Examining Biological Relevance Of Fused S Heterocycles
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Examining Biological Relevance Of Fused S Heterocycles
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Author : Kulkarni, Shrikaant
language : en
Publisher: IGI Global
Release Date : 2024-11-27
Examining Biological Relevance Of Fused S Heterocycles written by Kulkarni, Shrikaant and has been published by IGI Global this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-11-27 with Science categories.
Fused S-heterocycles have gained attention in medicinal chemistry and drug discovery due to their promising biological activity and pharmacological potential. The unique electronic properties and structural diversity of fused S-heterocycles make them valuable in the development of therapeutics, particularly in the treatment of diseases like cancer, infectious diseases, and neurological disorders. Examining the biological relevance of these compounds involves understanding how their chemical properties influence interactions with biological targets. As research into their biological activity increases, fused S-heterocycles emerge as important candidates for the development of next-generation drugs with enhanced specificity, efficacy, and minimal side effects. Further exploration may help integrate fused S-heterocycles into standard medical practice. Examining Biological Relevance of Fused S-Heterocycles explores the synthetic methods used to create fused S-heterocycles. It covers both traditional and modern techniques, offering an understanding of the synthesis, structure, reactivity, and diverse applications of these compounds. This book covers topics such as therapeutics, chemistry, and medical treatment, and is a useful resource for medical professionals, healthcare workers, engineers, data scientists, biologists, academicians, and researchers.
S Heterocycles
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Author : Keshav Lalit Ameta
language : en
Publisher: Springer Nature
Release Date : 2024-08-02
S Heterocycles written by Keshav Lalit Ameta and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-08-02 with Science categories.
This book presents the recent research on sulfur-containing heterocyclic scaffolds that are crucial for biological processes. The numerous synthetic techniques utilized for the design and synthesis of different sized S-heterocycles, particularly biologically active frameworks with their pharmacological significance, are discussed in this book. This book is a useful reference for students, researchers and professionals working in the chemical and pharmaceutical industries.
Synthesis Of 6 And 7 Membered Heterocycles
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Author : Navjeet Kaur
language : en
Publisher: Elsevier
Release Date : 2023-09-23
Synthesis Of 6 And 7 Membered Heterocycles written by Navjeet Kaur and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-23 with Science categories.
Synthesis of Six- and Seven-Membered Heterocycles: The Role of DMF and its Synthesis compares different synthetic approaches using DMF, including the advantages and disadvantages of those reactions, green methods, and the sustainability of reported synthetic methodologies, especially the microwave methods. The book presents several methodologies for the synthesis of six- and seven-membered heterocyclic compounds using dimethylformamide. Users will find the most up-to-date information in this fast-moving field which can be particularly challenging. With DMF drawing the attention of synthetic organic chemists, this book will help readers understand further developments in the uses of dimethylformamide beyond just its use as a polar solvent. As it can be expected that the use of dimethylformamide as a precursor will continue to grow in organic synthesis with new applications in sustainable and green chemistry, this book provides an ideal primer on the topics covered. - Compares different methods, reagents, reaction conditions, advantages and disadvantages - Discusses and compares different methodologies with green techniques - Includes reaction schemes, reaction mechanisms and the structure of reactive intermediates
Green Synthetic Approaches For Biologically Relevant Heterocycles
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Author : Goutam Brahmachari
language : en
Publisher: Elsevier
Release Date : 2014-11-08
Green Synthetic Approaches For Biologically Relevant Heterocycles written by Goutam Brahmachari and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-08 with Science categories.
Green Synthetic Approaches for Biologically Relevant Heterocycles reviews this significant group of organic compounds within the context of sustainable methods and processes. Each clearly structured chapter features in-depth coverage of various green protocols for the synthesis of a wide variety of bioactive heterocycles classified on the basis of ring-size and/or presence of heteratoms(s). Techniques covered include microwave heating, ultrasound, ionic liquids, solid phase, solvent-free, heterogeneous catalysis, and aqueous media, along with multi-component reaction strategies. This book also integrates advances in green chemistry research into industrial applications and process developments. Green Synthetic Approaches for Biologically Relevant Heterocycles is an essential resource on green chemistry technologies for academic researchers, R&D professionals, and students working in medicinal, organic, natural product, and agricultural chemistry. - Includes global coverage of a wide variety of green synthetic techniques - Features cutting-edge research in the field of bioactive heterocyclic compounds - Focuses extensively on applications, with numerous examples of biologically relevant heterocycles
Fused Pyrimidine Based Drug Discovery
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Author : Raj Kumar
language : en
Publisher: Elsevier
Release Date : 2022-10-08
Fused Pyrimidine Based Drug Discovery written by Raj Kumar and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-10-08 with Science categories.
