Fk866 Reduces Axon Pathology In In Vitro And In Vivo Models Of Huntington S Disease And Alzheimer S Disease And Attenuates Behavioral Abnormalities
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Pathogenesis Of Neurodegenerative Disorders
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Author : Mark P. Mattson
language : en
Publisher: Springer Science & Business Media
Release Date : 2001
Pathogenesis Of Neurodegenerative Disorders written by Mark P. Mattson and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with Medical categories.
During the past decade many advances in our understanding of the molecular genetics and environmental factors that either cause or increase risk for age-related neurodegenerative disorders have been made. This book elucidates the fundamental mechanisms involved in neurodegenerative disorders such as Alzheimer's Parkinson's, and Huntington's diseases. In addition mechanisms that may prevent age-related neurodegenerative disorders are also provided. Pathogenesis of Neurodegenerative disorders will provide a valuable reference to graduate students and post docs as well as to senior scientists by allowing them to integrate information on cellular and molecular mechanisms across the wide field of neurodegenerative disorders.
Endocrine Secrets
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Author : Michael T. McDermott, MD
language : en
Publisher: Elsevier Health Sciences
Release Date : 2013-04-18
Endocrine Secrets written by Michael T. McDermott, MD and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-18 with Medical categories.
The thoroughly updated Endocrine Secrets, 6th Edition continues the tradition of the highly popular Secrets Series®, offering fast answers to the most essential clinical endocrinology questions. A user-friendly Q&A format, replete with valuable pearls, tips, and memory aids, helps you to learn and study efficiently. It all adds up to a perfect concise board review or handy clinical endocrinology resource. Expedite your reference and review with a question-and-answer format that's conversational and easy to read. Zero in on key information with bulleted lists, mnemonics, practical tips from prominent endocrinologists, and "Key Points" boxes that provide a concise overview of important board-relevant content. Quickly review essential material with a chapter containing the "Top 100 Secrets" in endocrinology. Take your Secrets anywhere thanks to a convenient, pocket-sized design! Remain at the forefront of medical endocrinology with updates on new techniques and technologies, as well as changing treatment options and drug information. Equip yourself for effective practice with coverage of the most current developments in obesity management, weight loss drugs, and bariatric surgery; the newest guidelines for the pharmacological treatment of type 2 diabetes mellitus; and much more. Make use of practical tips on intensive insulin therapy, and apply evidence-based techniques to achieve appropriate glucose control in hospitalized patients and effectively manage thyroid cancer. Access the latest research concerning the benefits and risks of the wide range of osteoporosis therapies.
Medicinal Foods As Potential Therapies For Type 2 Diabetes And Associated Diseases
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Author : Solomon Habtemariam
language : en
Publisher: Academic Press
Release Date : 2019-06-08
Medicinal Foods As Potential Therapies For Type 2 Diabetes And Associated Diseases written by Solomon Habtemariam and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-08 with Medical categories.
Medicinal Foods as Potential Therapies for Type-2 Diabetes and Associated Diseases: The Chemical and Pharmacological Basis of their Action focuses on active pharmacological principles that modulate diabetes, associated risk factors, complications and the mechanism of action of widely used anti-diabetic herbal plants—rather than just the nutritional composition of certain foods. The book provides up-to-date information on acclaimed antidiabetic super fruits, spices and other food ingredients. Sections cover diabetes and obesity at the global level, the physiological control of carbohydrate and lipid metabolism, the pathophysiology of type-2 diabetes, the chemistry and pharmacology of a variety of spices, and much more. This book will be invaluable for research scientists and students in the medical and pharmaceutical sciences, medicinal chemistry, herbal medicine, drug discovery/development, nutrition science, and for herbal practitioners and those from the nutraceutical and pharm industries. Provides background knowledge on type-2 diabetes and its pathophysiology and therapeutic targets down to the molecular level Explores, in detail, the chemistry or secondary metabolites of the indicated foods that potentially modify diabetes and/or associated diseases Examines the pharmacological findings on medicinal foods, including available clinical trials
Natural Products And Drug Discovery
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Author : Subhash C. Mandal
language : en
Publisher: Elsevier
Release Date : 2018-02-16
Natural Products And Drug Discovery written by Subhash C. Mandal and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-02-16 with Science categories.
Natural Products and Drug Discovery: An Integrated Approach provides an applied overview of the field, from traditional medicinal targets, to cutting-edge molecular techniques. Natural products have always been of key importance to drug discovery, but as modern techniques and technologies have allowed researchers to identify, isolate, extract and synthesize their active compounds in new ways, they are once again coming to the forefront of drug discovery. Combining the potential of traditional medicine with the refinement of modern chemical technology, the use of natural products as the basis for drugs can help in the development of more environmentally sound, economical, and effective drug discovery processes. Natural Products & Drug Discovery: An Integrated Approach reflects on the current changes in this field, giving context to the current shift and using supportive case studies to highlight the challenges and successes faced by researchers in integrating traditional medicinal sources with modern chemical technologies. It therefore acts as a useful reference to medicinal chemists, phytochemists, biochemists, pharma R&D professionals, and drug discovery students and researchers. Reviews the changing role of natural products in drug discovery, integrating traditional knowledge with modern molecular technologies Highlights the potential future role of natural products in preventative medicine Supported by real world case studies throughout
Inflammasomes Clinical And Therapeutic Implications
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Author : Mario D. Cordero
language : en
Publisher: Springer
Release Date : 2018-09-04
Inflammasomes Clinical And Therapeutic Implications written by Mario D. Cordero and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-09-04 with Science categories.
