Fitness Evolution And Generation Of Resistant Variants During Large Population Transmission Of Vesicular Stomatitis Virus In Interferon Treated Cells
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Fitness Evolution And Generation Of Resistant Variants During Large Population Transmission Of Vesicular Stomatitis Virus In Interferon Treated Cells
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Author : Martin J. Cilnis
language : en
Publisher:
Release Date : 1995
Fitness Evolution And Generation Of Resistant Variants During Large Population Transmission Of Vesicular Stomatitis Virus In Interferon Treated Cells written by Martin J. Cilnis and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with categories.
Variation And Evolution In Plants And Microorganisms
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Author : National Academy of Sciences
language : en
Publisher: National Academies Press
Release Date : 2000-10-11
Variation And Evolution In Plants And Microorganisms written by National Academy of Sciences and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-10-11 with Science categories.
"The present book is intended as a progress report on [the] synthetic approach to evolution as it applies to the plant kingdom." With this simple statement, G. Ledyard Stebbins formulated the objectives of Variation and Evolution in Plants, published in 1950, setting forth for plants what became known as the "synthetic theory of evolution" or "the modern synthesis." The pervading conceit of the book was the molding of Darwin's evolution by natural selection within the framework of rapidly advancing genetic knowledge. At the time, Variation and Evolution in Plants significantly extended the scope of the science of plants. Plants, with their unique genetic, physiological, and evolutionary features, had all but been left completely out of the synthesis until that point. Fifty years later, the National Academy of Sciences convened a colloquium to update the advances made by Stebbins. This collection of 17 papers marks the 50th anniversary of the publication of Stebbins' classic. Organized into five sections, the book covers: early evolution and the origin of cells, virus and bacterial models, protoctist models, population variation, and trends and patterns in plant evolution.
Virus As Populations
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Author : Esteban Domingo
language : en
Publisher: Academic Press
Release Date : 2019-11-06
Virus As Populations written by Esteban Domingo and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-06 with Science categories.
Virus as Composition, Complexity, Quasispecies, Dynamics, and Biological Implications, Second Edition, explains the fundamental concepts surrounding viruses as complex populations during replication in infected hosts. Fundamental phenomena in virus behavior, such as adaptation to changing environments, capacity to produce disease, and the probability to be transmitted or respond to treatment all depend on virus population numbers. Concepts such as quasispecies dynamics, mutations rates, viral fitness, the effect of bottleneck events, population numbers in virus transmission and disease emergence, and new antiviral strategies are included. The book's main concepts are framed by recent observations on general virus diversity derived from metagenomic studies and current views on the origin and role of viruses in the evolution of the biosphere. Features current views on key steps in the origin of life and origins of viruses Includes examples relating ancestral features of viruses with their current adaptive capacity Explains complex phenomena in an organized and coherent fashion that is easy to comprehend and enjoyable to read Considers quasispecies as a framework to understand virus adaptability and disease processes
Origin And Evolution Of Viruses
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Author : Esteban Domingo
language : en
Publisher: Elsevier
Release Date : 2008-06-23
Origin And Evolution Of Viruses written by Esteban Domingo and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-06-23 with Science categories.
New viral diseases are emerging continuously. Viruses adapt to new environments at astounding rates. Genetic variability of viruses jeopardizes vaccine efficacy. For many viruses mutants resistant to antiviral agents or host immune responses arise readily, for example, with HIV and influenza. These variations are all of utmost importance for human and animal health as they have prevented us from controlling these epidemic pathogens. This book focuses on the mechanisms that viruses use to evolve, survive and cause disease in their hosts. Covering human, animal, plant and bacterial viruses, it provides both the basic foundations for the evolutionary dynamics of viruses and specific examples of emerging diseases. NEW - methods to establish relationships among viruses and the mechanisms that affect virus evolution UNIQUE - combines theoretical concepts in evolution with detailed analyses of the evolution of important virus groups SPECIFIC - Bacterial, plant, animal and human viruses are compared regarding their interation with their hosts
Structural Virology
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Author : Mavis Agbandje-McKenna
language : en
Publisher: Royal Society of Chemistry
Release Date : 2010-11-11
Structural Virology written by Mavis Agbandje-McKenna and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-11-11 with Medical categories.
