Pathogenesis Of Neurodegenerative Disorders
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Pathogenesis Of Neurodegenerative Disorders
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Author : Mark P. Mattson
language : en
Publisher: Springer Science & Business Media
Release Date : 2001-06-01
Pathogenesis Of Neurodegenerative Disorders written by Mark P. Mattson and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-06-01 with Medical categories.
As the average life expectancy of many populations throughout the world increases, so to does the incidence of such age-related neurodegenerative disorders as Alzheimer's, Parkinson's, and Huntington's diseases. Rapid advances in our understanding of the molecular genetics and environmental factors that either cause or increase risk for age-related neurodegenerative disor ders have been made in the past decade. The ability to evaluate, at the cellular and molecular level, abnormalities in postmortem brain tissue from patients, when taken together with the development of valuable animal and cell-culture models of neurodegenerative disorders has allowed the identification of sequences of events within neurons that result in their demise in specific neurodegenerative disorders. Though the genetic and environmental factors that pro mote neurodegeneration may differ among disorders, shared biochemical cascades that will ultimately lead to the death of neurons have been identified. These cascades involve oxyradical production, aberrant regulation of cellular ion homeostasis and activation of a stereotyped sequence of events involving mitochondrial dysfunction and activa tion of specific proteases. Pathogenesis of Neurodegenerative Disorders provides a timely compilation of articles that encompasses fundamental mechanisms involved in neurodegenerative disorders. In addition, mechanisms that may prevent age-related neurodegenerative disorders are presented. Each chapter is written by an expert in the particular neurodegenerative disorder or mechanism or neuronal death discussed.
Neurodegenerative Diseases
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Author : M. Flint Beal
language : en
Publisher: Cambridge University Press
Release Date : 2005-06-02
Neurodegenerative Diseases written by M. Flint Beal and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-06-02 with Medical categories.
Neurodegenerative diseases are major contributors to disability and disease, with Alzheimer's and Parkinson's diseases the most prevalent. This major reference reviews the rapidly advancing knowledge of pathogenesis and treatment of neurodegenerative diseases in the context of a comprehensive survey of each disease and its clinical features. The editors and contributors are among the leading experts in the field internationally. Covering basic science, diagnostic tools and therapeutic approaches, the book focuses on all aspects of neurodegenerative disease, including the normal aging process. The dementias, prion diseases, Parkinson's disease and atypical parkinsonisms, neurodegenerative ataxias, motor neuron diseases, degenerative diseases with chorea, iron and copper disorders, and mitochondrial diseases, are all methodically presented and discussed, with extensive illustrations. In each case the underlying genetics, neuropathological and clinical issues are fully reviewed, making this the most complete as well as the most authoritative reference available to clinicians and neuroscientists.
Pathogenesis Of Neurodegenerative Disorders
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Author : Mark P. Mattson
language : en
Publisher:
Release Date : 2014-01-15
Pathogenesis Of Neurodegenerative Disorders written by Mark P. Mattson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-01-15 with categories.
Hypothesis And Dynamics In The Pathogenesis Of Neurodegenerative Disorders
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Author : Lawrence M. Agius
language : en
Publisher: Bentham Science Publishers
Release Date : 2009
Hypothesis And Dynamics In The Pathogenesis Of Neurodegenerative Disorders written by Lawrence M. Agius and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Medical categories.
This book presents a series of clinical and pathologic observations that are thought to contribute to progressive incremental severity in neuronal cell loss and tissue atrophy in the cerebral cortex. The book includes a critical reappraisal of lesions in
Pathology Prevention And Therapeutics Of Neurodegenerative Disease
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Author : Sarika Singh
language : en
Publisher: Springer
Release Date : 2018-09-24
Pathology Prevention And Therapeutics Of Neurodegenerative Disease written by Sarika Singh and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-09-24 with Medical categories.
This book, written by a leading panel of experts in the field of neurosciences, provides a comprehensive overview of the pathology of neurodegenerative diseases as well as the preventive measures. Prevention is important due to the lack of early diagnostic markers and the limitations/ problems of treating neurodegenerative diseases
Neurodegenerative Disorders As Systemic Diseases
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Author : Keiji Wada
language : en
Publisher: Springer
Release Date : 2015-10-21
Neurodegenerative Disorders As Systemic Diseases written by Keiji Wada and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-10-21 with Medical categories.
This book sheds new light on neurodegenerative disorders as systemic diseases. Classically, neuronal cell death was a hallmark of such disorders. However, it has become evident that neural dysfunction is more important in the pathophysiology of neurodegenerative disorders. More recently, the prionoid-spreading hypothesis of disease-causing molecules has attracted a great deal of attention. Therapeutic strategies thus must be reconsidered in the light that neurodegenerative disorders are indeed systemic diseases. The first part of this book introduces the concept of neurodegeneration in biology and pathophysiology. The second part focuses on clinical evaluation and biomarkers from the perspective of this new concept, while the third summarizes the risk factors of neurodegeneration. The fourth part of this work indicates future directions of treatment, and the final part discusses health promotion for prevention and quality of life. This book will be of interest to both researchers and medical personnel, and provides a fresh approach to neurodegenerative diseases, paving the way to new research and improved quality of health care for patients.
