Functional Imaging Of The Lungs Using Magnetic Resonance Imaging Of Inert Fluorinated Gases
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Functional Imaging Of The Lungs Using Magnetic Resonance Imaging Of Inert Fluorinated Gases
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Author : Marcus Couch
language : en
Publisher:
Release Date : 2016
Functional Imaging Of The Lungs Using Magnetic Resonance Imaging Of Inert Fluorinated Gases written by Marcus Couch and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with categories.
Fluorine-19 (19F) magnetic resonance imaging (MRI) of the lungs using inhaled inert fluorinated gases can potentially provide high quality anatomical and functional images of the lungs. This technique is able to visualize the distribution of the inhaled gas, similar to hyperpolarized (HP) helium-3 (3He) and xenon-129 (129Xe) MRI. Inert fluorinated gases have the advantages of being nontoxic, abundant, and inexpensive compared to HP gases. Due to the high gyromagnetic ratio of 19F, there is sufficient thermally polarized signal for imaging, and averaging within a single breath-hold is possible due to short longitudinal relaxation times. Since inert fluorinated gases do not need to be hyperpolarized prior to their use in MRI, this eliminates the need for an expensive polarizer and expensive isotopes. Inert fluorinated gas MRI of the lungs has been studied extensively in animals since the 1980s, and more recently in healthy volunteers and patients with lung diseases. This thesis focused on the development of static breath-hold inert fluorinated gas MR imaging techniques, as well as the development functional imaging biomarkers in humans and animal models of pulmonary disease. Optimized ultrashort echo time (UTE) 19F MR imaging was performed in healthy volunteers, and images from different gas breathing techniques were quantitatively compared. 19F UTE MR imaging was then quantitatively compared to 19F gradient echo imaging in both healthy volunteers and in a resolution phantom. A preliminary comparison to HP 3He MR imaging is also presented, along with preliminary 19F measurements of the apparent diffusion coefficient (ADC) and iv gravitational gradients of ventilation in healthy volunteers. The potential of inert fluorinated gas MRI in detecting pulmonary diseases was further explored by performing ventilation mapping in animal models of inflammation and fibrosis. Overall, interest in pulmonary 19F MRI of inert fluorinated gases is increasing, and numerous sites around the world are now interested in developing this technique. This work may help to demonstrate that inert fluorinated gas MRI has the potential to be a viable clinical imaging modality that can provide useful information for the diagnosis and management of chronic respiratory diseases.
Fluorine Magnetic Resonance Imaging
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Author : Ulrich Flogel
language : en
Publisher: CRC Press
Release Date : 2016-10-26
Fluorine Magnetic Resonance Imaging written by Ulrich Flogel and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-26 with Medical categories.
Over the past decade, fluorine (19F) magnetic resonance imaging (MRI) has garnered significant scientific interest in the biomedical research community owing to the unique properties of fluorinated materials and the 19F nucleus. Fluorine has an intrinsically sensitive nucleus for MRI. There is negligible endogenous 19F in the body and thus there is no background signal. Fluorine-containing compounds are ideal tracer labels for a wide variety of MRI applications. Moreover, the chemical shift and nuclear relaxation rate can be made responsive to physiology via creative molecular design. This book is an interdisciplinary compendium that details cutting-edge science and medical research in the emerging field of 19F MRI. Edited by Ulrich Flögel and Eric Ahrens, two prominent MRI researchers, this book will appeal to investigators involved in MRI, biomedicine, immunology, pharmacology, probe chemistry, and imaging physics.
Pulmonary Functional Imaging
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Author : Yoshiharu Ohno
language : en
Publisher: Springer Nature
Release Date : 2020-12-11
Pulmonary Functional Imaging written by Yoshiharu Ohno and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-11 with Medical categories.
