From Genotype To Phenotype
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From Genotype To Phenotype
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Author : Sue Malcolm
language : en
Publisher: Gulf Professional Publishing
Release Date : 2001-11-19
From Genotype To Phenotype written by Sue Malcolm and has been published by Gulf Professional Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-11-19 with Medical categories.
This volume of the Human Molecular Genetics series covers such genotype-phenotype correlations as clinical and environmental aspects, gene structure, expression, and mutation. Also discussed are models of certain diseases and future prospects for treatment and prevention. This book provides the reader with a basic overview of the physical expression of genetic disease before discussing in detail the most recent research and therapeutic developments.
Phenotypes And Genotypes
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Author : Florian Frommlet
language : en
Publisher: Springer
Release Date : 2016-02-12
Phenotypes And Genotypes written by Florian Frommlet and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-02-12 with Computers categories.
This timely text presents a comprehensive guide to genetic association, a new and rapidly expanding field that aims to elucidate how our genetic code (genotypes) influences the traits we possess (phenotypes). The book provides a detailed review of methods of gene mapping used in association with experimental crosses, as well as genome-wide association studies. Emphasis is placed on model selection procedures for analyzing data from large-scale genome scans based on specifically designed modifications of the Bayesian information criterion. Features: presents a thorough introduction to the theoretical background to studies of genetic association (both genetic and statistical); reviews the latest advances in the field; illustrates the properties of methods for mapping quantitative trait loci using computer simulations and the analysis of real data; discusses open challenges; includes an extensive statistical appendix as a reference for those who are not totally familiar with the fundamentals of statistics.
Problems And Solutions For Strachan And Read S Human Molecular Genetics 2
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Author : David James Matthes
language : en
Publisher:
Release Date : 2001
Problems And Solutions For Strachan And Read S Human Molecular Genetics 2 written by David James Matthes and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with Human molecular genetics categories.
Epigenetics
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Author : Benedikt Hallgrímsson
language : en
Publisher: Univ of California Press
Release Date : 2011-04-11
Epigenetics written by Benedikt Hallgrímsson and has been published by Univ of California Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-11 with Science categories.
“If you want to understand evolution, you need to understand the murky world of epigenetics. A hearty congratulations should be paid to Hallgrimsson and Hall, who provide reliable and steady illumination.”-Bernard Wood, Center for the Advanced Study of Hominid Paleobiology, George Washington University
The Extended Phenotype
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Author : Richard Dawkins
language : en
Publisher: Oxford University Press
Release Date : 2016
The Extended Phenotype written by Richard Dawkins and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with Nature categories.
In The Selfish Gene, Richard Dawkins crystallized the gene's eye view of evolution developed by W.D. Hamilton and others. The book provoked widespread and heated debate. Written in part as a response, The Extended Phenotype gave a deeper clarification of the central concept of the gene as the unit of selection; but it did much more besides. In it, Dawkins extended the gene's eye view to argue that the genes that sit within an organism have an influence that reaches out beyond the visible traits in that body - the phenotype - to the wider environment, which can include other individuals. So, for instance, the genes of the beaver drive it to gather twigs to produce the substantial physical structure of a dam; and the genes of the cuckoo chick produce effects that manipulate the behaviour of the host bird, making it nurture the intruder as one of its own. This notion of the extended phenotype has proved to be highly influential in the way we understand evolution and the natural world. It represents a key scientific contribution to evolutionary biology, and it continues to play an important role in research in the life sciences. The Extended Phenotype is a conceptually deep book that forms important reading for biologists and students. But Dawkins' clear exposition is accessible to all who are prepared to put in a little effort. Oxford Landmark Science books are 'must-read' classics of modern science writing which have crystallized big ideas, and shaped the way we think.
Autism Spectrum Disorders From Genotypes To Phenotypes
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Author : Valsamma Eapen
language : en
Publisher: Frontiers Media SA
Release Date : 2015-12-10
Autism Spectrum Disorders From Genotypes To Phenotypes written by Valsamma Eapen and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-12-10 with Autism categories.