The Molecular And Clinical Pathology Of Neurodegenerative Disease
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Author : Patrick A. Lewis
language : en
Publisher: Academic Press
Release Date : 2018-11-16
The Molecular And Clinical Pathology Of Neurodegenerative Disease written by Patrick A. Lewis and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-16 with Science categories.
The Molecular and Clinical Pathology of Neurodegenerative Disease brings together in one volume our current understanding of the molecular basis of neurodegeneration in humans, targeted at neuroscientists and graduate students in neuroscience, and the biomedical and biological sciences. Bringing together up-to-date molecular biology data with clinical evidence, this book sheds a light on common molecular mechanisms that underlie many different neurodegenerative diseases and addresses the molecular pathologies in each. The combined research and clinical background of the authors provides a unique perspective in relating clinical experiences with the molecular understanding needed to examine these diseases and is a must-read for anyone who wants to learn more about neurodegeneration. Provides an up-to-date summary of neurodegeneration at a molecular, cellular, and tissue level for the most common human disorders Describes the clinical background and underlying molecular processes for Alzheimer’s disease, Parkinson’s, Prion, Motor Neuron, Huntington’s, and Multiple Sclerosis Highlights the state-of-the-art treatment options for each disorder Details examples of relevant cutting edge experimental systems, including genome editing and human pluripotent stem cell-derived neuronal models
Role Of Misfolded Proteins In The Pathogenesis Of Neurodegenerative Disorders And Challenges Impacting The Development Of Novel Therapies An Overview
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Author : Dr.Hakim Saboowala
language : en
Publisher: Dr.Hakim Saboowala
Release Date : 2020-11-09
Role Of Misfolded Proteins In The Pathogenesis Of Neurodegenerative Disorders And Challenges Impacting The Development Of Novel Therapies An Overview written by Dr.Hakim Saboowala and has been published by Dr.Hakim Saboowala this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-09 with Medical categories.
Role of Misfolded Proteins in the Pathogenesis of Neurodegenerative Disorders and Challenges impacting the development of Novel Therapies. An Overview. A hallmark of neurodegenerative proteinopathies is the formation of misfolded protein aggregates that cause cellular toxicity and contribute to cellular proteostatic collapse. Therapeutic targeting of protein misfolding has generated unique challenges for drug discovery and development for several reasons, including: 1)The dynamic nature of the protein species involved, 2)Uncertainty about which forms of a given disease protein such as Monomers, Oligomers, or Insoluble aggregates, are primarily responsible for cellular toxicity, 3)Our still limited understanding about which components of the cellular proteo-static machinery these disease proteins interact with and 4) Lack of well-validated biomarkers for clinical trials. Therapeutic options are currently being explored that target different steps in the production and processing of proteins implicated in neurodegenerative disease, including synthesis, chaperone-assisted folding and trafficking, and degradation via the proteasome and autophagy pathways. Other therapies, like mTOR inhibitors and activators of the heat shock response, can rebalance the entire proteostatic network. Hence an attempt has been made in this E-Booklet to discuss major challenges that impact the development of novel therapies, including incomplete knowledge of druggable disease targets and their mechanism of action as well as a lack of biomarkers to monitor disease progression and therapeutic response. …Dr. H. K. Saboowala. M.B.(Bom) .M.R.S.H.(London)
Primary Glial And Immune Cell Pathology In Neurodegenerative Diseases
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Author : Andras Lakatos
language : en
Publisher: Frontiers Media SA
Release Date : 2021-12-21
Primary Glial And Immune Cell Pathology In Neurodegenerative Diseases written by Andras Lakatos and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-21 with Medical categories.
Neurodegenerative Diseases
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Author : M. Flint Beal
language : en
Publisher: Cambridge University Press
Release Date : 2005-06-02
Neurodegenerative Diseases written by M. Flint Beal and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-06-02 with Medical categories.
Neurodegenerative diseases are major contributors to disability and disease, with Alzheimer's and Parkinson's diseases the most prevalent. This major reference reviews the rapidly advancing knowledge of pathogenesis and treatment of neurodegenerative diseases in the context of a comprehensive survey of each disease and its clinical features. The editors and contributors are among the leading experts in the field internationally. Covering basic science, diagnostic tools and therapeutic approaches, the book focuses on all aspects of neurodegenerative disease, including the normal aging process. The dementias, prion diseases, Parkinson's disease and atypical parkinsonisms, neurodegenerative ataxias, motor neuron diseases, degenerative diseases with chorea, iron and copper disorders, and mitochondrial diseases, are all methodically presented and discussed, with extensive illustrations. In each case the underlying genetics, neuropathological and clinical issues are fully reviewed, making this the most complete as well as the most authoritative reference available to clinicians and neuroscientists.