From Gwas Hits To Treatment Targets
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From Gwas Hits To Treatment Targets
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Author : Jeanette Erdmann
language : en
Publisher: Frontiers Media SA
Release Date : 2019-08-16
From Gwas Hits To Treatment Targets written by Jeanette Erdmann and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-16 with categories.
Genome-wide association (GWA) studies, as a prototype of large-scale OMICs studies, have advanced our understanding of the genetic basis of many common diseases. With respect to coronary artery disease (CAD) and cardiovascular risk factors, like lipids, blood pressure or BMI, they have identified hundreds of chromosomal loci that modulate disease risk. Despite their scientific success, GWA studies have been criticized for having failed so far in delivering diagnostically or therapeutically relevant products. However, the ability to achieve such goals has been strengthened recently by further layers of OMICs-based data, including large-scale transcriptomics data, and better annotation of regulatory sequences and epigenetic changes in the genome (e.g. through the ENCODE project), as well as novel tools for bioinformatics analysis, allowing a systems medicine based approach to be applied. All in all, the last decade with its “gold rush of genomic discovery” led to the identification of known and novel pathways involved in the pathogenesis of cardiovascular diseases and point to novel treatment targets. This Research Topic has gathered contributions from scientists working in the field of cardiovascular genetics who have common interests in understanding the pathomechanisms linking genetic association findings and disease to finally translate the findings from large-scale genetic studies into novel treatment options.
Migraine
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Author : David Dodick
language : en
Publisher: Oxford University Press
Release Date : 2016
Migraine written by David Dodick and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with Medical categories.
Preceded by: Migraine: manifestations, pathogenesis, and management / Robert A. Davidoff. 2nd ed. 2002.
Migraine
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Author : David Dodick FRCP (C), FACP, MD
language : en
Publisher: Oxford University Press
Release Date : 2016-03-16
Migraine written by David Dodick FRCP (C), FACP, MD and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-03-16 with Medical categories.
Migraine is a complex neurological disorder that is characterized by a complex neurobiology, clinical features that may overlap with over 300 causes of headache, and an association with major medical illnesses and comorbid diseases. This books draws upon the authors' vast clinical experience and exhaustive knowledge of the science of migraine and the practice of headache medicine and provides this knowledge in a comprehensive yet digestible format. While migraine is often a subject in other textbooks on headache, it is the sole focus of this volume. The authors provide an up-to-date overview of the evidence base and combine this with their experience and expertise to help practitioners make informed treatment decisions. This book also provides a glimpse into the future describing new treatment modalities, including neurostimulation technologies and biologics that are emerging as potentially valuable treatment options. The authors also deal extensively with the unique and complex management of migraine in women throughout the reproductive life cycle. For those looking for a practical, insightful, and in-depth review on the subject of migraine, there is no other option.
Recent Advances In Cardiology 16
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Author : Derek Rowlands
language : en
Publisher: JP Medical Ltd
Release Date : 2014-02-10
Recent Advances In Cardiology 16 written by Derek Rowlands and has been published by JP Medical Ltd this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-02-10 with Medical categories.
Part of the Recent Advnaces series, Cardiology is a collection of comprehensive reviews, with emphasis on breakthroughs and their practical relevance to clinical practice, providing essential reading to help clinicians and trainees remain up to date in the field.
Handbook Of Ptsd
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Author : Matthew J. Friedman
language : en
Publisher: Guilford Publications
Release Date : 2023-11-03
Handbook Of Ptsd written by Matthew J. Friedman and has been published by Guilford Publications this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-11-03 with Medical categories.
Now in an extensively revised third edition with 65% new material, this is the authoritative reference on posttraumatic stress disorder (PTSD). Contributors examine the breadth of current knowledge on the mechanisms by which stressful events can alter psychological processes, brain function, and individual behavior. Risk and protective factors across development and in specific populations are explored. Reviewing the state of the science of assessment and treatment, the volume covers early intervention and evidence-based individual, couple/family, and group therapies. Conceptual and diagnostic issues are addressed and key questions for the next generation of researchers are identified. New to This Edition *Thoroughly revised to reflect the accelerating pace of scientific and clinical progress; includes a range of new authors. *Chapters on new topics: treatment of PTSD with comorbid disorders, and postmortem brain banking. *New chapters on previously covered topics, including DSM-5 and ICD-11 diagnostic criteria, the psychoneurobiology of resilience, and challenges in implementing clinical best practices. *New or updated discussions of such timely issues as treatment of refugees, telemental health, and technology-based interventions.
