Experimental Methods In Organic Fluorine Chemistry

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Experimental Methods In Organic Fluorine Chemistry

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Author : Tomoya Kitazume
language : en
Publisher: Routledge
Release Date : 2019-06-14

Experimental Methods In Organic Fluorine Chemistry written by Tomoya Kitazume and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-14 with Science categories.

In the fields of biologically active materials and functional materials, fluorinated organic materials are becoming a focus of significant interest. Over the past decade synthetic methodologies and reagents in fluorine chemistry have been developed, especially stereocontrolled synthetic methods, enzymatic resolution to synthesize enantiomers, fluoromethylated reagents, and fluorination reagents. These methods have contributed to the opening of new pathways for fluorinated materials. However, few fluorinated materials have been put to commercial use. Furthermore, there remain problems to be solved, such as the handling of the materials, availability of reagents and selectivity (stereo-, regio-, and/or chemoselectivity). Research chemists, technical engineers, and graduate students in all branches of chemistry, pharmaceutics, and material science interested in fluorinated materials need to know detailed experimental procedures of how to synthesize the target fluorinated materials. This volume summarizes the chemical and microbial methods for obtaining functionalized fluorinated materials for use as building blocks; detailed experimental methods (reaction conditions, solvent, temperature, handling techniques, etc.); and the stereoview (possible absolute configuration) of the structures with spectral data. Mono-, di-, tri-, and polyfluorinated materials derived from fluorinating agents, fluoromethylated reagents and building blocks are summarized. A chemical name index, molecular formula index, and reagent index are also included. The publication of this monograph will provide access to the enormous possibilities in fluorine chemistry, biological material chemistry, and functionalized material chemistry.

Fluorine In Medicinal Chemistry And Chemical Biology

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Author : Iwao Ojima
language : en
Publisher: John Wiley & Sons
Release Date : 2009-03-23

Fluorine In Medicinal Chemistry And Chemical Biology written by Iwao Ojima and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-03-23 with Science categories.

The extraordinary potential of fluorine-containing molecules in medicinal chemistry and chemical biology has been recognized by researchers outside of the traditional fluorine chemistry field, and thus a new wave of fluorine chemistry is rapidly expanding its biomedical frontiers. With several of the best selling drugs in the world crucially containing fluorine atoms, the incorporation of fluorine to drug leads has become an essential practice in biomedical research, especially for drug design and discovery as well as development. Focusing on the unique and significant roles that fluorine plays in medicinal chemistry and chemical biology, this book reviews recent advances and future prospects in this rapidly developing field. Topics covered include: Discovery and development of fluorine containing drugs and drug candidates. New and efficient synthetic methods for medicinal chemistry and the optimisation of fluorine-containing drug candidates. Structural and chemical biology of fluorinated amino acids and peptides. Fluorine labels as probes in metabolic study, protein engineering and clinical diagnosis. Applications of 19F NMR spectroscopy in biomedical research. An appendix presents an invaluable index of all fluorine-containing drugs that have been approved by the US Food and Drug Administration, including information on structure and pharmaceutical action. Fluorine in Medicinal Chemistry and Chemical Biology will serve as an excellent reference source for graduate students as well as academic and industrial researchers who want to take advantage of fluorine in biomedical research.

Organofluorine Compounds

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Author : Tamejiro Hiyama
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-09

Organofluorine Compounds written by Tamejiro Hiyama and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-09 with Science categories.

In view of increasing interest in organofluorine compounds, this book was undertaken to describe biological and physical properties of organofluorine compounds, synthetic methods of these, their roles in pharmaceutical, agrochemical and material sciences. In particular, the book will emphasize on the usefulness of fluorination reaction, availability of fluorination agents, so that even graduate students who are unfamiliar to this field can understand and participate in this fascinating heteroatom chemistry.

Concise Handbook Of Fluorocarbon Gases

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Author : Sina Ebnesajjad
language : en
Publisher: John Wiley & Sons
Release Date : 2021-03-09

Concise Handbook Of Fluorocarbon Gases written by Sina Ebnesajjad and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-09 with Technology & Engineering categories.

This book describes fluorocarbons gases’ preparation process, properties, applications and their evolution over time. The impact of fluorocarbons on the ozone layer and global and the development to mitigate those effects have been specially emphasized. The first major industrial fluorinated compound was developed in the 1920’s, to replace ammonia and sulfur dioxide refrigerants, at the General Motors Frigidaire Division by Thomas Midgley, Jr. and Albert Leon Henne. They developed a family of fluorocarbons trademarked Freon® for auto air conditioning units revolutionizing the auto industry. Other applications were developed over time including fire extinguishers, propellants, blowing agents, cleaners, anesthesia, artificial blood and others impacting every facet of life. In spite of being in broad global use for nearly a century, fluorocarbon gases have gone through great evolution during the last few decades. In the 1980s it was discovered chlorofluorocarbon (CFC) gases are harmful to the ozone layer, mainly because of their chlorine content. Chlorine was released in the upper atmosphere when chlorofluorocarbon molecules were broken down by the high energy cosmic radiation. CFCs were progressively banned following the Montreal Protocol of 1987. CFCs were replaced by fluorinated gases containing either less chlorine (hydrofluoro-chlorocarbons, or HCFCs), which are much less damaging (about 90% less) to the ozone layer or with fluorinated gases containing no chlorine, i.e. hydrofluorocarbons or HFCs. HFC have no impact on the ozone layer but impact global warming detrimentally. HFCs are usable without need for changes to the existing refrigeration or air conditioning installations. More recently hydrofluoroolefins (HFOs), which have little or no negative impact on global warming, have been developed to replace or reduce the use of HFCs. HFOs are used as single compounds or in blends. Research and development continues to develop and replace the HCFCs and HFCs completely with environmentally friendly products. Concise Handbook of Fluorocarbon Gases presents a reference and text for the commercial fluorocarbon gases which have great many application in a wide range of industries such as refrigeration and air conditioning, as well as consumer products.

