Functional Studies Using Nmr
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Functional Studies Using Nmr
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Author : V. Ralph McCready
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Functional Studies Using Nmr written by V. Ralph McCready and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
This volume is based on a series of lectures delivered at a one-day teach ing symposium on functional and metabolic aspects of NMR measure ments held at the Middlesex Hospital Medical School on 1st September 1985 as a part of the European Nuclear Medicine Society Congress. Currently the major emphasis in medical NMR in vivo is on its poten tial to image and display abnormalities in conventional radiological im ages, providing increased contrast between normal and abnormal tissue, improved definition of vasculature, and possibly an increased potential for differential diagnosis. Although these areas are undeniably of major importance, it is probable that NMR will continue to complement con ventional measurement methods. The major potential benefits to be de rived from in vivo NMR measurements are likely to arise from its use as an instrument for functional and metabolic studies in both clinical re search and in the everyday management of patients. It is to this area that this volume is directed.
Nmr Spectroscopy For Probing Functional Dynamics At Biological Interfaces
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Author : Anirban Bhunia
language : en
Publisher: Royal Society of Chemistry
Release Date : 2022-08-17
Nmr Spectroscopy For Probing Functional Dynamics At Biological Interfaces written by Anirban Bhunia and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-17 with Science categories.
NMR spectroscopy has found a wide range of applications in life sciences over recent decades. Providing a comprehensive amalgamation of the scattered knowledge of how to apply high-resolution NMR techniques to biomolecular systems, this book will break down the conventional stereotypes in the use of NMR for structural studies. The major focus is on novel approaches in NMR which deal with the functional interface of either protein-protein interactions or protein-lipid interactions. Bridging the gaps between structural and functional studies, the Editors believe a thorough compilation of these studies will open an entirely new dimension of understanding of crucial functional motifs. This in turn will be helpful for future applications into drug design or better understanding of systems. The book will appeal to NMR practitioners in industry and academia who are looking for a comprehensive understanding of the possibilities of applying high-resolution NMR spectroscopic techniques in probing biomolecular interactions.
Structural And Functional Studies Of Proteins Related To Ribosomal And Non Ribosomal Peptide Natural Product Biosynthesis By Nmr Spectroscopy
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Author : Carolin Hacker
language : en
Publisher:
Release Date : 2018
Structural And Functional Studies Of Proteins Related To Ribosomal And Non Ribosomal Peptide Natural Product Biosynthesis By Nmr Spectroscopy written by Carolin Hacker and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with categories.
Structural And Functional Studies Of Biomolecules With Nmr And Cd Spectroscopy
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Author :
language : en
Publisher:
Release Date : 2008
Structural And Functional Studies Of Biomolecules With Nmr And Cd Spectroscopy written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with categories.
Structural And Functional Studies Of Fungal Cellulose Binding Domains By Nmr Spectroscopy
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Author : Maija-Liisa Mattinen
language : en
Publisher:
Release Date : 1998
Structural And Functional Studies Of Fungal Cellulose Binding Domains By Nmr Spectroscopy written by Maija-Liisa Mattinen and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Cellulose categories.
Improved Methods For Characterization Of Protein Dynamics By Nmr Spectroscopy And Studies Of The Ephb2 Kinase Domain
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Author : Alexandra Ahlner
language : en
Publisher: Linköping University Electronic Press
Release Date : 2015-04-15
Improved Methods For Characterization Of Protein Dynamics By Nmr Spectroscopy And Studies Of The Ephb2 Kinase Domain written by Alexandra Ahlner and has been published by Linköping University Electronic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-04-15 with Nuclear magnetic resonance spectroscopy categories.
Proteins are essential for all known forms of life and in many lethal diseases protein failure is the cause of the disease. To understand proteins and the processes they are involved in, it is valuable to know their structures as well as their dynamics and interactions. The structures may not be directly inspected because proteins are too small to be visible in a light microscope, which is why indirect methods such as nuclear magnetic resonance (NMR) spectroscopy have to be utilized. This method provides atomic information about the protein and, in contrast to other methods with similar resolution, the measurements are performed in solution resulting in more physiological conditions, enabling analysis of dynamics. Important dynamical processes are the ones on the millisecond timeframe, which may contribute to interactions of proteins and their catalysis of chemical reactions, both of significant value for the function of the proteins. To better understand proteins, not only do we need to study them, but also develop the methods we are using. This thesis presents four papers about improved NMR techniques as well as a fifth where the kinase domain of ephrinB receptor 2 (EphB2) has been studied regarding the importance of millisecond dynamics and interactions for the activation process. The first paper presents the software COMPASS, which combines statistics and the calculation power of a computer with the flexibility and experience of the user to facilitate and speed up the process of assigning NMR signals to the atoms in the protein. The computer program PINT has been developed for easier and faster evaluation of NMR experiments, such as those that evaluate protein dynamics. It is especially helpful for NMR signals that are difficult to distinguish, so called overlapped peaks, and the soft- ware also converts the detected signals to the indirectly measured physical quantities, such as relaxation rate constants, principal for dynamics. Next are two new versions of the Carr-Purcell-Maiboom-Gill (CPMG) dispersion pulse sequences, designed to measure millisecond dynamics in a way so that the signals are more separated than in standard experiments, to reduce problems with overlaps. To speed up the collection time of the data set, a subset is collected and the entire data set is then reconstructed, by multi-dimensional decomposition co-processing. Described in the thesis is also a way to produce suitably labeled proteins, to detect millisecond dynamics at C? positions in proteins, using the CPMG dispersion relaxation experiment at lower protein concentrations. Lastly, the kinase domain of EphB2 is shown to be more dynamic on the millisecond time scale as well as more prone to interact with itself in the active form than in the inactive one. This is important for the receptor function of the protein, when and how it mediates signals. To conclude, this work has extended the possibilities to study protein dynamics by NMR spectroscopy and contributed to increased understanding of the activation process of EphB2 and its signaling mechanism.
