Exploring Maternal Fetal Pharmacology Through Pbpk Modeling Approaches
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Exploring Maternal Fetal Pharmacology Through Pbpk Modeling Approaches
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Author : André Dallmann
language : en
Publisher: Frontiers Media SA
Release Date : 2022-06-06
Exploring Maternal Fetal Pharmacology Through Pbpk Modeling Approaches written by André Dallmann and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-06-06 with Science categories.
Emerging Researchers In Frontiers In Pharmacology Obstetric And Pediatric Pharmacology 2022
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Author : Qiwei Yang
language : en
Publisher: Frontiers Media SA
Release Date : 2023-06-27
Emerging Researchers In Frontiers In Pharmacology Obstetric And Pediatric Pharmacology 2022 written by Qiwei Yang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-27 with Science categories.
Atkinson S Principles Of Clinical Pharmacology
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Author : Shiew-Mei Huang
language : en
Publisher: Academic Press
Release Date : 2021-10-16
Atkinson S Principles Of Clinical Pharmacology written by Shiew-Mei Huang and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-16 with Medical categories.
**Selected for Doody's Core Titles® 2024 in Pharmacology**Atkinson's Principles of Clinical Pharmacology, Fourth Edition is the essential reference on the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development. This well-regarded survey continues to focus on the basics of clinical pharmacology for the development, evaluation and clinical use of pharmaceutical products while also addressing the most recent advances in the field. Written by leading experts in academia, industry, clinical and regulatory settings, the fourth edition has been thoroughly updated to provide readers with an ideal reference on the wide range of important topics impacting clinical pharmacology. - Presents the essential knowledge for effective practice of clinical pharmacology - Includes a new chapter and extended discussion on the role of personalized and precision medicine in clinical pharmacology - Offers an extensive regulatory section that addresses US and international issues and guidelines - Provides extended coverage of earlier chapters on transporters, pharmacogenetics and biomarkers, along with further discussion on "Phase 0" studies (microdosing) and PBPK
New Horizons In Predictive Drug Metabolism And Pharmacokinetics
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Author : Alan G E Wilson
language : en
Publisher: Royal Society of Chemistry
Release Date : 2015-11-20
New Horizons In Predictive Drug Metabolism And Pharmacokinetics written by Alan G E Wilson and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-11-20 with Medical categories.
Drug metabolism, pharmacokinetics and toxicokinetics as determinants of drug attrition and the safety of xenobiotics are critically important. This book presents a comprehensive treatise on the current issues and challenges facing drug metabolism and pharmacokinetics. Readers will find a thorough exploration of their predictive role in impacting drug discovery and development and in improving the success rate and safety assessment of pharmaceuticals and industrial or occupational chemicals. Chapters not only focus on the current state of art, with distinct examples, but on future needs and approaches likely to improve our prediction of potential human risk. Discussions of critical properties that are determinants of a compound’s metabolic and pharmacokinetic fate follow introductory chapters. The Drug Discovery process increasingly incorporates pharmacokinetics and drug metabolism screening and focus has shifted towards in silico, computational and systems biology approaches. Core chapters reflect this and the recent interest and need to assess the role of transporters, along with drug metabolizing enzymes, as potential determinants of pharmacokinetic behaviour, toxicity and drug-drug interactions. Lastly, chapters cover the issues and factors involved in translating pharmacokinetics from in silico to in vivo and from animal models to man, and postulate future directions and opportunities. Leading experts from academia, industry and regulatory bodies across the globe contribute their knowledge to this book, which scientists involved in many aspects of the drug discovery process, as well as regulators and postgraduate students, will find a useful resource.
Clinical Pharmacology During Pregnancy
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Author : Donald Mattison
language : en
Publisher: Academic Press
Release Date : 2012-12-05
Clinical Pharmacology During Pregnancy written by Donald Mattison and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-05 with Medical categories.
Clinical Pharmacology During Pregnancy is written for clinicians, physicians, midwives, nurses, pharmacists and other medical professionals directly involved in the care of women during pregnancy. This book focuses on the impact of pregnancy on drug disposition and also includes coverage of treatments for diseases of specific body systems, as well as essential content on dosing and efficacy. Written in a clear and practical manner, this reference provides easily accessible information and clinical guidance on how best to treat women with medications during pregnancy.
Cumulated Index Medicus
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Author :
language : en
Publisher:
Release Date : 1997
Cumulated Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Medicine categories.
Improving The Delivery Of Pre Exposure Prophylaxis Prep To Eliminate Vertical Hiv Transmission
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Author : Dvora Joseph Davey
language : en
Publisher: Frontiers Media SA
Release Date : 2024-10-30
Improving The Delivery Of Pre Exposure Prophylaxis Prep To Eliminate Vertical Hiv Transmission written by Dvora Joseph Davey and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-10-30 with Medical categories.
