Fundamentals Of Neurodegeneration And Protein Misfolding Disorders
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Fundamentals Of Neurodegeneration And Protein Misfolding Disorders
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Author : Martin Beckerman
language : en
Publisher:
Release Date : 2015
Fundamentals Of Neurodegeneration And Protein Misfolding Disorders written by Martin Beckerman and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with categories.
This unique text introduces students and researchers to the world of misfolded proteins, toxic oligomers, and amyloid assemblages, and the diseases of the brain that result. During the past few years the connections between failures in protein quality control and neurological disorders have been reinforced and strengthened by discoveries on multiple fronts. These findings provide novel insights on how amyloidogenic oligomers and fibrils form, interconvert from one state to another, and propagate from cell to cell and region to region. Starting with protein folding and protein quality control basics, the reader will learn how misfolded proteins can cause diseases ranging from prion diseases to Alzheimer's disease and Parkinson's disease to Huntington's disease, amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Authoritative but written in a clear and engaging style, Fundamentals of Neurodegeneration and Protein Misfolding Disorders addresses one of today's forefront areas of science and medicine. The text emphasizes the new groundbreaking biophysical and biochemical methods that enable molecular-level explorations and the conceptual breakthroughs that result. It contains separate chapters on each of the major disease classes. Special emphasis is placed on those factors and themes that are common to the diseases, especially failures in synaptic transmission, mitochondrial control, and axonal transport; breakdowns in RNA processing; the potential role of environmental factors; and the confounding effects of neuroinflammation. The book is ideal for use in teaching at the advanced undergraduate and graduate levels, and serves as a comprehensive reference for a broad audience of students and researchers in neuroscience, molecular biology, biological physics and biomedical engineering.
Fundamentals Of Neurodegeneration And Protein Misfolding Disorders
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Author : Martin Beckerman
language : en
Publisher: Springer
Release Date : 2015-11-06
Fundamentals Of Neurodegeneration And Protein Misfolding Disorders written by Martin Beckerman and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-11-06 with Medical categories.
This unique text introduces students and researchers to the world of misfolded proteins, toxic oligomers, and amyloid assemblages, and the diseases of the brain that result. During the past few years the connections between failures in protein quality control and neurological disorders have been reinforced and strengthened by discoveries on multiple fronts. These findings provide novel insights on how amyloidogenic oligomers and fibrils form, interconvert from one state to another, and propagate from cell to cell and region to region. Starting with protein folding and protein quality control basics, the reader will learn how misfolded proteins can cause diseases ranging from prion diseases to Alzheimer’s disease and Parkinson’s disease to Huntington’s disease, amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Authoritative but written in a clear and engaging style, Fundamentals of Neurodegeneration and Protein Misfolding Disorders addresses one of today’s forefront areas of science and medicine. The text emphasizes the new groundbreaking biophysical and biochemical methods that enable molecular-level explorations and the conceptual breakthroughs that result. It contains separate chapters on each of the major disease classes. Special emphasis is placed on those factors and themes that are common to the diseases, especially failures in synaptic transmission, mitochondrial control, and axonal transport; breakdowns in RNA processing; the potential role of environmental factors; and the confounding effects of neuroinflammation. The book is ideal for use in teaching at the advanced undergraduate and graduate levels, and serves as a comprehensive reference for a broad audience of students and researchers in neuroscience, molecular biology, biological physics and biomedical engineering.
Diseased Existents Or Existent Diseases
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Author : Walter Lips
language : en
Publisher: CANOPUS EDITORIAL DIGITAL SA
Release Date : 2024-10-01
Diseased Existents Or Existent Diseases written by Walter Lips and has been published by CANOPUS EDITORIAL DIGITAL SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-10-01 with Health & Fitness categories.
This book aims to cover both the ontological determination and the characterization of what we call with terms such as disease and others related. The current edition is a more complete version of the first edition in Spanish that was published four years ago. In this edition, both semantic and gnoseological as well as ontological issues have been developed in more detail and depth. The foregoing is due to the fact that we could establish the meaning of the disease concept based on its explicit ontological reference, namely, the question about the existence of disease. Furthermore, to achieve that aim, it is appropriate to consider the essential properties of live systems. Consequently, this edition has reviewed in greater depth what is related to bioplasticity and macromolecular interactive processes of live systems, including epigenetic processes.