In Cell Nmr For Structural And Functional Studies Of Proteins In Their Native Environment
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Author : Enrico Luchinat
language : en
Publisher:
Release Date : 2013
In Cell Nmr For Structural And Functional Studies Of Proteins In Their Native Environment written by Enrico Luchinat and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with categories.
Intrinsically Disordered Proteins Studied By Nmr Spectroscopy
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Author : Isabella C. Felli
language : en
Publisher: Springer
Release Date : 2015-09-19
Intrinsically Disordered Proteins Studied By Nmr Spectroscopy written by Isabella C. Felli and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-09-19 with Science categories.
This book discusses the paradigm-shifting phenomenon of intrinsically disordered proteins (IDPs) and hybrid proteins containing ordered domains and functional IDP regions (IDPRs). The properties of IDPs and IDPRs are highly complementary to those deriving from the presence of a unique and well-defined three-dimensional fold. Ignored for a long time in high-resolution studies of proteins, intrinsic protein disorder is now recognized as one of the key features for a large variety of cellular functions, where structural flexibility presents a functional advantage in terms of binding plasticity and promiscuity and this volume explores this exciting new research. Recent progress in the field has radically changed our perspective to study IDPs through NMR: increasingly complex IDPs can now be characterized, a wide range of observables can be determined reporting on the structural and dynamic properties, computational methods to describe the structure and dynamics are in continuous development and IDPs can be studied in environments as complex as whole cells. This volume communicates the new exciting possibilities offered by NMR and presents open questions to foster further developments. Intrinsically Disordered Proteins Studied by NMR Spectroscopy provides a snapshot to researchers entering the field as well as providing a current overview for more experienced scientists in related areas.
Metabolomics By In Vivo Nmr
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Author : Robert G. Shulman
language : en
Publisher: John Wiley & Sons
Release Date : 2005-06-10
Metabolomics By In Vivo Nmr written by Robert G. Shulman and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-06-10 with Medical categories.
Metabolism By In Vivo NMR reviews and extends the experimental and theoretical reports concerning in vivo NMR, a pioneering approach that offers versatile new ways of studying metabolic pathways. Perfectly timed to coincide with recent findings that demonstrate the novelty and strength of this approach, the book covers recent applications in biochemistry, medicine, and psychology; in vivo NMR techniques; MCA; glucose metabolism focusing on glycogen; the value of muscle glycogen measurements in exercise; and much more. This book is unique in linking in vivo 13C NMR measurements of neuronal activity and energetics with applications to functional imaging and certain disease states Provides a fundamental neurochemical explanation of brain activity applicable to functional imaging, theories of neuronal activity and disease states, e.g. epilepsy, psychiatric diseases and developmental disorders Novel and potentially controversial Will inspire future research directions.
Annual Reports On Nmr Spectroscopy
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Author : Graham A. Webb
language : en
Publisher: Academic Press
Release Date : 2022-03-04
Annual Reports On Nmr Spectroscopy written by Graham A. Webb and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-04 with Science categories.
Annual Reports on NMR Spectroscopy, Volume 105, the latest release in a series that has established itself as a premier resource for both specialists and non-specialists interested in new techniques and applications pertaining to NMR spectroscopy includes a variety of updated chapters covering NMR Studies of Membrane Bound Proteins, DNP NMR Spectroscopy of Cross-Linked Organic Polymers, and Solid-State NMR Studies of Lithium Ion Dynamics Across Materials Classes. Serves as the premier resource for learning new techniques and applications in NMR spectroscopy Provides a key reference for chemists and physicists using NMR spectroscopy to study the structure and dynamics of molecules Covers all aspects of molecular science, including MRI (Magnetic Resonance Imaging)