Exploring Oncolytic Virotherapy In Solid Tumor Treatment
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Exploring Oncolytic Virotherapy In Solid Tumor Treatment
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Author : Peng Qu
language : en
Publisher: Frontiers Media SA
Release Date : 2025-03-26
Exploring Oncolytic Virotherapy In Solid Tumor Treatment written by Peng Qu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-03-26 with Medical categories.
Oncolytic virus therapy for solid tumor is an well-established concept as a promising tumor treatment strategy. Oncolytic viruses, either naturally occurring or genetically engineered, have the ability to replicate and destroy tumor cells while sparing normal cells. The lysis of tumor cells triggers potent antitumor responses and mediates tumor regression at distant sites not exposed to the virus. In 2015, the U.S. Food and Drug Administration (FDA) approved the first Oncolytic virus (OV) therapy for the treatment of melanoma lesions in the skin and lymph nodes. Despite these advancements, there are still unresolved issues regarding virus selection, dosage, and optimal administration route. The primary objective of this research topic is to monitor the latest developments in oncolytic virotherapy for solid tumors, including non-small cell lung cancer, gastric cancer, breast cancer, colorectal tumor, hepatic carcinoma, and others. The focus will be on the changes in both the immune microenvironment and immune cells induced by oncolytic virotherapy. Additionally, the research aims to discover novel oncolytic viruses or other combined therapies to enhance the safety and efficacy of oncolytic virotherapy.
Oncolytic Viruses Genetically Engineering The Future Of Cancer Therapy
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Author : Benjamin Gesundheit
language : en
Publisher: Frontiers Media SA
Release Date : 2016-11-22
Oncolytic Viruses Genetically Engineering The Future Of Cancer Therapy written by Benjamin Gesundheit and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-22 with categories.
The ability to genetically engineer oncolytic viruses in order to minimize side effects and improve the selective targeting of tumor cells has opened up novel opportunities for treating cancer. Understanding the mechanisms involved and the complex interaction between the viruses and the immune system will undoubtedly help guide the development of new strategies. Theranostic biomarkers to monitor these therapies in clinical trials serve an important need in this innovative field and demand further research.
Textbook Of General Virology
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Author : Sachin Kumar
language : en
Publisher: CRC Press
Release Date : 2025-03-31
Textbook Of General Virology written by Sachin Kumar and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-03-31 with Science categories.
This book is an introductory text that presents fundamental knowledge and recent advances in virology. It provides comprehensive coverage of different aspects like classification, structure, emerging viruses, cancer-causing viruses, and viral vaccines. It covers the basic biology of virus existence, evolution, and reoccurrence. It also incorporates the fundamentals of biophysical and biochemical aspects of viral replication. The book discusses important topics such as immunity to viral infections, bacteriophages, and techniques used in virology. The Textbook of General Virology is meant for undergraduate and postgraduate students of microbiology, immunology, genetics, and medicine. Key Features: Discusses introductory and foundational knowledge of viruses for students of life sciences and medicine Covers the virus history, diversity of its infection strategy, and classification Summarizes the characteristics of different viruses on the basis of nucleic acid genome type Describes the biology of RNA and DNA viruses and their effect on cell growth control in animals and humans after infection Reviews topics like immunity to viruses and viral vaccines
Handbook Of Brain Tumor Chemotherapy Molecular Therapeutics And Immunotherapy
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Author : Herbert B. Newton
language : en
Publisher: Academic Press
Release Date : 2018-03-28
Handbook Of Brain Tumor Chemotherapy Molecular Therapeutics And Immunotherapy written by Herbert B. Newton and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-03-28 with Medical categories.
Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy, Second Edition, provides a comprehensive overview of the molecular methodologies in the neuro-oncology field. There have been profound changes in the landscape of approaches to brain tumor therapy since the first edition—mainly in the areas of molecular biology and molecular therapeutics, as well as in the maturation of immunotherapy approaches (e.g., vaccines). This updated edition has a new, primary focus on multidisciplinary molecular methods, and is broadened to include the latest cutting-edge molecular biology, therapeutics, immunobiology and immunotherapy approaches. As the first comprehensive book to address the molecular research into these concepts, users will find it to be an invaluable resource on the topics discussed. - Provides the most up-to-date information regarding conventional forms of cytotoxic chemotherapy, as well as the basic science and clinical application of molecular therapeutics for the treatment of brain tumors - Broadly appeals to anyone interested in neuro-oncology and the treatment of brain tumors - Features updated chapters on molecular biology, molecular therapeutics, maturation of immunotherapy approaches, and a focus on multidisciplinary molecular methods - Includes a new section on the basic science of immunology, as well as thorough updates on the use of vaccine technology and immunotherapy for the treatment of brain tumors
Innate Immune Cell Therapy Of Cancer
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Author : Asha B. Pillai
language : en
Publisher: Frontiers Media SA
Release Date : 2023-09-13
Innate Immune Cell Therapy Of Cancer written by Asha B. Pillai and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-13 with Science categories.
Adoptive cellular immunotherapy of cancer, particularly chimeric antigen receptor-transduced T cell (CAR-T) therapies, have enjoyed an explosion of clinical trials and translational and basic research in the past decade. The concept and design of the CAR, though originally intended to optimize targeting of innate natural killer cells (NK cells) to tumor-specific antigens, was laterally applied in the past decade to conventional autologous and later third-party allogeneic T cells with first-in-kind successes in leukemia immunotherapy in both adults and children. This approach also spawned the development of an entire industry focused on cancer immunotherapy, laying the foundation for the current paradigm shifts away from toxic chemo/radiotherapy to immune targeting. Aside from cytokine-release toxicities, specific obstacles plaguing existing CAR-T cell therapies include suboptimal killing by fatigued or senescent autologous patient-derived T cells derived, acquisition of tumor resistance to T-cell based immune therapies, and graft-versus-host disease (GVHD) associated with allogeneic conventional T cell therapies.
