Pharmacoresistance In Epilepsy
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Pharmacoresistance In Epilepsy
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Author : Luisa Rocha
language : en
Publisher: Springer Science & Business Media
Release Date : 2014-07-08
Pharmacoresistance In Epilepsy written by Luisa Rocha and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-07-08 with Medical categories.
Although more than 10 new antiepileptic drugs have been developed in the past decade, epilepsy remains resistant to drug therapy in about one third of patients, many of whom struggle with the disease their entire lives. Managing these patients is a challenge and requires a structured multidisciplinary approach. The book includes chapters on all issues related to pharmacoresistance in epilepsy and describes recent developments in the pathogenesis and treatment of this disorder. It addresses abnormalities in inhibitory mechanisms, epilepsy-related changes to the immune system, development of pharmacoresistance caused by chronic exposure to antiepileptic drugs, and novel therapeutic strategies for preventing or slowing down the progression of the disease. Clinicians and basic scientists alike will find up-to-date information on the development of pharmacoesistance, as well as reviews of mechanisms associated with epilepsy that may help them consider novel strategies for preventing the development of pharmacoresistance in the first place. The book also features information on new therapeutic strategies for control of epilepsy, such as transcutaneous electrical stimulation and virtual screening of new antiepileptic drugs. Pharmacoresistance in Epilepsy: From Genes and Molecules to Promising Therapies is useful to anyone working in the field, whether they’re studying epilepsy in the lab or treating it in a doctor’s office.”
Drug Resistant Epilepsies
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Author : Philippe Kahane, Anne Berg, Wolfgang Löscher, Doug Nordli, Emilio Perucca
language : en
Publisher: John Libbey Eurotext
Release Date : 2013-09-18
Drug Resistant Epilepsies written by Philippe Kahane, Anne Berg, Wolfgang Löscher, Doug Nordli, Emilio Perucca and has been published by John Libbey Eurotext this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-09-18 with categories.
Over 12 million people with epilepsy have seizures that cannot be controlled by antiepileptic drugs. The term "drug-resistance" is abundantly used in the epilepsy literature but the definitions proposed differ considerably. It is used indifferently in a number of different settings: as a criterion for selection of patients eligible for new antiepileptic drug trials, for the selection of surgical candidates, for the design of epidemiological studies, for the design of studies on quality of life, for the definition of the epileptic encephalopathies (in comparison to more benign epilepsy syndromes), to mention but a few. As a result, available studies are usually not comparable and referral to epilepsy specialists is unacceptably delayed. The volume includes several focused chapters on all issues relating to drug-resistance and offers the basis for a consensus on a clinically meaningful core definition.
Drug Resistant Epilepsies
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Author : Philippe Kahane
language : en
Publisher: John Libbey Eurotext
Release Date : 2008
Drug Resistant Epilepsies written by Philippe Kahane and has been published by John Libbey Eurotext this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with categories.
More than 12 million people with epilepsy have seizures that cannot be controlled by antiepileptic drugs. The term "drug-resistance" is abundantly used in the epilepsy literature but the definitions proposed differ considerably. It is used indifferently in a number of different settings: as a criterion for selection of patients eligible for new antiepileptic drug trials, for the selection of surgical candidates, for the design of epidemiological studies, for the design of studies on quality of life, for the definition of the epileptic encephalopathies (in comparison to more benign epilepsy syndromes), to mention but a few. As a result, available studies are usually not comparable and referral to epilepsy specialists is unacceptably delayed. The present volume of Progress in Epileptic Disorders includes several focused chapters on all issues relating to drug-resistance and offers the basis for a consensus on a clinically meaningful core definition.
Intractable Seizures
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Author : W. McIntyre Burnham
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Intractable Seizures written by W. McIntyre Burnham and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
About 20% of people with epilepsy have seizures which are resistant to anticonvulsant medications. These drug-resistant seizures are called `intractable', and the patients who have them - about 1 in 500 of the general population - present a major challenge to neurologists and epilepsy associations. The present volume describes the symptomatology of the major `intractable' syndromes, the most appropriate drugs for each, and the possibilities for surgical control. Research related to the causes and effects of unchecked seizures is presented, and new directions in prevention and therapy are discussed.
Genetics Of Epilepsy And Refractory Epilepsy
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Author : Alberto Lazarowski
language : en
Publisher: Biota Publishing
Release Date : 2013-03-01
Genetics Of Epilepsy And Refractory Epilepsy written by Alberto Lazarowski and has been published by Biota Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-01 with Science categories.
