Evolution Oriented Genome Personalised
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Evolution Oriented Genome Personalised
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Author : Hani K. RIZK
language : en
Publisher: Hani K. RIZK
Release Date : 2017-10-01
Evolution Oriented Genome Personalised written by Hani K. RIZK and has been published by Hani K. RIZK this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-10-01 with Science categories.
ABOUT THE BOOK The Book is an interdisciplinary textbook, written with the intent of introducing two new concepts. A. The Association Constant (Ka) versus Entropy and Chaos. 1. The formation and evolution of chemical and biological compounds on atomic and molecular scales are the work of the four natural forces, enhanced by the existence of the natural constants and their remarkable adjustment. And the work of the covalent and noncovalent forces (bonds) being derived from the natural forces. So is the evolution of living organisms but with the essential and indispensable impact of the environment, violent and punctuate. 2. The effects of the natural forces (through the covalent and noncovalent bonds) is expressed by Ka. Therefore, Ka preserves what nature accomplishes by protecting matter against the action of entropy (a faulty distribution of matter), and by preserving free energy (-ΔG) against the action of chaos (a faulty distribution of energy). Evolution is an obligation to elegance and wisdom. 3. The Book draws straight and clear line connecting general relativity, i.e. gravity (the infinite large), quantum mechanics (the infinite small), and biology (the infinite complex). B. Individuality of the Human Genome. 1. Our uniqueness as species (Homo sapiens) is invariantly encoded in the protein-coding genes (about 2 percent of our DNA). These genes are invariably found in every human being. They are species - specific, responsible for the human genesis and form the human genophenotype. Our uniqueness as individuals variantly resides in the rest of our DNA (the nonprotein-coding DNA, about 98 percent of our genome) and in the histones (chemical modifications and compaction of nucleosomes). They constitute the epigenetic factors responsible for the formation of the epigenetic phenotype, which is variably different from one individual to another. They are individual - specific. Epigenetic factors variantly effect and regulate gene expression. For example, the craniofacial structure in mice is encoded in 300 protein-coding genes. The expression of these genes is regulated by 4000 different sequences of nonprotein-coding DNA called enhancers. Thus, the number of different forms of the craniofacial structure that might develop in mice is 300 exponentiated 4000 epiphenotypes. Other than enhancers, there are the mobile elements of DNA, dsRNA-coding DNA, chemical modification of DNA (e.g., methylation), and so forth. 2. Mind exclusively exists in man as an emergent phenomenon. 3. All scientific data presented in the Book are entirely intended to reflect, to explain, or to prove the Two Concepts rather than to discuss their significances and originalities. The interdisciplinarity of the Book offers a unique opportunity for understanding how astrophysics, quantum mechanics, thermodynamics, and biology are interrelated. Hani K. Rizk
P5 Ehealth An Agenda For The Health Technologies Of The Future
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Author : Gabriella Pravettoni
language : en
Publisher: Springer Nature
Release Date : 2019-11-29
P5 Ehealth An Agenda For The Health Technologies Of The Future written by Gabriella Pravettoni and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-29 with Psychology categories.
This open access volume focuses on the development of a P5 eHealth, or better, a methodological resource for developing the health technologies of the future, based on patients’ personal characteristics and needs as the fundamental guidelines for design. It provides practical guidelines and evidence based examples on how to design, implement, use and elevate new technologies for healthcare to support the management of incurable, chronic conditions. The volume further discusses the criticalities of eHealth, why it is difficult to employ eHealth from an organizational point of view or why patients do not always accept the technology, and how eHealth interventions can be improved in the future. By dealing with the state-of-the-art in eHealth technologies, this volume is of great interest to researchers in the field of physical and mental healthcare, psychologists, stakeholders and policymakers as well as technology developers working in the healthcare sector.
Personalised Cancer Medicine
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Author : Anne Kerr
language : en
Publisher:
Release Date : 2021-02-23
Personalised Cancer Medicine written by Anne Kerr and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-02-23 with Medical categories.
Omics For Personalized Medicine
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Author : Debmalya Barh
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-10-14
Omics For Personalized Medicine written by Debmalya Barh and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-14 with Medical categories.
