Evidence Biased Antidepressant Prescription
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Evidence Biased Antidepressant Prescription
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Author : Michael P. Hengartner
language : en
Publisher:
Release Date : 2022
Evidence Biased Antidepressant Prescription written by Michael P. Hengartner and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with categories.
This book addresses the over-prescribing of antidepressants in people with mostly mild and subthreshold depression. It outlines the steep increase in antidepressant prescription and critically examines the current scientific evidence on the efficacy and safety of antidepressants in depression. The book is not only concerned with the conflicting views as to whether antidepressants are useful or ineffective in various forms of depression, but also aims at detailing how flaws in the conduct and reporting of antidepressant trials have led to an overestimation of benefits and underestimation of harms. The transformation of the diagnostic concept of depression from a rare but serious disorder to an over-inclusive, highly prevalent but predominantly mild and self-limiting disorder is central to the books argument. It maintains that biological reductionism in psychiatry and pharmaceutical marketing reframed depression as a brain disorder, corroborating the overemphasis on drug treatment in both research and practice. Finally, the author goes on to explore how pharmaceutical companies have distorted the scientific literature on the efficacy and safety of antidepressants and how patient advocacy groups, leading academics, and medical organisations with pervasive financial ties to the industry helped to promote systematically biased benefit-harm evaluations, affecting public attitudes towards antidepressants as well as medical education, training, and practice. Michael P. Hengartner is a senior researcher and lecturer at the Zurich University of Applied Sciences, Switzerland. He has published over 130 peer-reviewed journal articles and four book chapters. He was an expert evaluator for the European Research Council and the World Health Organization and currently is a member of the Swiss School of Public Health, the German Society for Social Psychiatry, and the European Public Health Association.
The Evidence Based Guide To Antidepressant Medications
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Author : Anthony J. Rothschild
language : en
Publisher: American Psychiatric Pub
Release Date : 2012
The Evidence Based Guide To Antidepressant Medications written by Anthony J. Rothschild and has been published by American Psychiatric Pub this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Medical categories.
"The Evidence-Based Guide to Antipsychotic Medications" is a table-rich, comprehensive overview of current knowledge regarding the use of antipsychotic medications to treat a broad range of psychiatric conditions, from anxiety disorders to schizophrenia.
Evidence Biased Antidepressant Prescription
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Author : Michael P. Hengartner
language : en
Publisher: Springer Nature
Release Date : 2021-12-09
Evidence Biased Antidepressant Prescription written by Michael P. Hengartner and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-09 with Psychology categories.
This book addresses the over-prescribing of antidepressants in people with mostly mild and subthreshold depression. It outlines the steep increase in antidepressant prescription and critically examines the current scientific evidence on the efficacy and safety of antidepressants in depression. The book is not only concerned with the conflicting views as to whether antidepressants are useful or ineffective in various forms of depression, but also aims at detailing how flaws in the conduct and reporting of antidepressant trials have led to an overestimation of benefits and underestimation of harms. The transformation of the diagnostic concept of depression from a rare but serious disorder to an over-inclusive, highly prevalent but predominantly mild and self-limiting disorder is central to the books argument. It maintains that biological reductionism in psychiatry and pharmaceutical marketing reframed depression as a brain disorder, corroborating the overemphasis on drug treatment in both research and practice. Finally, the author goes on to explore how pharmaceutical companies have distorted the scientific literature on the efficacy and safety of antidepressants and how patient advocacy groups, leading academics, and medical organisations with pervasive financial ties to the industry helped to promote systematically biased benefit-harm evaluations, affecting public attitudes towards antidepressants as well as medical education, training, and practice.
05 Use Of Antidepressant In Elderly From Current Evidence To Clinical Practice
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Author : Carlota Romeromartin
language : en
Publisher:
Release Date : 2017
05 Use Of Antidepressant In Elderly From Current Evidence To Clinical Practice written by Carlota Romeromartin and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.
USE OF ANTIDEPRESSANT IN ELDERLY: FROM CURRENT EVIDENCE TO CLINICAL PRACTICEINTRODUCTION: in choosing an antidepressant in an older depressed patients it is recommended that selection be based on the best side effect profile, lowest risk of drug-drug interactions and pharmacokinetics profile in elderly. The aim of this study was to evaluate antidepressant prescription adequacy in institutionalized elderly based on the current evidence.OBJECTIVES: describe antidepressant prescriptions in a sociosanitary center and evaluate its adequacy according to the latest guidelines for antidepressant prescription in elderly.METHODS: retrospective, descriptive and transversal study about the use of antidepressants in elderly that involved 114 institutionalized patients 65 years of age and older. Evaluation of the adequacy of antidepressants prescription was evaluated in based of: indication and dosage in elderly. We obtained data of: age, sex, diagnosis, antidepressant and dosage from the electronic prescription and a computer-based medication prescription system for dispensing drugs in the sociosanitary center.RESULTS: We included 114 institutionalized patients (60% women, average age 87 [65-99]. 48,2% (n=55) were receiving any antidepressant: 32,7% (n=18) trazodone, 27,2% (n=15) escitalopram, 18,1% (n=10) mirtazapine, 11% (n=6) paroxetine, 5,4% (n=3) venlafaxine, 3,6% (n=2) sertraline and 1,8% (n=1) fluoxetine. We detected 7,3% (n=4) trazodone and escitalopram prescriptions using a higher than advised doses in elderly patients.CONCLUSION: there are more women institutionalized in geriatric centers. Almost 50% percent of institutionalized patients were taking any antidepressant. Trazodone and escitalopram were the drugs most prescribed. Trazodone prescriptions using a higher than referred doses were detected in less than 10% in our sample.
