Epileptic Focus In Drug Resistant Epilepsy
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Epileptic Focus In Drug Resistant Epilepsy
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Author : Darya Sitovskaya
language : en
Publisher:
Release Date : 2020
Epileptic Focus In Drug Resistant Epilepsy written by Darya Sitovskaya and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with Electronic books categories.
The chapter focuses on how different cutting-edge techniques can be used to study electrophysiological, pathomorphological, and biochemical changes in the ,Äúepileptic focus,Äù area of the cerebral cortex and white matter to see how epileptic seizures become drug-resistant and how it affects the other regions of the brain. The authors highlight the significance of neuroinflammation and apoptosis in the epilepsy pathogenesis providing EEG characteristics and describing structural changes in the cortex and white matter under such conditions as focal cortical dysplasia and epileptic leukoencephalopathy. Particular focus is given to structural and functional changes in the hippocampus and the role of hippocampal sclerosis in epilepsy. Key conceptions regarding the epileptic focus formation are outlined.
Drug Resistant Epilepsies
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Author : Philippe Kahane, Anne Berg, Wolfgang Löscher, Doug Nordli, Emilio Perucca
language : en
Publisher: John Libbey Eurotext
Release Date : 2013-09-18
Drug Resistant Epilepsies written by Philippe Kahane, Anne Berg, Wolfgang Löscher, Doug Nordli, Emilio Perucca and has been published by John Libbey Eurotext this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-09-18 with categories.
Over 12 million people with epilepsy have seizures that cannot be controlled by antiepileptic drugs. The term "drug-resistance" is abundantly used in the epilepsy literature but the definitions proposed differ considerably. It is used indifferently in a number of different settings: as a criterion for selection of patients eligible for new antiepileptic drug trials, for the selection of surgical candidates, for the design of epidemiological studies, for the design of studies on quality of life, for the definition of the epileptic encephalopathies (in comparison to more benign epilepsy syndromes), to mention but a few. As a result, available studies are usually not comparable and referral to epilepsy specialists is unacceptably delayed. The volume includes several focused chapters on all issues relating to drug-resistance and offers the basis for a consensus on a clinically meaningful core definition.
Medication Resistant Epilepsy
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Author : John M. Stern
language : en
Publisher: Cambridge University Press
Release Date : 2020-09-10
Medication Resistant Epilepsy written by John M. Stern and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-10 with Medical categories.
A practical yet comprehensive review of the underlying causes of medication-resistant epilepsy and effective forms of treatment.
The Treatment Of Epilepsy
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Author : Simon Shorvon
language : en
Publisher: John Wiley & Sons
Release Date : 2015-09-23
The Treatment Of Epilepsy written by Simon Shorvon and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-09-23 with Medical categories.
Highly Commended at the British Medical Association Book Awards 2016 The Treatment of Epilepsy, fourth edition, is a comprehensive reference and clinical guide to the pharmacological, medical and surgical options available in the treatment of epilepsy. The text is compiled by a group of internationally renowned editors and contributors and is now in full color and extensively illustrated The first two sections cover the background to, and principles of, treatment in different clinical situations Section three comprises a series of systematic reviews of contemporary drug therapy, devoting one chapter to each anti-epileptic drug and covering all clinically-relevant aspects Section four focuses on the surgical options, devoting individual chapters to each of the modalities of presurgical assessment and to each surgical operation or approach This 4th edition is extensively revised incorporating the many recent developments in therapy, and comprises 81 chapters from world experts from 18 countries
Refractory Status Epilepticus
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Author : Xuefeng Wang
language : en
Publisher: Springer
Release Date : 2017-09-05
Refractory Status Epilepticus written by Xuefeng Wang and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-05 with Medical categories.
