Genome Chaos
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Genome Chaos
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Author : Henry H. Heng
language : en
Publisher: Academic Press
Release Date : 2019-05-25
Genome Chaos written by Henry H. Heng and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-25 with Medical categories.
Genome Chaos: Rethinking Genetics, Evolution, and Molecular Medicine transports readers from Mendelian Genetics to 4D-genomics, building a case for genes and genomes as distinct biological entities, and positing that the genome, rather than individual genes, defines system inheritance and represents a clear unit of selection for macro-evolution. In authoring this thought-provoking text, Dr. Heng invigorates fresh discussions in genome theory and helps readers reevaluate their current understanding of human genetics, evolution, and new pathways for advancing molecular and precision medicine. Bridges basic research and clinical application and provides a foundation for re-examining the results of large-scale omics studies and advancing molecular medicine Gathers the most pressing questions in genomic and cytogenomic research Offers alternative explanations to timely puzzles in the field Contains eight evidence-based chapters that discuss 4d-genomics, genes and genomes as distinct biological entities, genome chaos and macro-cellular evolution, evolutionary cytogenetics and cancer, chromosomal coding and fuzzy inheritance, and more
Debating Cancer
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Author : Henry H Heng
language : en
Publisher: World Scientific
Release Date : 2015-10-08
Debating Cancer written by Henry H Heng and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-10-08 with Science categories.
Cancer research is at a crossroads. Traditionally, cancer has been thought of as a disease of gene mutation, where the stepwise accumulation of cancer gene mutations is the key, and the identification of common gene mutations has been considered to be essential for diagnosis and treatment. Despite extensive research efforts and accumulated knowledge on cancer genes and pathways, the clinical benefits of this traditional approach have been limited. Recently, cancer genome sequencing has revealed an extensive amount of genetic heterogeneity where the long-expected common mutation drivers have been difficult, if not impossible, to identify. These realities ultimately challenge the conceptual framework of current cancer biology. This book introduces a new concept of genome theory of cancer evolution, in an attempt to unify the field. Many important and representative, but often confusing, questions and paradoxes are critically analyzed. By comparing gene- and genome-based theories, the hidden flaws of many popular viewpoints are addressed. This discussion is intended to initiate a much-needed critical re-evaluation of current cancer research. Contents:Introduction: Why Debate Cancer, and Why Now?The Gene Mutation Theory of CancerAlternative Theories to Explain CancerThe Surprise Cancer Genome Landscape Revealed by Cancer Genome Sequencing ProjectsUnraveling the Mystery of Cancer: Understanding Genome Variation Mediated Cancer EvolutionSignificance of the Insignificant: Why "Noise" is Essential for Cancer EvolutionDo Different Cancers Represent Different Species?Facts vs. Myths Readership: This book will be appreciated by the research community at large. It will also serve as an excellent resource for a wide range of readers, including researchers, graduate students, physicians, science reporters, and even policy-makers. Key Features:Currently, there exists no such book. This title represents a much-needed effort to systematically re-examine many concepts in cancer research which have remained relatively the same for decadesThe topics discussed are well-known paradoxes to researchers (over 50 of them). Addressing these questions will not only provide answers to key puzzles in the field but also introduce a new conceptual framework, the genome-based cancer evolution theoryThis book will encourage new ideas/approaches that bridge basic research and clinical applications. The analysis of provocative questions will spur a long overdue debate on this subjectKeywords:Cancer Evolution;Genome Theory;Cancer Heterogeneity;Cancer Landscape;Cancer Theories;Drug Resistance;Cancer Diagnosis;Cancer Research
The Nonlinear Workbook
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Author : Willi-Hans Steeb
language : en
Publisher: World Scientific Publishing Company
Release Date : 2011-03-16
The Nonlinear Workbook written by Willi-Hans Steeb and has been published by World Scientific Publishing Company this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-03-16 with Science categories.
The Nonlinear Workbook provides a comprehensive treatment of all the techniques in nonlinear dynamics together with C++, Java and SymbolicC++ implementations. The book not only covers the theoretical aspects of the topics but also provides the practical tools. To understand the material, more than 100 worked out examples and 150 ready to run programs are included. New topics added to the fifth edition are Langton's ant, chaotic data communication, self-controlling feedback, differential forms and optimization, T-norms and T-conorms with applications.
The Chaos Machine
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Author : Max Fisher
language : en
Publisher: Hachette UK
Release Date : 2022-09-06
The Chaos Machine written by Max Fisher and has been published by Hachette UK this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-06 with Social Science categories.
Finalist for the Helen Bernstein Book Award for Excellence in Journalism From a New York Times investigative reporter, this “authoritative and devastating account of the impacts of social media” (New York Times Book Review) tracks the high-stakes inside story of how Big Tech’s breakneck race to drive engagement—and profits—at all costs fractured the world. The Chaos Machine is “an essential book for our times” (Ezra Klein). We all have a vague sense that social media is bad for our minds, for our children, and for our democracies. But the truth is that its reach and impact run far deeper than we have understood. Building on years of international reporting, Max Fisher tells the gripping and galling inside story of how Facebook, Twitter, YouTube, and other social network preyed on psychological frailties to create the algorithms that drive everyday users to extreme opinions and, increasingly, extreme actions. As Fisher demonstrates, the companies’ founding tenets, combined with a blinkered focus on maximizing engagement, have led to a destabilized world for everyone. Traversing the planet, Fisher tracks the ubiquity of hate speech and its spillover into violence, ills that first festered in far-off locales, to their dark culmination in America during the pandemic, the 2020 election, and the Capitol Insurrection. Through it all, the social-media giants refused to intervene in any meaningful way, claiming to champion free speech when in fact what they most prized were limitless profits. The result, as Fisher shows, is a cultural shift toward a world in which people are polarized not by beliefs based on facts, but by misinformation, outrage, and fear. His narrative is about more than the villains, however. Fisher also weaves together the stories of the heroic outsiders and Silicon Valley defectors who raised the alarm and revealed what was happening behind the closed doors of Big Tech. Both panoramic and intimate, The Chaos Machine is the definitive account of the meteoric rise and troubled legacy of the tech titans, as well as a rousing and hopeful call to arrest the havoc wreaked on our minds and our world before it’s too late.