The Evidence Based Guide To Antidepressant Medications
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Author : Anthony J. Rothschild
language : en
Publisher: American Psychiatric Pub
Release Date : 2012-09-24
The Evidence Based Guide To Antidepressant Medications written by Anthony J. Rothschild and has been published by American Psychiatric Pub this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-09-24 with Medical categories.
The second book in the Evidence-Based Guides series, The Evidence-Based Guide to Antidepressant Medications, provides a clear reference to the current knowledge and evidence base for the use of antidepressants among a variety of patients across a wide range of disorders. Chapters within this guide are authored by experts in their respective areas of practice, and synthesize a large amount of medical literature into a comprehensive, yet understandable, concise, reader-friendly guide. Each chapter covers both the FDA-approved and off-label use of antidepressant medications and the evidence base for their use. Each chapter also features useful tables pertaining to specific topics, such as summaries of uses and efficacy, and important clinical pearls of wisdom in the Key Clinical Concepts. Topics covered in chapters within this text include: Use of selective serotonin reuptake inhibitors, MAOIs, and tricyclic antidepressants in major depressive disorder, bipolar depression, psychotic depression, and treatment-resistant depression. Acute management of anxiety disorders, obsessive-compulsive disorder, and specific phobias through antidepressant use. Use of antidepressant medication in medically ill patients, such as those with cardiovascular, pulmonary, gastrointestinal, renal, and endocrine diseases, as well as cancer, chronic pain, HIV, burns and hospital-based trauma. Developmental considerations necessary to keep in mind when prescribing antidepressants to children and adolescents, along with an outline of controlled studies and their special attention to safety. Medication management in geriatric patients, including antidepressant use among depressed elderly patients with dementia, stroke, or Parkinson's disease. Risks and benefits of prescribing antidepressants during pregnancy and lactation. Together, the authors have synthesized a large amount of medical literature into a comprehensive, yet understandable, concise, reader-friendly guide. The Evidence-Based Guide to Antidepressant Medications is a must-have reference for psychiatrists and other practicing clinicians, residents in training, psychiatric nurses, social workers and researchers.
Successful Psychopharmacology Evidence Based Treatment Solutions For Achieving Remission
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Author : Stephen V. Sobel
language : en
Publisher: W. W. Norton & Company
Release Date : 2012-11-05
Successful Psychopharmacology Evidence Based Treatment Solutions For Achieving Remission written by Stephen V. Sobel and has been published by W. W. Norton & Company this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-11-05 with Psychology categories.
A guide for physicians and clinicians to understanding and choosing the proper psychiatric medications and for their patients who want to learn how this should be done. This book teaches mental health professionals how to choose and use psychotropic medications to address the biological etiology of psychiatric disease and mental health. It helps readers understand the key aspects of psychotherapy to deal with the psychosocial factors that prescribers need to know to use these medications within the context of the patient’s life. This book is based on the premise that all mental health—in the most symptomatic, impaired individual and in the most mentally healthy individual—is caused by a combination of biopsychosocial factors. Mental health professionals need to recognize and understand these factors and their interactions, and correct them. An understanding of all these factors, and of psychopharmacology, can lead to better treatment decisions. This book is for many readers: for psychiatrists who recognize the daily challenges in treating patients; for primary care physicians who identify psychiatric disorders in their patients; for non-medically-trained mental health professionals who want a more sophisticated understanding of psychopharmacology; and even for patients who want and need a better understanding of the medications their doctors have prescribed them.
Lost Connections
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Author : Johann Hari
language : en
Publisher: Bloomsbury Publishing
Release Date : 2020-11-12
Lost Connections written by Johann Hari and has been published by Bloomsbury Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-12 with Psychology categories.
THE INTERNATIONAL BESTSELLER: A radically new way of thinking about depression and anxiety 'A book that could actually make us happy' SIMON AMSTELL 'This amazing book will change your life' ELTON JOHN 'One of the most important texts of recent years' BRITISH JOURNAL OF GENERAL PRACTICE 'Brilliant, stimulating, radical' MATT HAIG 'The more people read this book, the better off the world will be' NAOMI KLEIN 'Wonderful' HILLARY CLINTON 'Eye-opening' GUARDIAN 'Brilliant for anyone wanting a better understanding of mental health' ZOE BALL 'A game-changer' DAVINA MCCALL 'Extraordinary' DR MAX PEMBERTON Depression and anxiety are now at epidemic levels. Why? Across the world, scientists have uncovered evidence for nine different causes. Some are in our biology, but most are in the way we are living today. Lost Connections offers a radical new way of thinking about this crisis. It shows that once we understand the real causes, we can begin to turn to pioneering new solutions – ones that offer real hope.