Fused Pyrimidine-Based Drug Discovery covers all categories of fused-pyrimidines along with pharmacological and in silico studies. It covers the chemistry and biological activities, as well as the design of novel fused-pyrimidine scaffolds. N-Heterocyclic scaffolds are found in most known drug candidates, and are of interest to medicinal and organic chemists to design, synthesize and evaluate their biological properties. A variety of fused-pyrimidine molecules have been synthesized and extracted from natural resources, and are found to exhibit various biological activities such as antifolates, anticancer agents, analgesics, antimetabolites, CNS active agents and many more. Some of these scaffolds like purines are also known to have involvement in biological processes and are part of the framework of genetic material. This book focuses on the classification, structural chemistry, and chemical and physical properties along with various approaches for their synthesis. This book is ideal for researchers in organic chemistry both in academic and industrial settings, postgraduates in chemistry and medicinal chemistry. - Covers US FDA approved fused pyrimidine containing drugs and their analyses - Comprises classification based upon fusion of carbocyclic/heterocyclic rings(s) with a pyrimidine ring, and features their synthetic schemes, approaches and strategies - Includes new fused-pyrimidine scaffolds, allowing the researcher to predict the mechanisms involved in their synthesis - Covers fused pyrimidine containing bioactive compounds from the natural sources - Covers in silico studies of known fused pyrimidines and Structure-Activity Relationship (SAR), which will encourage the development of new or modified existing scaffolds with specific biological activities
The Chemical Biology Of Carbon
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Author : Christopher T. Walsh
language : en
Publisher: Royal Society of Chemistry
Release Date : 2023-04-05
The Chemical Biology Of Carbon written by Christopher T. Walsh and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-04-05 with Science categories.
Building upon the previous volumes, The Chemical Biology of Sulfur, The Chemical Biology of Phosphorus, and The Chemical Biology of Nitrogen, this book examines the organic chemistry of life, The Chemical Biology of Carbon. It examines chemical biology open to carbon-containing natural metabolites that allow both retrospective and predictive behaviours of both biosynthetic and degradative metabolism in primary and secondary pathways. This book also notes the centrality of a core set of heterocycles in metabolites and coenzyme forms of vitamins and how that chemistry enables life. The organic chemical fundamental considerations are always tied to specific metabolites and metabolic transformations. This context makes this volume not a classical organic or even bioorganic approach to organic chemistry in vivo but instead a unique analysis of how the rules and reactivities of organic chemistry underlie the organic chemistry of life. The Chemical Biology of Carbon is an ideal reference and guide for medicinal chemists, chemical biologists, organic chemists as well as postgraduate, graduate and advanced undergraduate students in these areas and related disciplines.
The Chemical Biology Of Nitrogen
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Author : Christopher Walsh
language : en
Publisher: Royal Society of Chemistry
Release Date : 2021-05-21
The Chemical Biology Of Nitrogen written by Christopher Walsh and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-05-21 with Science categories.
The Chemical Biology of Nitrogen book provides a chemocentric approach to both the inorganic and organic chemical biology of nitrogen. Following an introduction to nitrogen trivalency the book progresses through the logic of inorganic nitrogen metabolism and organic nitrogen metabolites to nitrogen proteomics.
S Heterocycles
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Author : Shrikaant Kulkarni
language : en
Publisher: Royal Society of Chemistry
Release Date : 2024-07-24
S Heterocycles written by Shrikaant Kulkarni and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-07-24 with Medical categories.
Heterocyclic compounds are vital in synthetic chemistry, pharmaceuticals, agrochemicals, and materials science. The concept of S-heterocyclic compounds revolves around organic compounds that contain heterocyclic rings, and sulfur (S) is one of the heteroatoms within the ring structure. S-enabled heterocycles have emerged as one of the key classes of heterocycles and have attracted tremendous attention attributed to their identity as ‘privileged pharmacological structures’ across natural products and highly active pharmaceutical agents. This edited volume reports the latest developments in practical and selective reactions and methods and provides details of the structural diversity of heterocycles. Together, the chapters provide a comprehensive view of the diversity of methods, properties, and the variety of applications in the construction of S-heterocycles. Divided into four parts, the book covers in part one the chemistry, synthesis pathways, property profile, and applications of thiazoles, and includes five chapters. Part two details thiadiazoles and part three thiopyrans, thiazine, and thiazepine. Lastly, part four focuses on thiophenes. This volume will be of immense help to academicians, researchers, and students pursuing research and looking at the future of heterocyclic chemistry.