This book aims to offer the accumulated fertile experience of treating drug-resistant epileptic patients collected over the past few decades, focusing on aspects of neurology, neurosurgery, emergency care, critical care medicine and basic medical research. Refractory status epilepticus is one of the most common severe and acute diseases in neurology and neurocritical care; it is also the main cause of death in epileptic patients. In the context of prevention and treatment processes, it is not only necessary to terminate epileptic seizures, but to also address the disruption of the patient’s internal environment and provide critical life support. Effective treatment calls for multi-disciplinary support from neurology, neurosurgery, emergency care, critical care medicine, and other fields. Further, since the clinical features of epileptic seizure are not specific, it is necessary to differentiate it from other diseases that produce convulsions, disorders of consciousness, syncope, mental and behavioral disorders, myoclonus, etc., to avoid misdiagnosis. In this book, it comprehensively and systematically describes the basic knowledge as well as prevention and treatment tips, providing an invaluable reference resource for medical students and professionals in neurology, neurosurgery, emergency care and critical care medicine.
Diagnosis And Surgical Treatment Of Epilepsy
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Author : Warren W. Boling
language : en
Publisher: MDPI
Release Date : 2019-01-09
Diagnosis And Surgical Treatment Of Epilepsy written by Warren W. Boling and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-09 with Biology (General) categories.
This book is a printed edition of the Special Issue "Diagnosis and Surgical Treatment of Epilepsy" that was published in Brain Sciences
Pharmacoresistance In Epilepsy
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Author : Luisa L. Rocha
language : en
Publisher: Springer Nature
Release Date : 2023-08-29
Pharmacoresistance In Epilepsy written by Luisa L. Rocha and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-08-29 with Medical categories.
This new edition of Pharmacoresistance in Epilepsy addresses all issues relating to drug-resistance in epilepsy, including studies in patients as well in experimental models and presents the basis for an understanding of recent developments in the pathogenesis and treatment of this condition. Important issues associated with drug-resistant epilepsy are reviewed and updated, such as abnormalities in inhibitory mechanisms, neurotoxicity and changes the immune system associated with this disorder, and the development of drug-resistance as consequence of chronic exposure to antiseizure-medications. Considering that a major obstacle is that epilepsy associated with drug-resistance cannot be controlled with the traditional antiseizure medications, specific chapters describe therapeutic strategies to prevent or reduce the progression of the disease with complementary medical therapies, such as transcranial focal stimulation to promote neuroprotection. Pharmacoresistance in Epilepsy is a valuable resource for anyone working in the field, whether studying epilepsy in the lab or treating it in an office.
The Epilepsies
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Author : Chrysostomos P. Panayiotopoulos
language : en
Publisher: Springer
Release Date : 2005
The Epilepsies written by Chrysostomos P. Panayiotopoulos and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Medical categories.
This book gives an exhaustive account of the classification and management of epileptic disorders. It provides clear didactic guidance on the diagnosis and treatment of epileptic syndromes and seizures through thirteen chapters, complemented by a pharmacopoeia and CD ROM of video-EEGs.
Recent Advances In The Treatment Of Epilepsy
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Author : Khojasteh Malekmohammad
language : en
Publisher: Frontiers Media SA
Release Date : 2024-07-22
Recent Advances In The Treatment Of Epilepsy written by Khojasteh Malekmohammad and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-07-22 with Science categories.
