Estrogen Receptor Gene Alterations In Human Breast Cancer
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Estrogen Receptor Gene Alterations In Human Breast Cancer
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Author : Qiu-Xia Zhang
language : en
Publisher:
Release Date : 1997
Estrogen Receptor Gene Alterations In Human Breast Cancer written by Qiu-Xia Zhang and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Breast categories.
Multiple Genetic Alterations In Breast Cancer
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Author : Mien-Chie Hung
language : en
Publisher:
Release Date : 1998
Multiple Genetic Alterations In Breast Cancer written by Mien-Chie Hung and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with categories.
Overexpression of HER-2/neu (a member of the EGF receptor family) and inactivation of estrogen receptor (ER) or the tumor suppressor gene, Rb, are known to be involved in the development of human breast cancer. Expression of HER-2/neu can be regulated by ER or Rb. In addition, expression of other EGF receptor family genes (EGF receptor, HER-3 and HER-4) and Heregulin, a ligand for the HER-3 and HER-4 encoded receptor has also been found in some breast cancer cells and may contribute to malignant transformation of breast cancer. The current progress report focuses on the role of the EGF receptor family genes, Heregulin, ER, Rb, and their interrelationship in breast cancer. The technical objectives are: (1) Systematic studies on the expression of EGF receptor family genes, Heregulin, and ER in breast tumor specimens and correlation of the expression with tumor stages and patient survival; (2) Potential paracrine and autocrine loops for EGF receptor family molecules and Heregulin; (3) Effects of ER on malignant transformation phenotypes breast cancer cells; and (4) Effects of Rb on malignant transformation phenotypes breast cancer cells. Expression of EGF receptor family genes, Heregulin, and ER in the same breast tumor specimens were examined by immunohistochemical staining, and western blotting. The relationship between expression of these molecules, tumor grades, and patient's survival will be evaluated Using gene transfer technique, Heregulin, ER or Rb gene are being introduced into HER-2/neu-expressing breast cancer cells. The effect on their malignant transformations will be examined. This project may help to develop a more reliable molecular prognostic strategy and to understand how interactions among multiple genetic factors are involved in the development of breast cancer.
Biologic Effects Of Her 2 Neu Gene Overexpression And Agonists And Antagonists To The Receptor In Human Breast Cancer
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Author :
language : en
Publisher:
Release Date : 1998
Biologic Effects Of Her 2 Neu Gene Overexpression And Agonists And Antagonists To The Receptor In Human Breast Cancer written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with categories.
Alteration of the HER-2/neu gene has been shown to correlate with poor prognosis in patients whose tumors contain it. This led to studies from our laboratory indicating it may play a role in the pathogenesis of the disease for some patients. Given that the HER-2/neu gene encodes a growth factor receptor found on the membrane of tumor cells and given its potential role in the pathogenesis of some human breast cancers, it is a logical target for the development of new therapeutic approaches directed at this alteration. Studies with monoclonal antibodies directed against the extra cellular domain of the receptor indicate that many may have significant growth inhibitory properties. Recently ligands have been identified which interact either directly or indirectly with the human HER-2/neu receptor, however little is known about the biologic effects of these molecules. There is some controversy as to whether the ligands mediate growth stimulatory or growth inhibitory effects or both. A greater understanding about the biologic effects of HER- 2/neu overexpression as well as the impact of agonists and antagonists to the receptor has been and will continue to be required to fully therapeutically exploit this gene alteration in human breast cancer. Finally, little is know about the biologic effects of other molecular alterations which may occur in combination with HER-2/neu expression such as changes in the estrogen receptor. The proposal has been conducted to expand our knowledge base regarding the role of this critical gene in human breast cancer and to determine how to exploit this information clinically.
Estrogen Receptor Mutants Variants In Human Breast Cancer
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Author :
language : en
Publisher:
Release Date : 1997
Estrogen Receptor Mutants Variants In Human Breast Cancer written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with categories.
Our results suggest that estrogen receptor mediated signal transduction may be quite complex in human breast cancer. We have identified the frequent expression of several alternatively spliced variants of the classical ER-a as well as a second novel ER gene (ER-beta), at least, at the mRNA level, in both normal and neoplastic human breast tissues. Further we have both published and preliminary data showing alterations in the relative expression of several of these ER-like molecules during human breast tumorigenesis and breast cancer progression. Our data suggest a possible role(s) of these ER-like molecules in altered ER signal transduction during breast tumorigenesis and progression.