Advancing Gene Targeted Therapies For Central Nervous System Disorders
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Author : National Academies of Sciences, Engineering, and Medicine
language : en
Publisher: National Academies Press
Release Date : 2019-12-01
Advancing Gene Targeted Therapies For Central Nervous System Disorders written by National Academies of Sciences, Engineering, and Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-12-01 with Medical categories.
On April 23 and 24, 2019 the Forum on Neuroscience and Nervous System Disorders convened a workshop titled "Advancing Gene-Targeted Therapies for Central Nervous System Disorders" in Washington, DC. This public workshop brought together experts and key stakeholders from academia, government, industry, philanthropic foundations, and disease/patient-focused nonprofit organizations to explore approaches for advancing the development of gene-targeted therapies for central nervous system (CNS) disorders, and implications of developing these therapies. Participants explored lessons learned from both successful and unsuccessful clinical development programs; new knowledge about the genetic underpinnings of brain disorders; the current status and future potential of gene-targeted therapies for CNS disorders; challenges and potential solutions for translating preclinical findings to approved therapies; and patient and caregiver perspectives. They also discussed what will be needed to develop these therapies for common disorders such as Alzheimer's and Parkinson's disease, as well as neuropsychiatric and neurodevelopmental disorders such as schizophrenia and autism. The workshop included approaches that target both DNA and RNA, as well as gene products using viral vectors, antisense oligonucleotides, and RNA interference. This publication summarizes the presentations and discussion of the workshop.
Decreasing The Impact Of Treatment Resistance In Schizophrenia Identifying Novel Molecular Targets Pathways To Increase Treatment Efficacy
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Author : Mirko Manchia
language : en
Publisher: Frontiers Media SA
Release Date : 2020-08-27
Decreasing The Impact Of Treatment Resistance In Schizophrenia Identifying Novel Molecular Targets Pathways To Increase Treatment Efficacy written by Mirko Manchia and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-27 with categories.
New Oxford Textbook Of Psychiatry
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Author : John R. Geddes
language : en
Publisher: Oxford University Press, USA
Release Date : 2020-02-20
New Oxford Textbook Of Psychiatry written by John R. Geddes and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-20 with Medical categories.
Over its two editions, The New Oxford Textbook of Psychiatry has come to be regarded as one of the most popular and trusted standard psychiatry texts among psychiatrists and trainees. Bringing together 146 chapters from the leading figures in the discipline, it presents a comprehensive account of clinical psychiatry, with reference to its scientific basis and to the patient's perspective throughout. The New Oxford Textbook of Psychiatry, Third Edition has been extensively re-structured and streamlined to keep pace with the significant developments that have taken place in the fields of clinical psychiatry and neuroscience since publication of the second edition in 2009. The new edition has been updated throughout to include the most recent versions of the two main classification systems---the DSM-5 and the ICD-11---used throughout the world for the diagnosis of mental disorders. In the years since publication of the first edition, many new and exciting discoveries have occurred in the biological sciences, which are having a major impact on how we study and practise psychiatry. In addition, psychiatry has fostered closer ties with philosophy, and these are leading to healthy discussions about how we should diagnose and treat mental illness. This new edition recognises these and other developments. Throughout, accounts of clinical practice are linked to the underlying science, and to the evidence for the efficacy of treatments. Physical and psychological treatments, including psychodynamic approaches, are covered in depth. The history of psychiatry, ethics, public health aspects, and public attitudes to psychiatry and to patients are all given due attention.
Progress Of Translational Medicine In Alzheimer S Disease
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Author : Can Martin Zhang
language : en
Publisher: Frontiers Media SA
Release Date : 2022-08-04
Progress Of Translational Medicine In Alzheimer S Disease written by Can Martin Zhang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-04 with Science categories.
Recent Advances On The Multimodal Search For Markers Of Treatment Response In Affective Disorders From Bench To Bedside
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Author : Frank M Schmidt
language : en
Publisher: Frontiers Media SA
Release Date : 2019-11-28
Recent Advances On The Multimodal Search For Markers Of Treatment Response In Affective Disorders From Bench To Bedside written by Frank M Schmidt and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-28 with categories.