Experimental Models Of Parkinson S Disease With Levodopa Induced Dyskinesias And Gait Dysfunction
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Experimental Models Of Parkinson S Disease With Levodopa Induced Dyskinesias And Gait Dysfunction
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Author : Xingxing Jin
language : en
Publisher:
Release Date : 2015
Experimental Models Of Parkinson S Disease With Levodopa Induced Dyskinesias And Gait Dysfunction written by Xingxing Jin and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with categories.
Levodopa Induced Dyskinesia In Parkinson S Disease
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Author : Susan H. Fox
language : en
Publisher: Springer
Release Date : 2014-10-08
Levodopa Induced Dyskinesia In Parkinson S Disease written by Susan H. Fox and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-08 with Medical categories.
This book aims to provide a single reference source on levodopa-induced dyskinesias (LID) from ‘bench to bedside’. Initial chapters review the clinical features and phenomenology of LID with video examples; epidemiology and genetic risk factors for LID are covered as a background to understanding risk factors for developing LID. The following chapters cover the latest preclinical studies aiming to understand the pathophysiology of LID at the cellular, neurochemical, neurophysiological and circuitry level with detailed discussion of mechanisms and future directions to take the field forward; clinical studies from phase II to phase IV; on going RCTs in LID and evidence-based medicine reviews of treatment options. Levodopa-Induced Dyskinesia in Parkinson’s Disease is aimed at an international audience of movement disorder neurologists; neuroscientists; trainees and graduate and post-graduate students.
Levodopa Induced Dyskinesias In Parkinson S Disease Current Knowledge And Future Scenarios
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Author : Antonio Cerasa
language : en
Publisher: Frontiers Media SA
Release Date : 2015-05-13
Levodopa Induced Dyskinesias In Parkinson S Disease Current Knowledge And Future Scenarios written by Antonio Cerasa and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-05-13 with Medicine (General) categories.
This topic aims to pool the most recent advances in the phenomenology and pathophysiology of levodopa-induced dyskinesias. The papers in this eBook have strongly contributed to reduce the gaps in our knowledge of LIDs pathogenesis.
Pathophysiology Of Levodopa Induced Dyskinesia In Animal Models Of Parkinson S Disease
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Author : Montague Adam Silverdale
language : en
Publisher:
Release Date : 2003
Pathophysiology Of Levodopa Induced Dyskinesia In Animal Models Of Parkinson S Disease written by Montague Adam Silverdale and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with categories.
Symptoms Of Parkinson S Disease
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Author : Md, Frcpc, Frcp (hon), Abdul Qayyum Rana
language : en
Publisher: BoD – Books on Demand
Release Date : 2011-09-22
Symptoms Of Parkinson S Disease written by Md, Frcpc, Frcp (hon), Abdul Qayyum Rana and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-22 with Medical categories.
This book about Parkinson's disease provides a detailed account of various aspects of this complicated neurological condition. Although most of the important motor and non-motor symptoms of Parkinson's disease have been discussed in this book, but in particular a detailed account has been provided about the most disabling symptoms such as dementia, depression, and other psychiatric as well as gastrointestinal symptoms. The mechanisms responsible for the development of these symptoms have also been discussed. Not only the clinicians may benefit from this book but also basic scientists can get enough information from the various chapters which have been written by well known faculty.
Establishing Mechanisms Of Levodopa Induced Dyskinesias In Parkinson S Disease In Post Mortem Human Brain Tissue
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Author : Perdita Anne Cheshire
language : en
Publisher:
Release Date : 2013
Establishing Mechanisms Of Levodopa Induced Dyskinesias In Parkinson S Disease In Post Mortem Human Brain Tissue written by Perdita Anne Cheshire and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with categories.