Characterization Of Functional Mutations In The Human Estrogen Receptor Gene In Breast Cancer
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Author : Shelia G. Roth
language : en
Publisher:
Release Date : 2000
Characterization Of Functional Mutations In The Human Estrogen Receptor Gene In Breast Cancer written by Shelia G. Roth and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with categories.
Estrogens Estrogen Receptor And Breast Cancer
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Author : Fritz F. Parl
language : en
Publisher: IOS Press
Release Date : 2000
Estrogens Estrogen Receptor And Breast Cancer written by Fritz F. Parl and has been published by IOS Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Breast categories.
Estrogens have been implicated to play a role in the development of breast cancer. The purpose of this book is to provide a comprehensive analysis of experimental, clinical and epidemiological evidence in support of the carcinogenicity of estrogens.
Understanding Breast Cancer Genetics
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Author : Barbara T. Zimmerman
language : en
Publisher: Univ. Press of Mississippi
Release Date : 2004
Understanding Breast Cancer Genetics written by Barbara T. Zimmerman and has been published by Univ. Press of Mississippi this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Health & Fitness categories.
Health & Sickness -- Consumer Health This book by a scientist whose background is in cellular and molecular biology examines the fearsome disease that strikes one in eight women in the United States. Although women are more likely to die of heart disease or of lung cancer, a diagnosis of breast cancer is the medical pronouncement that a woman is most likely to fear. It kills more than 40,000 Americans annually. Why are some women more vulnerable than others? The interplay between genetics and environment is suspected. Thus this book for general readers will help them understand the genetic bases of both sporadic and inherited breast cancers. Although only five to ten percent of breast cancer patients have inherited mutations in these genes, all women need to understand the genetic implications of the disease. In clear, concise language Barbara T. Zimmerman guides the reader through the complexities, discussing in detail the genes that are known to increase susceptibility and the ways they are passed on. Examining the general biology of breast cancer, Zimmerman describes how sporadic and inherited forms of the disease arise and how the location of the tumors can affect the body. She discusses genetic mutations and their roles in the development of tumors and tells how these potentially cancer-inducing genes were discovered. Covered too are the issues of risk, prevention, screening, diagnosis, therapy, and genetic testing and counseling. Zimmerman concludes with a comprehensive analysis of current research and with an emphasis on how a woman's understanding of inherited breast cancer can help doctors seeking to design better methods for prevention and therapy. A useful list of resources for further information about the genetic causes of breast cancer is included. Barbara T. Zimmerman did her graduate work in experimental pathology and her post-doctoral research in the cellular and molecular processes of disease. Widely published, she is the manager of the Denver-based firm Biomedical Communication and Consulting.
Molecular Mechanisms Of Drug Resistance And Strategies Of Sensitization In Breast Cancer 2nd Edition
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Author : Yan Cheng
language : en
Publisher: Frontiers Media SA
Release Date : 2024-01-11
Molecular Mechanisms Of Drug Resistance And Strategies Of Sensitization In Breast Cancer 2nd Edition written by Yan Cheng and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-01-11 with Medical categories.
Basic scientific background Breast cancer is one of the most common cancer and the most frequent cause of cancer death among women worldwide. Currently, subtyping breast cancers into hormone receptor (HR) positive, human epidermal growth factor receptor-2 overexpressing (HER2+), and triple negative breast cancer (TNBC) is the basis of diagnosing and treating this disease. The main treatment strategies for breast cancer include surgery, endocrine therapy, molecular targeted therapy, chemotherapy, radiotherapy, immunotherapy and gene therapy. However, resistance of breast cancer cells to chemotherapeutic agents, molecular targeted therapies and immunotherapy may occur either intrinsically or de nova, and is often ultimately responsible for treatment failure. Therefore, drug resistance poses a major challenge to breast cancer treatment. Current developments: Drug resistance in breast cancer is a complex clinical condition originating from a wide range of molecular alterations. The development of endocrine therapy resistance is believed to be associated with many cellular changes, such as ESR1 gene mutations, bypassing estrogen signaling pathway and altered tamoxifen metabolism. Meanwhile, changes in immune response, alternation of drug-binding property and downstream pathways are involved in the mechanisms of drug resistance in HER2+ breast cancer. In addition, resistance to chemotherapeutic agents predominantly arises from increased drug efflux and cross resistance. Current studies suggest that treatment strategies and therapeutics have to be designed specifically to each patient in different clinical situations. The use of modern genomic, proteomic and functional analytical techniques has contributed to identify novel genes and signaling networks involved in breast cancer drug resistance. Moreover, the use of high-throughput