Foundations Of Theoretical Approaches In Systems Biology
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Foundations Of Theoretical Approaches In Systems Biology
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Author : Alberto Marin-Sanguino
language : en
Publisher: Frontiers Media SA
Release Date : 2019-01-11
Foundations Of Theoretical Approaches In Systems Biology written by Alberto Marin-Sanguino and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-11 with categories.
If biology in the 20th century was characterized by an explosion of new technologies and experimental methods, that of the 21st has seen an equally exuberant proliferation of mathematical and computational methods that attempt to systematize and explain the abundance of available data. As we live through the consolidation of a new paradigm where experimental data goes hand in hand with computational analysis, we contemplate the challenge of fusing these two aspects of the new biology into a consistent theoretical framework. Whether systems biology will survive as a field or be washed away by the tides of future fads will ultimately depend on its success to achieve this type of synthesis. The famous quote attributed to Kurt Lewin comes to mind: "there is nothing more practical than a good theory". This book presents a wide assortment of articles on systems biology in an attempt to capture the variety of current methods in systems biology and show how they can help to find answers to the challenges of modern biology.
Foundations Of Systems Biology
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Author : Hiroaki Kitano
language : en
Publisher: MIT Press (MA)
Release Date : 2001
Foundations Of Systems Biology written by Hiroaki Kitano and has been published by MIT Press (MA) this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with Computers categories.
An overview of the methodologies and techniques of the emerging field of systems biology.
Systems Biology
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Author : Fred Boogerd
language : en
Publisher: Elsevier
Release Date : 2007-03-20
Systems Biology written by Fred Boogerd and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-03-20 with Mathematics categories.
Systems biology is a vigorous and expanding discipline, in many ways a successor to genomics and perhaps unprecedented in its combination of biology with a great many other sciences, from physics to ecology, from mathematics to medicine, and from philosophy to chemistry. Studying the philosophical foundations of systems biology may resolve a longer standing issue, i.e., the extent to which Biology is entitled to its own scientific foundations rather than being dominated by existing philosophies.* Answers the question of what distinguishes the living from the non-living* An in-depth look to a vigorous and expanding discipline, from molecule to system* Explores the region between individual components and the system
Systems Biology
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Author : A.K. Konopka
language : en
Publisher: CRC Press
Release Date : 2006-11-20
Systems Biology written by A.K. Konopka and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-11-20 with Science categories.
With extraordinary clarity,the Systems Biology: Principles, Methods, and Concepts focuses on the technical practical aspects of modeling complex or organic general systems. It also provides in-depth coverage of modeling biochemical, thermodynamic, engineering, and ecological systems. Among other methods and concepts based in logic, computer
Systems Biology
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Author : Robert A. Meyers
language : en
Publisher: John Wiley & Sons
Release Date : 2012-12-05
Systems Biology written by Robert A. Meyers and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-05 with Science categories.
Systems biology is a relatively new biological study field that focuses on the systematic study of complex interactions in biological systems, thus using a new perspective (integration instead of reduction) to study them. Particularly from year 2000 onwards, the term is used widely in the biosciences, and in a variety of contexts. Systems biology is the study of the interconnected aspect of molecular, cellular, tissue, whole animal and ecological processes, and comprises mathematical and mechanistic studies of dynamical, mesoscopic, open, spatiotemporally defined, nonlinear, complex systems that are far from thermodynamic equilibrium.
Modeling In Systems Biology
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Author : Ina Koch
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-10-21
Modeling In Systems Biology written by Ina Koch and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-10-21 with Computers categories.
The emerging, multi-disciplinary field of systems biology is devoted to the study of the relationships between various parts of a biological system, and computer modeling plays a vital role in the drive to understand the processes of life from an holistic viewpoint. Advancements in experimental technologies in biology and medicine have generated an enormous amount of biological data on the dependencies and interactions of many different molecular cell processes, fueling the development of numerous computational methods for exploring this data. The mathematical formalism of Petri net theory is able to encompass many of these techniques. This essential text/reference presents a comprehensive overview of cutting-edge research in applications of Petri nets in systems biology, with contributions from an international selection of experts. Those unfamiliar with the field are also provided with a general introduction to systems biology, the foundations of biochemistry, and the basics of Petri net theory. Further chapters address Petri net modeling techniques for building and analyzing biological models, as well as network prediction approaches, before reviewing the applications to networks of different biological classification. Topics and features: investigates the modular, qualitative modeling of regulatory networks using Petri nets, and examines an Hybrid Functional Petri net simulation case study; contains a glossary of the concepts and notation used in the book, in addition to exercises at the end of each chapter; covers the topological analysis of metabolic and regulatory networks, the analysis of models of signaling networks, and the prediction of network structure; provides a biological case study on the conversion of logical networks into Petri nets; discusses discrete modeling, stochastic modeling, fuzzy modeling, dynamic pathway modeling, genetic regulatory network modeling, and quantitative analysis techniques; includes a Foreword by Professor Jens Reich, Professor of Bioinformatics at Humboldt University and Max Delbrück Center for Molecular Medicine in Berlin. This unique guide to the modeling of biochemical systems using Petri net concepts will be of real utility to researchers and students of computational biology, systems biology, bioinformatics, computer science, and biochemistry.