“Omics for Personalized Medicine” will give to its prospective readers the insight of both the current developments and the future potential of personalized medicine. The book brings into light how the pharmacogenomics and omics technologies are bringing a revolution in transforming the medicine and the health care sector for the better. Students of biomedical research and medicine along with medical professionals will benefit tremendously from the book by gaining from the diverse fields of knowledge of new age personalized medicine presented in the highly detailed chapters of the book. The book chapters are divided into two sections for convenient reading with the first section covering the general aspects of pharmaocogenomic technology that includes latest research and development in omics technologies. The first section also highlights the role of omics in modern clinical trials and even discusses the ethical consideration in pharmocogenomics. The second section is focusing on the development of personalized medicine in several areas of human health. The topics covered range from metabolic and neurological disorders to non-communicable as well as infectious diseases, and even explores the role of pharmacogenomics in cell therapy and transplantation technology. Thirty-four chapters of the book cover several aspects of pharmacogenomics and personalized medicine and have taken into consideration the varied interest of the readers from different fields of biomedical research and medicine. Advent of pharmacogenomics is the future of modern medicine, which has resulted from culmination of decades of research and now is showing the way forward. The book is an honest endeavour of researchers from all over the world to disseminate the latest knowledge and knowhow in personalized medicine to the community health researchers in particular and the educated public in general.
Genome Chaos
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Author : Henry H. Heng
language : en
Publisher: Academic Press
Release Date : 2019-05-25
Genome Chaos written by Henry H. Heng and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-25 with Medical categories.
Genome Chaos: Rethinking Genetics, Evolution, and Molecular Medicine transports readers from Mendelian Genetics to 4D-genomics, building a case for genes and genomes as distinct biological entities, and positing that the genome, rather than individual genes, defines system inheritance and represents a clear unit of selection for macro-evolution. In authoring this thought-provoking text, Dr. Heng invigorates fresh discussions in genome theory and helps readers reevaluate their current understanding of human genetics, evolution, and new pathways for advancing molecular and precision medicine. Bridges basic research and clinical application and provides a foundation for re-examining the results of large-scale omics studies and advancing molecular medicine Gathers the most pressing questions in genomic and cytogenomic research Offers alternative explanations to timely puzzles in the field Contains eight evidence-based chapters that discuss 4d-genomics, genes and genomes as distinct biological entities, genome chaos and macro-cellular evolution, evolutionary cytogenetics and cancer, chromosomal coding and fuzzy inheritance, and more
The Princeton Guide To Evolution
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Author : David A. Baum
language : en
Publisher: Princeton University Press
Release Date : 2013-11-04
The Princeton Guide To Evolution written by David A. Baum and has been published by Princeton University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-04 with Science categories.
The Princeton Guide to Evolution is a comprehensive, concise, and authoritative reference to the major subjects and key concepts in evolutionary biology, from genes to mass extinctions. Edited by a distinguished team of evolutionary biologists, with contributions from leading researchers, the guide contains some 100 clear, accurate, and up-to-date articles on the most important topics in seven major areas: phylogenetics and the history of life; selection and adaptation; evolutionary processes; genes, genomes, and phenotypes; speciation and macroevolution; evolution of behavior, society, and humans; and evolution and modern society. Complete with more than 100 illustrations (including eight pages in color), glossaries of key terms, suggestions for further reading on each topic, and an index, this is an essential volume for undergraduate and graduate students, scientists in related fields, and anyone else with a serious interest in evolution. Explains key topics in some 100 concise and authoritative articles written by a team of leading evolutionary biologists Contains more than 100 illustrations, including eight pages in color Each article includes an outline, glossary, bibliography, and cross-references Covers phylogenetics and the history of life; selection and adaptation; evolutionary processes; genes, genomes, and phenotypes; speciation and macroevolution; evolution of behavior, society, and humans; and evolution and modern society
Evolution Driven By Organismal Behavior
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Author : Rui Diogo
language : en
Publisher: Springer
Release Date : 2017-03-08
Evolution Driven By Organismal Behavior written by Rui Diogo and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-08 with Science categories.
