From Immunotherapy Of Cancer To The Discovery Of Kidney Cancer Genes
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From Immunotherapy Of Cancer To The Discovery Of Kidney Cancer Genes
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Author : Berton Zbar
language : en
Publisher: Biota Publishing
Release Date : 2013-03-01
From Immunotherapy Of Cancer To The Discovery Of Kidney Cancer Genes written by Berton Zbar and has been published by Biota Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-01 with Science categories.
I had the good fortune to work at the National Cancer Institute from 1965 to 2005. The National Cancer Institute provided an environment that permitted my curiosity to flourish. Colleagues, particularly Marston Linehan, were essential to performance of the work. The work described in this manuscript was performed during a period of rapid advances in genetics. I was able to apply my clinical training and new genetic tools to study human kidney cancer. With the support of the National Cancer Institute, I was able to canvas physicians throughout the United States and Canada for referrals of families with multiple members affected with renal cancer. I was able to visit these families in their communities and determine the clinical and genetic features of their hereditary susceptibility to renal cancer, and to bring these families to Bethesda for comprehensive examinations. Using DNA analytic tools, we were able to identify several tumor suppressor genes that play major roles in the pathogenesis of human renal carcinoma thus opening up new fields for biochemical research into the pathogenesis of human renal carcinoma.
Renal Cell Carcinoma
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Author : Robert A. Figlin
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-03-01
Renal Cell Carcinoma written by Robert A. Figlin and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-03-01 with Medical categories.
This book provides a comprehensive look at renal cell carcinoma, exploring its biology as well as current and future molecular targets for renal cancer carcinoma.
Renal Cell Carcinoma
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Author : Ronald M. Bukowski
language : en
Publisher: Springer
Release Date : 2014-11-27
Renal Cell Carcinoma written by Ronald M. Bukowski and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-27 with Medical categories.
The third edition of this critically acclaimed book has updated and expanded the survey of clinical, biological and pathological management of localized and advanced renal cell carcinoma. Internationally renowned editors and contributors explore the latest developments in molecular genetics, focusing on the novel targets that have been discovered in epithelial renal tumors. Comprehensive and authoritative, Renal Cell Carcinoma: Molecular Targets and Clinical Applications, Third Edition is the definitive text on the rapidly evolving landscape of experimental therapeutics, written and edited by leaders of the field.
Evolving Trends In Kidney Cancer
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Author : Sashi S. Kommu
language : en
Publisher: BoD – Books on Demand
Release Date : 2020-07-22
Evolving Trends In Kidney Cancer written by Sashi S. Kommu and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-22 with Medical categories.
Kidney cancer imposes a significant cancer burden and its incidence continues to rise globally. Mortality in advanced kidney cancer remains high despite oncological, surgical and multimodal optimisation. Genetic associations, heterogeneity and limitations in early diagnosis through lack of optimal biomarkers add to the challenges. Over the last two decades there has been an exponential increase in diagnostic and therapeutic advances in the management of kidney cancer. The coupling of scientific advances in engineering and technology with oncological therapeutics has recently ushered a renewed optimism. The role of minimally invasive approaches through focal therapy and surgical extirpation using the robotic platform has been unprecedented and paramount. Virtual augmentation and mixed reality platforms have proved useful supplementary tools in surgical planning. The role of surgical simulation and training in development of surgeons with the optimal skill set is essential to provide optimal care. This book is the first in a series that explores the evolving trends in kidney cancer. The focus of the book is broad and includes topics ranging from immunotherapy to surgical simulation. Some chapters explore leading edge concepts while others capture the evolving trends and future concepts. The Editors aim to stimulate the readers to explore the key concepts and to encourage research and innovation along the main themes presented.
Kidney Cancer
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Author : O. Hino
language : en
Publisher:
Release Date : 1999
Kidney Cancer written by O. Hino and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Medical categories.
Cancer is above all a heritable disorder of somatic cells and gene expression, but environment is also involved in its origin. Hereditary kidney cancer should prove valuable to understand the mechanisms of disease and to the development of therapeutic measures. Recently, scientists have succeeded in cloning and identifying the genes responsible for the following familial kidney cancers: von Hippel-Lindau disease, papillary renal cell carcinoma, tuberous sclerosis and Wilms tumor (all autosomal dominant). This book brings together some of the most recent advances made with respect to kidney cancers: Leading investigators present recent results on VHL, MET, TSC1 and TSC2 and WT1 genes, among others, as well as on environmentally induced kidney cancers (caused by long-term hemodialysis or induced chemically) and their treatments (surgery and gene therapy), providing an excellent survey of this field. This publication will be of interest to both researchers and clinicians concerned with cancer of the kidney.
Contemporary Research On Renal Cell Carcinoma
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Author : Gerd Staehler
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Contemporary Research On Renal Cell Carcinoma written by Gerd Staehler and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The management of advanced renal cell carcinoma is still problematic. Surgery, although the therapy of choice for locally advanced renal tumors, is still controversial as the treatment for metastases. The role of surgery in the management of patients with pulmonary, bony, and liver metastasis is one of the subject matters discussed in this book. Our results with series of patients undergoing resection of metastases from the lung, bone, and liver show that surgery may be appropriate in selected patients with a good performance status, although most of them certainly cannot be cured by this procedure alone, i.e., in the absence of effective adjuvant therapies. As recent developments show, new strategies for immunotherapy of renal cell carcinoma represent a modest advance over traditional approaches in the treatment of this cancer, such as chemo- and radiotherapy. Clinical trials employing recombinant interferon-a and interleukin 2 produced response rates in up to 30% of patients treated, as evidenced by the European Immunotherapy Trials Program. The adverse reactions and the lack of efficacy in the majority of patients warrants the search for new immunotherapeutic approaches.
Nephron Sparing Surgery
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Author : Krishna Sasidharan
language : en
Publisher: CRC Press
Release Date : 2007-10-18
Nephron Sparing Surgery written by Krishna Sasidharan and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-10-18 with Medical categories.
Despite the rising popularity of the minimally invasive laparoscopic option, open nephron-sparing surgery is still seen by many experts as the 'gold standard' for open surgery for kidney tumors and should remain the first choice for many patients. This challenges the idea that less-invasive therapies are always more desirable than open surgery. Whi
Fortschritte Der Chirurgie
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Author :
language : en
Publisher:
Release Date : 1961
Fortschritte Der Chirurgie written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1961 with Surgery categories.
From Gene To Therapy
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Author : Michael Dean
language : en
Publisher: Biota Publishing
Release Date : 2017-09-13
From Gene To Therapy written by Michael Dean and has been published by Biota Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-13 with Science categories.
Lecture provides an overview of the progress made in molecular medicine applying genetics and genomics to the understanding, diagnosis, and treatment of human diseases. Specifically, the methods for identifying genes involved in human diseases are described. Examples from 10 genes and diseases will be provided, drawing on the author's research. Topics include examples from simple Mendelian diseases, such as cystic fibrosis, inherited cancers, oncogenes activated by chromosomal translocations, host genes involved in infectious disease, genes identified via genomewide association studies, pathogens causing cancer, and gene families contributing to multiple diseases. For each example, historical details will be provided as background for readers to understand the context and process of the discoveries, technologies explained, and current understanding and treatment implications detailed.
Immunotherapy Of Renal Cell Carcinoma
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Author : Frans M.J. Debruyne
language : en
Publisher: Springer
Release Date : 1991-01-29
Immunotherapy Of Renal Cell Carcinoma written by Frans M.J. Debruyne and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991-01-29 with Medical categories.
With contributions by numerous experts