Plasticity Of Gabaergic Synapses
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Plasticity Of Gabaergic Synapses
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Author : Andrea Barberis
language : en
Publisher: Frontiers Media SA
Release Date : 2016-01-22
Plasticity Of Gabaergic Synapses written by Andrea Barberis and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-01-22 with Learning categories.
Learning and memory are believed to depend on plastic changes of neuronal circuits due to activity-dependent potentiation or depression of specific synapses. During the last two decades, plasticity of brain circuits was hypothesized to mainly rely on the flexibility of glutamatergic excitatory synapses, whereas inhibitory synapses were assumed relatively invariant, to ensure stable and reliable control of the neuronal network. As a consequence, while considerable efforts were made to clarify the main mechanisms underlying plasticity at excitatory synapses, the study of the cellular/molecular mechanisms of inhibitory plasticity has received much less attention. Nevertheless, an increasing body of evidence has revealed that inhibitory synapses undergo several types of plasticity at both pre- and postsynaptic levels. Given the crucial role of inhibitory interneurons in shaping network activities, such as generation of oscillations, selection of cell assemblies and signal integration, modifications of the inhibitory synaptic strength represents an extraordinary source of versatility for the fine control of brain states. This versatility also results from the rich diversity of GABAergic neurons in several brain areas, the specific role played by each inhibitory neuron subtype within a given circuit, and the heterogeneity of the properties and modulation of GABAergic synapses formed by specific interneuron classes. The molecular mechanisms underlying the potentiation or depression of inhibitory synapses are now beginning to be unraveled. At the presynaptic level, retrograde synaptic signaling was demonstrated to modulate GABA release, whereas postsynaptic forms of plasticity involve changes in the number/gating properties of GABAA receptors and/or shifts of chloride gradients. In addition, recent research indicates that GABAergic tonic inhibition can also be plastic, adding a further level of complexity to the control of the excitatory/inhibitory balance in the brain. The present Topic will focus on plasticity of GABAergic synapses, with special emphasis on the molecular mechanisms of plasticity induction and/or expression.
Inhibitory Synaptic Plasticity
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Author : Melanie A. Woodin
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-11-02
Inhibitory Synaptic Plasticity written by Melanie A. Woodin and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-11-02 with Science categories.
This volume will explore the most recent findings on cellular mechanisms of inhibitory plasticity and its functional role in shaping neuronal circuits, their rewiring in response to experience, drug addiction and in neuropathology. Inhibitory Synaptic Plasticity will be of particular interest to neuroscientists and neurophysiologists.
From Molecules To Networks
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Author : John H. Byrne
language : en
Publisher: Academic Press
Release Date : 2009
From Molecules To Networks written by John H. Byrne and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Medical categories.
An understanding of the nervous system at virtually any level of analysis requires an understanding of its basic building block, the neuron. This book provides the solid foundation of the morphological, biochemical, and biophysical properties of nerve cells. All chapters have been thoroughly revised for this second edition to reflect the significant advances of the past five years. The new edition expands on the network aspects of cellular neurobiology by adding a new chapter, Information Processing in Neural Networks, and on the relation of cell biological processes to various neurological diseases. The new concluding chapter illustrates how the great strides in understanding the biochemical and biophysical properties of nerve cells have led to fundamental insights into important aspects of neurodegenerative disease. Includes two new chapters: Information Processing in Neural Networks - describes the principles of operation of neural networks and the key circuit motifs that are common to many networks in the nervous system. Molecular and Cellular Mechanisms of Neurodegenerative Disease - introduces the progress made in the last 20 years in elucidating the cellular and molecular mechanisms underlying brain disorders, including Amyotrophic Lateral Sclerosis (ALS), Parkinson disease, and Alzheimer's disease.
Synaptic Plasticity And Transsynaptic Signaling
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Author : Patric K. Stanton
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-06-14
Synaptic Plasticity And Transsynaptic Signaling written by Patric K. Stanton and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-06-14 with Science categories.
