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Nmr Spectroscopy For Probing Functional Dynamics At Biological Interfaces


Nmr Spectroscopy For Probing Functional Dynamics At Biological Interfaces
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Nmr Spectroscopy For Probing Functional Dynamics At Biological Interfaces


Nmr Spectroscopy For Probing Functional Dynamics At Biological Interfaces
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Author : Anirban Bhunia
language : en
Publisher: Royal Society of Chemistry
Release Date : 2022-08-17

Nmr Spectroscopy For Probing Functional Dynamics At Biological Interfaces written by Anirban Bhunia and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-17 with Science categories.


NMR spectroscopy has found a wide range of applications in life sciences over recent decades. Providing a comprehensive amalgamation of the scattered knowledge of how to apply high-resolution NMR techniques to biomolecular systems, this book will break down the conventional stereotypes in the use of NMR for structural studies. The major focus is on novel approaches in NMR which deal with the functional interface of either protein-protein interactions or protein-lipid interactions. Bridging the gaps between structural and functional studies, the Editors believe a thorough compilation of these studies will open an entirely new dimension of understanding of crucial functional motifs. This in turn will be helpful for future applications into drug design or better understanding of systems. The book will appeal to NMR practitioners in industry and academia who are looking for a comprehensive understanding of the possibilities of applying high-resolution NMR spectroscopic techniques in probing biomolecular interactions.



The Three Functional States Of Proteins


The Three Functional States Of Proteins
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Author : Timir Tripathi
language : en
Publisher: Elsevier
Release Date : 2024-11-17

The Three Functional States Of Proteins written by Timir Tripathi and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-11-17 with Science categories.


The Three Functional States of Proteins explores how structured proteins, intrinsically disordered proteins, and phase separated proteins contribute to the complexity of cellular life, and offers insights into their roles in both health and disease. It discusses the latest research findings and highlight groundbreaking discoveries and innovative methodologies used to study these protein states.Traditionally, the different states of proteins have been defined based on their structures and functions. However, it is becoming increasingly clear that these criteria alone may not be sufficient to capture the complex and multifaceted properties of these molecules. Definitions based on thermodynamics and kinetics are now recognized as potentially more appropriate for comprehensively understanding protein states. Emerging evidence indicates that under physiological conditions, a majority of proteins possess the capability to exist in and transition between the native, droplet, and amyloid states. These distinct states play crucial roles in various cellular functions, influenced significantly by their physicochemical and structural properties. The book also considers the interactions among these states and discusses how their internal organization as individual molecules, as well as their collective organization as molecular assemblies are stabilized. Furthermore, it examines the processes by which these states are formed and the cellular functions associated with each specific state. - The book serves as an introduction to a unique volume that provides comprehensive coverage of these three functional states of proteins - The chapters are written by leading global scientists who are actively engaged in research on these specific protein states - It presents a broad picture of the current, emerging, and evolving research on these protein states - Given that this book comprehensively addresses both foundational concepts and recent advancements in the field, it will appeal a broad spectrum of readers from various academic disciplines



Integrated Structural Biology


Integrated Structural Biology
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Author : Tatyana Polenova
language : en
Publisher: Royal Society of Chemistry
Release Date : 2023-12-08

Integrated Structural Biology written by Tatyana Polenova and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-12-08 with Science categories.


Modern research in biology increasingly relies on multiple techniques for describing structures and mechanisms. This book provides an overview of the contemporary integrated biology approaches for solving structures and understanding mechanisms of complex biological systems. It includes several methodology chapters discussing the current developments in the areas of cryo-electron microscopy (EM) and cryo-electron tomography (ET), computational biophysics, solution NMR spectroscopy, solid-state NMR spectroscopy and dynamic nuclear polarization (DNP), electron paramagnetic resonance (EPR), (photo-)chemically induced dynamic nuclear polarization (CIDNP), X-ray crystallography and small-angle X-ray and neutron scattering (SAXS/SANS). Several subsequent chapters demonstrate how these methods are used in synergy to address problems at the forefront of structural biology, with particular emphasis on examples where individual techniques are insufficient. Examples of biological systems include membrane proteins, viral protein assemblies, cytoskeleton protein assemblies, photosynthetic reaction centers, large enzyme complexes and whole cells. The book is targeted to both the current practitioners of structural biology and scientists who are interested in entering the fields of structural biology or biophysical chemistry.



Two Dimensional 2d Nmr Methods


Two Dimensional 2d Nmr Methods
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Author : K. L. Ivanov
language : en
Publisher: John Wiley & Sons
Release Date : 2023-04-19

Two Dimensional 2d Nmr Methods written by K. L. Ivanov and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-04-19 with Science categories.


