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From Development To Degeneration And Regeneration Of The Nervous System

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Author : Charles E. Ribak PhD
language : en
Publisher: Oxford University Press
Release Date : 2009

From Development To Degeneration And Regeneration Of The Nervous System written by Charles E. Ribak PhD and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Medical categories.

This book provides current information about the three areas mentioned in the title: Neuronal Migration and Development, Degenerative Brain Diseases, and Neural Plasticity and Regeneration. The chapters about brain development examine the cellular and molecular mechanisms by which neurons are generated from the ventricular zone in the forebrain and migrate to their destinations in the cerebral cortext. This description of cortical development also includes a discussions of the Cajal-Retzius cell. Another chapter provides insight about the development of another forebrain region, the hypothalamus. The remaining chapters of this section examine the clinical relevance of brain development in certain disease states in humans: neural tube defects and the normal and abnormal development of human electroencephalographic recordings during the first year of age.The second section on degenerative disorders of the brain begins wtih details about the dopaminergic neurons in the substantia niger and their loss in Parkinson's disease. Two subsequent chapters describe changes in brain aging, including changes in the numbers of myelinated axons. Other chapters in this section describe important cellular and molecular changes found in Alzheimer's disease and human epilepsy. Together, these chapters summarize much of our current knowledge about the major molecular and cellular changes found in several degenerative diseases of the brain.The last section addresses the issues of brain plasticity and regeneration in the adult brain and begins with a chapter on how the brain's own stem cells provide newly generated neurons to the hippocampal dentate gyrus and how these neurons become integrated into neural circuitry. The following two chapters examine some of the neuroplastic changes that take place in motor and sensory cortices of awake behaving primates. The concluding two chapters address the issue of regeneration in the injured spinal cord and the factors that may contribute to its success.

Neuronal Degeneration And Regeneration From Basic Mechanisms To Prospects For Therapy

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Author : F.W. Van Leeuwen
language : en
Publisher: Elsevier
Release Date : 1998-11-09

Neuronal Degeneration And Regeneration From Basic Mechanisms To Prospects For Therapy written by F.W. Van Leeuwen and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-11-09 with Science categories.

This book is the result of the 20th International Summer School in Brain Research, organized in August 1997 in Amsterdam, by the Netherlands Institute for Brain Research at the Royal Netherlands Academy of Sciences. It is the first book that provides a complete overview of the field of neurodegeneration and regeneration including spinal cord injury, neurodegenerative diseases and therapy. Divided into five sections, the first two sections give an overview of fundamental research on nerve cell death, neuronal survival, neurite outgrowth and guidance. Extensive attention is given to the role of neurotrophins, their receptor tyrosine kinases and cell-adhesion molecules in development and regeneration of the nervous system. The third section of the book is devoted to research involving human neurodegenerative diseases and emerging treatment strategies. Section four focusses on recent advances in the understanding of pathophysiological mechanisms underlying neurodegenerative diseases, including Alzheimer's, Parkinson's and Huntington's diseases along with prion diseases. Novel insights into the neuropathological hallmarks of these diseases, as well as into transgenic animal models, the involvement of environmental factors, and genomic and mRNA changes that can cause neurodegeneration. The final section of this volume reveals recent developments in the use of cell and gene therapy to treat neurodegenerative disease and lesion-related deficits. Implantation of genetically modified cells, direct gene transfer with viral vectors and the first clinical trials with encapsulated genetically modified cells in patients suffering from amyotrophic lateral scelerosis are examples of new therapeutic strategies treating neurodegenerative diseases. The book is of particular interest to departments of neuroscience, neurological clinics and departments, the pharmalogical industry and medical libraries.

Cajal S Degeneration And Regeneration Of The Nervous System

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Author : Santiago Ramón y Cajal
language : en
Publisher: History of Neuroscience
Release Date : 1991

Cajal S Degeneration And Regeneration Of The Nervous System written by Santiago Ramón y Cajal and has been published by History of Neuroscience this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Nervous system categories.

This book is a reprint of an English translation of Cajal's original work, with abundant notes and commentaries by the editor. This text describes Cajal's fundamental contributions to neuroscience, which continue to be important today. It accurately details Cajal's ideas and data, and providesreaders with the opportunity to learn what Cajal thought about his research career and the significance of his observations. Excerpts from Tello's memorial lectures also provide a contemporary view of Cajal's work.

Degeneration Regeneration Of The Nervous System

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Author : Santiago Ramón y Cajal
language : en
Publisher:
Release Date : 1928

Degeneration Regeneration Of The Nervous System written by Santiago Ramón y Cajal and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1928 with Nerves categories.

Degeneration And Regeneration In The Nervous System

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Author : Norman Saunders
language : en
Publisher: CRC Press
Release Date : 2020-06-30

Degeneration And Regeneration In The Nervous System written by Norman Saunders and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-06-30 with categories.

Degeneration and Regeneration in the Nervous System brings together an international team of contributors to produce a series of critical reviews appraising key papers in the field. The pace of research on brain and spinal cord injury quickened considerably in the last ten years and there is much that is new and important that is covered in this book. However, there is still a long way to go before our knowledge will explain fully why the central nervous system has such a limited capacity for regeneration, and before experimental solutions can be applied to the patient. With emphasis on actual and therapeutic importance of the work reviewed, Degeneration and Regeneration in the Nervous System is a useful overview for graduate students, their teachers and researchers working in this field.

Degeneration Regeneration Of The Nervous System

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Author : Santiago Ramón y Cajal
language : en
Publisher:
Release Date : 1968

Wiring The Nervous System Mechanisms Of Axonal And Dendritic Remodelling In Health And Disease

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Author : Tracy S. Tran
language : en
Publisher: CRC Press
Release Date : 2024-01-31

Wiring The Nervous System Mechanisms Of Axonal And Dendritic Remodelling In Health And Disease written by Tracy S. Tran and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-01-31 with Science categories.

This book examines recent key findings on the mechanisms of axonal and dendritic remodeling in different model organisms. Each chapter is contributed by a panel of experts in their respective subfields of neurosciences, to provide and discuss the latest discoveries ranging from neuronal morphogenesis during development, experience-dependent structural plasticity, to neuronal degeneration, regeneration, and pathologies in neurological disorders. The process of neuronal remodeling, specifically their axons and dendrites, is essential for the proper wiring of the nervous system during early development and continues during postnatal ages to shape the pattern of synaptic connections throughout the life of the organism, including humans. Over recent years, substantial progress has been made in our understanding of the cellular and molecular mechanisms that control neuronal remodeling. In addition, there is accumulating evidence demonstrating how the nervous system could remodel in response to injury and in pathological conditions. Topics discussed in the book include: Axonal degeneration during development and in pathological or disease conditions Neuronal morphogenesis (axons and dendrites) Experience-dependent structural plasticity to synaptogenesis Dendrite degeneration and regeneration