Mapping And Sequencing The Human Genome
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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 1988-01-01
Mapping And Sequencing The Human Genome written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988-01-01 with Science categories.
There is growing enthusiasm in the scientific community about the prospect of mapping and sequencing the human genome, a monumental project that will have far-reaching consequences for medicine, biology, technology, and other fields. But how will such an effort be organized and funded? How will we develop the new technologies that are needed? What new legal, social, and ethical questions will be raised? Mapping and Sequencing the Human Genome is a blueprint for this proposed project. The authors offer a highly readable explanation of the technical aspects of genetic mapping and sequencing, and they recommend specific interim and long-range research goals, organizational strategies, and funding levels. They also outline some of the legal and social questions that might arise and urge their early consideration by policymakers.
Genome The Autobiography Of A Species In 23 Chapters
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Author : Matt Ridley
language : en
Publisher: HarperCollins UK
Release Date : 2017-04-27
Genome The Autobiography Of A Species In 23 Chapters written by Matt Ridley and has been published by HarperCollins UK this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-04-27 with Science categories.
The most important investigation of genetic science since The Selfish Gene, from the author of the critically acclaimed and best-selling The Red Queen and The Origins of Virtue.
The Selfish Gene
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Author : Richard Dawkins
language : en
Publisher: Oxford University Press, USA
Release Date : 1989
The Selfish Gene written by Richard Dawkins and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989 with Medical categories.
Science need not be dull and bogged down by jargon, as Richard Dawkins proves in this entertaining look at evolution. The themes he takes up are the concepts of altruistic and selfish behaviour; the genetical definition of selfish interest; the evolution of aggressive behaviour; kinshiptheory; sex ratio theory; reciprocal altruism; deceit; and the natural selection of sex differences. 'Should be read, can be read by almost anyone. It describes with great skill a new face of the theory of evolution.' W.D. Hamilton, Science
The Collapse Of Chaos
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Author : Ian Stewart
language : en
Publisher: Penguin UK
Release Date : 2000-03-02
The Collapse Of Chaos written by Ian Stewart and has been published by Penguin UK this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-03-02 with Science categories.
Do we live in a simple or a complex universe? Jack Cohen and Ian Stewart explore the ability of complicated rules to generate simple behaviour in nature through 'the collapse of chaos'. 'The most startling, thought-provoking book I've read all year. I was pleased to learn that most of the things I thought I knew were wrong' -- Terry Pratchett
Chaos Engineering
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Author : Casey Rosenthal
language : en
Publisher: "O'Reilly Media, Inc."
Release Date : 2020-04-06
Chaos Engineering written by Casey Rosenthal and has been published by "O'Reilly Media, Inc." this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-06 with Computers categories.
As more companies move toward microservices and other distributed technologies, the complexity of these systems increases. You can't remove the complexity, but through Chaos Engineering you can discover vulnerabilities and prevent outages before they impact your customers. This practical guide shows engineers how to navigate complex systems while optimizing to meet business goals. Two of the field's prominent figures, Casey Rosenthal and Nora Jones, pioneered the discipline while working together at Netflix. In this book, they expound on the what, how, and why of Chaos Engineering while facilitating a conversation from practitioners across industries. Many chapters are written by contributing authors to widen the perspective across verticals within (and beyond) the software industry. Learn how Chaos Engineering enables your organization to navigate complexity Explore a methodology to avoid failures within your application, network, and infrastructure Move from theory to practice through real-world stories from industry experts at Google, Microsoft, Slack, and LinkedIn, among others Establish a framework for thinking about complexity within software systems Design a Chaos Engineering program around game days and move toward highly targeted, automated experiments Learn how to design continuous collaborative chaos experiments
Deep Simplicity
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Author : John Gribbin
language : en
Publisher: Penguin UK
Release Date : 2009-08-27
Deep Simplicity written by John Gribbin and has been published by Penguin UK this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-08-27 with Science categories.
'Gribbin takes us through the basics with his customary talent for accessibility and clarity' Sunday Times The world around us can be a complex, confusing place. Earthquakes happen without warning, stock markets fluctuate, weather forecasters seldom seem to get it right - even other people continue to baffle us. How do we make sense of it all? In fact, John Gribbin reveals, our seemingly random universe is actually built on simple laws of cause and effect that can explain why, for example, just one vehicle braking can cause a traffic jam; why wild storms result from a slight atmospheric change; even how we evolved from the most basic materials. Like a zen painting, a fractal image or the pattern on a butterfly's wings, simple elements form the bedrock of a sophisticated whole. Synthesizing chaos and complexity theory for the perplexed, Deep Simplicity brilliantly illuminates the harmony underlying our existence.