Experimental Approaches For The Investigation Of Innate Immunity The Human Innate Immunity Handbook
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Experimental Approaches For The Investigation Of Innate Immunity The Human Innate Immunity Handbook
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Author : Richard Bucala
language : en
Publisher: World Scientific
Release Date : 2016-01-15
Experimental Approaches For The Investigation Of Innate Immunity The Human Innate Immunity Handbook written by Richard Bucala and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-01-15 with Medical categories.
The recent explosion of information in innate immune pathways for recognition, effect or responses, and genetic regulation has given impetus to investigations into analogous pathways in the human immune response, which in turn has produced attendant insights into both normal physiology and immunopathology. This volume presents a compendium of methods and protocols for the investigation of human innate immunity with application to the study of normal immune function, immunosenescence, autoimmunity and infectious diseases. Among the topics covered are quantitative flow cytometry for Toll-like receptor expression and function; multidimensional single cell mass cytometry (CyTOF) in complex immune interactions and tumor immunity; imaging techniques such as Imagestream high resolution microscopy coupled to flow cytometry, immune cell infiltration of organotypic, biomimetic organs; high-throughput single cell secretion profiling; multiplexed transcriptomic profiling; microsatellite and microRNA methodologies, RNA interference; and the latest bioinformatics and biostatistical methodologies, including in-depth statistical modeling, genetic mapping, and systems approaches.
Mouse Models Of Innate Immunity
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Author : Irving C. Allen
language : en
Publisher: Humana
Release Date : 2016-08-27
Mouse Models Of Innate Immunity written by Irving C. Allen and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-27 with Medical categories.
The innate immune system represents a critical arm of the immune response by providing immediate and robust host defense; however, human studies of its function are often limited by ethical, logistical, and technical obstacles. In Mouse Models of Innate Immunity: Methods and Protocols, experts in the field explore the design and execution of experiments used to thoroughly evaluate critical elements associated with the host innate immune response. The volume opens with methods that are essential for collecting and assessing various primary cells that are highly relevant to innate immunity, and it continues with in vivo protocols commonly used to evaluate the innate immune response in the mouse, including mouse models of respiratory infection, gastrointestinal inflammation, fungal and parasitic diseases, sepsis, and HIV-1 infection. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and easy to use, Mouse Models of Innate Immunity: Methods and Protocols will serve the research community by providing expert advice and protocols that allow both experienced and novice investigators to successfully plan, implement, and assess disease processes associated with the innate immune response.
Toll Like Receptors Tlrs And Innate Immunity
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Author : Stefan Bauer
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-12-11
Toll Like Receptors Tlrs And Innate Immunity written by Stefan Bauer and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-12-11 with Medical categories.
Overall recent research on TLRs has led to tremendous increase in our understanding of early steps in pathogen recognition and will presumably lead to potent TLR targeting therapeutics in the future. This book reviews and highlights our recent understanding on the function and ligands of TLRs as well as their role in autoimmunity, dendritic cell activation and target structures for therapeutic intervention.
Handbook Of Human Stress And Immunity
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Author : Ronald Glaser
language : en
Publisher: Academic Press
Release Date : 2014-06-28
Handbook Of Human Stress And Immunity written by Ronald Glaser and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-06-28 with Science categories.
In 1964, George Solomon coined the term psychoneuroimmunology. In the intervening 30 years, this term has emerged into a dynamic field of study which investigates the unique interactions between the nervous, endocrine, and immune systems. The Handbook of Human Stress and Immunity is a comprehensive reference for this dynamic new field. Focusing on how stressors impact the central nervous system and the resulting changes in immune responses, the Handbook is the first to describehow stress specifically affects human immune systems. It discusses how stress generally makes people more susceptible to infection, how personal support systems can counteract the physiological effects of stress, and how stress, or lack of stress, affects the aging process. Chapters are authored by the leading names in the field and cover such diseases as autoimmune disease, viral pathogenesis, herpes, HIV, and AIDS.
Handbook On Immunosenescence
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Author : Tamas Fulop
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-02-27
Handbook On Immunosenescence written by Tamas Fulop and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-02-27 with Medical categories.
This authoritative handbook covers all aspects of immunosenescence, with contributions from experts in the research and clinical areas. It examines methods and models for studying immunosenescence; genetics; mechanisms including receptors and signal transduction; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; and much more.
Conn S Handbook Of Models For Human Aging
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Author : Jeffrey L. Ram
language : en
Publisher: Academic Press
Release Date : 2018-04-05
Conn S Handbook Of Models For Human Aging written by Jeffrey L. Ram and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-04-05 with Medical categories.
Conn's Handbook of Models for Human Aging, Second Edition, presents key aspects of biology, nutrition, factors affecting lifespan, methods of age determination, use in research and the disadvantages/advantages of use. Using a multidisciplinary approach, this updated edition is designed as the only comprehensive, current work that covers the diversity in aging models. Chapters on comparative models explore age-related diseases, including Alzheimer's, joint disease, cataracts, cancer and obesity. Also included are new tricks and approaches not available in primary publications. This must-have handbook is an indispensable resource for researchers interested in the mechanisms of aging, gerontologists, health professionals, allied health practitioners and students. Combines both the methods of study for human aging and animal models Provides a historical overview and discussion of model availability, key methods and ethical issues Contains over 200 full color illustrations
Handbook Of Mouse Auditory Research
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Author : James F. Willott
language : en
Publisher: CRC Press
Release Date : 2001-05-23
Handbook Of Mouse Auditory Research written by James F. Willott and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-05-23 with Medical categories.
This unique compilation of chapters reviews a broad range of topics at the cutting edge of hearing research. The authors include many of the top auditory scientists in the world as well as some of the brightest rising stars. Although the book obviously focuses on the exciting, revolutionary work being done with mice, the authors have made a strong
Essential Immunology For Surgeons
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Author : Oleg Eremin
language : en
Publisher: Oxford University Press
Release Date : 2011-04-28
Essential Immunology For Surgeons written by Oleg Eremin and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-28 with Medical categories.
Previously published as: The Immunological basis of surgical science and practice, 1992.
Corneal Transplantation An Immunological Guide To The Clinical Problem With Cd Rom
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Author : John V Forrester
language : en
Publisher: World Scientific
Release Date : 2004-07-05
Corneal Transplantation An Immunological Guide To The Clinical Problem With Cd Rom written by John V Forrester and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-07-05 with Medical categories.
This book provides a summary of the various aspects of corneal transplantation — the clinical, experimental (including multimedia display of the surgical techniques), immunological, therapeutic and prosthetic components — in one volume. The interested specialist in one field can thus have access to information from the other fields and develop a broad concept of the challenges to be faced in achieving the ultimate goal, i.e. an optically clear, visually satisfactory, functioning corneal graft which is tolerated in the long term without the need for systemic immunosuppression. A second purpose of the book is to provide information regarding current immunological concepts of the process of corneal graft rejection. In particular, recent work in the fields of innate versus adaptive immunity, novel therapeutics and corneal xenografts is presented.
Handbook Of Laboratory Animal Science Volume Iii
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Author : Jann Hau
language : en
Publisher: CRC Press
Release Date : 2013-12-26
Handbook Of Laboratory Animal Science Volume Iii written by Jann Hau and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-26 with Medical categories.
While replacing and reducing the use of laboratory animals are integral parts of the 3Rs-replace, reduce, refine-which form the cornerstones of laboratory animal science, biomedical research involving animals remains absolutely essential for the advancement of the medical, veterinary, agricultural, and biological sciences. Building upon the bestsel