Epigenetics In The Microbiome Host Crosstalk From Mechanisms To Therapeutics

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Epigenetics In The Microbiome Host Crosstalk From Mechanisms To Therapeutics

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Author : Chengfei Liu
language : en
Publisher: Frontiers Media SA
Release Date : 2025-04-01

Epigenetics In The Microbiome Host Crosstalk From Mechanisms To Therapeutics written by Chengfei Liu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-04-01 with Medical categories.

Epigenetic modifications allow cells to change gene expression without altering the genetic code, by dynamically regulating chromatin accessibility, which is controlled by the activity of associated enzymes such as DNA/histone methyltransferases and histone acetyltransferases. This represents a potent mechanism through which mammalian hosts adapt their transcriptional program to environmental cues. Indeed, trillions of commensal microbes, termed microbiota, along with their metabolites and their signaling, are environmental stimuli that can direct host health and disease. They are being increasingly recognized as a source of epigenetic substrates, cofactors, and regulators of epigenetic-modifying enzymes. Recent research has shown that perturbation of microbiota-host interactions with pathologies of inflammatory diseases or metabolic syndrome correlated with altered epigenetic patterning. Microbiota-sensitive epigenetic mechanisms may include synthesizing biological compounds that affect the availability of methyl/ acetyl donors for DNA or histone modifications; modulating epigenetic modifying enzyme activity; influencing host-cell intrinsic epigenetic pathways; or regulating non-coding RNAs. Nevertheless, a deeper understanding of this epigenetic regulation is required in guiding therapeutic approaches to prevent or combat diseases driven by disrupted microbiota-host crosstalk.

Role Of Gut Microbiota And Postbiotics For Colorectal Cancer

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Author : Neeraj Mishra
language : en
Publisher: Springer Nature
Release Date : 2025-07-01

Role Of Gut Microbiota And Postbiotics For Colorectal Cancer written by Neeraj Mishra and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-07-01 with Medical categories.

The emerging role of gut microbiota and postbiotics has implications for the management of not only human health and diseases, but also colorectal cancer in particular, as these elements influence colorectal cancer pathogenesis, treatment, and prevention. This book bridges the gap between cutting-edge research and practical clinical applications in the management of colorectal cancer by offering a fresh perspective on potential therapeutic strategies and exploring the significance of microbiota in the oncology landscape. Chapters delve into the specific impacts of postbiotics, linking them to immune response modulation, inflammation reduction, and direct anticancer effects. Chapters also explore current and emerging therapies, including the manipulation of gut microbiota and the use of postbiotics supplements. Clinical trial results, case studies, and expert opinions are interwoven to present a realistic view of the benefits, limitations, and future prospects of these innovative therapeutic strategies. This book is rounded out with perspectives on future research directions in this area, discussing potential next-generation therapies such as personalized medicine approaches and biotechnological advancements, and further contemplating broader implications of microbiota research on public health strategies. Informative and engaging, this book provides clinicians and researchers alike with a deeper understanding of how postbiotics can be harnessed in colorectal cancer treatment and potentially, the treatment of other cancers influenced by gut health.

Inflammatory Immune Disease Molecular Mechanisms Translational Approaches And Therapeutics

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Author : Tao Xu
language : en
Publisher: Frontiers Media SA
Release Date : 2022-07-05

Inflammatory Immune Disease Molecular Mechanisms Translational Approaches And Therapeutics written by Tao Xu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-05 with Science categories.

Epigenetics As A Deep Intimate Dialogue Between Host And Symbionts

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Author : Ilaria Negri
language : en
Publisher: Frontiers Media SA
Release Date : 2016-06-30

Epigenetics As A Deep Intimate Dialogue Between Host And Symbionts written by Ilaria Negri and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-06-30 with Genetics categories.

Symbiosis is an intimate relationship between different living entities and is widespread in virtually all organisms. It was critical for the origin and diversification of Eukaryotes and represents a major driving force in evolution. Indeed, symbiosis may support a wide range of biological processes, including those underlying the physiology, development, reproduction, health, behavior, ecology and evolution of the organisms involved in the relationship. Although often confused with mutualism, when both organisms benefit from the association, symbiosis actually encompasses several and variable relationships. Among them is parasitism, when one organism benefits but the other is harmed, and commensalism, when one organism benefits and the other remains unaffected. Even if many symbiotic lifestyles do exist in nature, in many cases the intimacy between the partners is so deep that the “symbiont” (sensu strictu) resides into the tissues and/or cells of the other partner. Since the partners frequently belong to different kingdoms, e.g. bacteria, fungi, protists and viruses living in association with animal and plant hosts, their shared “language” should be a basic and ancient form of communication able to effectively blur the boundaries between extremely different living entities. In recent years studies on the role of epigenetics in shaping host-symbiont interactions have been flourishing. Epigenetic changes include, but are not limited to, DNA methylation, remodelling of chromatin structure through histone chemical modifications and RNA interference. In this E-book we present a series of papers exploring the fascinating developmental and evolutionary relationship between symbionts and hosts, by focusing on the mediating epigenetic processes that enable the communication to be effective and robust at both the individual, the ecological and the evolutionary time scales. In particular, the papers consider the role of epigenetic factors and mechanisms in the interactions among different species, comprising the holobiont and host-parasite relationships. On the whole, since epigenetics is fast-acting and reversible, enabling dynamic developmental communication between hosts and symbionts at several different time scale, we argue that it could account for the enormous plasticity that characterizes the interactions between all the organisms living symbiotically on our planet.

