Hypothesis And Dynamics In The Pathogenesis Of Neurodegenerative Disorders
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Hypothesis And Dynamics In The Pathogenesis Of Neurodegenerative Disorders
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Author : Lawrence M. Agius
language : en
Publisher: Bentham Science Publishers
Release Date : 2009
Hypothesis And Dynamics In The Pathogenesis Of Neurodegenerative Disorders written by Lawrence M. Agius and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Medical categories.
This book presents a series of clinical and pathologic observations that are thought to contribute to progressive incremental severity in neuronal cell loss and tissue atrophy in the cerebral cortex. The book includes a critical reappraisal of lesions in
Hypothesis And Dynamics In The Pathogenesis Of Neurodegenerative Disorders
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Author : Domenico Ribatti
language : en
Publisher:
Release Date : 2009-11-24
Hypothesis And Dynamics In The Pathogenesis Of Neurodegenerative Disorders written by Domenico Ribatti and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-11-24 with categories.
This book presents a series of clinical and pathologic observations that are thought to contribute to progressive incremental severity in neuronal cell loss and tissue atrophy in the cerebral cortex. The book includes a critical reappraisal of lesions in
Neurobiology Of Huntington S Disease
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Author : Donald C. Lo
language : en
Publisher: CRC Press
Release Date : 2010-07-02
Neurobiology Of Huntington S Disease written by Donald C. Lo and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-07-02 with Medical categories.
In 1993, the genetic mutation responsible for Huntington's disease (HD) was identified. Considered a milestone in human genomics, this discovery has led to nearly two decades of remarkable progress that has greatly increased our knowledge of HD, and documented an unexpectedly large and diverse range of biochemical and genetic perturbations that see
Mitochondrial Dynamics And Neurodegeneration
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Author : Bingwei Lu
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-05-16
Mitochondrial Dynamics And Neurodegeneration written by Bingwei Lu and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-05-16 with Science categories.
Mitochondria are essential organelles in eukaryotic cells that control such diverse processes as energy metabolism, calcium buffering, and cell death. Recent studies have revealed that changes in mitochondrial morphology by fission and fusion, a process known as mitochondrial dynamics, is particularly important for neuronal function and survival. Defects in this process are commonly found in neurodegenerative diseases, offering a new paradigm for investigating mechanisms of neurodegeneration. To provide researchers working on neurodegenerative diseases and mitochondria with updated information on this rapidly progressing field, we have invited experts in the field to critically review recent progresses and identify future research directions. The topics include genetics of mitochondrial dynamics, mitochondrial dynamics and bioenergetics, autophagy, apoptosis, and axonal transport, and its role in neurological diseases, including Alzheimer’s, Parkinson’s, and Huntington’s diseases.
The Charnolosome As A Novel Nanothereranostic Biomarker
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Author : Sushil Sharma
language : en
Publisher: Elsevier
Release Date : 2024-09-30
The Charnolosome As A Novel Nanothereranostic Biomarker written by Sushil Sharma and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-09-30 with Science categories.
The Charnolosome as a Novel Nanothereranostic Biomarker: Overcoming Future Challenges in Medicine provides an overview of the charnolosome and its potential as a biomarker of cell injury. Based on the author's original discovery of the charnoly body in the developing, undernourished rat cerebellar Purkinje neurons, this book delves into the potential for utilizing this mitochondria and lysosomal-derived intracellular organelle as a nanotheranostic biomarker to prevent and cure various diseases.The book discusses the cellular, molecular, genetic, and epigenetic mechanisms of charnolosomes and charnolosome-derived nano-vesicles. It also investigates the molecular mechanisms underlying auto-inflammatory, autoimmune, and infectious diseases resulting from their compromised mitochondrial bioenergetics, and the potential use of the charnolosome in preventing and curing such conditions. - Shares the latest knowledge on the charnolosome and charnolosome-derived nano-vesicles and their significance at a cellular and molecular level - Considers the charnolosome in relation to a range of conditions, including neurodegenerative, metabolic, and multi-drug resistant systemic diseases - Presents future perspectives of the charnolosome in personalized nanotheranostics
Methods In Neurodegenerative Disease Drug Discovery
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Author : Diego Muñoz-Torrero
language : en
Publisher: Springer Nature
Release Date : 2024-12-26
Methods In Neurodegenerative Disease Drug Discovery written by Diego Muñoz-Torrero and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-12-26 with Science categories.
This book explores the latest developments in the identification of biomarkers for early diagnosis of neurodegenerative diseases and methodologies for the biophysical; in vitro; cell-based; and in vivo profiling, during the early phases of drug discovery, new hits, leads, and drug candidates directed to a variety of biological targets with key pathogenic roles in neurodegenerative diseases. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Comprehensive and thorough, Methods in Neurodegenerative Disease Drug Discovery offers practical guidance to researchers in the medicinal chemistry community. The methods described in this book can be readily implemented in many laboratories and will aid new and experienced researchers with creating future treatments for these devastating diseases.
