Experimental And Computational Aspects Of Bioactive Proteins From Animal Venoms An Insight Into Pharmacological Properties And Drug Discovery
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Experimental And Computational Aspects Of Bioactive Proteins From Animal Venoms An Insight Into Pharmacological Properties And Drug Discovery
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Author : Michelle Yap
language : en
Publisher: Frontiers Media SA
Release Date : 2024-02-23
Experimental And Computational Aspects Of Bioactive Proteins From Animal Venoms An Insight Into Pharmacological Properties And Drug Discovery written by Michelle Yap and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-02-23 with Science categories.
Animal venoms are complex mixtures of bioactive peptides and proteins with diverse pharmacological effects. These active molecules make up the components of venom toxins responsible for many pathological outcomes in snake envenomation. Although venom toxins can be deadly, they can potentially be lifesaving once their respective pharmacological targets and mechanistic actions are better understood. For example, the discovery of captopril from Brazilian viper, Bothrops jararaca venom which has been shown to antagonise angiotensin-converting enzyme (ACE) for the treatment of hypertension.
Venoms To Drugs
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Author : Glenn F. King
language : en
Publisher: Royal Society of Chemistry
Release Date : 2015-01-27
Venoms To Drugs written by Glenn F. King and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-01-27 with Science categories.
The pharmaceutical industry has become increasingly interested in biologics from animal venoms as a potential source for therapeutic agents in recent years, with a particularly emphasis on peptides. To date six drugs derived from venom peptides or proteins have been approved by the FDA, with nine further agents currently being investigated in clinical trials. In addition to these drugs in approved or advanced stages of development, many more peptides and proteins are being studied in varying stages of preclinical development. This unique book provides an up to date and comprehensive account of the potential of peptides and proteins from animal venoms as possible therapeutics. Topics covered include chemistry and structural biology of animal venoms, proteomic and transcriptomic approaches to drug discovery, bioassays, high-throughput screens and target identification, and reptile, scorpion, spider and cone snail venoms as a platform for drug development. Case studies are used to illustrate methods and successes and highlight issues surrounding administration and other important lessons that have been learnt from the development of approved therapeutics based on venoms. The first text to focus on this fascinating area and bridging an important gap, this book provides the reader with essential and current knowledge on this fast-developing area. Venoms to Drugs will find wide readership with researchers working in academia and industry working in all medicinal and pharmaceutical areas.
Toxins And Drug Discovery
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Author : P. Gopalakrishnakone
language : en
Publisher: Springer
Release Date : 2019-09-11
Toxins And Drug Discovery written by P. Gopalakrishnakone and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-11 with Medical categories.
In recent years, the field of Toxinology has expanded substantially. On the one hand it studies venomous animals, plants and micro organisms in detail to understand their mode of action on targets. While on the other, it explores the biochemical composition, genomics and proteomics of toxins and venoms to understand their three interaction with life forms (especially humans), development of antidotes and exploring their pharmacological potential. Therefore, Toxinology has deep linkages with biochemistry, molecular biology, anatomy and pharmacology. In addition, there is a fast developing applied subfield, clinical toxinology, which deals with understanding and managing medical effects of toxins on human body. Given the huge impact of toxin-based deaths globally, and the potential of venom in generation of drugs for so-far incurable diseases (for example, Diabetes, Chronic Pain), the continued research and growth of the field is imminent. This has led to the growth of research in the area and the consequent scholarly output by way of publications in journals and books. Despite this ever growing body of literature within biomedical sciences, there is still no all-inclusive reference work available that collects all of the important biochemical, biomedical and clinical insights relating to Toxinology. The Handbook of Toxinology aims to address this gap and cover the field of Toxinology comprehensively.
Snake Venoms
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Author : P. Gopalakrishnakone
language : en
Publisher:
Release Date : 2015
Snake Venoms written by P. Gopalakrishnakone and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with Poisonous snakes categories.
Animal Toxins
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Author : Findlay E. Russell
language : en
Publisher:
Release Date : 1967
Animal Toxins written by Findlay E. Russell and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1967 with Toxins categories.
