Free Radicals In Digestive Diseases
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Free Radical Biology In Digestive Diseases
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Author : Yuji Naito
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2011
Free Radical Biology In Digestive Diseases written by Yuji Naito and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Medical categories.
There is a growing body of experimental and clinical data to suggest that the organs of the digestive system may be subjected to considerable oxidative stress associated with acute and chronic inflammation. Although inflammation and ischemia play a key role in producing oxygen-derived free radicals in the digestive tract, the contribution of other factors, such as transition metal imbalances, lipid and glucose metabolic disturbance, and the interaction with gaseous molecules including nitric oxide and carbon monoxide, has also been suggested. Recent studies have demonstrated that several biomarkers indicating oxidative stress-mediated damage may help in monitoring the degree of disease and planning the design of new therapeutic strategies. In addition, recent advances in 'omics' research (genomics, proteomics, metabolomics, etc.) may bring a breakthrough in the field of gastroenterology and hepatology: Several molecular targets for oxidative stress have been presented by the 'omics'. This book includes up-to-date reviews on the relevant issues in free radical biology in a combination with expert basic research reviews and clinical aspects in gastroenterology and hepatology. Providing information about new molecular targets for the treatment or prevention of digestive diseases, this book should be read by clinical and basic researchers in gastroenterology and hepatology.
Free Radicals In Digestive Diseases
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Author : Masaharu Tsuchiya
language : en
Publisher:
Release Date : 1988
Free Radicals In Digestive Diseases written by Masaharu Tsuchiya and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988 with Medical categories.
Oxidative Stress And Digestive Diseases
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Author : Toshikazu Yoshikawa
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2001-01-01
Oxidative Stress And Digestive Diseases written by Toshikazu Yoshikawa and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-01-01 with Medical categories.
In the 1980s, biochemists and biologists were attracted by the role of reactive oxygen species in the irreversible damage or modification of the structure of biological molecules. However, in the 1990s, reactive oxygen species have been recognized to be involved in reversible structural alterations of molecules: The homeostatic modulation of oxidant levels is a highly efficient mechanism that allows all cells to tightly control their redox status within a very narrow range. Especially the activity of the Rel/NF-kB family of transcriptional factors that regulate responses in inflammation, reperfusion injury and apoptosis is controlled by intracellular reactive oxygen species levels. Our understanding of how these transcriptional factors are negatively or positively regulated by oxidative stress has since greatly increased. Questions for future investigation center on the modulation of oxidative stress by personal genome information for the prevention of several pathologic states.
Gastrointestinal Tissue
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Author : Jordi Gracia-Sancho
language : en
Publisher: Academic Press
Release Date : 2017-05-10
Gastrointestinal Tissue written by Jordi Gracia-Sancho and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-05-10 with Medical categories.
Gastrointestinal Tissue: Oxidative Stress and Dietary Antioxidants brings together leading experts from world renowned institutions, combining the basic mechanisms of gastrointestinal diseases with information regarding new and alternative treatments. The processes within the science of oxidative stress are described in concert with other processes, including apoptosis, cell signaling and receptor mediated responses, further recognizing that diseases are often multifactorial with oxidative stress as a component. By combining the critical molecular processes underlying free radical mediated pathologies and the role of dietary antioxidant molecules, a connection is made that helps advance therapies and the prevention of gastrointestinal pathological processes. This important reference is well designed with two complementary sections. Section One, Oxidative Stress and Gastroenterology, covers the basic processes of oxidative stress from molecular biology to whole organs, the gastrointestinal anatomy and sources of oxidative stress and free radicals and their products in gastrointestinal diseases. Section Two, Antioxidants and Gastroenterology covers antioxidants in foods, including plants and components. Covers the science of oxidative stress in gastrointestinal tissue and associated conditions and scenarios Provides information on optimal levels for human consumption of antioxidants, suggested requirements per day, recommended dietary allowances and curative/preventive effects of dietary antioxidants Presents an easy to reference guide with two complementary sections that discuss the pathophysiology of gastrointestinal diseases in relation to oxidative stress and antioxidant therapies
Free Radicals And The Liver
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Author : Geza Csomos
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Free Radicals And The Liver written by Geza Csomos and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Based on the results of the latest congress of the European Association for the Study of the Liver (EASL), this volume makes excellent reading since it explores in detail the role of free radical reactions in liver diseases. Studies in recent years using various methods have shown that free radicals play an important role in toxic liver disorders. For this reason, the current scientific knowledge is presented in this balanced, clinical portrayal. The account refers to the many observations, experiencesand evaluations that have been made both clinically and experimentally. Two major areas discussed concern the pathophysiological changes by free radicals and the therapeutic possibilities that have come to light.