This book reviews the basics of pulmonary functional imaging using new CT and MR techniques and describes the clinical applications of these techniques in detail. The intention is to equip readers with a full understanding of pulmonary functional imaging that will allow optimal application of all relevant techniques in the assessment of a variety of diseases, including COPD, asthma, cystic fibrosis, pulmonary thromboembolism, pulmonary hypertension, lung cancer and pulmonary nodule. Pulmonary functional imaging has been promoted as a research and diagnostic tool that has the capability to overcome the limitations of morphological assessments as well as functional evaluation based on traditional nuclear medicine studies. The recent advances in CT and MRI and in medical image processing and analysis have given further impetus to pulmonary functional imaging and provide the basis for future expansion of its use in clinical applications. In documenting the utility of state-of-the-art pulmonary functional imaging in diagnostic radiology and pulmonary medicine, this book will be of high value for chest radiologists, pulmonologists, pulmonary surgeons, and radiation technologists.
Hyperpolarized And Inert Gas Mri
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Author : Mitchell S. Albert
language : en
Publisher: Academic Press
Release Date : 2016-11-17
Hyperpolarized And Inert Gas Mri written by Mitchell S. Albert and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-17 with Science categories.
Hyperpolarized and Inert Gas MRI: Theory and Applications in Research and Medicine is the first comprehensive volume published on HP gas MRI. Since the 1990's, when HP gas MRI was invented by Dr. Albert and his colleagues, the HP gas MRI field has grown dramatically. The technique has proven to be a useful tool for diagnosis, disease staging, and therapy evaluation for obstructive lung diseases, including asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis. HP gas MRI has also been developed for functional imaging of the brain and is presently being developed for molecular imaging, including molecules associated with lung cancer, breast cancer, and Alzheimer's disease. Taking into account the ongoing growth of this field and the potential for future clinical applications, the book pulls together the most relevant and cutting-edge research available in HP gas MRI into one resource. - Presents the most comprehensive, relevant, and accurate information on HP gas MRI - Co-edited by the co-inventor of HP gas MRI, Dr. Albert, with chapter authors who are the leading experts in their respective sub-disciplines - Serves as a foundation of understanding of HP gas MRI for researchers and clinicians involved in research, technology development, and clinical use with HP gas MRI - Covers all hyperpolarized gases, including helium, the gas with which the majority of HP gas MRI has been conducted
Mri Of The Lung
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Author : Hans-Ulrich Kauczor
language : en
Publisher: Springer
Release Date : 2018-11-28
Mri Of The Lung written by Hans-Ulrich Kauczor and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-28 with Medical categories.
This book provides a comprehensive overview of how to use MRI for the imaging of lung disease. Special emphasis is placed on routine applications and the clinical impact of MRI in each setting. In addition, current technological developments are reviewed and information presented on dedicated applications of MRI in preclinical and translational research, clinical trials, and specialized institutions. During the past two decades, significant advances in the technology have enabled MRI to enter and mature in the clinical arena of chest imaging. Standard protocols are now readily available on MR scanners, and MRI is recommended as the first- or second-line imaging modality for a variety of lung diseases, not limited to cystic fibrosis, pulmonary hypertension, and lung cancer. The benefits and added value of MRI originate from its ability to both visualize lung structure and provide information on different aspects of lung function, such as perfusion, respiratory motion, ventilation, and gas exchange. On this basis, novel quantitative surrogates for lung function and therapy control (imaging biomarkers) are generated. The second edition of MRI of the Lung has been fully updated to take account of recent advances. It is written by an internationally balanced team of renowned authors representing all major groups in the field.
Functional Lung Imaging
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Author : David Lipson
language : en
Publisher: CRC Press
Release Date : 2005-05-24
Functional Lung Imaging written by David Lipson and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-05-24 with Medical categories.
Written by world authorities, this reference explores the utilization and advancement of state-of-the-art imaging modalities for the analysis of pulmonary function-providing an up-to-date and global perspective of imaging applications with detailed contributions from experts in Europe, North America, Japan, and Australia.
Functional Imaging Of The Chest
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Author : Hans-Ulrich Kauczor
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Functional Imaging Of The Chest written by Hans-Ulrich Kauczor and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
For a long time, imaging of the chest was based on the use of either radiography, demonstrating lung morphology, or scintigraphy, looking at lung function. However, as a result of recent developments in CT and MRI technology it is now possible to perform dedicated investigations of different aspects of lung function, such as ventilation, perfusion, gas exchange, and respiratory mechanics. This volume, written by acknowledged experts in the field, provides a well-illustrated and comprehensive review of these novel approaches to functional imaging of the chest. It will be of great assistance to all who are establishing such strategies in the research or clinical arenas for the diagnostic work-up and follow-up of patients with lung diseases.