Over the last ten years, much effort has been devoted to improving the biophysical techniques used in the study of viruses. This has resulted in the visualization of these large macromolecular assemblages at atomic level, thus providing the platform for functional interpretation and therapeutic design. Structural Virology covers a wide range of topics and is split into three sections. The first discusses the vast biophysical methodologies used in structural virology, including sample production and purification, confocal microscopy, mass spectrometry, negative-stain and cryo-electron microscopy, X-ray crystallography and nuclear magnetic resonance spectroscopy. The second discusses the role of virus capsid protein structures in determining the functional roles required for receptor recognition, cellular entry, capsid assembly, genome packaging and mechanisms of host immune system evasion. The last section discusses therapeutic strategies based on virus protein structures, including the design of antiviral drugs and the development of viral capsids as vehicles for foreign gene delivery. Each topic covered will begin with a review of the current literature followed by a more detailed discussion of experimental procedures, a step in the viral life cycle, or strategies for therapeutic development. With contributions from experts in the field of structural biology and virology this exceptional monograph will appeal to biomedical scientists involved in basic and /or applied research on viruses. It also provides up-to-date reference material for students entering the field of structural virology as well as scientists already familiar with the area.
Chimpanzees In Biomedical And Behavioral Research
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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 2011-12-05
Chimpanzees In Biomedical And Behavioral Research written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-12-05 with Science categories.
For many years, experiments using chimpanzees have been instrumental in advancing scientific knowledge and have led to new medicines to prevent life-threatening and debilitating diseases. However, recent advances in alternate research tools have rendered chimpanzees largely unnecessary as research subjects. The Institute of Medicine, in collaboration with the National Research Council, conducted an in-depth analysis of the scientific necessity for chimpanzees in NIH-funded biomedical and behavioral research. The committee concludes that while the chimpanzee has been a valuable animal model in the past, most current biomedical research use of chimpanzees is not necessary, though noted that it is impossible to predict whether research on emerging or new diseases may necessitate chimpanzees in the future.
Quasispecies And Rna Virus Evolution
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Author : Esteban Domingo
language : en
Publisher:
Release Date : 2001
Quasispecies And Rna Virus Evolution written by Esteban Domingo and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with Medical categories.
Quasispecies From Theory To Experimental Systems
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Author : Esteban Domingo
language : en
Publisher: Springer
Release Date : 2016-03-18
Quasispecies From Theory To Experimental Systems written by Esteban Domingo and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-03-18 with Medical categories.
This volume brings together recent developments in quasispecies theory extended to variable environments and practical applications in elucidating viral dynamics and treatment designs. In particular, the existence of an error threshold in rugged fitness landscapes has opened the way to a new antiviral strategy termed lethal mutagenesis, which is now under intensive theoretical, experimental and clinical investigation. As such the book explains how an understanding of quasispecies dynamics within infected organisms has increased our knowledge of viral disease events. From a clinical perspective, population dynamics highlights important problems for viral disease control, such as the selection of drug-resistant mutants that often accompanies treatment failures, and suggests means of increasing the effectiveness of antiviral treatments. The book is intended for students and scientists interested in basic and applied aspects of biophysics, chemistry, biology, evolution and medical virology.
Encyclopedia Of Infectious Diseases
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Author : Michel Tibayrenc
language : en
Publisher: John Wiley & Sons
Release Date : 2007-07-31
Encyclopedia Of Infectious Diseases written by Michel Tibayrenc and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-07-31 with Science categories.
Discover how the application of novel multidisciplinary, integrative approaches and technologies are dramatically changing our understanding of the pathogenesis of infectious diseases and their treatments. Each article presents the state of the science, with a strong emphasis on new and emerging medical applications. The Encyclopedia of Infectious Diseases is organized into five parts. The first part examines current threats such as AIDS, malaria, SARS, and influenza. The second part addresses the evolution of pathogens and the relationship between human genetic diversity and the spread of infectious diseases. The next two parts highlight the most promising uses of molecular identification, vector control, satellite detection, surveillance, modeling, and high-throughput technologies. The final part explores specialized topics of current concern, including bioterrorism, world market and infectious diseases, and antibiotics for public health. Each article is written by one or more leading experts in the field of infectious diseases. These experts place all the latest findings from various disciplines in context, helping readers understand what is currently known, what the next generation of breakthroughs is likely to be, and where more research is needed. Several features facilitate research and deepen readers' understanding of infectious diseases: Illustrations help readers understand the pathogenesis and diagnosis of infectious diseases Lists of Web resources serve as a gateway to important research centers, government agencies, and other sources of information from around the world Information boxes highlight basic principles and specialized terminology International contributions offer perspectives on how infectious diseases are viewed by different cultures A special chapter discusses the representation of infectious diseases in art With its multidisciplinary approach, this encyclopedia helps point researchers in new promising directions and helps health professionals better understand the nature and treatment of infectious diseases.
Parasite Diversity And Diversification
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Author : Serge Morand
language : en
Publisher: Cambridge University Press
Release Date : 2015-02-26
Parasite Diversity And Diversification written by Serge Morand and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-02-26 with Medical categories.
By joining phylogenetics and evolutionary ecology, this book explores the patterns of parasite diversity while revealing diversification processes.