Fundamentals Of Molecular Structural Biology

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Fundamentals Of Molecular Structural Biology

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Author : Subrata Pal
language : en
Publisher: Academic Press
Release Date : 2019-08-15

Fundamentals Of Molecular Structural Biology written by Subrata Pal and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-15 with Science categories.

Fundamentals of Molecular Structural Biology reviews the mathematical and physical foundations of molecular structural biology. Based on these fundamental concepts, it then describes molecular structure and explains basic genetic mechanisms. Given the increasingly interdisciplinary nature of research, early career researchers and those shifting into an adjacent field often require a "fundamentals" book to get them up-to-speed on the foundations of a particular field. This book fills that niche.

Fundamentals Of Molecular Structural Biology

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Author : Subrata Pal
language : en
Publisher: Academic Press
Release Date : 2019-08-13

Fundamentals Of Molecular Structural Biology written by Subrata Pal and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-13 with Science categories.

Fundamentals of Molecular Structural Biology reviews the mathematical and physical foundations of molecular structural biology. Based on these fundamental concepts, it then describes molecular structure and explains basic genetic mechanisms. Given the increasingly interdisciplinary nature of research, early career researchers and those shifting into an adjacent field often require a "fundamentals" book to get them up-to-speed on the foundations of a particular field. This book fills that niche. - Provides a current and easily digestible resource on molecular structural biology, discussing both foundations and the latest advances - Addresses critical issues surrounding macromolecular structures, such as structure-based drug discovery, single-particle analysis, computational molecular biology/molecular dynamic simulation, cell signaling and immune response, macromolecular assemblies, and systems biology - Presents discussions that ultimately lead the reader toward a more detailed understanding of the basis and origin of disease

Algorithms In Structural Molecular Biology

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Author : Bruce R. Donald
language : en
Publisher: MIT Press
Release Date : 2023-08-15

Algorithms In Structural Molecular Biology written by Bruce R. Donald and has been published by MIT Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-08-15 with Science categories.

An overview of algorithms important to computational structural biology that addresses such topics as NMR and design and analysis of proteins.Using the tools of information technology to understand the molecular machinery of the cell offers both challenges and opportunities to computational scientists. Over the past decade, novel algorithms have been developed both for analyzing biological data and for synthetic biology problems such as protein engineering. This book explains the algorithmic foundations and computational approaches underlying areas of structural biology including NMR (nuclear magnetic resonance); X-ray crystallography; and the design and analysis of proteins, peptides, and small molecules. Each chapter offers a concise overview of important concepts, focusing on a key topic in the field. Four chapters offer a short course in algorithmic and computational issues related to NMR structural biology, giving the reader a useful toolkit with which to approach the fascinating yet thorny computational problems in this area. A recurrent theme is understanding the interplay between biophysical experiments and computational algorithms. The text emphasizes the mathematical foundations of structural biology while maintaining a balance between algorithms and a nuanced understanding of experimental data. Three emerging areas, particularly fertile ground for research students, are highlighted: NMR methodology, design of proteins and other molecules, and the modeling of protein flexibility. The next generation of computational structural biologists will need training in geometric algorithms, provably good approximation algorithms, scientific computation, and an array of techniques for handling noise and uncertainty in combinatorial geometry and computational biophysics. This book is an essential guide for young scientists on their way to research success in this exciting field.

Mathematical Approaches To Molecular Structural Biology

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Author : Subrata Pal
language : en
Publisher: Elsevier
Release Date : 2022-11-19

Mathematical Approaches To Molecular Structural Biology written by Subrata Pal and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-19 with Science categories.

Mathematical Approaches to Molecular Structural Biology offers a comprehensive overview of the mathematical foundations behind the study of biomolecular structure. Initial chapters provide an introduction to the mathematics associated with the study of molecular structure, such as vector spaces and matrices, linear systems, matrix decomposition, vector calculus, probability and statistics. The book then moves on to more advanced areas of molecular structural biology based on the mathematical concepts discussed in earlier chapters. Here, key methods such as X-ray crystallography and cryo-electron microscopy are explored, in addition to biomolecular structure dynamics within the context of mathematics and physics. This book equips readers with an understanding of the fundamental principles behind structural biology, providing researchers with a strong groundwork for further investigation in both this and related fields. - Includes a detailed introduction to key mathematical principles and their application to molecular structural biology - Explores the mathematical underpinnings behind advanced techniques such as X-ray crystallography and Cryo-electron microscopy - Features step-by-step protocols that illustrate mathematical and statistical principles for studying molecular structure and dynamics - Provides a basis for further investigation into the field of computational molecular biology - Includes figures and graphs throughout to visually demonstrate the concepts discussed

Membrane Structural Biology

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Author : Mary Luckey
language : en
Publisher: Cambridge University Press
Release Date : 2008-03-17

Membrane Structural Biology written by Mary Luckey and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-03-17 with Science categories.

