Free Radical
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Techniques In Free Radical Research
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Author : A.T. Diplock
language : en
Publisher: Elsevier
Release Date : 1991-12-11
Techniques In Free Radical Research written by A.T. Diplock and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991-12-11 with Science categories.
Free radical species are generally short-lived due to their high reactivity and thus direct measurement and identification are often impossible. ESR is the only technique which has the potential for direct detection of radicals but in biological systems even these must be trapped by a spin-trapping agent. Thus most investigations involve recognition of indicators of the presence of radicals in vivo or "FOOTPRINTS" of radical-mediated damage. Techniques in Free Radical Research assembles and critically assesses the most relevant and reliable experimental approaches used towards the measurement of radicals and radical-mediated damage in chemical systems, in cells and in tissues under the following six headings: a) Footprints of DNA damage, b) Footprints of protein damage, c) Footprints of lipid peroxidation, d) Footprints of antioxidant consumption, e) Footprints via indirect radical assays, and f) Footprints via the availability of transition metal complexes.
Free Radicals In Chemistry Biology And Medicine
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Author : Toshikazu Yoshikawa
language : en
Publisher:
Release Date : 2000
Free Radicals In Chemistry Biology And Medicine written by Toshikazu Yoshikawa and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Antioxidants categories.
Systems Biology Of Free Radicals And Antioxidants
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Author : Ismail Laher
language : en
Publisher: Springer
Release Date : 2014-06-16
Systems Biology Of Free Radicals And Antioxidants written by Ismail Laher and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-06-16 with Medical categories.
The focus of this collection of illustrated reviews is to discuss the systems biology of free radicals and anti-oxidants. Free radical induced cellular damage in a variety of tissues and organs is reviewed, with detailed discussion of molecular and cellular mechanisms. The collection is aimed at those new to the field, as well as clinicians and scientists with long standing interests in free radical biology. A feature of this collection is that the material also brings insights into various diseases where free radicals are thought to play a role. There is extensive discussion of the success and limitations of the use of antioxidants in several clinical settings.
Free Radicals In Diagnostic Medicine
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Author : Donald Armstrong
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Free Radicals In Diagnostic Medicine written by Donald Armstrong and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
An International Syaposiua on Free Radicals in Diagnostic Medicine was co-sponsored by the state University of New York at Buffalo, Roswell Park Cancer Institute, and the Upstate NY Section of the American Association of Clinical Chemistry. The theme was "A Systems Approach To Laboratory Technology, Clinical Correlations And Antioxidant Therapy." The symposium was held on October 7-8, 1993 at the Hyatt Hotel and on October 9 at Roswell Park Cancer Institute, Buffalo, New York. This proceedings volume contains chapters from platform presentations, poster sessions and from invited special lectures in the areas of basic science, clinical applications and efficacy of treatment. A Special Lecture on the relevance of free radical analysis to clinical medicine was presented by Professor Kunio Yagi of Japan. The Yagi procedure to measure thiobarbituric acid (TBA) reaction reflects the amount of reactive substances, lipid peroxides and aldehydes, in the sample. For example, normal subjects will have less than 4 nmol/ml of serum lipid peroxides, while a person with diabetes generally has equal or greater than 5.0 and a diabetic person with vascular complications often exceeds 7.5 nmol/ml. Serum TBA is a clinically important measure that relates to aging, gender and estrogen as an antioxidant, in the prognosis for vascular disorders, and in pathological conditions relative to the amount of lipid peroxidation. The BASIC SCIENCES portion of the program examined: "Mechanisms of Action, Pathophysiology and Laboratory Tests" in six presentations.
Free Radical Damage And Its Control
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Author : C.A. Rice-Evans
language : en
Publisher: Elsevier
Release Date : 1994-02-09
Free Radical Damage And Its Control written by C.A. Rice-Evans and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994-02-09 with Science categories.
This book provides a comprehensive treatise on the chemical and biochemical consequences of damaging free radical reactions, the implications for the pathogenesis of disease and how this might be controlled endogenously and by radical scavenging drugs. Oxidative stress may be influenced by exogenous agents of oxidative stress, radiation, trauma, drug activation, oxygen excess, or by exogenous oxidative stress which is associated with many pathological states including chronic inflammatory disorders, cardiovascular disease, injury to the central nervous system, and connective tissue damage. This and many other such aspects are presented clearly and in depth. The development of antioxidant drugs depends on the understanding of the mechanisms underlying the generation of excessive free radicals in vivo, the factors controlling their release and the site of their action. This excellent volume presents an up-to-date account of the current state of knowledge in these areas.
Free Radical Induced Dna Damage And Its Repair
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Author : Clemens Sonntag
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-03-20
Free Radical Induced Dna Damage And Its Repair written by Clemens Sonntag and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-03-20 with Science categories.