Brain functions are realized by the activity of neuronal networks composed of a huge number of neurons. The efficiency of information transfer within the networks is changeable. Even the networks themselves can change through experience. Information transfer between neurons is performed at the synapse (the site of the neurons’ contact) by release of neurotransmitters from the pre-synaptic cell and capture of neurotransmitters by the post-synaptic cell. The amount of released neurotransmitter or the efficacy of capture can change. Moreover, synapses are found to be newly formed upon activity or abandoned upon inactivity. These changes are called "synaptic plasticity". This text focuses on one component of synaptic plasticity called transsynaptic signaling, or communication of synapses during their formation.
Emerging Mechanisms In Dynamic Gabaergic Inhibition
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Author : Shiva K. Tyagarajan
language : en
Publisher: Frontiers Media SA
Release Date : 2021-12-01
Emerging Mechanisms In Dynamic Gabaergic Inhibition written by Shiva K. Tyagarajan and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-01 with Science categories.
The Hippocampus Book
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Author : Per Andersen
language : en
Publisher: Oxford University Press
Release Date : 2007
The Hippocampus Book written by Per Andersen and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Medical categories.
The hippocampus is one of a group of remarkable structures embedded within the brain's medial temporal lobe. Long known to be important for memory, it has been a prime focus of neuroscience research for many years. The Hippocampus Book promises to facilitate developments in the field in a major way by bringing together, for the first time, contributions by leading international scientists knowledgeable about hippocampal anatomy, physiology, and function. This authoritative volume offers the most comprehensive, up-to-date account of what the hippocampus does, how it does it, and what happens when things go wrong. At the same time, it illustrates how research focusing on this single brain structure has revealed principles of wider generality for the whole brain in relation to anatomical connectivity, synaptic plasticity, cognition and behavior, and computational algorithms. Well-organized in its presentation of both theory and experimental data, this peerless work vividly illustrates the astonishing progress that has been made in unraveling the workings of the brain. The Hippocampus Book is destined to take a central place on every neuroscientist's bookshelf.
The Emerging Role Of Endocannabinoids In Synaptic Plasticity Reward And Addiction
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Author : Jeffrey G. Edwards
language : en
Publisher: Frontiers Media SA
Release Date : 2022-05-27
The Emerging Role Of Endocannabinoids In Synaptic Plasticity Reward And Addiction written by Jeffrey G. Edwards and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-27 with Science categories.
Learning And Memory A Comprehensive Reference
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Author :
language : en
Publisher: Academic Press
Release Date : 2017-07-07
Learning And Memory A Comprehensive Reference written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-07-07 with Medical categories.
Learning and Memory: A Comprehensive Reference, Second Edition, Four Volume Set is the authoritative resource for scientists and students interested in all facets of learning and memory. This updated edition includes chapters that reflect the state-of-the-art of research in this area. Coverage of sleep and memory has been significantly expanded, while neuromodulators in memory processing, neurogenesis and epigenetics are also covered in greater detail. New chapters have been included to reflect the massive increase in research into working memory and the educational relevance of memory research. No other reference work covers so wide a territory and in so much depth. Provides the most comprehensive and authoritative resource available on the study of learning and memory and its mechanisms Incorporates the expertise of over 150 outstanding investigators in the field, providing a ‘one-stop’ resource of reputable information from world-leading scholars with easy cross-referencing of related articles to promote understanding and further research Includes further reading for each chapter that helps readers continue their research Includes a glossary of key terms that is helpful for users who are unfamiliar with neuroscience terminology
The Role Of Gaba Shift In Neurodevelopment And Psychiatric Disorders
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Author : Lorenz S. Neuwirth
language : en
Publisher: Frontiers Media SA
Release Date : 2023-03-30
The Role Of Gaba Shift In Neurodevelopment And Psychiatric Disorders written by Lorenz S. Neuwirth and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-30 with Science categories.
Cellular And Molecular Mechanisms Of Synaptic Plasticity At Hippocampal And Cortical Synapses
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Author : Roberto De Pasquale
language : en
Publisher: Frontiers Media SA
Release Date : 2022-08-11
Cellular And Molecular Mechanisms Of Synaptic Plasticity At Hippocampal And Cortical Synapses written by Roberto De Pasquale and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-11 with Science categories.