Functional Neural Transplantation
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Functional Neural Transplantation Iv
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Author :
language : en
Publisher: Academic Press
Release Date : 2017-05-25
Functional Neural Transplantation Iv written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-05-25 with Medical categories.
Functional Neural Transplantation IV: Translation to Clinical Application, Volume 230 provides the current status of cell transplantation in the nervous system, with a focus on the conditions for achieving structural repair and functional recovery after brain damage or in neurodegenerative disease. New to this release are chapters that delve into the Mechanisms and Use of Neural Transplants for Brain Repair, Reprogramming of Somatic Cells: iPS and iN Cells, Brain Repair from Intrinsic Cell Sources: Turning Reactive Glia into Neurons, and Ex Vivo Gene Therapy for the Treatment of Neurological Disorders, Preparation, Characterization and Banking of Clinical-grade Cells for Neural Transplantation. As the fourth in a periodic series of updates at 5-7 year intervals, this volume highlights recent developments related to the application of advances in cellular and molecular science, providing an understanding of the fundamental principles of neuroplasticity and regeneration in the brain and spinal cord, and also addressing the topic of the power of pluripotent stem cells to generate new sources of precisely specified neurons for utilization in brain repair. - Comprehensive set of critical reviews covering the field - Presents state-of-the-art topics in science and translational medicine - Written by international leaders in the field of neural transplantation
Functional Neural Transplantation Iii
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Author :
language : en
Publisher: Newnes
Release Date : 2012-12-31
Functional Neural Transplantation Iii written by and has been published by Newnes this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-31 with Science categories.
This issue of Progress in Brain Research is split over 2 volumes, bringing together cutting-edge research on Functional Neural Transplantation. The 2 volumes review current knowledge and understanding, provide a starting point for researchers and practitioners entering the field, and build a platform for further research and discovery. - Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research - Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered - All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist
Neural Transplantation In Neurodegenerative Disease
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Author : Derek J. Chadwick
language : en
Publisher: John Wiley & Sons
Release Date : 2003-10-31
Neural Transplantation In Neurodegenerative Disease written by Derek J. Chadwick and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-10-31 with Medical categories.
The field of neural transplantation is at a crucial stage, with important clinical trials on transplantation in patients with Parkinson's disease nearing completion and novel, alternative approaches to fetal transplantation being developed. This timely book brings together leading neuroscientists, clinicians, and cell and developmental biologists to discuss the use of neural transplants in neurodegenerative disorders, such as Parkinson's disease, Huntington's chorea, amyotrophic lateral sclerosis, multiple sclerosis and spinal cord injury. There is also extensive coverage of the potential alternatives to freshly derived fetal tissue as the source of transplants, for example xenografts, encapsulated cells and immortalized stem cells. With authoritative contributions and lively discussion sections, this book presents much new and exciting work in this field and identifies promising new research directions.
Functional Neural Transplantation
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Author : Stephen B. Dunnett
language : en
Publisher: Lippincott Williams & Wilkins
Release Date : 1994
Functional Neural Transplantation written by Stephen B. Dunnett and has been published by Lippincott Williams & Wilkins this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with Medical categories.
Functional Neural Transplantation Iii
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Author : Stephen B. Dunnett
language : en
Publisher:
Release Date : 2012
Functional Neural Transplantation Iii written by Stephen B. Dunnett and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Brain categories.
"This issue of Progress in Brain Research is split over 2 volumes, bringing together cutting-edge research on functional neural transplantation. The 2 volumes review current knowledge and understanding, provide a starting point for researchers and practitioners entering the field, and build a platform for further research and discovery."--Publisher's website
Neural Transplantation
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Author : William J. Freed
language : en
Publisher: MIT Press
Release Date : 2000
Neural Transplantation written by William J. Freed and has been published by MIT Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Medical categories.
After providing basic background on transplantation, brain structure, and development, the book discusses Parkinson's disease, the use of transplants to influence localized brain functions, circuit reconstruction, and genetic engineering and other future technologies.