This Research Topic covers the pathogenetic processes in Autism Spectrum Disorder (ASD) that underpin the translation of genetic vulnerability to clinically significant symptoms. Available research data in ASD suggests that it is a neural connectivity disorder and that the social communication and related neurobehavioural symptoms result from reduced synchronization between key "social brain" regions. These interconnected neural systems can be understood through the relationship between functionally relevant anatomic areas and neurochemical pathways, the programming of which are genetically modulated during neurodevelopment and mediated through a range of epigenetic and environmental modulators. Elucidating the underlying molecular mechanisms can provide an invaluable window for understanding the neural wiring that regulates higher brain functions and consequent clinical phenotypes. In keeping with the multi modal and diverse origins of ASD, this Research Topic explores the genetic underpinnings and environmental modulation in the aetiology; neural substrates, biomarkers and endophenotypes that underlie clinical characteristics; as well as neurochemical pathways and pathophysiological mechanisms that pave the way for therapeutic interventions. Furthermore, since genetically mediated deficits and consequent functional impairments involve activity-dependent synapse development that depends on postnatal learning and experience, the trajectory towards the final clinical expression could be modulated by early interventions that exploit the neuronal maturation and brain plasticity. However, identifying these diverse pathogenetic processes and tailoring interventions would require subtyping ASD into homogeneous subgroups. In this regard, this topic covers the current state of evidence in the literature through topic reviews as well as ongoing original work that provides tangible hypotheses and directions for future research.
The Concept Of The Gene In Development And Evolution
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Author : Peter J. Beurton
language : en
Publisher: Cambridge University Press
Release Date : 2000-05-29
The Concept Of The Gene In Development And Evolution written by Peter J. Beurton and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-05-29 with Philosophy categories.
Advances in molecular biological research in the latter half of the twentieth century have made the story of the gene vastly complicated: the more we learn about genes, the less sure we are of what a gene really is. Knowledge about the structure and functioning of genes abounds, but the gene has also become curiously intangible. This collection of essays renews the question: what are genes? Philosophers, historians and working scientists re-evaluate the question in this volume, treating the gene as a focal point of interdisciplinary and international research. It will be of interest to professionals and students in the philosophy and history of science, genetics and molecular biology.
Multi Omics And Computational Biology In Horticultural Plants From Genotype To Phenotype Volume Ii
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Author : Yunpeng Cao
language : en
Publisher: Frontiers Media SA
Release Date : 2024-02-13
Multi Omics And Computational Biology In Horticultural Plants From Genotype To Phenotype Volume Ii written by Yunpeng Cao and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-02-13 with Science categories.
This Research Topic is part of the article collection series - Multi-omics and Computational Biology in Horticultural Plants: From Genotype to Phenotype. Horticultural plants play an important role for humans by providing herbal medicines, beverages, vegetables, fruits, and ornamentals. High-throughput technologies have revolutionised the time scale and power of detecting insights into physiological changes and biological mechanisms in plants. All sequencing data and tools have helped us better understand the evolutionary histories of horticultural plants and provide genotype and phenotype resources for molecular studies on economically important traits. The integration of these -omics technologies (e.g., genomics, transcriptomics, proteomics, metabolomics, lipidomics, ionomics, and redoxomics) is currently at the forefront of plant research. The genomes of horticultural plants are highly diverse and complex, often with a high degree of heterozygosity and polyploidy. Novel computational methods need to be developed to take advantage of state-of-the-art genomic technologies. As a result, the mining of multi-omics data and the development of new computational biology approaches for the reliable and efficient analysis of plant traits is necessary.
Genotype To Phenotype Therapy
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Author :
language : en
Publisher:
Release Date : 1996
Genotype To Phenotype Therapy written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Mucopolysaccharidoses categories.
Epistasis
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Author : Ka-Chun Wong
language : en
Publisher: Humana
Release Date : 2021-03-18
Epistasis written by Ka-Chun Wong and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-18 with Medical categories.
This volume explores methods and protocols for detecting epistasis from genetic data. Chapters provide methods and protocols demonstrating approaches to identify epistasis, genetic epistasis testing, genome-wide epistatic SNP networks, epistasis detection through machine learning, and complex interaction analysis using trigenic synthetic genetic array (τ-SGA). Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, application details for both the expert and non-expert reader, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Epistasis: Methods and Protocols aims to ensure successful results in the further study of this vital field. "Simulating Evolution in Asexual Populations with Epistasis” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.