Epilepsy is one of the most common neurological chronic disorders characterized by unpredictable recurrent seizures, which leads to brain dysfunction, cognitive, psychological, and social disorders. Various treatment options for epilepsy are: antiepileptic drugs, surgery, neuromodulation, gene therapy and ketogenic diet. However, definitions, diagnosis and treatment of epilepsy are still challenging issues for clinicians and researchers. Antiepileptic drugs play a central and crucial role in the treatment of epilepsy patients. Brivaracetam Cannabidiol (CBD), Cenobamate, Everolimus and Fenfluramine are the five novel anticonvulsant drugs during the last 5 years. Brivaracetam anticonvulsant effects are due to its highly selective affinity for synaptic vesicle protein 2A (SV2A) in the brain. It is act as an SV2A ligand. Among these drugs Cannabidiol is one of the prominent phytocannabinoids derived from the cannabis sativa. The anticonvulsant mechanisms of action of CBD including antagonism of G protein-coupled receptor 55 (GPR55), desensitization of transient receptor potential vanilloid type 1 (TRPV1) channels, and potentiation of adenosine-mediated signaling through inhibition of the equilibrative nucleoside transporter 1 (ENT-1) and enhancement of GABAergic transmission. The mechanisms of the antiseizure effect of Cenobamate are: increasing the inactivated state of voltage-gated sodium channels, and acting as a positive allosteric modulator of the GABA-A receptors by binding at a non-benzodiazepine site. Everolimus is a mammalian target of rapamycin (mTOR) inhibitor. Fenfluramine is able to enhance extracellular serotonin levels, modulate serotonergic and other neurologic receptors. Nevertheless, the exact mechanism of action of most of these drugs is unknown. At least 30% of people with epilepsy have drug-resistant epilepsy (DRE), therefore, non-pharmacological treatments have been considered. the Vagus Nerve Stimulation (VNS), Trigeminal Nerve Stimulation (TNS), Transcranial Direct Current Stimulation (tDCS), Transcranial Magnetic Stimulation (TMS) are the most common neuromodulation-based approaches. Also, in recent years, a new field of GABA-, adenosine-, galanin-, and neuropeptide Y- based cell and gene therapies for refractory epilepsy has emerged. In spite of these advances, significant gaps in knowledge still remain. In particular, the mechanisms underlying epilepsy, including status epilepticus, drug and surgical treatments are still not well elucidated. Novel insights on pathophysiological mechanisms of epilepsy and new treatment options prompted us to collect the most recent publications on pharmacological and non-pharmacological treatments of epilepsy. So, in this Research Topic, we will focus on the advances in the field of treatment in epilepsy, the pathophysiology and molecular aspects of seizure attacks and novel antiseizure medications.
Quantitative Multimodal Mapping Of Seizure Networks In Drug Resistant Epilepsy
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Author : Preya Shah
language : en
Publisher:
Release Date : 2018
Quantitative Multimodal Mapping Of Seizure Networks In Drug Resistant Epilepsy written by Preya Shah and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with categories.
Over 15 million people worldwide suffer from localization-related drug-resistant epilepsy. These patients are candidates for targeted surgical therapies such as surgical resection, laser thermal ablation, and neurostimulation. While seizure localization is needed prior to surgical intervention, this process is challenging, invasive, and often inconclusive. In this work, I aim to exploit the power of multimodal high-resolution imaging and intracranial electroencephalography (iEEG) data to map seizure networks in drug-resistant epilepsy patients, with a focus on minimizing invasiveness. Given compelling evidence that epilepsy is a disease of distorted brain networks as opposed to well-defined focal lesions, I employ a graph-theoretical approach to map structural and functional brain networks and identify putative targets for removal. The first section focuses on mesial temporal lobe epilepsy (TLE), the most common type of localization-related epilepsy. Using high-resolution structural and functional 7T MRI, I demonstrate that noninvasive neuroimaging-based network properties within the medial temporal lobe can serve as useful biomarkers for TLE cases in which conventional imaging and volumetric analysis are insufficient. The second section expands to all forms of localization-related epilepsy. Using iEEG recordings, I provide a framework for the utility of interictal network synchrony in identifying candidate resection zones, with the goal of reducing the need for prolonged invasive implants. In the third section, I generate a pipeline for integrated analysis of iEEG and MRI networks, paving the way for future large-scale studies that can effectively harness synergy between different modalities. This multimodal approach has the potential to provide fundamental insights into the pathology of an epileptic brain, robustly identify areas of seizure onset and spread, and ultimately inform clinical decision making.