation in pancreatic cancer, Epigenome Editing in Cancer: Advances and Challenges for Potential Therapeutic Options, Inhibition of epigenetic mechanisms in cancer, and Epigenetics as a determinant of radiation response in cancer.
Epigenetics In Biology And Medicine
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Author : Manel Esteller
language : en
Publisher: CRC Press
Release Date : 2008-09-17
Epigenetics In Biology And Medicine written by Manel Esteller and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-09-17 with Science categories.
Anomalous epigenetic patterns touch many areas of study including biomedical, scientific, and industrial. With perspectives from international experts, this resource offers an all-inclusive overview of epigenetics, which bridge DNA information and function by regulating gene expression without modifying the DNA sequence itself. Epigenetics, in its
Metabolism And Epigenetic Regulation Implications In Cancer
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Author : Tapas Kumar Kundu
language : en
Publisher: Springer Nature
Release Date : 2022-10-27
Metabolism And Epigenetic Regulation Implications In Cancer written by Tapas Kumar Kundu and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-10-27 with Science categories.
Metabolic programs of individuals are key determinants for disease susceptibility and immune response. This book, edited by experts in the field, summarizes epigenetic signaling pathways that regulate metabolic programs associated with cancer and cancer-related secondary diseases. The first part of the book highlights key metabolic pathways that are implicated in cancer and provides a comprehensive overview on the carbohydrate, protein, lipid, amino- and nucleic acid metabolic pathways that are deregulated in cancer. Special attention is paid to the altered tumor micro-environment that is influenced by the metabolic milieu. Furthermore, the fundamental relationship between the cellular metabolic environment and cell death-mediated autophagy is discussed. The second part of the book covers our understanding of the fundamental epigenetic regulations that are implicated in controlling the metabolic programs in cancer cells. Many aspects of epigenetic regulation of non-coding RNAs as well as DNA/RNA methylation, which influencing metabolic homeostasis in cancer, are discussed in detail. Special emphasis is placed on the epigenetic regulation of the amino acid, glucose/carbohydrate metabolism and epigenetic regulation during hypoxia and its connection to cancer. Last but not least, the third part of the book covers small molecule modulators of histone modifying enzymes, which can be used as therapeutic tools. The readers learn about the cross-talk between epigenetics and immunometabolims, as well as the epigenetic regulation of oncometabolites to combat cancer. Given its scope, the book will appeal to a broad readership interested in epigenetic, cancer and metabolic research.
Epigenetic Reduction Of Dna Repair In Progression To Cancer
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Author : Carol Bernstein
language : en
Publisher:
Release Date : 2015
Epigenetic Reduction Of Dna Repair In Progression To Cancer written by Carol Bernstein and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with Medicine categories.
Epigenetic Reduction of DNA Repair in Progression to Cancer.