Over half of HIV infections globally occur among cisgender women. High HIV incidence among young (ie, 15–30 years old) African cisgender women persists during pregnancy and postpartum, and there is evidence that HIV acquisition risk more than doubles during this period. A new HIV infection has important short- and long-term consequences for the mother’s health. Acute maternal HIV infection is also associated with increased vertical transmission risk, making prevention of HIV among pregnant and breastfeeding populations a global health priority. As access to antiretroviral therapy continues to expand, new—and often undiagnosed—maternal HIV infections during pregnancy and breastfeeding contribute to a growing proportion of new pediatric HIV cases, and urgent focus of interventions to eliminate vertical HIV transmission. To address this important gap, The World Health Organization (WHO) and several national HIV programs recommend offering pre-exposure prophylaxis (PrEP) to pregnant and breastfeeding populations at substantial risk for HIV. To fully realize the promise of PrEP in antenatal and postnatal settings, however, “real world” clinical and implementation data are urgently needed. Further, there is a need for research on novel, long-acting tools that prevent HIV acquisition in all populations, including pregnant and breastfeeding populations.
Dissertation Abstracts International
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Author :
language : en
Publisher:
Release Date : 1993-10
Dissertation Abstracts International written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993-10 with Dissertations, Academic categories.
Pharmacokinetic And Pharmacodynamic Data Analysis Concepts And Applications Third Edition
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Author : Johan Gabrielsson
language : en
Publisher: CRC Press
Release Date : 2001-11-30
Pharmacokinetic And Pharmacodynamic Data Analysis Concepts And Applications Third Edition written by Johan Gabrielsson and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-11-30 with Medical categories.
This is a revised and very expanded version of the previous second edition of the book. "Pharmacokinetic and Pharmacodynamic Data Analysis" provides an introduction into pharmacokinetic and pharmacodynamic concepts using simple illustrations and reasoning. It describes ways in which pharmacodynamic and pharmacodynamic theory may be used to give insight into modeling questions and how these questions can in turn lead to new knowledge. This book differentiates itself from other texts in this area in that it bridges the gap between relevant theory and the actual application of the theory to real life situations. The book is divided into two parts; the first introduces fundamental principles of PK and PD concepts, and principles of mathematical modeling, while the second provides case studies obtained from drug industry and academia. Topics included in the first part include a discussion of the statistical principles of model fitting, including how to assess the adequacy of the fit of a model, as well as strategies for selection of time points to be included in the design of a study. The first part also introduces basic pharmacokinetic and pharmacodynamic concepts, including an excellent discussion of effect compartment (link) models as well as indirect response models. The second part of the text includes over 70 modeling case studies. These include a discussion of the selection of the model, derivation of initial parameter estimates and interpretation of the corresponding output. Finally, the authors discuss a number of pharmacodynamic modeling situations including receptor binding models, synergy, and tolerance models (feedback and precursor models). This book will be of interest to researchers, to graduate students and advanced undergraduate students in the PK/PD area who wish to learn how to analyze biological data and build models and to become familiar with new areas of application. In addition, the text will be of interest to toxicologists interested in learning about determinants of exposure and performing toxicokinetic modeling. The inclusion of the numerous exercises and models makes it an excellent primary or adjutant text for traditional PK courses taught in pharmacy and medical schools. A diskette is included with the text that includes all of the exercises and solutions using WinNonlin.
Fundamentals Of Medical Surgical Nursing
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Author : Anne-Marie Brady
language : en
Publisher: John Wiley & Sons
Release Date : 2014-01-28
Fundamentals Of Medical Surgical Nursing written by Anne-Marie Brady and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-01-28 with Medical categories.
Fundamentals of Medical-Surgical Nursing Fundamentals of Medical-Surgical Nursing A Systems Approach Fundamentals of Medical-Surgical Nursing is a comprehensive yet easy-to-read overview of medical and surgical nursing, designed specifically to support all nursing students learning to care for the adult patient. Highly illustrated and with an easy-to-follow systems-based structure, it provides a thorough foundation in anatomy and physiology, pathophysiology, medical management, and nursing care for the full spectrum of adult health conditions. KEY FEATURES: Extensive coverage of principles of nursing assessment, medication administration, infection prevention and control, and nutritional care Key need-to-know-information and definitions for the anatomy, physiology, and pathology of a range of illnesses and conditions Detailed overviews of nursing care, including patient education, treatment, and complications An online resource centre with a range of extras for both lecturers and students, including case studies, reflective activities, interactive multiple choice questions, and further reading lists Fundamentals of Medical-Surgical Nursing is the ideal textbook to help students succeed on their adult nursing course. with online self-test www.wileyfundamentalseries.com/medicalnursing Interactive multiple-choice questions Reflective questions for downloading Case studies Links to online resources When you purchase the book you also receive access to the Wiley E-Text: Powered by VitalSource. This is an interactive digital version of the book, featuring downloadable text and images, highlighting and notetaking facilities, bookmarking, cross-referencing, in-text searching, and linking to references and abbreviations. Fundamentals of Medical-Surgical Nursing is also available on CourseSmart, offering extra functionality as well as an immediate way to access the book. For more details, see www.coursesmart.co.uk/9780470658239.