Nutrition In The Control Of Inflammation

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Author : Bradley S. Ferguson
language : en
Publisher: Elsevier
Release Date : 2024-11-22

Nutrition In The Control Of Inflammation written by Bradley S. Ferguson and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-11-22 with Technology & Engineering categories.

Nutrition in the Control of Inflammation: Emerging Roles for the Microbiome and Epigenome offers a comprehensive overview of how our diet promotes or attenuates inflammation to regulate inflammatory diseases.Broken into five sections, this book presents an introduction to the microbiome and epigenome in nutrition and subsequently covers diet, lifestyle, and the microbiome in development and inflammatory diseases, nutrition and the epigenome in metabolic and cardiovascular diseases, diet, epigenetics and the microbiome in inflammatory disease, and addresses health-disparities in diet, epigenetics and gut microbes.This reference will be of interest to nutrition researchers, nutritionists, and postgraduate students, as well as others working in, studying, and researching related fields. - Discusses the latest topics in the microbiome and nutritional epigenome surrounding the regulation of aging, development, metabolic disease, and heart disease - Summarizes our current understanding of nutritional intervention in epigenetic reprogramming and microbial changes in the treatment and prevention of disease - Provides practical applications for diet and lifestyle to reduce inflammation and improve overall health

Molecular Mechanisms In Nutritional Epigenetics

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Author : Luis M. Vaschetto
language : en
Publisher: Springer Nature
Release Date : 2024-05-23

Molecular Mechanisms In Nutritional Epigenetics written by Luis M. Vaschetto and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-23 with Science categories.

This volume in the Epigenetics and Human Health series explores the intersection of diet and epigenetic modifications. It provides the reader with the latest research on how diet can influence our genetic and epigenetic profiles, thereby affecting our health and susceptibility to disease. In recent years, the field of nutritional epigenetics/nutri-epigenetics has expanded significantly, shedding light on how environmentally-driven epigenetic pathways can be modulated through nutrition and eating habits. The book provides a comprehensive introduction to the various epigenetic mechanisms affected by dietary compounds and focuses on specific topics such as the relationship between diet and the gut microbiome, the impact of diet on cardiovascular disease and psychopathology and the role of diet in pregnancy. Written by an international team of experts, this book reveals the molecular mechanisms underlying the influence of diet on epigenetic modifications and discusses the prospect of personalized medicine using dietary strategies to promote well-being and protect against diseases. The book is aimed at researchers and students in the fields of human nutrition, genetics, and medicine.

Epigenetic Biomarker And Personalized Precision Medicine

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Author : Jiucun Wang
language : en
Publisher: Frontiers Media SA
Release Date : 2020-12-21

Epigenetic Biomarker And Personalized Precision Medicine written by Jiucun Wang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-21 with Science categories.

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Current Trends In Exploiting Molecular Signaling In Bacteria Host Crosstalk

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Author : Monica Cartelle Gestal
language : en
Publisher: Frontiers Media SA
Release Date : 2022-06-27

Current Trends In Exploiting Molecular Signaling In Bacteria Host Crosstalk written by Monica Cartelle Gestal and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-06-27 with Science categories.

The Role Of Interplay Between Metabolism And Chromosomes In Tumorigenesis

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Author : Jiayi Wang
language : en
Publisher: Frontiers Media SA
Release Date : 2022-09-22

The Role Of Interplay Between Metabolism And Chromosomes In Tumorigenesis written by Jiayi Wang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-22 with Science categories.

Microbial Crosstalk With Immune System

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Author : Asmita Das
language : en
Publisher: Academic Press
Release Date : 2022-07-26

Microbial Crosstalk With Immune System written by Asmita Das and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-26 with Medical categories.

Our body is not sterile and harbors enumerable microflora that are now being understood to play a complex role in immune regulation and shaping of the immune system in a continuous and dynamic way. In 8 chapters, Microbial Crosstalk with Immune System: New Insights in Therapeutics provides an overall introduction with special focus on how the immune system which is specifically geared to get rid of non-self-antigens, allows numerous microbes to colonize the human body. In the presence of microbes there are several observations that suggest that there are multiple roles that are played by these microbes in tumor progression and shaping of our immune system which is explained at length in subsequent chapters. Microbial Crosstalk with Immune System: New Insights in Therapeutics discusses the emerging mechanisms of immune-therapeutics as well as its limitations while emphasizing the potential role of microbes in shaping immune-therapeutic and evolving novel strategies to deal with any limitations. - Focuses on the modulation of immune system by the microbiome, thus affecting cancer prognosis - Discusses various current research strategies in the field that are still in experimental stages. enabling readers to gain a perspective on the ongoing research in the field - Gives insight into the emerging mechanisms of immune-therapeutics and its limitations - Emphasizes the potential role of microbes in shaping immune-therapeutics