Eskape Pathogens
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Eskape Pathogens
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Author : Siddhardha Busi
language : en
Publisher: Springer Nature
Release Date :
Eskape Pathogens written by Siddhardha Busi and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
Eskape Pathogens
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Author : Busi Siddhardha
language : en
Publisher: Springer
Release Date : 2024-02-28
Eskape Pathogens written by Busi Siddhardha and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-02-28 with Medical categories.
This book explores the medical importance of Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp. (ESKAPE) pathogens, and the challenges posed by antibiotic resistance. It covers the antibiotic resistance profile and detection of ESKAPE pathogens, as well as the mechanistic understanding of antibiotic resistance in these pathogens. The book discusses standard microbiological techniques, including staining, morphological and cultural characteristics, biochemical properties, and serotyping, as well as nucleic acid amplification and molecular diagnostic techniques for the detection of ESKAPE pathogens. In addition, the book explores biochemical, molecular, and computational techniques for the determination of virulence factors of ESKAPE pathogens. It also examines the synthesis, structure, function, and inhibitors of virulence factors and biofilm components in these pathogens. The book explores various strategies for combating ESKAPE pathogens, including antibiotic adjuvants and their synergistic activity, phytochemicals as potential antibacterial agents, photodynamic therapy, antimicrobial peptides and antibacterial antibodies, antimicrobial activity of Nanomaterials and Nanocomposites, and bacteriophage therapy. Finally, the book discusses in silico and computational approaches for the inhibition of ESKAPE pathogens. This comprehensive book is of interest to researchers, students, and healthcare professionals interested in the diagnosis, prevention, and treatment of ESKAPE pathogens.
The Role Of Lipid A In The Virulence Of Eskape Pathogens
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Author : Toby Bartholomew
language : en
Publisher:
Release Date : 2019
The Role Of Lipid A In The Virulence Of Eskape Pathogens written by Toby Bartholomew and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with categories.
Advanced Pharmacological Uses Of Medicinal Plants And Natural Products
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Author : Singh, Ajeet
language : en
Publisher: IGI Global
Release Date : 2020-02-21
Advanced Pharmacological Uses Of Medicinal Plants And Natural Products written by Singh, Ajeet and has been published by IGI Global this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-21 with Medical categories.
A vast majority of the world’s population lacks access to essential medicines and the provision of safe healthcare services. Medicinal plants and herbal medicines can be applied for pharmacognosy, or the discovery of new drugs, or as an aid for plant physiology studies. In recent years, there has been increased interest in the search for new chemical entities and the expression of resistance of many drugs available in the market has led to a shift in paradigm towards medicinal research. Herbal treatments, the most popular form of folk medicine, may become an important way of increasing access to healthcare services. Advanced Pharmacological Uses of Medicinal Plants and Natural Products provides emerging research exploring the theoretical and practical aspects of drug discovery from natural sources that allow for the effective treatment of human health problems without any side effects, toxicity, or drug resistance. Featuring coverage on a broad range of topics such as ethnobotany, therapeutic applications, and bioactive compounds, this book is ideally designed for pharmacologists, scientists, ethnobotanists, botanists, health researchers, professors, industry professionals, and health students in fields that include pharmaceutical drug development and discovery.
The Role Of Lipid A In The Virulence Of Eskape Pathogens
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Author : Toby Leigh Bartholomew
language : en
Publisher:
Release Date : 2019
The Role Of Lipid A In The Virulence Of Eskape Pathogens written by Toby Leigh Bartholomew and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with categories.
Antimicrobial Resistance
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Author : Vinay Kumar
language : en
Publisher: Springer Nature
Release Date : 2022-01-03
Antimicrobial Resistance written by Vinay Kumar and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-03 with Medical categories.
Antimicrobial resistance (AMR) is a global public health threat that needs immediate attention and action from the scientific community. This book compiles and presents the latest and most important aspects of AMR, including the biology involved, its persistence and spread, and novel approaches to tackle this threat. The book first describes the mechanisms and spread of AMR, and then discusses the various approaches and strategies for combating it. Important topics include, microbial pathogenesis, AMR traits and major mechanisms underlying drug-resistance and the emerging strategies and technologies for combating AMR. Emphasis has been given on current developments about natural products including potent phyto-molecules, antimicrobial peptides and endophytes effective against the drug-resistant microbes and target the main drug-resistance determinants (efflux pumps, biofilms, quorum sensing, plasmids, etc.) in these bacterial pathogens. Other exciting topics include applications of nanomaterials in tackling AMR and CRISPR-Cas based precise sequence-specific antimicrobials. This informative book is meant for students and researchers in basic and medical microbiology and biotechnology. It is also useful to public health professionals and industry experts involved in AMR research and related drug-designing.
Bacterial Zoonoses
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Author : Gamal Wareth
language : de
Publisher:
Release Date : 2023
Bacterial Zoonoses written by Gamal Wareth and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023 with categories.