Cancer Immunology And Immunotherapy
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Author : Mansoor M. Amiji
language : en
Publisher: Elsevier
Release Date : 2021-08-27
Cancer Immunology And Immunotherapy written by Mansoor M. Amiji and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-27 with Business & Economics categories.
Delivery Technologies for Immuno-Oncology: Volume 1: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy examines the challenges of delivering immuno-oncology therapies. Immuno-oncology (IO) is a growing field of medicine at the interface of immunology and cancer biology leading to development of novel therapeutic approaches, such as chimeric antigen receptor T-cell (CAR-T) and immune checkpoint blockade antibodies, that are clinically approved approaches for cancer therapy. Although currently approved IO approaches have shown tremendous promise for select types of cancers, broad application of IO strategies could even further improve the clinical success, especially for diseases such as pancreatic cancer, brain tumors where the success of IO so far has been limited. Nanotechnology-based targeted delivery strategies could improve the delivery efficiency of IO agents as well as provide additional avenues for novel therapeutic and vaccination strategies. Additionally, a number of locally-administered immunogenic scaffolds and therapeutic strategies, such as the use of STING agonist, could benefit from rationally designed biomaterials and delivery approaches. Delivery Technologies for Immuno-Oncology: Volume 1: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy creates a comprehensive treaty that engages the scientific and medical community who are involved in the challenges of immunology, cancer biology, and therapeutics with possible solutions from the nanotechnology and drug delivery side. Comprehensive treaty covering all aspects of immuno-oncology (IO) Novel strategies for delivery of IO therapeutics and vaccines Forecasting on the future of nanotechnology and drug delivery for IO
Exploration Of Innovative Strategies Focusing On Advanced Nanobiomaterials For Optimizing Oncological Treatment And Tissue Restoration
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Author : Weifeng Lin
language : en
Publisher: Frontiers Media SA
Release Date : 2023-09-08
Exploration Of Innovative Strategies Focusing On Advanced Nanobiomaterials For Optimizing Oncological Treatment And Tissue Restoration written by Weifeng Lin and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-08 with Science categories.
Tumor Associated Antigens And Their Autoantibodies From Discovering To Clinical Utilization
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Author : Xiangqian Guo
language : en
Publisher: Frontiers Media SA
Release Date : 2022-08-18
Tumor Associated Antigens And Their Autoantibodies From Discovering To Clinical Utilization written by Xiangqian Guo and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-18 with Medical categories.
A Beginner S Guide To Targeted Cancer Treatments
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Author : Elaine Vickers
language : en
Publisher: John Wiley & Sons
Release Date : 2018-05-08
A Beginner S Guide To Targeted Cancer Treatments written by Elaine Vickers and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-08 with Medical categories.
Highly Commended in the category of Oncology at the British Medical Association Awards 2019 The accessible guide to the principles behind new, more targeted drug treatments for cancer Written for anyone who encounters cancer patients, cancer data or cancer terminology, but have no more than a passing knowledge of cell biology. A Beginner's Guide to Targeted Cancer Treatments provides an understanding of how cancer works and the many new treatments available. Using over 100 original illustrations, this accessible handbook covers the biology and mechanisms behind a huge range of targeted drug treatments, including many new immunotherapies. Dr Vickers translates a complex and often overwhelming topic into something digestible and easily understood. She also explains what cancer is, how it behaves and how our understanding of cancer has changed in recent years. Each chapter takes the reader through how new cancer drugs work and their benefits and limitations. With the help of this book, readers will be able to better understand more complex, in-depth articles in journals and books and develop their knowledge. This vital resource: Offers the latest insights into cancer biology Provides a broad understanding of how targeted cancer treatments work Describes many of the new immunotherapy approaches to cancer treatment, such as checkpoint inhibitors and CAR-modified T cells Helps readers feel confident discussing treatment options with colleagues and patients Provides an overview of which treatments are relevant to each of the most common solid tumours and haematological cancers, and the rationale behind them Demystifies the jargon – terms such as the EMT, cancer stem cells, monoclonal antibodies, kinase inhibitors, angiogenesis inhibitors etc. Explains the resistance mechanisms to many new treatments, including issues such as the way cancer cells diversify and evolve and the complex environment in which they live
Cancer Immunosurveillance
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Author : Alejandro López-Soto
language : en
Publisher: Humana
Release Date : 2025-06-09
Cancer Immunosurveillance written by Alejandro López-Soto and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-06-09 with Medical categories.
This new edition explores the innovation and improvement of experimental techniques harnessed to dissect the complex relationship between cancer cells and the immune system of the host. Beginning with spectral and multicolor flow cytometric methods to characterize the immune contexture of different forms of metastases, the book continues with functional assays to study the activation status of immune cells with antitumor properties, bioinformatic approaches of interest for cancer immunology research, techniques for performing epigenetic studies, as well as methods related to translational research. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Cancer Immunosurveillance: Methods and Protocols, Second Edition serves as a valuable resource for scientists seeking inspiration for new ideas and research in the field of tumor immunology.