Free Radicals In Human Health And Disease
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Author : Vibha Rani
language : en
Publisher: Springer
Release Date : 2014-11-14
Free Radicals In Human Health And Disease written by Vibha Rani and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-14 with Science categories.
The role of oxidative stress in human disease has become an area of intense interest. Free radicals, a normal product of metabolism, exist in all aerobic cells in balance with biochemical antioxidants. Environmental stress increases the levels of free radicals drastically, thereby disturbing the equilibrium between free radical production and the antioxidant capability causing oxidative stress. Over the years, ROS has been implicated in the pathologies of various diseases like cancer, neurological disorder, cardiovascular diseases rheumatoid arthritis, diabetes etc. This book provides an in depth critical state-of-art reviews from established investigators on free radicals, ROS associated pathogenesis of human diseases, biomarkers of oxidative damage, antioxidants, phytonutrients and other related health concerns of modern society. The present book is aimed at graduate students, researchers in academia, industry and clinicians with the interest in redox biology. Special attention has been devoted to the topic of ROS signalling, oxidative stress induced human pathologies & antioxidative therapies. The book consists of four parts in specified topics based on the current literatures for the better understanding of the readers with respect to their subject-wise interests. The first section of the book provides an overview about the ROS production and their measuring tools and techniques followed by the mechanisms involved in the oxidative stress in the second section. The third section describes the involvement of oxidative stress in different human diseases and the last section focuses on the different strategies to ameliorate oxidative stress induced stress.
Immunopharmacology Of The Gastrointestinal System
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Author : John L. Wallace
language : en
Publisher: Academic Press
Release Date : 1993-03-01
Immunopharmacology Of The Gastrointestinal System written by John L. Wallace and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993-03-01 with Medical categories.
Diseases of the digestive system have a higher morbidity rate than any other group of disorder. There is a growing body of evidence that the immune system participates in the pathogenesis of a wide range of these diseases, including peptic ulcer disease and the gastropathy induced by nonsteroidal anti-inflammatory drugs (NSAIDS). For these reasons, efforts to develop novel therapies for digestive diseases are increasingly focused on the immune system. This volume reviews the immunopharmacology of the gastrointestinal tract at four distinct levels: Immunomodulation at a cellular level Cellular targers for immunomodulating drugs Specific classes of inflammatory mediators Utility and mechanisms of action of glucocorticoids in the treatment of diseases of the gastrointestinal tract.
Free Radicals Antioxidants And Diseases
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Author : Rizwan Ahmad
language : en
Publisher: BoD – Books on Demand
Release Date : 2018-08-01
Free Radicals Antioxidants And Diseases written by Rizwan Ahmad and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-08-01 with Science categories.
The current book entitled Free Radicals, Antioxidants, and Diseases gives an idea of detecting free radicals in vivo by newer techniques and provides insights into the roles played by various antioxidants in combating diseases caused by oxidative stress. The chapters included in this volume showcase new investigation in this field by the research groups around the world.
Free Radicals And The Liver
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Author : Geza Csomos
language : en
Publisher: Springer
Release Date : 1992-06-23
Free Radicals And The Liver written by Geza Csomos and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992-06-23 with Medical categories.
Based on the results of the latest congress of the European Association for the Study of the Liver (EASL), this volume makes excellent reading since it explores in detail the role of free radical reactions in liver diseases. Studies in recent years using various methods have shown that free radicals play an important role in toxic liver disorders. For this reason, the current scientific knowledge is presented in this balanced, clinical portrayal. The account refers to the many observations, experiencesand evaluations that have been made both clinically and experimentally. Two major areas discussed concern the pathophysiological changes by free radicals and the therapeutic possibilities that have come to light.
Fate Of Antioxidants In Gut And Interaction Of Gut Metabolites And Gut Microbiota
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Author : Baojun Xu
language : en
Publisher: Mdpi AG
Release Date : 2023-08-17
Fate Of Antioxidants In Gut And Interaction Of Gut Metabolites And Gut Microbiota written by Baojun Xu and has been published by Mdpi AG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-08-17 with Science categories.
It is widely accepted that antioxidants can help in disease prevention by effectively quenching free radicals or inhibiting damage caused by oxidative stress. However, the final fate of antioxidants in the gut, how antioxidant metabolites affect gut microbiota, and how gut microbiota affect the metabolism of antioxidants are not fully understood. This Special Issue collected the latest research findings and review articles, bringing together current research and critical thinking on the fate of phytochemical antioxidants in the gut and the role antioxidant gut metabolites play in reducing oxidative stress in various gut and metabolic diseases. Both in vitro and in vivo studies relating to any of the following topics will be considered: fate of antioxidants in the gut; antioxidative activities of phytochemicals in the digestive system; molecular mechanisms of phytochemical antioxidants in maintaining gut health; and interactions of antioxidant metabolites and gut microbiota.