The extensive use of broad-spectrum antibiotics in human medicine, farm animals, and the food industry has led to multidrug-resistant bacteria. The studies carried out within the scope of this Habilitation work aimed at resistance profiling and better understanding the mechanisms of resistance development and pathogenicity in the leading multiple drug resistance (MDR) bacterial pathogens known to cause nosocomial infections, such as ESKAPE pathogens, i.e. Acinetobacter baumannii, Klebsiella pneumoniae and methicillin-resistant Staphylococcus aureus (MRSA), as well as bacteria causing neglected zoonoses such as Brucella. Combined in-vitro phenotyping with in-silico molecular analysis using Illumina MiSeq Next-Generation-Sequencing (NGS) technology and BioIT pipelines on a large number of clinical and non-clinical strains collected from Europe, Asia, and Africa were applied to achieve the goal of the One-Health approach. Antimicrobial resistance is a growing concern in veterinary medicine, the food chain, and the environment as in human medicine. However, data on animals, foods and environmental sources are still scarce. The emergence and dissemination of certain ESKAPE pathogens such as A. baumannii and K. pneumonia were reported since the late 20th century and increased over time in developed and developing countries. Whole-genome sequencing (WGS) is a powerful tool for rapidly identifying antimicrobial resistance (AMR) genes and can define resistance-associated determinants with much greater precision compared to conventional phenotypic tools. Continuous susceptibility testing, updating breakpoints, and assessing mutations that lead to resistance are needed for fastidious bacteria.
Bacterial Infectious Diseases Annual Volume 2023
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Author :
language : en
Publisher: BoD – Books on Demand
Release Date : 2023-12-20
Bacterial Infectious Diseases Annual Volume 2023 written by and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-12-20 with Medical categories.
Despite the development of numerous antimicrobial agents, the successful eradication of bacterial infections remains a challenge, and bacteria continue to pose a major public health threat. It is estimated that, due to the increasing prevalence of antibiotic resistance, infectious diseases will become a leading cause of death by 2050. The current annual focus is on the challenges and advantages in the prevention and diagnosis of infections caused by ESKAPE pathogens. The book also includes a dedicated chapter on the diagnosis of tuberculosis, one of the leading infectious causes of death worldwide. Additionally, readers will find chapters describing achievements in the diagnosis and detection of common gastrointestinal tract pathogens, Listeria monocytogenes and Campylobacter jejuni, authored by experts in their fields.
Bacterial Zoonose
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Author : Gamal Wareth
language : en
Publisher:
Release Date : 2023*
Bacterial Zoonose written by Gamal Wareth and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023* with categories.
The extensive use of broad-spectrum antibiotics in human medicine, farm animals, and the food industry has led to multidrug-resistant bacteria. The studies carried out within the scope of this Habilitation work aimed at resistance profiling and better understanding the mechanisms of resistance development and pathogenicity in the leading multiple drug resistance (MDR) bacterial pathogens known to cause nosocomial infections, such as ESKAPE pathogens, i.e. Acinetobacter baumannii, Klebsiella pneumoniae and methicillin-resistant Staphylococcus aureus (MRSA), as well as bacteria causing neglected zoonoses such as Brucella. Combined in-vitro phenotyping with in-silico molecular analysis using Illumina MiSeq Next-Generation-Sequencing (NGS) technology and BioIT pipelines on a large number of clinical and non-clinical strains collected from Europe, Asia, and Africa were applied to achieve the goal of the One-Health approach. Antimicrobial resistance is a growing concern in veterinary medicine, the food chain, and the environment as in human medicine. However, data on animals, foods and environmental sources are still scarce. The emergence and dissemination of certain ESKAPE pathogens such as A. baumannii and K. pneumonia were reported since the late 20th century and increased over time in developed and developing countries. Whole-genome sequencing (WGS) is a powerful tool for rapidly identifying antimicrobial resistance (AMR) genes and can define resistance-associated determinants with much greater precision compared to conventional phenotypic tools. Continuous susceptibility testing, updating breakpoints, and assessing mutations that lead to resistance are needed for fastidious bacteria.
Antimicrobial Drug Discovery
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Author : G. Tegos
language : en
Publisher: CABI
Release Date : 2012
Antimicrobial Drug Discovery written by G. Tegos and has been published by CABI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Anti-infective agents categories.
Drug resistance is increasing among a variety of human pathogenic microorganisms such as Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumaniii, Pseudomonas aeruginosa and Enterobacter spp. (currently dubbed the 'ESKAPE' pathogens), and has emerged as one of the most important clinical challenges of this century. Increased general awareness and fear of these pathogens means there is a growing demand for research to tackle the threat of multidrug resistance. Documenting the latest research in the field, this book discusses current and promising activities to discover new antimicrobials in five key areas: molecular genetics and systems microbiology; synthetic, computational chemistry and chemoinformatics; High Throughput Screening (HTS); non-vertebrate model hosts; and light- and nano-based technologies.