Medicinal Plants For The Management Of Neurodegenerative Diseases
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Author : Jamal Akhtar
language : en
Publisher: CRC Press
Release Date : 2024-06-17
Medicinal Plants For The Management Of Neurodegenerative Diseases written by Jamal Akhtar and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-06-17 with Science categories.
Ageing is the main reason for most neurodegenerative diseases, including Alzheimer’s disease (AD) and Parkinson’s disease (PD). About 10% of individuals aged ≥65 years develop AD, which continuously increases with growing age. Medicinal plants have been used for age-related neurodegenerative disorders for a long time. These plants are rich in terms of various phytochemical constituents such as flavonoids, sterols, alkaloids, saponins, and terpenoids. Different scientific studies have been carried out on these medicinal herbs, e.g., anti-inflammatory, antioxidant, and neuro-regenerative activities that may be used in the treatment of AD and other age-related diseases. These medicinal plants, e.g., Curcuma longa, Bacopa monniera, Glycyrrhiza glabra, Commiphora whighitti, and Acorus calamus L., have anti-inflammatory properties that may decrease swelling of the brain tissue in AD. Despite this, there is currently no book available in the market that provides full information on the phytochemical and medicinal uses of the medicinal plants exclusively used for the management of neurodegenerative diseases in the elderly. This book aims to provide some important and evidence-based information on the plants used for neurodegenerative diseases in the elderly, especially AD and PD, in a planned manner so the academicians, researchers, and students working in the fields of medicinal plants, plant science, chemistry, biotechnology, pharmacognosy, pharmaceuticals, biochemistry, and many other interdisciplinary subjects may benefit. This book will also be useful in identifying a few medicinal plants and their prospects for the synthesis or preparation of new drugs for neurodegenerative diseases. Features: · An overview of the medicinal plants that can be helpful for neurodegenerative disorders. · Recent research results and some pointers for the management of neurodegenerative diseases. This book serve as comprehensive information about the description, phytochemistry, actions, and medicinal use of plants that are used in neurodegenerative diseases. In addition, this book will also ease the understanding and interaction of medicinal plants used in neurodegenerative diseases.
Fundamentals Of Biochemistry International Adaptation
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Author : Destin Heilman
language : en
Publisher: John Wiley & Sons
Release Date : 2025-08-20
Fundamentals Of Biochemistry International Adaptation written by Destin Heilman and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-08-20 with Science categories.
Essentials Of Medical Biochemistry
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Author : Chung Eun Ha
language : en
Publisher: Academic Press
Release Date : 2022-12-16
Essentials Of Medical Biochemistry written by Chung Eun Ha and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-12-16 with Science categories.
Essentials of Medical Biochemistry, Third Edition offers a condensed, yet detailed overview of clinical biochemistry, spanning fundamentals and relevant physiologic and pathophysiologic concepts. Pivotal clinical case studies aid in understanding basic science in the context of diagnosis and treatment of human diseases, and the text illuminates key topics in molecular immunology and hemostasis. Users will find fundamental concepts aiding students and professionals in biochemistry, medicine, and other healthcare disciplines. The text is a useful refresher that will help users meet USMLE and other professional licensing examination requirements, providing thorough introductions, key points, multicolored illustrations of chemical structures and figures, fact-filled tables, and recommended reading lists. This Third Edition has been fully updated to address evolving techniques in the biological sciences, including genomics, metabolomics, transcriptomics, epigenomics, proteomics, and gene therapy, among other methods. In addition, each chapter has been fully revised for current science and now features learning objectives and chapter summaries, supplemental reading, and 5 clinical case based multiple choice questions. New clinical cases have been added throughout. - Integrates the biochemical principles with physiological, pharmacological, and pathological aspects of human diseases - Each chapter features learning objectives, summaries, required and supplemental reading lists, clinical cases, and multiple-choice questions - Presents essential biochemical concepts within the context of their biological functions Offers instructional overview figures, flowcharts, tables and multi-colored illustrations - Provides an online ancillary package with PowerPoint images and an additional 500 study questions to aid in comprehension and USMLE exam preparation
Fundamentals Of Molecular Virology
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Author : Christopher D. Richardson
language : en
Publisher: John Wiley & Sons
Release Date : 2025-04-22
Fundamentals Of Molecular Virology written by Christopher D. Richardson and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-04-22 with Science categories.