Respiratory Physiology New Knowledge Better Diagnosis
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Author : Raffaele Dellacà
language : en
Publisher: European Respiratory Society
Release Date : 2025-04-01
Respiratory Physiology New Knowledge Better Diagnosis written by Raffaele Dellacà and has been published by European Respiratory Society this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-04-01 with Medical categories.
Respiratory physiology is a key clinical domain that directly affects patient care – a truth that is deftly demonstrated by the Guest Editors of this Monograph, the distinguished bioengineers Raffaele Dellacà and Andrea Aliverti. By integrating classical concepts with the latest advancements, the Guest Editors and authors provide a comprehensive overview of the field. The Monograph highlights cutting-edge diagnostic techniques and bridges the gap between basic physiology and clinical practice, offering insight into how physiological principles inform disease diagnosis and management. It also explores emerging challenges and research directions, including the impact of ageing, sex and the environment. Providing an accessible insight into the exciting world of physiology, this Monograph is a must for all clinicians, researchers and trainees in pulmonary medicine.
X Nuclei Magnetic Resonance Imaging
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Author : Guillaume Madelin
language : en
Publisher: CRC Press
Release Date : 2022-03-14
X Nuclei Magnetic Resonance Imaging written by Guillaume Madelin and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-14 with Medical categories.
Standard magnetic resonance imaging (MRI) is a prominent clinical imaging modality used to diagnose and study diseases in vivo. It is principally based on the detection of the nuclei of hydrogen atoms (the proton; symbol 1H) in water molecules in tissues. X-nuclei MRI (also called non-proton MRI) is based on the detection of the nuclei of other atoms (X-nuclei) in the body, such as sodium (23Na), phosphorus (31P), chlorine (35Cl), potassium (39K), deuterium (2H), oxygen (17O), lithium (7Li), and fluorine (19F) using modified software and hardware. X-nuclei MRI can provide fundamental, new metabolic information related to cellular energetic metabolism and ion homeostasis in tissues that cannot be assessed using standard hydrogen MRI. This book is an introduction to the techniques and biomedical applications of X-nuclei MRI. It describes the theoretical and experimental basis of X-nuclei MRI, the limitations of this technique, and its potential biomedical applications for the diagnosis and prognosis of many disorders or for quantitative monitoring of therapies in a wide range of diseases. The book is divided into four parts. Part I includes a general description of X-nuclei nuclear magnetic resonance physics and imaging. Part II deals with the MRI of endogenous nuclei such as 23Na, 31P, 35Cl, and 39K; Part III, the MRI of endogenous/exogenous nuclei such as 2H and 17O; and Part IV, the MRI of exogenous nuclei such as 7Li and 19F. The book is illustrated throughout with many representative figures and includes references and reading suggestions in each section. It is the first book to introduce X-nuclei MRI to researchers, clinicians, students, and general readers who are interested in the development of imaging methods for assessing new metabolic information in tissues in vivo in order to diagnose diseases, improve prognosis, or measure the efficiency of therapies in a timely and quantitative manner. It is an ideal starting point for a clinical or scientific research project in non-proton MRI techniques.
Magnetic Resonance Imaging
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Author : Lachezar Manchev
language : en
Publisher: BoD – Books on Demand
Release Date : 2019-07-17
Magnetic Resonance Imaging written by Lachezar Manchev and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-07-17 with Medical categories.
Diagnostic imaging has undergone many changes over the last several years. Technical developments have defined Magnetic Resonance Imaging (MRI) as the leading diagnostic modality in different diseases. MRI is definitive and sensitive and the current requirements of medicine call for radiologists to be proficient in its use. This book provides complete and detailed information about the fast-developing field of MRI from physicians, radiologists, and other clinical specialists. It is a practical guide to using MRI in areas such as cardiology and pulmonology, among others.