Contrast Agents For Mri

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Author : Valérie C Pierre
language : en
Publisher: Royal Society of Chemistry
Release Date : 2017-11-09

Contrast Agents For Mri written by Valérie C Pierre and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-09 with Medical categories.

As a practical reference guide for designing and performing experiments, this book focuses on the five most common classes of contrast agents for MRI namely gadolinium complexes, chemical exchange saturation transfer agents, iron oxide nanoparticles, manganese complexes and fluorine contrast agents. It describes how to characterize and evaluate them and for each class, a description of the theory behind their mechanisms is discussed briefly to orient the new reader. Detailed subchapters discuss the different physical chemistry methods used to characterize them in terms of their efficacy, safety and in vivo behavior. Important consideration is also given to the different physical properties that affect the performance of the contrast agents. The editors and contributors are at the forefront of research in the field of MRI contrast agents and this unique, cutting edge book is a timely addition to the literature in this area.

Organic And Inorganic Fluorine Chemistry

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Author : Axel Haupt
language : en
Publisher: Walter de Gruyter GmbH & Co KG
Release Date : 2021-03-22

Organic And Inorganic Fluorine Chemistry written by Axel Haupt and has been published by Walter de Gruyter GmbH & Co KG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-22 with Science categories.

Organic and Inorganic Fluorine Chemistry provides an introduction to fluorine chemistry and an overview of the most important fluorinated compounds and general preparation techniques. The book is divided into three parts, covering general aspects, inorganic fluorides and fluoroorganic compounds. The inorganic part presents the most important element fluorides and oxyfluorides, their preparation as well as their most characteristic properties. The organic section focuses on the different types of fluorination and the corresponding reagents. The application of these techniques is discussed for many different types of substrates. The book addresses advanced students in chemistry as well as researchers in academia and industry. The readers will benefit from a large number of original references which give access to further information. In addition, study questions at the end of each chapter will help to repeat and internalise the most important aspects.

Nuclear Science Abstracts

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Author :
language : en
Publisher:
Release Date : 1976-04

Nuclear Science Abstracts written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1976-04 with Nuclear energy categories.

Fluorine Containing Reagents

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Author : Leo A. Paquette
language : en
Publisher: Wiley-Interscience
Release Date : 2007-11-19

Fluorine Containing Reagents written by Leo A. Paquette and has been published by Wiley-Interscience this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-11-19 with Science categories.

Another hot-topic volume in the Handbook of Reagents for Organic Synthesis series! This is the first book with all relevant Fluorine containing reagents, and it is an important addition to the vast list of existing books on organic and inorganic Fluorine synthesis. Synthetic chemists, most particularly medicinal and pharmaceutical chemists, are often called upon to prepare compounds that contain Fluorine as a key structural feature. In the past, this seemed to be a domain for specialists, today every synthetic chemist working in these area is expected to synthesize compounds containing Fluorides. This book will be an important source of information for the selection and handling of the right reagents. A must-to-have resource for all synthetic chemists working in drug development and medicinal chemistry Makes use of the leading reagent database e-EROS.

Air Force Scientific Research Bibliography 1950 56

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Author : Library of Congress. Science and Technology Division
language : en
Publisher:
Release Date : 1961

Air Force Scientific Research Bibliography 1950 56 written by Library of Congress. Science and Technology Division and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1961 with Military research categories.

High Resolution Nmr Techniques In Organic Chemistry

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Author : Timothy D.W. Claridge
language : en
Publisher: Elsevier
Release Date : 2016-04-22

High Resolution Nmr Techniques In Organic Chemistry written by Timothy D.W. Claridge and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-22 with Science categories.

High-Resolution NMR Techniques in Organic Chemistry, Third Edition describes the most important NMR spectroscopy techniques for the structure elucidation of organic molecules and the investigation of their behaviour in solution. Appropriate for advanced undergraduate and graduate students, research chemists and NMR facility managers, this thorough revision covers practical aspects of NMR techniques and instrumentation, data collection, and spectrum interpretation. It describes all major classes of one- and two-dimensional NMR experiments including homonuclear and heteronuclear correlations, the nuclear Overhauser effect, diffusion measurements, and techniques for studying protein–ligand interactions. A trusted authority on this critical expertise, High-Resolution NMR Techniques in Organic Chemistry, Third Edition is an essential resource for every chemist and NMR spectroscopist.