Epilepsy affects approximately 3% of the population, and is usually defined as a tendency to experience recurrent seizures arising from periodic neuronal hyperexcitability of unknown causes. Different genetic factors, through various mechanisms, can cause this abnormal neuronal behavior. The etiology of epilepsy is a major determinant of clinical course and prognosis. Many of the genes that have been implicated in idiopathic epilepsies code for ion channels, whereas a wide spectrum of syndromes where epilepsy is a main clinical feature are caused by mutated genes that are involved in functions as diverse as cortical development, brain malformations, mitochondrial function, and cell metabolism. Similarly, different conditions as hypoxia, trauma, infections, or metabolic unbalances can develop epileptic syndromes where upregulation of several genes could be related to the epileptogenic mechanisms. The most common human genetic epilepsies display a complex pattern of inheritance, and the susceptible genes are largely unknown. However, major advances have recently been made in our understanding of the genetic basis of monogenic inherited epilepsies. As we continue to unravel the molecular genetic basis for epilepsies, it will increasingly influence their classification and diagnosis. A majority of epileptic patients may control their crisis with anticonvulsant drugs, however 30%–40% became refractory to pharmacological therapies and require surgical treatment. The challenge of the molecular revolution will be the design of the best treatment protocols based on genetic profiles that include both the specific mechanistic etiology of the epilepsies, as well as their potential refractory behavior to current medications. This includes also the design of new therapeutic agents and targets, so as to reduce the number of cases with refractory epilepsy and epileptogenesis, and perhaps avoid the current surgical treatment (a procedure that was first described more than 4000 years ago) except as a last option.
Neuromodulation For Pharmacoresistant Epilepsy From Bench To Bed
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Author : Tianfu Li
language : en
Publisher: Frontiers Media SA
Release Date : 2024-03-05
Neuromodulation For Pharmacoresistant Epilepsy From Bench To Bed written by Tianfu Li and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-03-05 with Medical categories.
The Treatment Of Epilepsy
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Author : Simon Shorvon
language : en
Publisher: John Wiley & Sons
Release Date : 2015-09-23
The Treatment Of Epilepsy written by Simon Shorvon and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-09-23 with Medical categories.
Highly Commended at the British Medical Association Book Awards 2016 The Treatment of Epilepsy, fourth edition, is a comprehensive reference and clinical guide to the pharmacological, medical and surgical options available in the treatment of epilepsy. The text is compiled by a group of internationally renowned editors and contributors and is now in full color and extensively illustrated The first two sections cover the background to, and principles of, treatment in different clinical situations Section three comprises a series of systematic reviews of contemporary drug therapy, devoting one chapter to each anti-epileptic drug and covering all clinically-relevant aspects Section four focuses on the surgical options, devoting individual chapters to each of the modalities of presurgical assessment and to each surgical operation or approach This 4th edition is extensively revised incorporating the many recent developments in therapy, and comprises 81 chapters from world experts from 18 countries
Drug Resistance In Epilepsy
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Author : Gregory R. Bock
language : en
Publisher: Wiley
Release Date : 2002-04-26
Drug Resistance In Epilepsy written by Gregory R. Bock and has been published by Wiley this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-04-26 with Medical categories.
The object of this book is to gather together workers in the fields of epilepsy, those concerned with the basic science of resistance and the blood-brain barrier, and those with clinical experience of drug resistance in cancer, with a view to stimulating further work on drug resistance in epilepsy. Whilst resistance in cancer has been extensively studied, and trials of reversal of resistance have been undertaken, with some success, resistance in epilepsy has only just begun to be addressed.
Experimental And Translational Methods To Screen Drugs Effective Against Seizures And Epilepsy
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Author : Divya Vohora
language : en
Publisher: Humana
Release Date : 2021-06-23
Experimental And Translational Methods To Screen Drugs Effective Against Seizures And Epilepsy written by Divya Vohora and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-23 with Medical categories.
This volume discusses the latest experimental and clinical approaches to study seizures and epilepsy. Chapters in this book cover detailed protocols for ex vivo and in vitro experimental models and widely-used in vivo (acute and chronic seizure) models in epilepsy research. Chapters also cover techniques to screen the effective leads for the treatment of refractory seizures of pharmacoresistant epilepsy and invertebrate, non-mammalian models. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and practical, Experimental and Translational Methods to Screen Drugs Effective Against Seizures and Epilepsy is a valuable resource for researchers, in both industry and academia, interested in learning about this important and developing field.
Medically Refractory Epilepsy
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Author : Kurupath Radhakrishnan
language : en
Publisher: Sree Chitra Tirunal Institute Ology
Release Date : 1999-01-01
Medically Refractory Epilepsy written by Kurupath Radhakrishnan and has been published by Sree Chitra Tirunal Institute Ology this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-01-01 with categories.