Fibrosis
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Fibrosis In Disease
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Author : Monte S. Willis
language : en
Publisher: Springer
Release Date : 2018-11-10
Fibrosis In Disease written by Monte S. Willis and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-10 with Medical categories.
Fibroproliferative diseases are a broad spectrum of entities from organ-specific involvement (e.g., pulmonary, heart, liver, and kidney fibrosis) to multi-system diseases such as systemic sclerosis and sclerodermatous graft vs. host disease. These diseases also encompass pathophysiologies not readily recognizably related, such as macular degeneration and cancer metastasis. Fibroproliferative diseases are a leading cause of morbidity and mortality and can affect all tissues and organ systems. Remarkable progress in elucidating the pathogenesis of these common diseases with fibrotic components, including the critical roles of myofibroblasts and the molecular mechanisms driving the transcriptional activation involved in the induction of fibrosis. As the importance of these processes is realized in the long-term recovery and treatment of diseases, effective anti-fibrotic therapies targeting the underlying ongoing disease processes are lacking. The complexity of discovering and applying therapies to fibroproliferative disease may be due to the diversity of the systems the pathogenesis of disease itself involves. By nature, fibroproliferative diseases are interdisciplinary, involving multiple cell types (organ-specific epithelial cells), immune cells, endothelial cells, and fibroblasts. Bone marrow, cytokines, and organ-specific pathologies further speckle both the clinical and scientific disciplines in such a way that communication is often limited to the clinical or scientific tribes we live in, despite the greatest access to information known to man available today. Therefore, the primary focus of this text is to bring together authors from a diversity of both clinical, scientific, and therapeutic backgrounds for readers to more fully appreciate that fantastic platform that is available to build upon to lessen the isolation of the clinical and scientific disciplines. With advances in the discovery of pre-clinical therapeutic targets (at least 20+ to date) involving TGF-beta (and other cytokines), transcription factors, and downstream kinases, it’s important to both recognize the broader impact and potential opportunities that exist even today. This book will serve as a state-of-the-art resource for physicians and translational medical researchers alike who are interested in the rapidly evolving field of fibroproliferative diseases. The book will provide new insight into the fundamental mechanisms of classic fibrotic pathophysiologic processes like myocardial infarction, idiopathic pulmonary fibrosis, chronic kidney disease, wound healing, and systemic sclerosis. It will also highlight the many new areas of therapeutic investigation currently underway. Lastly, we will touch upon newly emerging fields investigating the role of fibrosis in macular degeneration and cancer metastasis. The chapters will be written by established experts in their fields, including clinicians (cardiologists, cardiovascular surgeons, pathologists, and general practitioners) and translational biomedical researchers in a wide range of disciplines. However, the material will certainly have a broader audience including medical residents, fellows, and general practitioners as well as M.D. or Ph.D. post-doctoral research fellows. While comprehensive, we'll attempt to present the material in a manner that simplifies the complex pathophysiologic mechanisms that underlie common fibroproliferative diseases while making it appealing to a broad audience.
Idiopathic Pulmonary Fibrosis
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Author : Keith C. Meyer
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-10-16
Idiopathic Pulmonary Fibrosis written by Keith C. Meyer and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-16 with Medical categories.
Idiopathic Pulmonary Fibrosis: A Comprehensive Clinical Guide delivers a concise review of our current understanding of disease pathogenesis and provides current evidence in the medical literature regarding its diagnosis and management. Each chapter includes key points and a summary aiming to update clinicians about various issues concerning the diagnosis and management of IPF. In addition to outlining the current state of knowledge, each chapter also provides a summary of ongoing research and identifies the needs for future research in the field. Idiopathic Pulmonary Fibrosis: A Comprehensive Clinical Guide is an important new text that provides its readers with a better understanding of the pathobiology and natural history of IPF as it continues to evolve.
Fibrosis Research
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Author : John Varga
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-02
Fibrosis Research written by John Varga and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-02 with Medical categories.
Leading investigators review the highlights of current fibrosis research and the experimental methodologies used uncover the mechanisms that drive it. In their discussion of research methodologies utilizing cultured cells to model various aspects of the fibrotic response in vitro, the authors describe the isolation, characterization, and propagation of mesenchymal cells, and highlight the similarities and differences between methods that are appropriate for different types of fibroblasts. Approaches for studying collagen gene regulation and TGF-b production are also discussed, along with experimental methodologies utilizing animal models to study the pathogenesis of fibrosis. The protocols follow the successful Methods in Molecular MedicineTM series format, each offering step-by-step laboratory instructions, an introduction outlining the principles behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.
Idiopathic Pulmonary Fibrosis
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Author : Jeffrey Swigris
language : en
Publisher: Elsevier Health Sciences
Release Date : 2018-07-25
Idiopathic Pulmonary Fibrosis written by Jeffrey Swigris and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-07-25 with Medical categories.
Designed with the practicing clinician in mind, Idiopathic Pulmonary Fibrosis provides a succinct, easy-to-digest overview of this challenging condition in which the cause of thickening lung tissue is unknown. This concise resource by Drs. Kevin K. Brown and Jeff Swigris provides essential information for the physician who sees pulmonary fibrosis patients, including epidemiology, genetics and biomarkers, pathology, diagnosis, disease monitoring, and therapeutics intended to improve the patient’s lifespan and quality of life.
Idiopathic Pulmonary Fibrosis
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Author : Ulrich Costabel
language : en
Publisher: European Respiratory Society
Release Date : 2016-03-01
Idiopathic Pulmonary Fibrosis written by Ulrich Costabel and has been published by European Respiratory Society this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-03-01 with Medical categories.