Pharmaceutical Organic Chemistry Iii
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Author : Dr. Srikanth Kumar Karumanchi
language : en
Publisher: JEC PUBLICATION
Release Date :
Pharmaceutical Organic Chemistry Iii written by Dr. Srikanth Kumar Karumanchi and has been published by JEC PUBLICATION this book supported file pdf, txt, epub, kindle and other format this book has been release on with Medical categories.
The creation of complex molecules that provide the basis for drug discovery is made possible by the dynamic fields of organic stereochemistry and heterocyclic chemistry, which are at the core of contemporary medicinal chemistry. Fundamentals of Organic Stereochemistry and Heterocyclic Chemistry: Synthesis, Reactions, and Medicinal Applications is a book that combines basic principles with cutting-edge knowledge of the most recent synthetic methods and their uses in medicinal chemistry to offer a thorough and approachable introduction to these important areas of chemistry. The fundamental principles of molecular architecture are derived from organic stereochemistry, which determines the three-dimensional configurations that impact molecules' biological functions. Comprehending stereochemistry is essential in creating medications with accurate safety, potency, and efficacy profiles. However, because of their wide range of biological activity and structural diversity, heterocyclic compounds—which make up one of the largest families of organic molecules—are essential in pharmaceutical research. The foundation of many pharmaceutical substances, including antibiotics and anticancer drugs, is formed by these two fields working together. In addition to examining the synthetic processes, reaction mechanisms, and potential applications in medicine, the main objective of this book is to provide a comprehensive introduction to the principles of stereochemistry and heterocyclic chemistry. It presents ideas in an organized and understandable way, making it useful for professionals, researchers, and students alike. In an effort to close the knowledge gap between theory and practice, the chapters develop in increasing detail, going from fundamental concepts to sophisticated uses in drug production. The growing need for novel therapeutic compounds that target complicated disorders and a better comprehension of the chemical frameworks behind their production have driven us to write this book. We hope that this collection will be useful as a reference for scholars as well as an inspiration to those working on the identification and creation of new medicinal agents. We want to thank everyone who helped with this project, especially my students and colleagues, whose advice and thoughts were constructive. I also want to thank the readers who will join me on this intellectual adventure. The knowledge they will gain from this will help them better grasp these critical facets of organic chemistry and encourage them to do more research. We sincerely hope that this book will be helpful to academics and professionals working in the field of medicinal chemistry. It is a starting point for understanding the synthesis, reactions, and uses of heterocyclic compounds and stereochemistry in drug design and development.
Five Membered Bioactive N And O Heterocycles Models And Medical Applications
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Author : Kulkarni, Shrikaant
language : en
Publisher: IGI Global
Release Date : 2025-02-21
Five Membered Bioactive N And O Heterocycles Models And Medical Applications written by Kulkarni, Shrikaant and has been published by IGI Global this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-02-21 with Technology & Engineering categories.
Five-membered bioactive heterocycles offer an in-depth exploration of the synthesis, properties, and wide-ranging medical applications of these molecular structures. From serving as the structural core of numerous pharmaceutical agents to directly engaging with biological targets, these molecules play a pivotal role in drug discovery and development. With applications spanning from antimicrobial and anticancer agents to treatments for neurological disorders, these compounds are integral to the design of targeted therapies. Their versatility and bioactivity make them valuable models for drug discovery, offering novel approaches to addressing a wide range of medical challenges. As research advances, the continued exploration of five-membered N- and O-heterocycles may help with the development of innovative treatments and the improvement of healthcare outcomes. Five Membered Bioactive N and O-Heterocycles: Models and Medical Applications examines the synthetic methodologies employed in the construction of five-membered heterocycles, providing insights into the strategies and techniques utilized to access these diverse compounds. It delves into their synthetic pathways, including both traditional and modern synthetic approaches, along with the key factors influencing regio- and stereo-selectivity. This book covers topics such as bioactivity, chemistry, and pharmacology, this book is an excellent resource for chemists, pharmaceutical researchers and professionals, biochemists, molecular biologists, graduate and postgraduate students, academicians, healthcare professionals, and more.