Fluoxetine
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Author : Graziano Pinna
language : en
Publisher:
Release Date : 2015-04-01
Fluoxetine written by Graziano Pinna and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-04-01 with categories.
Fluoxetine, best known by the trade name Prozac®, unlike other psychotropic drugs whose effects were serendipitously stumbled upon, was the first developed for a precise mechanism of action, that is, the ability to selectively inhibit serotonin reuptake, based upon the theory that increasing the availability of serotonin would treat major depression. Once approved by the FDA in 1987, fluoxetine quickly became the most prescribed psychotropic drug worldwide and its success in improving mood disorders has triggered the development of a large number of congener molecules, commonly known as SSRIs after their purported mechanism of action. However, a quarter of a century after its development, the idea that fluoxetine asserts its positive behavioral effect through inhibition of serotonergic reuptake is not firmly established. This book reviews several preclinical and clinical reports suggesting that the pharmacological effects of fluoxetine may be mediated by means other than the regulation of serotonin, including the regulation of gene expression, modifying epigenetic mechanisms as well as modifying microRNAs. One of the most prominent mechanisms for the therapeutic relevance of fluoxetine relates to influencing neuroplasticity by enhancing neurotropic factors, including BDNF signaling and altering adult neurogenesis. The ability of fluoxetine to rapidly increase neurosteroid levels accounts for the fast anxiolytic effects of this drug. Fluoxetine action at sigma-1 receptor or modulating glutamatergic neurotransmission as well as the combination of fluoxetine with other psychotropic drugs is discussed in relation to its therapeutic effects. While fluoxetine was primarily prescribed as an antidepressant, this drug currently represents a treatment of choice for a broad spectrum of psychiatric disorders, including post-traumatic stress disorder and a range of anxiety disorders. This drug even possesses analgesic actions and is a valuable therapy for stroke. This book also highlights emerging evidence on the gender-specific effects of fluoxetine, its potential adverse features, including its addiction liability in combination with psychostimulants, and the impact of perinatal fluoxetine exposure.
Unhinged
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Author : Daniel Carlat
language : en
Publisher: Simon and Schuster
Release Date : 2010-05-18
Unhinged written by Daniel Carlat and has been published by Simon and Schuster this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-05-18 with Psychology categories.
IN THIS STIRRING AND BEAUTIFULLY WRITTEN WAKE-UP CALL, psychiatrist Daniel Carlat exposes deeply disturbing problems plaguing his profession, revealing the ways it has abandoned its essential purpose: to understand the mind, so that psychiatrists can heal mental illness and not just treat symptoms. As he did in his hard-hitting and widely read New York Times Magazine article "Dr. Drug Rep," and as he continues to do in his popular watchdog newsletter, The Carlat Psychiatry Report, he writes with bracing honesty about how psychiatry has so largely forsaken the practice of talk therapy for the seductive—and more lucrative—practice of simply prescribing drugs, with a host of deeply troubling consequences. Psychiatrists have settled for treating symptoms rather than causes, embracing the apparent medical rigor of DSM diagnoses and prescription in place of learning the more challenging craft of therapeutic counseling, gaining only limited understanding of their patients’ lives. Talk therapy takes time, whereas the fifteen-minute "med check" allows for more patients and more insurance company reimbursement. Yet DSM diagnoses, he shows, are premised on a good deal less science than we would think. Writing from an insider’s perspective, with refreshing forthrightness about his own daily struggles as a practitioner, Dr. Carlat shares a wealth of stories from his own practice and those of others that demonstrate the glaring shortcomings of the standard fifteen-minute patient visit. He also reveals the dangers of rampant diagnoses of bipolar disorder, ADHD, and other "popular" psychiatric disorders, and exposes the risks of the cocktails of medications so many patients are put on. Especially disturbing are the terrible consequences of overprescription of drugs to children of ever younger ages. Taking us on a tour of the world of pharmaceutical marketing, he also reveals the inner workings of collusion between psychiatrists and drug companies. Concluding with a road map for exactly how the profession should be reformed, Unhinged is vital reading for all those in treatment or considering it, as well as a stirring call to action for the large community of psychiatrists themselves. As physicians and drug companies continue to work together in disquieting and harmful ways, and as diagnoses—and misdiagnoses—of mental disorders skyrocket, it’s essential that Dr. Carlat’s bold call for reform is heeded.
Escaping Depression
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Author : Dr. John A. Snyder
language : en
Publisher: AuthorHouse
Release Date : 2024-06-26
Escaping Depression written by Dr. John A. Snyder and has been published by AuthorHouse this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-06-26 with Self-Help categories.
Escaping Depression is rooted in 55 years of a psychotherapist’s clinical experience and adds a fresh perspective on the nature of joy and sadness. It challenges what most people have been persuaded to believe about “negative feelings,” the nature of depression and that certain emotional experiences constitute mental illnesses which can be cured by antidepressant medications.