techniques in combination with bioinformatics and systems biology approaches has aided the interrogation of clinical samples and allowed the identification of molecular signatures and genotypes that predict responses to certain drugs. Despite much progress has been made in the field of breast cancer drug resistance, such as combination therapy and drug-loaded nanoparticles, the complexity and variability of drug resistance mechanism still inevitably lead to the continuous occurrence of drug resistance. Therefore, with the increasing amounts of anti-breast cancer agents, there are now unprecedented opportunities to understand and overcome drug resistance through further research into mechanisms and corresponding strategies, which will help achieve lasting disease control and bring survival benefits to patients with advanced cancer. Papers of interest: The current Research Topic of Frontiers in Pharmacology focuses on publishing Original Research, Review articles and Case Reports focusing on (a) elucidating mechanisms of drug resistance in breast cancer, target mutations, tumor microenvironment, undiscovered genes and signaling pathways; (b) promising drug delivery systems that can enhance the sensitivity of anti- breast cancer agents to various tumors; (c) strategies that can improve patient care during bio-chemotherapeutic treatments; (d) small molecule compounds that are effective against drug-resistant breast tumors (e) biomarkers of chemotherapy resistance in breast cancer patients and (f) in vitro and in vivo models. Guidelines for article of submission: - Authors must stick to the set guidelines for ethical practices by the Frontiers journals. - The main content of the article must have certain innovation and research significance. - The authors should describe the construction method of drug-resistant cell lines when using them for experiments in the article.
Estrogen Receptor And Breast Cancer
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Author : Xiaoting Zhang
language : en
Publisher: Springer
Release Date : 2018-10-16
Estrogen Receptor And Breast Cancer written by Xiaoting Zhang and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-16 with Medical categories.
The discovery of ER by Dr. Elwood Jensen exactly 60 years ago has not only led to the birth of a whole new vital nuclear receptor research field but also made a rapid, direct and lasting impact on the treatment and prevention of breast cancer. Since that landmark discovery, tremendous progress has been made in our understanding of the molecular functions of ER and development of targeted therapies against ER pathways for breast cancer treatment. However, there is currently no book available addressing these discoveries and recent advancement in a historical and systematic fashion. This book is intended to provide comprehensive, most up-to-date information on the history and recent advancement of ER and breast cancer by world renowned leaders in the field. These chapters include the history of the discovery of ER; physiological and pathological roles of ER; recent discovery of ER cistrome, transcriptome and its regulation of noncoding RNAs such as microRNAs and enhancer RNAs in breast cancer; development and clinical practices of the first targeted therapy Tamoxifen and other antiestrogens for breast cancer treatment; structural basis of ER and antiestrogen actions; molecular insights into endocrine resistance; the role of ER mutants, ER-beta and environmental estrogens in breast cancer; and emerging state-of-the-art therapeutic approaches currently in development to overcome treatment resistance and future perspectives. The book will provide undergraduate and graduate students, basic scientists and clinical cancer researchers, residents, fellows, as well as clinicians, oncology educators and the general public a thorough and authoritative review of these exciting topics.
Regulatory Mechanisms In Breast Cancer
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Author : Marc E. Lippman
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Regulatory Mechanisms In Breast Cancer written by Marc E. Lippman and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
In Breast Cancer: Cellular and Molecular Biology [Kluwer Academic Pub lishers, 1988], we tried to present an introduction to the emerging basic studies on steroid receptors, oncogenes, and growth factors in the regulation of normal and malignant mammary epithelium. The response to this volume was superb, indicating a tremendous interest in basic growth regulatory mechanisms governing breast cancer and controlling its malignant progres sion. In the two years since its publication, much new and exciting in formation has been published and the full interplay of regulatory mechanisms is now beginning to emerge. We have divided this book into four sections that we hope will unify important concepts and help to crystallize areas of consensus and/or disagreement among a diverse group of basic and clinical scientists working on the disease. The first section is devoted to studies on oncogenes, antioncogenes, proliferation, and tumor prognosis. The first chapter, by Sunderland and McGuire, introduces the characteristics of breast cancer as studied by patho logists to establish prognostic outcome. Of particular interest is a new proto oncogene called HER-2 (or neu), which is rapidly becoming accepted as a valuable new tumor marker of poor prognosis. The second chapter, by Lee Bookstein and Lee, introduces the best known antioncogene, the retinoblas toma antioncogene, whose expression is sometimes lost in breast cancer. Malignant progression appears to be influenced by the balance of proto oncogene and antioncogene expression.