TWO-DIMENSIONAL (2D) NMR METHODS Practical guide explaining the fundamentals of 2D-NMR for experienced scientists as well as relevant for advanced students Two-Dimensional (2D) NMR Methods is a focused work presenting an overview of 2D-NMR concepts and techniques, including basic principles, practical applications, and how NMR pulse sequences work. Contributed to by global experts with extensive experience in the field, Two-Dimensional (2D) NMR Methods provides in-depth coverage of sample topics such as: Basics of 2D-NMR, data processing methods (Fourier and beyond), product operator formalism, basics of spin relaxation, and coherence transfer pathways Multidimensional methods (single- and multiple-quantum spectroscopy), NOESY (principles and applications), and DOSY methods Multiple acquisition strategies, anisotropic NMR in molecular analysis, ultrafast 2D methods, and multidimensional methods in bio-NMR TROSY (principles and applications), field-cycling and 2D NMR, multidimensional methods and paramagnetic NMR, and relaxation dispersion experiments This text is a highly useful resource for NMR specialists and advanced students studying NMR, along with users in research, academic and commercial laboratories that study or conduct experiments in NMR.



Introduction To Modern Biophysics


Introduction To Modern Biophysics
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Author : Mohammad Ashrafuzzaman
language : en
Publisher: CRC Press
Release Date : 2023-12-15

Introduction To Modern Biophysics written by Mohammad Ashrafuzzaman and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-12-15 with Science categories.


This textbook provides an introduction to the fundamental and applied aspects of biophysics for advanced undergraduate and graduate students of physics, chemistry, and biology. The application of physics principles and techniques in exploring biological systems has long been a tradition in scientific research. Biological systems hold naturally inbuilt physical principles and processes which are popularly explored. Systematic discoveries help us understand the structures and functions of individual biomolecules, biomolecular systems, cells, organelles, tissues, and even the physiological systems of animals and plants. Utilizing a physics- based scientific understanding of biological systems to explore disease is at the forefront of applied scientific research. This textbook covers key breakthroughs in biophysics whilst looking ahead to future horizons and directions of research. It contains models based on both classical and quantum mechanical treatments of biological systems. It explores diseases related to physical alterations in biomolecular structures and organizations alongside drug discovery strategies. It also discusses the cutting- edge applications of nanotechnologies in manipulating nanoprocesses in biological systems. Key Features: • Presents an accessible introduction to how physics principles and techniques can be used to understand biological and biochemical systems. • Addresses natural processes, mutations, and their purposeful manipulation. • Lays the groundwork for vitally important natural scientific, technological, and medical advances. Mohammad Ashrafuzzaman, a biophysicist and condensed matter scientist, is passionate about investigating biological and biochemical processes utilizing physics principles and techniques. He is a professor of biophysics at King Saud University’s Biochemistry Department in the College of Science, Riyadh, Saudi Arabia; the co- founder of MDT Canada Inc., and the founder of Child Life Development Institute, Edmonton, Canada. He has authored Biophysics and Nanotechnology of Ion Channels, Nanoscale Biophysics of the Cell, and Membrane Biophysics. He has also published about 50 peer- reviewed articles and several patents, edited two books, and has been serving on the editorial boards of Elsevier and Bentham Science journals. Dr. Ashrafuzzaman has held research and academic ranks at Bangladesh University of Engineering & Technology, University of Neuchatel (Switzerland), Helsinki University of Technology (Finland), Weill Medical College of Cornell University (USA), and University of Alberta (Canada). During 2013– 2018 he also served as a Visiting Professor at the Departments of Oncology, and Medical Microbiology and Immunology, of the University of Alberta. Dr. Ashrafuzzaman earned his highest academic degree, Doctor of Science (D.Sc.) in condensed matter physics from the University of Neuchatel, Switzerland in 2004.



Protein Folding Dynamics And Stability


Protein Folding Dynamics And Stability
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Author : Prakash Saudagar
language : en
Publisher: Springer Nature
Release Date : 2023-05-27

Protein Folding Dynamics And Stability written by Prakash Saudagar and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-27 with Science categories.


This book describes recent important advancements in protein folding dynamics and stability research, as well as explaining fundamentals and examining potential methodological approaches in protein science. In vitro, in silico, and in vivo method based research of how the stability and folding of proteins help regulate the cellular dynamics and impact cell function that are crucial in explaining various physiological and pathological processes. This book offers a comprehensive coverage on various techniques and related recent developments in the experimental and computational methods of protein folding, dynamics, and stability studies. The book is also structured in such a way as to summarize the latest developments in the fiddle and key concepts to ensure that readers can understand advanced concepts as well as the fundamental big picture. And most of all, fresh insights are provided into the convergence of protein science and technology. Protein Folding Dynamics and Stability is an ideal guide to the field that will be of value for all levels of researchers and advanced graduate students with training in biochemical laboratory research.