Parkinson‘s disease (PD) is a progressive and disabling neurodegenerative disease,characterized by a loss of dopamine neurons in the midbrain. Treatment of the motorsymptoms of PD relies on replacing lost dopamine with dopaminergic drugs, inparticular the pro-drug levodopa (L-DOPA). Chronic L-DOPA treatment leads tounwanted side-effects in the form of abnormal, involuntary movements (dyskinesias), which represent a major barrier to effective symptomatic management of PD. Although pre-clinical animal models provide compelling evidence as to the underlying mechanisms of levodopa-induced dyskinesias (LID), this has repeatedly failed to translate into treatment optionsAnimal model data implicates both pre-synaptic and post-synaptic mechanisms of LID; namely that serotonin neurons cause LID by aberrantly releasing dopamine, and thatpost-synaptic dopamine receptors become hypersensitised to dopamine resulting indyskinetic movements. Correlative data from human studies is notably lacking, but is acritical step in improving research translation. The research presented in this thesis aimed to address this translational gap by compiling two cohorts of post-mortem human brain tissue from PD patients characterised on the basis of their clinical LID phenotype, which provided an unprecedented opportunity to explore the pathophysiology of LID in PD.Studies were designed to determine whether hypotheses generated from animal modelscould be validated in human tissue. The results of these studies do not support a central role for serotonin neurons in LID, nor was post-synaptic sensitisation of dopamine receptors supported as a mechanism of LID. Putative genetic risk factors for developing LID identified from cross-sectional living cohorts were also excluded in a pathologicallyconfirmed study. The failure to demonstrate pathological markers of LID identified from animal models in human tissue challenges the adequacy of current pre-clinical animal models of LID, demonstrates the value of autopsy studies, and may go some way to explain why effective treatment of LID has so far proved elusive. These findings have important implications for the development of anti-dyskinetic agents but also contribute to the understanding of PD as a whole.
Non Motor Symptoms Of Parkinson S Disease
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Author : K. Ray Chaudhuri
language : en
Publisher: Oxford University Press, USA
Release Date : 2014
Non Motor Symptoms Of Parkinson S Disease written by K. Ray Chaudhuri and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with Medical categories.
Patients with Parkinson's disease (PD) are known to suffer from motor symptoms of the disease, but they also experience non-motor symptoms (NMS) that are often present before diagnosis or that inevitably emerge with disease progression. The motor symptoms of Parkinson's disease have been extensively researched, and effective clinical tools for their assessment and treatment have been developed and are readily available. In contrast, researchers have only recently begun to focus on the NMS of Parkinson's Disease, which are poorly recognized and inadequately treated by clinicians. The NMS of PD have a significant impact on patient quality of life and mortality and include neuropsychiatric, sleep-related, autonomic, gastrointestinal, and sensory symptoms. While some NMS can be improved with currently available treatments, others may be more refractory and will require research into novel (non-dopaminergic) drug therapies for the future. Edited by members of the UK Parkinson's Disease Non-Motor Group (PD-NMG) and with contributions from international experts, this new edition summarizes the current understanding of NMS symptoms in Parkinson's disease and points the way towards future research.
Pathophysiology Pharmacology And Biochemistry Of Dyskinesia
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Author : Jonathan Brotchie
language : en
Publisher: Academic Press
Release Date : 2011-09-19
Pathophysiology Pharmacology And Biochemistry Of Dyskinesia written by Jonathan Brotchie and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-19 with Medical categories.
Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. This volume reviews existing theories and current research surrounding the movement disorder Dyskinesia. Leading authors review state-of-the-art in their field of investigation and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist
Etiology Of Parkinson S Disease
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Author : Jonas H. Ellenberg
language : en
Publisher: CRC Press
Release Date : 1995-03-01
Etiology Of Parkinson S Disease written by Jonas H. Ellenberg and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-03-01 with Medical categories.
This comprehensive reference provides a detailed overview of current concepts regarding the cause of Parkinson's disease-emphasizing the issues involved in the design, implementation, and analysis of epidemiological studies of parkinsonism.
Balance Dysfunction In Parkinson S Disease
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Author : Martina Mancini
language : en
Publisher: Academic Press
Release Date : 2019-09-14
Balance Dysfunction In Parkinson S Disease written by Martina Mancini and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-14 with Medical categories.
Balance Dysfunction in Parkinson’s Disease: Basic Mechanisms to Clinical Management presents the most updated information on a variety of topics. Sections help clinicians evaluate the types of balance control issues, dynamic balance dysfunction during turning, and the effects of medication, deep brain stimulation, and rehabilitation intervention on balance control. This book is the first to review the four main postural control systems and how they are affected, including balance during quiet stance, reactive postural adjustments to external perturbations, anticipatory postural adjustments in preparation for voluntary movements, and dynamic balance control during walking and turning. In addition, the book's authors summarize the effects of levodopa, deep brain stimulation, and rehabilitation intervention for each balance domain. This book is recommended for anyone interested in how and why balance control is affected by PD. Provides the first comprehensive review of research to date on balance dysfunctions in Parkinson's disease Discusses how to translate current neuroscience research into practice regarding neural control of balance Provides evidence on the effects of current interventions on balance control