Neurodegenerative Diseases
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Author : Gary Fiskum
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-11
Neurodegenerative Diseases written by Gary Fiskum and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Science categories.
Proceedings of the Fifteenth Washington International Spring Symposium held at The George Washington University, Washington, D.C., May 15-17, 1995
Synaptic Plasticity In Neurodegenerative Disorders
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Author : Sangeeta Singh
language : en
Publisher: CRC Press
Release Date : 2024-12-24
Synaptic Plasticity In Neurodegenerative Disorders written by Sangeeta Singh and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-12-24 with Science categories.
This book explores the pivotal role of synaptic plasticity in the pathogenesis, progression, and potential treatment of neurodegenerative disorders. The initial chapter provides an in-depth understanding of the complexity and impact of neurodegenerative conditions. It discusses the association of mitochondrial dysfunction, epigenetic influences, and neuroinflammation with synaptic plasticity in neurodegenerative diseases. The following chapters review the dynamic changes that occur at the cellular and synaptic levels in Parkinson's disease, Alzheimer's disease, and Huntington's disease, paving the way for innovative therapeutic strategies. Furthermore, the book presents various computational tools and methodologies essential for enhancing our understanding of synaptic plasticity. It examines the transformative role of artificial intelligence tools in addressing synaptic impairment across various neurodegenerative diseases. Discusses the role of synaptic plasticity in neurodegenerative diseases, shedding light on how dynamic changes occur at the cellular and synaptic levels Explores the transformative role of artificial intelligence tools in addressing synaptic impairment across various neurodegenerative diseases Provides a comprehensive overview of neurodegenerative disorders, including pathogenesis, etiology, and treatment strategies Presents tools and techniques used to simulate the complex system biology of synaptic plasticity Examines the role of computational neuroscience in understanding and potentially treating conditions such as multiple sclerosis and amyotrophic lateral sclerosis Toward the end, the book explores the role of synaptic impairment and computational neuroscience in understanding and potentially treating conditions such as multiple sclerosis and amyotrophic lateral sclerosis. With its multifaceted approach, this book serves as a useful resource for researchers, clinicians, and students in the fields of neuroscience, computational biology, and neurology.
Neurodegenerative Diseases
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Author : Sachchida Nand Rai
language : en
Publisher: CRC Press
Release Date : 2024-12-02
Neurodegenerative Diseases written by Sachchida Nand Rai and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-12-02 with Science categories.
This reference book provides a comprehensive overview of models and therapeutic approaches against neurodegenerative diseases, including Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. It explores models based on the chemical, induced, cellular, genetic, transgenic, and 3D organoid approaches in neurodegenerative diseases. The book also reviews advantages and limitations of these models in designing the treatment strategies. Additionally, the book covers the emerging field of bioinformatics and its application in modeling various neurodegenerative diseases. Towards the end, the book highlights the role of holistic management, precision medicine, OMICS, and gene therapy against neurodegenerative disorders. It examines the implications and significance of stem cells therapy in translational models of neurodegenerative diseases. This book is an invaluable resource for researchers, neuroscientists, and neurosurgeons for getting in-depth information on the neurodegenerative models and therapeutic approaches. Key Features: Provides a comprehensive overview of neurodegenerative diseases and their models Examines the limitations associated with modeling neurodegenerative diseases Presents novel treatment strategies for Alzheimer's disease using cellular models Reviews importance of 3D organoid models for therapeutic approaches in Parkinson's disease Covers modeling techniques in understanding prion diseases Explores the role of genetic models in understanding Huntington's disease
Oxidative Stress And Neurodegenerative Disorders
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Author : G. Ali Qureshi
language : en
Publisher: Elsevier
Release Date : 2007-03-22
Oxidative Stress And Neurodegenerative Disorders written by G. Ali Qureshi and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-03-22 with Science categories.
Oxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species. Brain cells are continuously exposed to reactive oxygen species generated by oxidative metabolism, and in certain pathological conditions defense mechanisms against oxygen radicals may be weakened and/or overwhelmed. DNA is a potential target for oxidative damage, and genomic damage can contribute to neuropathogenesis. It is important therefore to identify tools for the quantitative analysis of DNA damage in models on neurological disorders. This book presents detailed information on various neurodegenerative disorders and their connection with oxidative stress. This information will provide clinicians with directions to treat these disorders with appropriate therapy and is also of vital importance for the drug industries for the design of new drugs for treatment of degenerative disorders.* Contains the latest information on the subject of neurodegenerative disorders* Reflects on various factors involved in degeneration and gives suggestions for how to tackle these problems