Fc Mediated Antibody Functions And Fc Receptor Polymorphism
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Fc Mediated Antibody Functions And Fc Receptor Polymorphism
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Author : Guido Ferrari
language : en
Publisher: Frontiers Media SA
Release Date : 2020-07-28
Fc Mediated Antibody Functions And Fc Receptor Polymorphism written by Guido Ferrari and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-28 with categories.
Fc Mediated Antibody Functions And Fc Receptor Polymorphism Volume Ii
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Author : Guido Ferrari
language : en
Publisher: Frontiers Media SA
Release Date : 2023-05-29
Fc Mediated Antibody Functions And Fc Receptor Polymorphism Volume Ii written by Guido Ferrari and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-29 with Medical categories.
Therapeutic Antibody Engineering
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Author : William R Strohl
language : en
Publisher: Elsevier
Release Date : 2012-10-16
Therapeutic Antibody Engineering written by William R Strohl and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-10-16 with Medical categories.
The field of antibody engineering has become a vital and integral part of making new, improved next generation therapeutic monoclonal antibodies, of which there are currently more than 300 in clinical trials across several therapeutic areas. Therapeutic antibody engineering examines all aspects of engineering monoclonal antibodies and analyses the effect that various genetic engineering approaches will have on future candidates. Chapters in the first part of the book provide an introduction to monoclonal antibodies, their discovery and development and the fundamental technologies used in their production. Following chapters cover a number of specific issues relating to different aspects of antibody engineering, including variable chain engineering, targets and mechanisms of action, classes of antibody and the use of antibody fragments, among many other topics. The last part of the book examines development issues, the interaction of human IgGs with non-human systems, and cell line development, before a conclusion looking at future issues affecting the field of therapeutic antibody engineering. - Goes beyond the standard engineering issues covered by most books and delves into structure-function relationships - Integration of knowledge across all areas of antibody engineering, development, and marketing - Discusses how current and future genetic engineering of cell lines will pave the way for much higher productivity
Antibody Fc
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Author : Margaret Ackerman
language : en
Publisher: Academic Press
Release Date : 2013-08-06
Antibody Fc written by Margaret Ackerman and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-08-06 with Medical categories.
Antibody Fc is the first single text to synthesize the literature on the mechanisms underlying the dramatic variability of antibodies to influence the immune response. The book demonstrates the importance of the Fc domain, including protective mechanisms, effector cell types, genetic data, and variability in Fc domain function. This volume is a critical single-source reference for researchers in vaccine discovery, immunologists, microbiologists, oncologists and protein engineers as well as graduate students in immunology and vaccinology. Antibodies represent the correlate of protection for numerous vaccines and are the most rapidly growing class of drugs, with applications ranging from cancer and infectious disease to autoimmunity. Researchers have long understood the variable domain of antibodies, which are responsible for antigen recognition, and can provide protection by blocking the function of their target antigen. However, recent developments in our understanding of the protection mediated by antibodies have highlighted the critical nature of the antibody constant, or Fc domain, in the biological activity of antibodies. The Fc domain allows antibodies to link the adaptive and innate immune systems, providing specificity to a wide range of innate effector cells. In addition, they provide a feedback loop to regulate the character of the immune response via interactions with B cells and antigen-presenting cells. - Clarifies the different mechanisms of IgG activity at the level of the different model systems used, including human genetic, mouse, and in vitro - Covers the role of antibodies in cancer, infectious disease, and autoimmunity and in the setting of monoclonal antibody therapy as well as naturally raised antibodies - Color illustrations enhance explanations of the immune system
Roles Of Fc Receptors In Disease And Therapy
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Author : Latha P. Ganesan
language : en
Publisher: Frontiers Media SA
Release Date : 2020-07-22
Roles Of Fc Receptors In Disease And Therapy written by Latha P. Ganesan and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-22 with categories.
Antibodies For Infectious Diseases
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Author : James E. Crowe, Jr.
language : en
Publisher: John Wiley & Sons
Release Date : 2020-07-24
Antibodies For Infectious Diseases written by James E. Crowe, Jr. and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-24 with Medical categories.