Idiopathic pulmonary fibrosis (IPF) is a steadily progressive and ultimately fatal disease of unknown origin. Recent years have seen advances in our understanding of IPF and a number of guidelines have been published. But many questions remain unanswered, particularly surrounding probable versus definite IPF. This Monograph aims to discuss the latest achievements in IPF, and covers key diagnostic issues, staging of the disease, complications and comorbidities, treatment, unmet patient needs and perspectives for the future. This book will be of interest to all clinicians and researchers in this area.
Guide To Clinical Management Of Idiopathic Pulmonary Fibrosis
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Author : Steven D Nathan
language : en
Publisher: Springer
Release Date : 2016-07-27
Guide To Clinical Management Of Idiopathic Pulmonary Fibrosis written by Steven D Nathan and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-07-27 with Medical categories.
This clinically focused pocket guide offers a concise yet complete overview of idiopathic pulmonary fibrosis, covering the most recent information on aspects such as pathophysiology, management, treatment, and clinical trials. The text is easily accessible and offers pulmonologists and other health care professionals with an excellent quick reference tool. Full color images and figures enhance and summarize key aspects of the text. Idiopathic pulmonary fibrosis is a condition that affects the alveoli and leads to serious lung damage, and the idiopathic nature of this disease means that the origin or cause is unknown. This disease is relatively rare, affecting 3 in 10,000 people, but it is becoming more common. Physicians should be aware of the early stages and symptoms of this disease so management strategies can be implemented quickly, and the best treatment can be administered.
Idiopathic Pulmonary Fibrosis
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Author : Hiroyuki Nakamura
language : en
Publisher: Springer
Release Date : 2015-09-28
Idiopathic Pulmonary Fibrosis written by Hiroyuki Nakamura and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-09-28 with Medical categories.
From epidemiology and pathogenesis to disease management, this book reviews our current understanding of and provides up-to-date information of Idiopathic Pulmonary Fibrosis (IPF). A subtype of Idiopathic Interstitial Pneumonias (IIP), IPF is one of the most elusive and intractable respiratory disease to date and its triggering factors remain unclear. However, new developments such as serum markers that are highly specific to IPF (i.e. KL-6, SP-A, and SP-D), the establishment of systematic diagnostic imaging (HRCT) and accumulated reports of treatment using an antifibrotic agent (pirfenidone) are slowly improving our understanding of the disease. Edited by an established authority in the field and written by experts, this book will be valuable to not only to beginning learners but also to physicians, instructors and researchers whose work involves IIPs. With each chapter exploring critical questions, with unresolved issues and future prospects, the book offers a valuable resource for understanding issues such as the newly proposed entity of interstitial pneumonia with emphysema (combined pulmonary fibrosis and emphysema: CPFE) and the mechanism of how so many IIP sufferers develop lung cancer.
Cystic Fibrosis
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Author : S. Karger AG
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2001-01-01
Cystic Fibrosis written by S. Karger AG and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-01-01 with Medical categories.
Treatment Of Cystic Fibrosis And Other Rare Lung Diseases
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Author : Arata Azuma
language : en
Publisher: Springer
Release Date : 2017-01-28
Treatment Of Cystic Fibrosis And Other Rare Lung Diseases written by Arata Azuma and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-28 with Medical categories.
This volume describes the pathogenesis and pathophysiology of several pulmonary diseases as well as their treatment. It also discusses the underlying genetic and molecular biological basis, which opens the way for new treatments for these conditions. It focuses on the treatment of cystic fibrosis including CFTR (cystic fibrosis transmembrane-conductance regulator) modulator therapies, drug therapies that augment airway surface liquid as well as anti-inflammatory and anti-infective therapies. Further topics include long-term, low-dose macrolide therapy for diffuse panbronchiolitis; novel agents for previously untreatable idiopathic pulmonary fibrosis; possible new treatments for pulmonary alveolar proteinosis (PAP); and multiple novel therapeutic targets for treating lymphangiomyomatosis. Research into these conditions has led to major advances in our understanding of the underlying genetic and molecular basis of this disease, and to dramatic improvements in survival and quality of life for affected individuals.
Cystic Fibrosis Third Edition
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Author : Margaret Hodson
language : en
Publisher: CRC Press
Release Date : 2012-12-11
Cystic Fibrosis Third Edition written by Margaret Hodson and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-11 with Medical categories.
This international and authoritative work, which brings together current knowledge in the field of cystic fibrosis, has become established in previous editions as a leading reference in the field. The third edition continues to provide everything that the clinician or allied health professional treating patients with cystic fibrosis will need in a single manageable volume. Thoroughly revised and updated throughout, it reflects the significant advances that have been made in the field since the second edition published in 2000. Cystic Fibrosis evaluates in detail the basic science that underlies the disease and its progression, putting it into a clinical context. Diagnostic and clinical aspects are covered in depth, as are monitoring the condition and the importance of multi-disciplinary care, reflected in the sections into which the new edition has been sub-divided to improve accessibility. Future developments, including novel therapies, are covered in a concluding section. The clinical areas have been much expanded, with the introduction of separate chapters covering sleep, lung mechanics and the work of breathing, upper airway disease, insulin deficiency and diabetes, bone disease, and sexual and reproductive issues. A new section on monitoring discusses the use of databases to improve patient care, and covers monitoring in different age groups, exercise testing and the outcomes of clinical trials in these areas. Separate chapters are devoted to paramedical issues, including nursing, physiotherapy, psychology, and palliative and spiritual care. Throughout, the emphasis is on providing an up-to-date and balanced review of both the clinical and basic sciences aspects of the subject, and to reflect the multi-disciplinary nature of the cystic fibrosis care team. Drawing on the expertise of a team of international specialists from a variety of backgrounds, the third edition of Cystic Fibrosiswill continue to find a broad readership among respiratory physicians, paediatricians, specialist nurses and other health professionals working with patients with cystic fibrosis.