Free Radical Synthesis And Functionalization Of Heterocycles
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Free Radical Synthesis And Functionalization Of Heterocycles
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Author : Yannick Landais
language : en
Publisher: Springer
Release Date : 2018-05-03
Free Radical Synthesis And Functionalization Of Heterocycles written by Yannick Landais and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-03 with Science categories.
This volume describes the recent developments in the free-radical mediated synthesis and elaboration of heterocycles. The first chapter, dealing with radical cascade processes illustrates the power and the beauty of radical chemistry with some striking examples of total synthesis of complex natural heterocycles. As organic chemists strive towards sustainability, radical chemistry has recently seen major advances and efforts in this direction, including C-H activation of arenes and unactivated alkyl groups. Photochemical activation, for a long time the preferred mode of activation in radical chemistry has also seen an unexpected revival with the advent of visible light metal- and organocatalyzed photoredox processes. A survey of these emerging areas is provided along with the concepts at the origin of these developments. The venerable Minisci reaction allows for direct access to functionalized heterocycles. This process has lately seen an interesting renaissance and is discussed in this volume. Addition of heteroatom-centered radicals onto unsaturated systems constitutes another powerful method to construct heterocycles. Examples of such a strategy are proposed along with the formation of various heterocycles relying on homolytic substitution at sulfur, phosphorus and selenium. Additionally free-radical functionalization of reactive functional groups including isonitriles, isothiocyanates and related unsaturated systems which offer a straightforward route towards useful aromatic and non-aromatic heterocycles are discussed. Finally, as metals are able to trigger single electron transfer both in reductive and oxidative modes this provides another possibility for the synthesis of heterocycles. Significant research efforts have focused on the use of samarium, copper and other metals to access a broad variety of heterocycles in a single pot process, starting from readily available raw material. Examples and mechanistic insights are discussed by experts in this area.
Heterocycles Via Cross Dehydrogenative Coupling
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Author : Ananya Srivastava
language : en
Publisher: Springer Nature
Release Date : 2019-08-23
Heterocycles Via Cross Dehydrogenative Coupling written by Ananya Srivastava and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-23 with Science categories.
This book discusses the developments in the synthesis and functionalization of different heterocycles based on the formation of carbon-carbon (C-C) and carbon-heteroatom (C-X) bonds using cross-dehydrogenative coupling (CDC). Consisting of 13 chapters, the book systematically describes the advances in the synthesis and functionalization of nitrogen, oxygen, and sulfur-containing heterocycles. It also discusses the various mechanistic pathways to help readers gain an in-depth understanding of the CDC reactions of heterocycles. Lastly, in order to promote green chemistry, it addresses a range of metal-free CDC reactions of heterocycles – an area that has attracted significant attention in both academic and industrial research.
Free Radicals In Organic Synthesis
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Author : D. I. Davies
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Free Radicals In Organic Synthesis written by D. I. Davies and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
Free Radicals In Synthesis And Biology
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Author : F. Minisci
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Free Radicals In Synthesis And Biology written by F. Minisci and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
Free-radical reactions have been for long time the domain of the physical chemists and the basic chemical industry (polymerization of vinyl monomers, oxidation by molecular oxygen, chlorination of methane etc.), where the use of simple molecules and the possibility of partial conversions without heavy problems of product separations makes less dramatic the aspects of regio and chemoselectivity. As synonym of unselectivity, free radical reactions were considered of poor use in the synthesis of fine chemicals or sophisticated molecules, where a high selectivity is an essential condition for the success, or in the involvement of biological processes. Within the last 15 years, however, an authentic explosion of synthetic applications of free radical reactions occurred; they have gained a remarkable position among the selective methods of synthesis. At the same time the great importance of free radical reactions in fundamental biological processes and in the metabolism of drugs has been recognized. Thus a specialized meeting on these topics was generally felt appropriate. I had the honour and the onus to organize this workshop because for more than 30 years I have been involved in the research of free radical reactions. Thanks to a generous grant from NATO Scientific Affairs Division and the financial support of CNR and chemical industry (Montedison, Enichem, Zambon) such a meeting among almost 50 specialists and 15 observers of sufficient standard to take advantage of the discussion, became possible at Bardolino (Italy).