The inflammasome is a protein complex composed of an intracellular sensor—typically a Nod-like receptor (NLR), the precursor procaspase-1, and the adaptor ASC. Inflammasome activation leads to the maturation of caspase-1 and the processing of its substrates, IL-1β and IL-18. The inflammasome has been implicated numerous diseases, and blockade of inflammasome-derived IL-1β has beneficial effects on several of these diseases. Different books have been edited about the biology of inflammasomes and about methods to study, however, the implication of this complex in the different diseases and pathological conditions show the need of a book about the clinical implications and therapeutic options. This project will show the context where inflammasomes are being studied and the molecular implications in the medical and clinical contexts. Other important topic of the inflammasomes will be the development of pharmacological inhibitors in order to improve new clinical applications. In this sense, we can find new drugs with inhibitory effects or old drugs with an inhibitory potential effect. There is a need for re-establishing the real benefits of the inflammasome inhibitions in pathological situations and the management of the differents diseases where inflammasomes are implicated.
Genome Stability
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Author : Igor Kovalchuk
language : en
Publisher: Academic Press
Release Date : 2021-07-17
Genome Stability written by Igor Kovalchuk and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-17 with Science categories.
Genome Stability: From Virus to Human Application, Second Edition, a volume in the Translational Epigenetics series, explores how various species maintain genome stability and genome diversification in response to environmental factors. Here, across thirty-eight chapters, leading researchers provide a deep analysis of genome stability in DNA/RNA viruses, prokaryotes, single cell eukaryotes, lower multicellular eukaryotes, and mammals, examining how epigenetic factors contribute to genome stability and how these species pass memories of encounters to progeny. Topics also include major DNA repair mechanisms, the role of chromatin in genome stability, human diseases associated with genome instability, and genome stability in response to aging. This second edition has been fully revised to address evolving research trends, including CRISPRs/Cas9 genome editing; conventional versus transgenic genome instability; breeding and genetic diseases associated with abnormal DNA repair; RNA and extrachromosomal DNA; cloning, stem cells, and embryo development; programmed genome instability; and conserved and divergent features of repair. This volume is an essential resource for geneticists, epigeneticists, and molecular biologists who are looking to gain a deeper understanding of this rapidly expanding field, and can also be of great use to advanced students who are looking to gain additional expertise in genome stability. A deep analysis of genome stability research from various kingdoms, including epigenetics and transgenerational effects Provides comprehensive coverage of mechanisms utilized by different organisms to maintain genomic stability Contains applications of genome instability research and outcomes for human disease Features all-new chapters on evolving areas of genome stability research, including CRISPRs/Cas9 genome editing, RNA and extrachromosomal DNA, programmed genome instability, and conserved and divergent features of repair
Animal Models Of Neurological Disease
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Author : Frank Clifford Rose
language : en
Publisher:
Release Date : 1980
Animal Models Of Neurological Disease written by Frank Clifford Rose and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1980 with Medical categories.
Cardiac And Vascular Diseases
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Author : Hadley L. Conn
language : en
Publisher:
Release Date : 1971
Cardiac And Vascular Diseases written by Hadley L. Conn and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1971 with Medical categories.
Nitric Oxide In The Nervous System
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Author :
language : en
Publisher: Elsevier
Release Date : 1995-04-07
Nitric Oxide In The Nervous System written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-04-07 with Medical categories.
The gas nitric oxide (NO) has burst upon neuroscience only recently, and yet it has permeated into almost every avenue of current research. The unique properties of this novel messenger have revolutionized our way ofthinking about neurotransmission. These special properties have also lead neuroscientists to invoke NO to explain many previously unexplained phenomena in neurobiology. Fortunately, the development of numerous pharmacological agents is now allowing thesehypotheses to be tested. This volume will provide a synopsis of what is now known about NO. How and where NO is produced, how it acts at the molecular level to activate the synthesis of cGMP, and the possible targets of cGMP in the nervous system are reviewed. The roles of theNO/cGMP signal transduction pathway in the central and peripheral nervous systems, in glial cells, and in neuropathology are then explored. Together, these reviews will lead to further work explaining the varied functions of NO. Key Features * Describes how and why NO is produced in the nervous system * Examines all that is known of NOs role as a neurotransmitter * Explores cellular actions and physiological roles in the brain and peripheral nervous system Covers NOs molecular synthesis to its role in neuropathology
Adipose Tissue
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Author : Bernard Jeanrenaud
language : en
Publisher:
Release Date : 1970
Adipose Tissue written by Bernard Jeanrenaud and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1970 with categories.