The free-radical chemistry of DNA had been discussed in some detail in 1987 in my book The Chemical Basis of Radiation Biology. Obviously, the more recent developments and the concomitant higher level of understanding of mechanistic details are missing. Moreover, in the living cell, free-radical DNA damage is not only induced by ionizing radiation, but free-radical-induced DNA damage is a much more general phenomenon. It was, therefore, felt that it is now timely to review our present knowledge of free-radical-induced DNA damage induced by all conceivable free-radical-generating sources. Originally, it had been thought to include also a very important aspect, the repair of DNA damage by the cell’s various repair enzymes. Kevin Prise (Cancer Campaign, Gray Laboratory, L- don) was so kind to agree to write this part. However, an adequate description of this strongly expanding area would have exceeded the allocated space by much, and this section had to be omitted. The directors of the Max-Planck-Institut für Strahlenchemie (now MPI für Bioanorganische Chemie), Karl Wieghardt and Wolfgang Lubitz, kindly allowed me to continue to use its facilities after my retirement in 2001. Notably, our - brarian, Mrs. Jutta Theurich, and her right-hand help, Mrs. Rosemarie Schr- er, were most helpful in getting hold of the literature. I thank them very much. Without their constant help, this would have been very difficult indeed.
Free Radical Induced Dna Damage And Its Repair
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Author : Clemens von Sonntag
language : en
Publisher: Springer Science & Business Media
Release Date : 2005-12-02
Free Radical Induced Dna Damage And Its Repair written by Clemens von Sonntag and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-12-02 with Science categories.
The free-radical chemistry of DNA had been discussed in some detail in 1987 in my book The Chemical Basis of Radiation Biology. Obviously, the more recent developments and the concomitant higher level of understanding of mechanistic details are missing. Moreover, in the living cell, free-radical DNA damage is not only induced by ionizing radiation, but free-radical-induced DNA damage is a much more general phenomenon. It was, therefore, felt that it is now timely to review our present knowledge of free-radical-induced DNA damage induced by all conceivable free-radical-generating sources. Originally, it had been thought to include also a very important aspect, the repair of DNA damage by the cell’s various repair enzymes. Kevin Prise (Cancer Campaign, Gray Laboratory, L- don) was so kind to agree to write this part. However, an adequate description of this strongly expanding area would have exceeded the allocated space by much, and this section had to be omitted. The directors of the Max-Planck-Institut für Strahlenchemie (now MPI für Bioanorganische Chemie), Karl Wieghardt and Wolfgang Lubitz, kindly allowed me to continue to use its facilities after my retirement in 2001. Notably, our - brarian, Mrs. Jutta Theurich, and her right-hand help, Mrs. Rosemarie Schr- er, were most helpful in getting hold of the literature. I thank them very much. Without their constant help, this would have been very difficult indeed.
Half A Century Of Free Radical Chemistry
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Author : Derek H. R. Barton
language : en
Publisher: Cambridge University Press
Release Date : 1993-04-15
Half A Century Of Free Radical Chemistry written by Derek H. R. Barton and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993-04-15 with Science categories.
This book describes the experience over 25 years of the senior author with the chemistry of organic free radicals. It begins with a mechanistic study of industrial importance on the pyrolysis of chlorinated alkanes. It continues with a theory on the biosynthesis of phenolate derived alkaloids involving phenolate radical coupling. There follows 20 years of practical work to prove the theory correct, especially in the case of morphine alkaloids. The book then describes the work on nitrile photolysis (Barton reaction) which involved the invention of new radical chemistry leading to a simple synthesis of the important hormone, aldosterone. There follows a description of the invention of an important new method for the deoxygenation of biologically important molecules, especially sugars and nucleosides, using radical chemistry applied to thiocarbonyl derivatives. Some years later, in a logical extension to carboxylic acids, another new reaction was invented which provides carbon, nitrogen, oxygen and other radicals under mild conditions. A final chapter summarizes recent applications of thiocarbonyl group derived radical reactions by other authors.
The Chemistry Of Free Radicals
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Author : Rayson L. Huang
language : en
Publisher: Hodder Education
Release Date : 1974
The Chemistry Of Free Radicals written by Rayson L. Huang and has been published by Hodder Education this book supported file pdf, txt, epub, kindle and other format this book has been release on 1974 with Carbonium ions categories.
Free Radicals
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Author : Michael Brooks
language : en
Publisher: Profile Books
Release Date : 2011-07-07
Free Radicals written by Michael Brooks and has been published by Profile Books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-07-07 with Science categories.
For more than a century, science has cultivated a sober public image for itself. But as bestselling author Michael Brooks explains, the truth is very different: many of our most successful scientists have more in common with libertines than librarians. This thrilling exploration of some of the greatest breakthroughs in science reveals the extreme lengths some scientists go to in order to make their theories public. Fraud, suppressing evidence and unethical or reckless PR games are sometimes necessary to bring the best and most brilliant discoveries to the world's attention. Inspiration can come from the most unorthodox of places, and Brooks introduces us to Nobel laureates who get their ideas through drugs, dreams and hallucinations. Science is a highly competitive and ruthless discipline, and only its most determined and passionate practitioners make headlines - and history. To succeed, knowledge must be pursued by any means: in science, anything goes. 'Brooks is an exemplary science writer' William Leith, Daily Telegraph