State-of-the-art reviews covering major aspects of antibodies and intervention against infectious diseases The connection between antibodies and infectious diseases has spawned entire related fields of study. Antibodies for Infectious Diseases presents perspectives from leading research scientists and summarizes the amazing progress in this area into a single definitive source. Providing a broad survey of the most important aspects of the field of antibodies for infectious diseases, this book presents general features pertaining to structure, function, isotype, and the role of complement in antibody function examines the role of antibodies in antimicrobial immunity with specific targets details new methods for expression of monoclonal antibodies, in plants or by transfer of antibody genes for in vivo expression in treated subjects Antibodies for Infectious Diseases is a comprehensive reference for researchers, pharmaceutical developers, and health care professionals on the status of the development of antibody-based therapies for treating infectious diseases. It is also useful as supplemental reading for upper level life sciences students. If you are looking for online access to the latest clinical microbiology content, please visit www.wiley.com/learn/clinmicronow.
Antibody Glycosylation
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Author : Marija Pezer
language : en
Publisher: Springer Nature
Release Date : 2021-10-22
Antibody Glycosylation written by Marija Pezer and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-22 with Medical categories.
This book summarizes recent advances in antibody glycosylation research. Covering major topics relevant for immunoglobulin glycosylation - analytical methods, biosynthesis and regulation, modulation of effector functions - it provides new perspectives for research and development in the field of therapeutic antibodies, biomarkers, vaccinations, and immunotherapy. Glycans attached to both variable and constant regions of antibodies are known to affect the antibody conformation, stability, and effector functions. Although it focuses on immunoglobulin G (IgG), the most explored antibody in this context, and unravels the natural phenomena resulting from the mixture of IgG glycovariants present in the human body, the book also discusses other classes of human immunoglobulins, as well as immunoglobulins produced in other species and production systems. Further, it reviews the glycoanalytical methods applied to antibodies and addresses a range of less commonly explored topics, such as automatization and bioinformatics aspects of high-throughput antibody glycosylation analysis. Lastly, the book highlights application areas ranging from the ones already benefitting from antibody glycoengineering (such as monoclonal antibody production), to those still in the research stages (such as exploration of antibody glycosylation as a clinical or biological age biomarker), and the potential use of antibody glycosylation in the optimization of vaccine production and immunization protocols. Summarizing the current knowledge on the broad topic of antibody glycosylation and its therapeutic and biomarker potential, this book will appeal to a wide biomedical readership in academia and industry alike. Chapter 4 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Tumor Immunology And Immunotherapy Cellular Methods Part B
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Author :
language : en
Publisher: Academic Press
Release Date : 2020-01-29
Tumor Immunology And Immunotherapy Cellular Methods Part B written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-29 with Science categories.
Tumor Immunology and Immunotherapy – Cellular Methods Part B, Volume 632, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Topics covered include Quantitation of calreticulin exposure associated with immunogenic cell death, Side-by-side comparisons of flow cytometry and immunohistochemistry for detection of calreticulin exposure in the course of immunogenic cell death, Quantitative determination of phagocytosis by bone marrow-derived dendritic cells via imaging flow cytometry, Cytofluorometric assessment of dendritic cell-mediated uptake of cancer cell apoptotic bodies, Methods to assess DC-dependent priming of T cell responses by dying cells, and more. - Contains content written by authorities in the field - Provides a comprehensive view on the topics covered - Includes a high level of detail
Effector Functions Of Therapeutic Antibodies
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Author : Peter Boross
language : en
Publisher: Frontiers Media SA
Release Date : 2023-02-15
Effector Functions Of Therapeutic Antibodies written by Peter Boross and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-02-15 with Medical categories.
Structure And Function Of Antibodies
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Author : Roy Jefferis
language : en
Publisher: MDPI
Release Date : 2021-02-05
Structure And Function Of Antibodies written by Roy Jefferis and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-02-05 with Science categories.
This book provides a detailed description of all kinds of therapeutic antibodies including IgGs, IgAs, IgEs, and IgMs, bispecific antibodies, chimeric antigen receptor antibodies, and antibody fragments. Details about how each of these antibodies interact with their ligands, the immune system, and their targets are provided. Additionally, this book delves into the details of antibody, Fc, and variable chain structures, and how subtle changes in structure, charge, flexibility, post-translational modification, and the ability to bind to natural antibody ligands can result in a significant impact on antibody activity and functionality. Finally, the book explains the critical quality attributes of modern therapeutic antibodies and how to ensure that antibodies entering development have the best possible chance of success.