Cutting-edge text providing a foundation for membrane biology suitable for advanced students and working scientists.

Fundamentals Of Protein Structure And Function

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Author : Engelbert Buxbaum
language : en
Publisher: Springer
Release Date : 2015-11-27

Fundamentals Of Protein Structure And Function written by Engelbert Buxbaum and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-11-27 with Science categories.

This book serves as an introduction to protein structure and function. Starting with their makeup from simple building blocks, called amino acids, the 3-dimensional structure of proteins is explained. This leads to a discussion how misfolding of proteins causes diseases like cancer, various encephalopathies, or diabetes. Enzymology and modern concepts of enzyme kinetics are then introduced, taking into account the physiological, pharmacological and medical significance of this often neglected topic. This is followed by thorough coverage of hæmoglobin and myoglobin, immunoproteins, motor proteins and movement, cell-cell interactions, molecular chaperones and chaperonins, transport of proteins to various cell compartments and solute transport across biological membranes. Proteins in the laboratory are also covered, including a detailed description of the purification and determination of proteins, as well as their characterisation for size and shape, structure and molecular interactions. The book emphasises the link between protein structure, physiological function and medical significance. This book can be used for graduate and advanced undergraduate classes covering protein structure and function and as an introductory text for researchers in protein biochemistry, molecular and cell biology, chemistry, biophysics, biomedicine and related courses. About the author: Dr. Buxbaum is a biochemist with interest in enzymology and protein science. He has been working on the biochemistry of membrane transport proteins for nearly thirty years and has taught courses in biochemistry and biomedicine at several universities.

Molecular Biology Of The Cell

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Author :
language : en
Publisher:
Release Date : 2004

Molecular Biology Of The Cell written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Cells categories.

Textbook Of Structural Biology Second Edition

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Author : Anders Liljas
language : en
Publisher: World Scientific
Release Date : 2016-09-27

Textbook Of Structural Biology Second Edition written by Anders Liljas and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-09-27 with Science categories.

This book provides a comprehensive coverage of the basic principles of structural biology, as well as an up-to-date summary of some main directions of research in the field. The relationship between structure and function is described in detail for soluble proteins, membrane proteins, membranes, and nucleic acids.There are several books covering protein structure and function, but none that give a complete picture, including nucleic acids, lipids, membranes and carbohydrates, all being of central importance in structural biology.The book covers state-of-the-art research in various areas. It is unique for its breadth of coverage by experts in the fields. The book is richly illustrated with more than 400 color figures to highlight the wide range of structures.

Structural Bioinformatics

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Author : Jenny Gu
language : en
Publisher: John Wiley & Sons
Release Date : 2009-03-16

Structural Bioinformatics written by Jenny Gu and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-03-16 with Science categories.

Structural Bioinformatics was the first major effort to show the application of the principles and basic knowledge of the larger field of bioinformatics to questions focusing on macromolecular structure, such as the prediction of protein structure and how proteins carry out cellular functions, and how the application of bioinformatics to these life science issues can improve healthcare by accelerating drug discovery and development. Designed primarily as a reference, the first edition nevertheless saw widespread use as a textbook in graduate and undergraduate university courses dealing with the theories and associated algorithms, resources, and tools used in the analysis, prediction, and theoretical underpinnings of DNA, RNA, and proteins. This new edition contains not only thorough updates of the advances in structural bioinformatics since publication of the first edition, but also features eleven new chapters dealing with frontier areas of high scientific impact, including: sampling and search techniques; use of mass spectrometry; genome functional annotation; and much more. Offering detailed coverage for practitioners while remaining accessible to the novice, Structural Bioinformatics, Second Edition is a valuable resource and an excellent textbook for a range of readers in the bioinformatics and advanced biology fields. Praise for the previous edition: "This book is a gold mine of fundamental and practical information in an area not previously well represented in book form." —Biochemistry and Molecular Education "... destined to become a classic reference work for workers at all levels in structural bioinformatics...recommended with great enthusiasm for educators, researchers, and graduate students." —BAMBED "...a useful and timely summary of a rapidly expanding field." —Nature Structural Biology "...a terrific job in this timely creation of a compilation of articles that appropriately addresses this issue." —Briefings in Bioinformatics

Biomolecular Crystallography

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Author : Bernhard Rupp
language : en
Publisher: Garland Science
Release Date : 2009-10-20

Biomolecular Crystallography written by Bernhard Rupp and has been published by Garland Science this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-10-20 with Science categories.

Synthesizing over thirty years of advances into a comprehensive textbook, Biomolecular Crystallography describes the fundamentals, practices, and applications of protein crystallography. Illustrated in full-color by the author, the text describes mathematical and physical concepts in accessible and accurate language. Biomolecular Crystallography will be a valuable resource for advanced undergraduate and graduate students and practitioners in structural biology, crystallography, and structural bioinformatics.