Snake Venom Metalloproteinases
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Author : Jay Fox
language : en
Publisher: MDPI
Release Date : 2018-07-10
Snake Venom Metalloproteinases written by Jay Fox and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-07-10 with categories.
This book is a printed edition of the Special Issue "Snake Venom Metalloproteinases" that was published in Toxins
Drug Discovery And Evaluation Pharmacological Assays
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Author : Hans Vogel
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-10-30
Drug Discovery And Evaluation Pharmacological Assays written by Hans Vogel and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-10-30 with Medical categories.
The new edition of this successful reference offers both cutting-edge and classic pharmacological methods. Thoroughly revised and expanded to two volumes, it offers an updated selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs. Every chapter has been updated, and numerous assays have been added. Each of the more than 1,000 assays comprises a detailed protocol outlining purpose and rationale, and a critical assessment of the results and their pharmacological and clinical relevance.
Who Global Report On Traditional And Complementary Medicine 2019
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Author : World Health Organization
language : en
Publisher: World Health Organization
Release Date : 2019-05-16
Who Global Report On Traditional And Complementary Medicine 2019 written by World Health Organization and has been published by World Health Organization this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-16 with Business & Economics categories.
This report is structured in five parts: national framework for traditional and complementary medicine (T&CM); product regulation; practices and practitioners; the challenges faced by countries; and finally the country profiles. Apart from the section on practices and practitioners the report is consistent with the format of the report of the first global survey in order to provide a useful comparison. The section on practices and practitioners which covers providers education and health insurance is a new section incorporated to reflect the emerging trends in T&CM and to gather new information regarding these topics at a national level. All new information received has been incorporated into individual country profiles and data graphs. The report captures the three phases of progress made by Member States; that is before and after the first WHO Traditional Medicine Strategy (1999?2005) from the first global survey to the second global survey (2005?2012) and from the second survey to the most recent timeline (2012?2018).
Handbook Of Marine Natural Products
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Author : Ernesto Fattorusso
language : en
Publisher: Springer
Release Date : 2012-04-21
Handbook Of Marine Natural Products written by Ernesto Fattorusso and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-04-21 with Science categories.
"Handbook of Marine Natural Products" takes a fresh approach to describing the major themes of research in this rapidly developing field. This two volume reference work begins with a section that provides a taxonomic survey of the secondary metabolites of diverse marine life including microbes, algae, and invertebrates. This is followed by a demonstration of the techniques and strategies employed in modern structure elucidation of complex natural products. The natural roles of marine natural products are then explored in a series of focused chapters which include the topics of symbiosis, anti-predation and antifouling, chemical interactions, and defence against UV stress. Various routes which facilitate the understanding of marine natural product biosynthesis are subsequently explained and these are followed by an extensive set of chapters on the biomedical potential of marine natural products. The latter portion of this section considers the technologies and scientific disciplines necessary for advancing bioactive marine natural product lead compounds into actual pharmaceuticals. The reference work finishes with a selection of chapters describing marine toxins and their impact on public health and seafood resources. Final thoughts presented at the end of the second volume focus on the future of this field of investigation and discovery research. This publication is presented as a reference handbook and general concepts are emphasized and illustrated with numerous interesting examples, graphical information, and a comprehensive index. "Handbook of Marine Natural Products" introduces students who are at advanced undergraduate and entry graduate student levels to this fascinating multidisciplinary field. It is an ideal desk companion for courses focusing on this contemporary area.
Molecular Insight Of Drug Design
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Author : Arli Aditya Parikesit
language : en
Publisher: BoD – Books on Demand
Release Date : 2018-08-29
Molecular Insight Of Drug Design written by Arli Aditya Parikesit and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-08-29 with Medical categories.
The approaches in drug design are mainly comprised of these three multidisciplinary sciences. First, Bioinformatics has successfully gather biological data in form of biomolecular sequences, in order to construct knowledge on drug and vaccine design. It is of considerable importance for drug designers to comprehend the utilization of bioinformatics tools for resolving their research questions. Second, Nanotechnology has made possible the design and delivery of the nano-based drug. Third, Pharmaceutical Chemistry made it possible to investigate the adsorption, distribution, metabolism, and toxicology of the drug candidates in a fine-grained resolution.