Gabaergic Synaptic Transmission
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Gabaergic Synaptic Transmission
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Author : Giovanni Biggio
language : en
Publisher: Raven Press (ID)
Release Date : 1992
Gabaergic Synaptic Transmission written by Giovanni Biggio and has been published by Raven Press (ID) this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with Medical categories.
Reviews research on the pharmacology and physiopathology of GABA receptors in the mammalian central nervous system. The coverage ranges from molecular biology, to molecular and clinical pharmacology, to new approaches to pharmacotherapy of convulsive, sleep, and anxiety disorders.
Plasticity Of Gabaergic Synapses
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Author : Andrea Barberis
language : en
Publisher: Frontiers Media SA
Release Date : 2016-01-22
Plasticity Of Gabaergic Synapses written by Andrea Barberis and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-01-22 with Learning categories.
Learning and memory are believed to depend on plastic changes of neuronal circuits due to activity-dependent potentiation or depression of specific synapses. During the last two decades, plasticity of brain circuits was hypothesized to mainly rely on the flexibility of glutamatergic excitatory synapses, whereas inhibitory synapses were assumed relatively invariant, to ensure stable and reliable control of the neuronal network. As a consequence, while considerable efforts were made to clarify the main mechanisms underlying plasticity at excitatory synapses, the study of the cellular/molecular mechanisms of inhibitory plasticity has received much less attention. Nevertheless, an increasing body of evidence has revealed that inhibitory synapses undergo several types of plasticity at both pre- and postsynaptic levels. Given the crucial role of inhibitory interneurons in shaping network activities, such as generation of oscillations, selection of cell assemblies and signal integration, modifications of the inhibitory synaptic strength represents an extraordinary source of versatility for the fine control of brain states. This versatility also results from the rich diversity of GABAergic neurons in several brain areas, the specific role played by each inhibitory neuron subtype within a given circuit, and the heterogeneity of the properties and modulation of GABAergic synapses formed by specific interneuron classes. The molecular mechanisms underlying the potentiation or depression of inhibitory synapses are now beginning to be unraveled. At the presynaptic level, retrograde synaptic signaling was demonstrated to modulate GABA release, whereas postsynaptic forms of plasticity involve changes in the number/gating properties of GABAA receptors and/or shifts of chloride gradients. In addition, recent research indicates that GABAergic tonic inhibition can also be plastic, adding a further level of complexity to the control of the excitatory/inhibitory balance in the brain. The present Topic will focus on plasticity of GABAergic synapses, with special emphasis on the molecular mechanisms of plasticity induction and/or expression.
Modulation Of Gabaergic Synaptic Transmission By Kainate Type Glutamate Receptors
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Author : Li Jiang
language : en
Publisher:
Release Date : 2002
Modulation Of Gabaergic Synaptic Transmission By Kainate Type Glutamate Receptors written by Li Jiang and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with categories.
Electrophysiological Investigation Of The Mechanisms Underlying Gabaergic Synaptic Transmission
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Author : Jack Robert Mellor
language : en
Publisher:
Release Date : 1999
Electrophysiological Investigation Of The Mechanisms Underlying Gabaergic Synaptic Transmission written by Jack Robert Mellor and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with categories.
Gabaergic Cell Types And Modulation Of Gabaergic Synaptic Transmission By Group Iii Metabotropic Glutamate Receptors In The Human Neocortex
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Author : Istvan Paul Lukacs
language : en
Publisher:
Release Date : 2021
Gabaergic Cell Types And Modulation Of Gabaergic Synaptic Transmission By Group Iii Metabotropic Glutamate Receptors In The Human Neocortex written by Istvan Paul Lukacs and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with categories.
Computational Analysis Of The Functional Role Of Gabaergic Synaptic Transmission In Striatal Medium Spiny Neurons
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Author : Martin Ayling
language : en
Publisher:
Release Date : 2008
Computational Analysis Of The Functional Role Of Gabaergic Synaptic Transmission In Striatal Medium Spiny Neurons written by Martin Ayling and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with categories.
Gabaergic Synaptic Transmission Plasticity And Integration In The Subthalamic Nucleus
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Author : Kai Yoon Fan
language : en
Publisher:
Release Date : 2012
Gabaergic Synaptic Transmission Plasticity And Integration In The Subthalamic Nucleus written by Kai Yoon Fan and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with categories.
The reciprocally connected GABAergic external globus pallidus (GPe) and glutamatergic subthalamic nucleus (STN) occupy pivotal positions in cortico-basal ganglia-thalamo-cortical networks essential for normal voluntary movement. In both idiopathic and experimental PD characterized by degeneration of midbrain dopamine neurons, the GPe and STN exhibit hypo- and hyper-activity, respectively, and hypersynchronous rhythmic burst firing (30 Hz). Deep brain stimulation (DBS) of STN (60 Hz) suppresses the pathological oscillations and improves motor impairments, although the therapeutic mechanisms are unclear. Given the GPe potently patterns STN activity, the decorrelated nature of GPe-STN network is intriguing. Therefore, the main objective of this thesis is to study the regulation of GPe-STN input in health, PD and DBS, using complementary anatomical, molecular, electrophysiological and computational modelling approaches. Studies comparing GPe-STN transmission in control and 6-OHDA-lesioned rodents revealed that following chronic dopamine depletion the GPe-STN projections strengthened remarkably through proliferation in the number of functional synaptic connections. The enhanced GPe-STN transmission is predicted to increase the capability of the GPe to generate synchronous rhythmic burst firing in the parkinsonian STN. Recent optogenetic studies showed that high-frequency driving of afferents expressing channelrhodopsin-2 (ChR2) in the STN of Thy1-ChR2 transgenic mice rescued parkinsonian symptoms. Characterization of the mouse line revealed ChR2 expression in not only glutamatergic but GABAergic afferents in the STN, implying DBS may exert its therapeutic effects through manipulation of GPe-STN transmission. The work from this thesis also demonstrates that GABAergic inhibition in STN neurons activates HCN channel currents that limit synaptic hyperpolarisation and deinactivation of low-voltage-activated Ca2+ channels, hence reducing the propensity of rebound burst firing. Uniform HCN channel distribution across the somatodendritic axis most effectively counteracts the GABAergic inhibition. These results suggest that HCN channels in STN neurons may partly underlie the decorrelated nature of GPe-STN activity and prevent excessive burst firing observed in PD.
Presynaptic Cell Type Dependent Regulation Of Gabaergic Synaptic Transmission By Nitric Oxide In Rat Insular Cortex
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Author :
language : en
Publisher:
Release Date : 2015
Presynaptic Cell Type Dependent Regulation Of Gabaergic Synaptic Transmission By Nitric Oxide In Rat Insular Cortex written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with categories.
Ablation Of C Fibers Decreases Quantal Size Of Gabaergic Synaptic Transmission In The Insular Cortex
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Author :
language : en
Publisher:
Release Date : 2017
Ablation Of C Fibers Decreases Quantal Size Of Gabaergic Synaptic Transmission In The Insular Cortex written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.
Cholinergic And Gabaergic Modulation Of Glutamatergic Synaptic Transmission In The Hippocampus
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Author : Terry Edwin Kremin
language : en
Publisher:
Release Date : 2004
Cholinergic And Gabaergic Modulation Of Glutamatergic Synaptic Transmission In The Hippocampus written by Terry Edwin Kremin and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Acetylcholine categories.