Excitatory Amino Acids And Second Messenger Systems


Excitatory Amino Acids And Second Messenger Systems
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Excitatory Amino Acids And Second Messenger Systems


Excitatory Amino Acids And Second Messenger Systems
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Author : Vivian I. Teichberg
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-21

Excitatory Amino Acids And Second Messenger Systems written by Vivian I. Teichberg and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-21 with Medical categories.


This book deals with the mechanisms through which glutamate, the principal excitatory neurotransmitter in the mammalian central nervous system, modifies neuronal membrane functions and intraneuronal functions. Discussed are the hypothesis that the glutamate receptor signal may be processed by archidonic acid, nitric oxide, Ca 2+ and protein kinases. A key routefor glutamate receptors in synaptic plasticity and neuronal degeneration is beeing increasingly recognized. This is one of the most important new areas of endeavor by neurobiologists. The book, written by some of the most wellknown scientists in this field, provides a comprehensive reviewof conceptual approaches along with experiments showing a link between excitation mediated by glutamate and second messenger systems.



Excitatory Amino Acids And Second Messenger Systems


Excitatory Amino Acids And Second Messenger Systems
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Author : Vivian I. Teichberg
language : en
Publisher: Springer
Release Date : 1992

Excitatory Amino Acids And Second Messenger Systems written by Vivian I. Teichberg and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with Excitatory amino acids categories.




Excitatory Amino Acid Transmission In Health And Disease


Excitatory Amino Acid Transmission In Health And Disease
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Author : Robert Balazs
language : en
Publisher: Oxford University Press
Release Date : 2006

Excitatory Amino Acid Transmission In Health And Disease written by Robert Balazs and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Medical categories.


Drawing on the individual properties of the receptors, transporters, and functional architecture of the synapse, the concluding chapters describe the functional integration of these components in the more complex physiological processes of plasticity and pathology. Recognition that the regulation of excitatory amino acid receptor activity underlies the pathology of many neurological diseases, including stroke, Altheimer's disease, and schizophrenia, has opened up an exciting frontier that will allow the translation of our understanding of these basic mechanisms into new concepts of pathology and new therapeutic strategies.



The Metabotropic Glutamate Receptors


The Metabotropic Glutamate Receptors
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Author : P. Jeffrey Conn
language : en
Publisher: Humana Press
Release Date : 1994-09-29

The Metabotropic Glutamate Receptors written by P. Jeffrey Conn and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994-09-29 with Medical categories.


It is the goal of The Metabotropic Glutamate Receptors to provide acomprehensive and forward-thinking review ofthe tremen dous advances that have occurred in less than a decade of metabotropic glutamate receptors (mGluR) research. Virtually every areaof mGluR research is covered, including the molecular biology, pharmacology, anatomical distribution, and physiological and pathological roles of mGluRs. It is our intention that this volume not only summarize what is now known about the mGluRs, but also illuminate the areas in which there is the greatest need for focused research. Glutamic acid is an amino acid that has long been known to play several important metabolic roles in central and peripheral tissues and to be a component of several naturally occurring molecules. The first evidence that glutamate mayaIso serve as a neurotransmitter in the central nervous system (CNS) came in the late 1950s and early 1960s when glutamate and other acidic amino acids were found to induce behavioral convulsions when topically applied to the cortex and to excite a wide variety of central neurons. These findings spurred a massive research effort that quickly established glutamate as the pri mary excitatory neurotransmitter in the vertebrate CNS. One of the most striking characteristics of glutamate that was quickly recognized was its ubiquitous role in serving as the neurotransmitter at the vast majority of excitatory synapses in the brain. It is now clear that most central neuronal circuits involve glutamatergic neurotransmission at some level.



Glutamate Related Biomarkers In Drug Development For Disorders Of The Nervous System


Glutamate Related Biomarkers In Drug Development For Disorders Of The Nervous System
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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 2011-07-05

Glutamate Related Biomarkers In Drug Development For Disorders Of The Nervous System written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-07-05 with Medical categories.