Comprehensive coverage of major families of viruses, including human pathogens and viruses of organisms from bacteria to plants, with updated information on antiviral drugs, vaccines, antiviral immunity, and gene therapy Fundamentals of Molecular Virology is a textbook designed for university students learning about viruses at the undergraduate or graduate levels. Chapters contributed by prominent virologists cover many of the major virus families. Each chapter is designed to tell a story about the viruses covered, including information on discovery, diseases and pathogenesis, virus structure, steps in replication, and interaction with cellular signaling pathways. This approach portrays the “personality” of each virus, helping students to learn the material and build up their knowledge of virology starting with smaller and simpler viruses and proceeding to more complex viruses. Major importance is given to viruses that infect humans and cause disease, but coverage is broad, including viruses of bacteria, Archaea, algae, invertebrates, and plants. Information boxes highlight applications and research directions of particular significance. Chapters conclude with sections presenting fundamental concepts, review questions, and lists of key terms, which are defined in a glossary at the end of the book. This 3rd edition of Fundamentals of Molecular Virology includes detailed information on the recent COVID-19 pandemic and mRNA vaccine technology, additional sections on pathogenic herpesviruses, and updates on recent outbreaks of Zika virus, Ebola virus and mpox diseases. New chapters describe hepatitis C virus, rhabdoviruses, viruses of invertebrates, oncolytic viruses, and virus-mediated gene therapy. All chapters, including those on innate and adaptive immune responses to virus infections, virus vaccines, and antiviral agents, were revised and updated.
Essentials Of Single Cell Analysis
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Author : Fan-Gang Tseng
language : en
Publisher: Springer
Release Date : 2016-01-21
Essentials Of Single Cell Analysis written by Fan-Gang Tseng and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-01-21 with Technology & Engineering categories.
This book provides an overview of single-cell isolation, separation, injection, lysis and dynamics analysis as well as a study of their heterogeneity using different miniaturized devices. As an important part of single-cell analysis, different techniques including electroporation, microinjection, optical trapping, optoporation, rapid electrokinetic patterning and optoelectronic tweezers are described in detail. It presents different fluidic systems (e.g. continuous micro/nano-fluidic devices, microfluidic cytometry) and their integration with sensor technology, optical and hydrodynamic stretchers etc., and demonstrates the applications of single-cell analysis in systems biology, proteomics, genomics, epigenomics, cancer transcriptomics, metabolomics, biomedicine and drug delivery systems. It also discusses the future challenges for single-cell analysis, including the advantages and limitations. This book is enjoyable reading material while at the same time providing essential information to scientists in academia and professionals in industry working on different aspects of single-cell analysis. Dr. Fan-Gang Tseng is a Distinguished Professor of Engineering and System Science at the National Tsing Hua University, Taiwan. Dr. Tuhin Subhra Santra is a Research Associate at the California Nano Systems Institute, University of California at Los Angeles, USA.
Protein Misfolding And Spreading Pathology In Neurodegenerative Diseases
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Author : Diana Fernandes Lázaro
language : en
Publisher: Frontiers Media SA
Release Date : 2020-02-20
Protein Misfolding And Spreading Pathology In Neurodegenerative Diseases written by Diana Fernandes Lázaro and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-20 with categories.
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Protein Misfolding In Neurodegenerative Diseases
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Author : Neha Gogia
language : en
Publisher: Elsevier
Release Date : 2025-03-17
Protein Misfolding In Neurodegenerative Diseases written by Neha Gogia and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-03-17 with Science categories.
Approx.280 pages - Discusses underlying cellular and molecular mechanisms altered in protein-associated neurodegenerative disorders - Describes methods for detection and analysis of protein aggregates - Features advancements in therapeutics and emerging techniques to treat these disorders - Covers implications in a variety of neurodegenerative diseases, including Alzheimer's, Parkinson's, ALS, Creutzfeldt-Jakob disease, Cystic fibrosis, Gaucher's disease, and Polyglutamine diseases, including Huntington's and other related proteinopathies