Anticipatory Systems
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Author : Robert Rosen
language : en
Publisher: Elsevier
Release Date : 2013-10-22
Anticipatory Systems written by Robert Rosen and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-22 with Science categories.
The first detailed study of this most important class of systems which contain internal predictive models of themselves and/or of their environments and whose predictions are utilized for purposes of present control. This book develops the basic concept of a predictive model, and shows how it can be embedded into a system of feedforward control. Includes many examples and stresses analogies between wired-in anticipatory control and processes of learning and adaption, at both individual and social levels. Shows how the basic theory of such systems throws a new light both on analytic problems (understanding what is going on in an organism or a social system) and synthetic ones (developing forecasting methods for making individual or collective decisions).
Foundations Of Complex System Theories
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Author : Sunny Y. Auyang
language : en
Publisher:
Release Date : 1998
Foundations Of Complex System Theories written by Sunny Y. Auyang and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Science categories.
Analyzes approaches to the study of complexity in the physical, biological, and social sciences.
Systems Biology
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Author : Bernhard Palsson
language : en
Publisher: Cambridge University Press
Release Date : 2015-01-26
Systems Biology written by Bernhard Palsson and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-01-26 with Medical categories.
The first comprehensive single-authored textbook on genome-scale models and the bottom-up approach to systems biology.
A Systems Theoretic Approach To Systems And Synthetic Biology I Models And System Characterizations
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Author : Vishwesh V. Kulkarni
language : en
Publisher: Springer
Release Date : 2014-07-03
A Systems Theoretic Approach To Systems And Synthetic Biology I Models And System Characterizations written by Vishwesh V. Kulkarni and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-07-03 with Medical categories.
The complexity of biological systems has intrigued scientists from many disciplines and has given birth to the highly influential field of systems biology wherein a wide array of mathematical techniques, such as flux balance analysis, and technology platforms, such as next generation sequencing, is used to understand, elucidate, and predict the functions of complex biological systems. More recently, the field of synthetic biology, i.e., de novo engineering of biological systems, has emerged. Scientists from various fields are focusing on how to render this engineering process more predictable, reliable, scalable, affordable, and easy. Systems and control theory is a branch of engineering and applied sciences that rigorously deals with the complexities and uncertainties of interconnected systems with the objective of characterising fundamental systemic properties such as stability, robustness, communication capacity, and other performance metrics. Systems and control theory also strives to offer concepts and methods that facilitate the design of systems with rigorous guarantees on these properties. Over the last 100 years, it has made stellar theoretical and technological contributions in diverse fields such as aerospace, telecommunication, storage, automotive, power systems, and others. Can it have, or evolve to have, a similar impact in biology? The chapters in this book demonstrate that, indeed, systems and control theoretic concepts and techniques can have a significant impact in systems and synthetic biology. Volume I provides a panoramic view that illustrates the potential of such mathematical methods in systems and synthetic biology. Recent advances in systems and synthetic biology have clearly demonstrated the benefits of a rigorous and systematic approach rooted in the principles of systems and control theory - not only does it lead to exciting insights and discoveries but it also reduces the inordinately lengthy trial-and-error process of wet-lab experimentation, thereby facilitating significant savings in human and financial resources. In Volume I, some of the leading researchers in the field of systems and synthetic biology demonstrate how systems and control theoretic concepts and techniques can be useful, or should evolve to be useful, in order to understand how biological systems function. As the eminent computer scientist Donald Knuth put it, "biology easily has 500 years of exciting problems to work on". This edited book presents but a small fraction of those for the benefit of (1) systems and control theorists interested in molecular and cellular biology and (2) biologists interested in rigorous modelling, analysis and control of biological systems.