Glutamate is the most pervasive neurotransmitter in the central nervous system (CNS). Despite this fact, no validated biological markers, or biomarkers, currently exist for measuring glutamate pathology in CNS disorders or injuries. Glutamate dysfunction has been associated with an extensive range of nervous system diseases and disorders. Problems with how the neurotransmitter glutamate functions in the brain have been linked to a wide variety of disorders, including schizophrenia, Alzheimer's, substance abuse, and traumatic brain injury. These conditions are widespread, affecting a large portion of the United States population, and remain difficult to treat. Efforts to understand, treat, and prevent glutamate-related disorders can be aided by the identification of valid biomarkers. The Institute of Medicine's Forum on Neuroscience and Nervous System Disorders held a workshop on June 21-22, 2010, to explore ways to accelerate the development, validation, and implementation of such biomarkers. Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System: Workshop Summary investigates promising current and emerging technologies, and outlines strategies to procure resources and tools to advance drug development for associated nervous system disorders. Moreover, this report highlights presentations by expert panelists, and the open panel discussions that occurred during the workshop.



Neuromodulatory Actions Of Acetylcholine


Neuromodulatory Actions Of Acetylcholine
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Author : Charles Leroy Cox
language : en
Publisher:
Release Date : 1993

Neuromodulatory Actions Of Acetylcholine written by Charles Leroy Cox and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Acetylcholine categories.




Cns Neurotransmitters And Neuromodulators


Cns Neurotransmitters And Neuromodulators
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Author : Trevor W. Stone
language : en
Publisher: CRC Press
Release Date : 1995-07-25

Cns Neurotransmitters And Neuromodulators written by Trevor W. Stone and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-07-25 with Science categories.


CNS Neurotransmitters and Neuromodulators is an indispensable and comprehensive reference for any research worker involved with glutamate in the CNS. An impressive group of well-known authors contribute up-to-date reviews that offer a global picture of the state of research in the area. The authors cover a wide range of interdisciplinary aspects of the subject, including anatomical, physiological, and biochemical. Topics in this volume range from the localization of synthetic enzymes through electrophysiology, pharmacology, and molecular biology to behavioral importance in learning and memory. No other single volume offers the depth or broad scope of material found here. In addition to being a definitive reference work, CNS Neurotransmitters and Neuromodulators is the perfect one-step introduction to glutamate in the CNS for undergraduates, postgraduates, or established researchers who want a comprehensive overview text to keep abreast of developments in several areas of neuroscience.



Excitatory Amino Acid Receptors


Excitatory Amino Acid Receptors
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Author : Povl Krogsgaard-Larsen
language : en
Publisher: Taylor & Francis
Release Date : 1992

Excitatory Amino Acid Receptors written by Povl Krogsgaard-Larsen and has been published by Taylor & Francis this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with Medical categories.


Designed to reflect the growing awareness of the chemical aspects of excitatory amino acids, this text uses computer-based methods and X-ray techniques to depict and analyze molecules and structure-activity relationships. The book incorporates stereochemical principles into all analyses.



Current Catalog


Current Catalog
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Author : National Library of Medicine (U.S.)
language : en
Publisher:
Release Date : 1993

Current Catalog written by National Library of Medicine (U.S.) and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Medicine categories.


First multi-year cumulation covers six years: 1965-70.



Sensory Mechanisms Of The Spinal Cord


Sensory Mechanisms Of The Spinal Cord
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Author : William D. Willis Jr.
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29

Sensory Mechanisms Of The Spinal Cord written by William D. Willis Jr. and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Medical categories.


As stated in the preface to the first edition, the goal of this monograph is to provide an overview of current thought about the spinal cord mechanisms responsible for sensory processing. We hope that the book will be of value to both basic neuroscientists and clinicians. The organization of the monograph has followed the original plan in most respects, although the emphasis has changed with respect to many topics because of recent advances. In particular, a substantial increase in the number of investigations of the dorsal root ganglion has led us to devote a chapter to this topic. The treatment of chemical neuroanatomy in the dorsal horn, as well as the relevant neuropharmacology, has also been expanded considerably. Another major emphasis is on the results of experiments employing microneurography in human subjects. We thank Margie Watson and Lyn Schilling for their assistance with the typing and Griselda Gonzales for preparing the illustrations.