Physical Principles Of Chirality In Nmr


Physical Principles Of Chirality In Nmr
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Author : Piotr Garbacz
language : en
Publisher: Royal Society of Chemistry
Release Date : 2024-09-20

Physical Principles Of Chirality In Nmr written by Piotr Garbacz and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-09-20 with Science categories.


How can we study one of the most elusive molecular properties, chirality, using nuclear interactions with the magnetic field that are apparently insensitive to handedness? This book answers this question from the physicochemical point of view by providing a clear, coherent, and comprehensive review of methods used in NMR studies of chirality. Presented arguments based on fundamental physical and chemical laws and in-depth descriptions of new methods utilizing purely physical interactions are mainly addressed to spectroscopists in both academia and industry. The introductory chapters provide the reader with the basics of NMR spectroscopy as a tool for the study of chiral compounds, and those more interested in the methods of chiral discrimination will benefit from the brief description of their common points and reasons why some of them may or may not work. In the following chapters, the book shows rapid progress in a newly emerging field of chirality-sensitive NMR, in particular, a search for effects that give direct information about the absolute configuration of a molecule.



Nmr Of Metal Organic Frameworks And Covalent Organic Frameworks


Nmr Of Metal Organic Frameworks And Covalent Organic Frameworks
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Author : Wei Wang
language : en
Publisher: Royal Society of Chemistry
Release Date : 2024-12-18

Nmr Of Metal Organic Frameworks And Covalent Organic Frameworks written by Wei Wang and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-12-18 with Technology & Engineering categories.


As new porous materials, metal organic frameworks (MOFs) and covalent organic frameworks (COFs) have been receiving an abundance of research interest in recent years. This book is the first comprehensive title to cover solid state NMR, 129Xe NMR and diffusion NMR methods that have been applied to solve the key scientific issues in the MOFs and COFs research like structural determination, examination of the local structures and host-guest interactions. Structural Information is crucial not only to understand the synthetic mechanisms but also to establish the structure-activity relationship of MOFs and COFs. In comparison to single-crystal X-ray diffraction and high-resolution electron microscopy, solid state NMR provides determinative or complementary information regarding MOFs and COFs. This book will benefit researchers who are interested in structural identification but have little expertise in NMR. It bridges a gap in knowledge and provides a unique reference work in this field of research.



Fast 2d Solution State Nmr


Fast 2d Solution State Nmr
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Author : Jean-Nicolas Dumez
language : en
Publisher: Royal Society of Chemistry
Release Date : 2023-05-17

Fast 2d Solution State Nmr written by Jean-Nicolas Dumez and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-17 with Science categories.


Written by active investigators in the field, this book describes state-of-the-art methods that can accelerate the acquisition of 2D NMR spectra in solution-state NMR. The acquisition of fast multi-dimensional NMR data has motivated numerous ground-breaking developments in NMR pulse sequences and associated data processing methods. These in turn have revolutionized the way 2D NMR acquisitions are performed, at the same time broadening the scope of applications of 2D NMR. The first part of the book provides an in-depth description of the concepts and implementation of major fast 2D NMR methods. The second part follows with illustrations of how such methods can be used in applications that require the acquisition of fast 2D NMR spectra, from reaction monitoring to hyperpolarization, including applications to a broad variety of samples and experimental conditions. Appealing to readers from both the methodology and applications communities, this title will fill a gap in the market for a book focused on small molecule NMR, and researchers from both academia and industry will find a rich plethora of knowledge.



Environment In A Magnet


Environment In A Magnet
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Author : Pellegrino Conte
language : en
Publisher: Royal Society of Chemistry
Release Date : 2024-03-04

Environment In A Magnet written by Pellegrino Conte and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-03-04 with Science categories.


Global climate change is the most important challenge humankind is facing in the modern era. One of the main scientific concerns is the monitoring of contaminants in the environment, which require the right environmental remediation strategies. In this context, nuclear magnetic resonance (NMR) techniques have a very important role in enabling the discovery of how pollutants are transformed, how they can move and how they can affect human health. This book discusses the present and the future perspectives of NMR techniques for environmental evaluations. It covers, amongst other topics, the importance of NMR as a contamination discovery tool, how to improve sensitivity in environmental NMR, and multiphase NMR for measurement of samples in their natural state. Samples include lubricant oils, soils and porous media. Due to the direct relationship between the environment and human health, there is information dedicated to the use of magnetic resonance imaging (MRI) to monitor human health as related to environmental pollution. There is also a chapter on how NMR is used in cultural heritage to measure artefacts directly affected by environmental pollution. Filling a gap in the literature, the book is for researchers explaining how to apply their knowledge of NMR techniques to solve environmental problems, and for students who want to deepen their understanding of this topic.