Modern Strategies For Heterocycle Synthesis
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Author : Gianfranco Favi
language : en
Publisher: MDPI
Release Date : 2021-03-17
Modern Strategies For Heterocycle Synthesis written by Gianfranco Favi and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-17 with Medical categories.
Heterocycles feature widely in natural products, agrochemicals, pharmaceuticals and dyes, and their synthesis is of great interest to synthetic chemists in both academia and industry. The contributions of recent applications of new methodologies in C–H activation, photoredox chemistry, cross-coupling strategies, borrowing hydrogen catalysis, multicomponent and solvent-free reactions, regio- and stereoselective syntheses, as well as other new, attractive approaches for the construction of heterocyclic scaffolds are of great interest. This Special Issue is dedicated to featuring the latest research that is ongoing in the field of heterocyclic synthesis. It is expected that most submissions will focus on five- and six-membered oxygen and nitrogen-containing heterocycles, but structures incorporating other rings/heteroatoms will also be considered. Original research (communications, full papers and reviews) that discusses innovative methodologies for assembling heterocycles with potential application in materials, catalysis and medicine are therefore welcome.
Free Radical Chain Reactions In Organic Synthesis
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Author : William B. Motherwell
language : en
Publisher: Elsevier
Release Date : 2013-10-22
Free Radical Chain Reactions In Organic Synthesis written by William B. Motherwell and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-22 with Science categories.
Written for both the experienced practitioner and the newcomer, this book provides essential guidance to the practical aspects of free radical chain reactions. The book presents tried and tested synthetic schemes as well as a selection of recently developed methods describing rationally designed, highly efficient syntheses giving high yield interconversions of functional groups and carbon*b1carbon bond formation under mild, neutral conditions. Written by two experienced practitioners in the field, this volume explodes the myth that free radicals are highly reactive, non-selective intermediates. Contains an extensive introduction discussing principles, advantages, and disadvantages of radical chain reactions Demonstrates functional group interconversions by radical chain reactions Lists carbon*b1carbon bond formations Presents inter- and intramolecular radical chain reactions Includes many examples and experimental details selected by experienced practitioners in this field
Novel Free Radical Synthesis Of Heterocycles
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Author : Emma Mann
language : en
Publisher:
Release Date : 2001
Novel Free Radical Synthesis Of Heterocycles written by Emma Mann and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with categories.
Synthesis Of O Heterocycles By Free Radical Methodology
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Author : Siti Asiah Ahmad Junan
language : en
Publisher:
Release Date : 1990
Synthesis Of O Heterocycles By Free Radical Methodology written by Siti Asiah Ahmad Junan and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990 with categories.
Metal Free C H Functionalization Of Aromatics
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Author : Valery Charushin
language : en
Publisher: Springer
Release Date : 2014-09-03
Metal Free C H Functionalization Of Aromatics written by Valery Charushin and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-03 with Science categories.
The series Topics in Heterocyclic Chemistry presents critical reviews on present and future trends in the research of heterocyclic compounds. Overall the scope is to cover topics dealing with all areas within heterocyclic chemistry, both experimental and theoretical, of interest to the general heterocyclic chemistry community. The series consists of topic related volumes edited by renowned editors with contributions of experts in the field.
Half A Century Of Free Radical Chemistry
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Author : Derek H. R. Barton
language : en
Publisher: Cambridge University Press
Release Date : 1993-04-15
Half A Century Of Free Radical Chemistry written by Derek H. R. Barton and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993-04-15 with Science categories.
This book describes the work of Nobel Laureate Derek Barton on the chemistry of organic free radicals, and the invention of new chemical reactions for use in the synthesis of biologically and economically important compounds. It begins with a mechanistic study of industrial significance on the pyrolysis of chlorinated alkanes. It continues with a theory on the biosynthesis of phenolate derived alkaloids involving phenolate radical coupling. The book then describes the work on nitrite photolysis (Barton reaction), which involved the invention of new radical chemistry leading to a simple synthesis of the important hormone, aldosterone. It also describes another new reaction extended to carboxlic acids that provides carbon, nitrogen, oxygen and other radicals under mild conditions. A final chapter summarizes recent applications of thiocarbonyl group derived radical reactions by other authors.