Dopaminergic Neuron Transplantation In The Weaver Mouse Model Of Parkinson S Disease
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Author : Lazaros C. Triarhou
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Dopaminergic Neuron Transplantation In The Weaver Mouse Model Of Parkinson S Disease written by Lazaros C. Triarhou and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
This book is the culmination of fifteen years of research on the transplantation of dopaminergic neurons in the striatum of the weaver mouse (wv/wv), a neurological mutant characterized by genetically-determined degeneration of midbrain dopamine neurons. This mutant constitutes the only available laboratory model with a chronic disorder that mimics Parkinson's disease. Structural and functional aspects of intrastriatal mesencephalic neuron grafting into the weaver model are reviewed, including histochemical correlates of graft survival and integration, numerical aspects of donor cell survival, ultrastructural findings on synaptogenesis, neurochemical indices of dopamine uptake and receptor binding, gene expression of structural and neurotransmitter-receptor related molecules, levels of striatal amino acid receptors, and behavioural effects of unilateral and bilateral neuronal transplantations.
Neural Transplantation Methods
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Author : Stephen B. Dunnett
language : en
Publisher: Springer Science & Business Media
Release Date : 1999-10-20
Neural Transplantation Methods written by Stephen B. Dunnett and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-10-20 with Medical categories.
we might seek alternative sources of donor tissues. Genetic en- neering, expansion of precursor cells, generation of immortalized cell lines, and transplantation between species are all under active investigation. Although significant difficulties remain for each of these alternatives, the problems appear soluble and relevant knowledge is expanding rapidly. As we enter the twenty-first century, the place of neural tra- plantation in experimental neuroscience is continuing to evolve. Rather than being a topic in its own right, neural transplantation increasingly serves as just another technique in the researcher's armory--alongside lesions, pharmaceuticals, gene transfer, and a variety of other techniques--for the experimental manipulation of brain structure and function. This is particularly true for studies of degeneration, plasticity, regeneration, and recovery of function in the nervous system, topics of increasing importance as experimental neurobiology is required to serve the higher needs of neurological and mental health in aging societies. Within this evolving context, Neural Transplantation Methods seeks to serve a particular need: to provide experimental neu- scientists with a source book of information to enable them to select and adapt transplantation techniques to their own expe- mental programs. All authors have been asked to address prac- cal issues, to enable the reader to assess what is available, what are the alternatives, what are the practical issues to be resolved in applying a particular protocol and getting it to work reliably in their unique experimental context.
Neural Transplantation Cns Neuronal Injury And Regeneration
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Author : Joe Marwah
language : en
Publisher: CRC Press
Release Date : 1994-02-23
Neural Transplantation Cns Neuronal Injury And Regeneration written by Joe Marwah and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994-02-23 with Medical categories.
This unique reference presents studies from leading laboratories that are studying the effects of CNS transplants on neuronal plasticity and recovery of function after CNS injury. Topics covered include tropic influences, reinnervation patterns, and prevention of cell death that range from pre-clinical models of Parkinson's disease in primates to studies of restoration of circadian rhythms in rats. Techniques of neurotransplantation are presented, including current limitations and future projections of advancement.
Neural Transplants
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Author : John R. Sladek
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-11
Neural Transplants written by John R. Sladek and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Science categories.
The story of mammalian neural transplantation really begins eighty-one years ago. In Chicago in December of 1903, a 34-year-old physician, Elizabeth Hopkins Dunn, working as a research assistant in neurology, initiated a series of experiments to examine the ability of neonatal rat cerebral tissue to survive transplantation into the brain of matched littermates. Out of 46 attempts, four clearly successful grafts were identified. The publication of Dunn's results in 1917, the first credible report to demonstrate the feasibility of mammalian CNS transplants, generated little interest. In fact, the next significant experiment in this field did not appear until 1930. The field continued to grow slowly and quietly as investigators gradually realized the value of neural trans plantation to study problems of development and plasticity in the mammalian nervous system. With the discovery in 1979 that grafted neurons were capable of appropriate and functional interactions with the host brain, interest in neural transplantation esca lated sharply. The extraordinary opportunities created by using functional neural trans plants in investigating basic issues in neurobiology, as well as the clinical implications, excited both scientists and the public. The popularity of neural transplantation has been growing rapidly in the past five years and shows no signs of abating. The present volume was designed to meet two needs created by the rapid growth of this subdiscipline of neurobiology. The first was to provide a thorough review of the experimental foundations of neural transplantation.