This book proposes a new way to think about evolution. The author carefully brings together evidence from diverse fields of science. In the process, he bridges the gaps between many different--and usually seen as conflicting--ideas to present one integrative theory named ONCE, which stands for Organic Nonoptimal Constrained Evolution. The author argues that evolution is mainly driven by the behavioral choices and persistence of organisms themselves, in a process in which Darwinian natural selection is mainly a secondary--but still crucial--evolutionary player. Within ONCE, evolution is therefore generally made of mistakes and mismatches and trial-and-error situations, and is not a process where organisms engage in an incessant, suffocating struggle in which they can't thrive if they are not optimally adapted to their habitats and the external environment. Therefore, this unifying view incorporates a more comprehensive view of the diversity and complexity of life by stressing that organisms are not merely passive evolutionary players under the rule of external factors. This insightful and well-reasoned argument is based on numerous fascinating case studies from a wide range of organisms, including bacteria, plants, insects and diverse examples from the evolution of our own species. The book has an appeal to researchers, students, teachers, and those with an interest in the history and philosophy of science, as well as to the broader public, as it brings life back into biology by emphasizing that organisms, including humans, are the key active players in evolution and thus in the future of life on this wonderful planet.
Human Gene Mutation
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Author : David N. Cooper
language : en
Publisher: Taylor & Francis
Release Date : 1995
Human Gene Mutation written by David N. Cooper and has been published by Taylor & Francis this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with Science categories.
Within the last decade, much progress has been made in the analysis and diagnosis of human inherited disease, and in the characterization of the underlying genes and their associated pathological lesions.
Genes On The Couch
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Author : Paul Gilbert
language : en
Publisher: Routledge
Release Date : 2014-07-10
Genes On The Couch written by Paul Gilbert and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-07-10 with Psychology categories.
Philosophers and therapists have long theorised about how psychological mechanisms for love, jealousy, anxiety, depression and many other human characteristics may have evolved over millions of years. In the dawn of the new insights on evolution, provided by Darwin's theories of natural selection, Freud, Jung and Klein sought to identify and understand human motives, emotions and information processing as functions deeply-rooted in our evolved history. Despite this promising start and major developments in modern evolutionary psychology, anthropology and sociobiology, the last fifty years has seen little in the way of therapies derived from an evolutionary understanding of human psychology. The contributors to this timely book illuminate how an evolution focused approach to psychopathology can offer new insights for different schools of therapy and provide a rationale for therapeutic integration. Genes on the Couch brings together respected clinicians who have integrated evolutionary insights into their case conceptualisations and therapeutic interventions. Various psychotherapy schools are represented, and each author provides illustrative examples of the interventions used. Specific topics addressed include the nature of evolved mental mechanisms; regulation/dysregulation of internal processes; attachment and kinship in therapy; the importance of internalising warmth as a therapeutic goal; kin selection and incest avoidance; co-operation and deception in social relations; difficulties in working with certain male clients; gender differences in therapy and the roles of shame and guilt in treatment. Providing up-to-date summaries of recent thinking in this increasing important but diverse area, Genes on the Couch will be of interest to psychotherapists, psychiatrists and a wide range of mental health professionals.
Toward Precision Medicine
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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 2012-01-16
Toward Precision Medicine written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-16 with Medical categories.
Motivated by the explosion of molecular data on humans-particularly data associated with individual patients-and the sense that there are large, as-yet-untapped opportunities to use this data to improve health outcomes, Toward Precision Medicine explores the feasibility and need for "a new taxonomy of human disease based on molecular biology" and develops a potential framework for creating one. The book says that a new data network that integrates emerging research on the molecular makeup of diseases with clinical data on individual patients could drive the development of a more accurate classification of diseases and ultimately enhance diagnosis and treatment. The "new taxonomy" that emerges would define diseases by their underlying molecular causes and other factors in addition to their traditional physical signs and symptoms. The book adds that the new data network could also improve biomedical research by enabling scientists to access patients' information during treatment while still protecting their rights. This would allow the marriage of molecular research and clinical data at the point of care, as opposed to research information continuing to reside primarily in academia. Toward Precision Medicine notes that moving toward individualized medicine requires that researchers and health care providers have access to very large sets of health- and disease-related data linked to individual patients. These data are also critical for developing the information commons, the knowledge network of disease, and ultimately the new taxonomy.