Emerging Mechanisms In Dynamic Gabaergic Inhibition

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Emerging Mechanisms In Dynamic Gabaergic Inhibition

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Author : Shiva K. Tyagarajan
language : en
Publisher: Frontiers Media SA
Release Date : 2021-12-01

Emerging Mechanisms In Dynamic Gabaergic Inhibition written by Shiva K. Tyagarajan and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-01 with Science categories.

Towards The Next Generation Of Deep Brain Stimulation Therapies Technological Advancements Computational Methods And New Targets

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Author : George C. McConnell
language : en
Publisher: Frontiers Media SA
Release Date : 2021-10-04

Towards The Next Generation Of Deep Brain Stimulation Therapies Technological Advancements Computational Methods And New Targets written by George C. McConnell and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-04 with Science categories.

Plasticity Of Gabaergic Synapses

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Author : Andrea Barberis
language : en
Publisher: Frontiers Media SA
Release Date : 2016-01-22

Plasticity Of Gabaergic Synapses written by Andrea Barberis and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-01-22 with Learning categories.

Learning and memory are believed to depend on plastic changes of neuronal circuits due to activity-dependent potentiation or depression of specific synapses. During the last two decades, plasticity of brain circuits was hypothesized to mainly rely on the flexibility of glutamatergic excitatory synapses, whereas inhibitory synapses were assumed relatively invariant, to ensure stable and reliable control of the neuronal network. As a consequence, while considerable efforts were made to clarify the main mechanisms underlying plasticity at excitatory synapses, the study of the cellular/molecular mechanisms of inhibitory plasticity has received much less attention. Nevertheless, an increasing body of evidence has revealed that inhibitory synapses undergo several types of plasticity at both pre- and postsynaptic levels. Given the crucial role of inhibitory interneurons in shaping network activities, such as generation of oscillations, selection of cell assemblies and signal integration, modifications of the inhibitory synaptic strength represents an extraordinary source of versatility for the fine control of brain states. This versatility also results from the rich diversity of GABAergic neurons in several brain areas, the specific role played by each inhibitory neuron subtype within a given circuit, and the heterogeneity of the properties and modulation of GABAergic synapses formed by specific interneuron classes. The molecular mechanisms underlying the potentiation or depression of inhibitory synapses are now beginning to be unraveled. At the presynaptic level, retrograde synaptic signaling was demonstrated to modulate GABA release, whereas postsynaptic forms of plasticity involve changes in the number/gating properties of GABAA receptors and/or shifts of chloride gradients. In addition, recent research indicates that GABAergic tonic inhibition can also be plastic, adding a further level of complexity to the control of the excitatory/inhibitory balance in the brain. The present Topic will focus on plasticity of GABAergic synapses, with special emphasis on the molecular mechanisms of plasticity induction and/or expression.

Emergent Brain Dynamics

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Author : April A. Benasich
language : en
Publisher: MIT Press
Release Date : 2022-06-07

Emergent Brain Dynamics written by April A. Benasich and has been published by MIT Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-06-07 with Science categories.

Experts explore the maturation of nonlinear brain dynamics from a developmental perspective and consider the relationship of neurodevelopmental disorders to early disruption in dynamic coordination. This volume in the Strüngmann Forum Reports series explores the complex mechanisms that accompany the dynamic processes by which the brain evolves and matures. Integrating perspectives from multiple disciplines, the book identifies knowledge gaps and proposes innovative ways forward for this emerging area of cross-disciplinary study. The contributors examine maturation of nonlinear brain dynamics across systems from a developmental perspective and relate these organizing networks to the establishment of normative cognition and pathology seen in many neurodevelopmental disorders. The book looks at key mechanistic questions, including: What role does dynamic coordination play in the establishment and maintenance of brain networks and structural and functional connectivity? How are local and global functional networks assembled and transformed over normative development? To what degree do oscillatory patterns vary across development? What is the impact of critical periods, and which factors initiate and terminate such periods? It also explores the potential of new technologies and techniques to enhance understanding of normative development and to enable early identification and remediation of neurodevelopmental and neuropsychiatric disorders that may result from early disruption in dynamic coordination. Contributors Sylvain Baillet, Yehezkel Ben-Ari, April A. Benasich, Olivier Bertrand, Gyorgy Buzsáki, Alain Chédotal, Sam M. Doesburg, Gordin Fishell, Adriana Galván, Jennifer N. Gelinas, Jay Giedd, Pierre Gressens, Ileana L. Hanganu-Opatz, Rowshanak Hashemiyoon, Takao K. Hensch, Suzana Herculano-Houzel, Mark Hübener, Mark, Matthias Kaschube, Michael S. Kobor, Bryan Kolb, Thorsten Kolling, Jean-Philippe Lachaux, Ulman Lindenberger, Heiko J. Luhmann, Hannah Monyer, Sarah R. Moore, Charles A. Nelson III, Tomáš Paus, Patrick L. Purdon, Pasko Rakic, Urs Ribary, Akira Sawa, Terrence J. Sejnowski, Wolf Singer, Cheryl L. Sisk, Nicholas C. Spitzer, Michael P. Stryker, Migranka Sur, Peter J. Uhlhaas

The New Frontier Of Network Physiology From Temporal Dynamics To The Synchronization And Principles Of Integration In Networks Of Physiological Systems

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Author : Plamen Ch. Ivanov
language : en
Publisher: Frontiers Media SA
Release Date : 2022-02-17

The New Frontier Of Network Physiology From Temporal Dynamics To The Synchronization And Principles Of Integration In Networks Of Physiological Systems written by Plamen Ch. Ivanov and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-17 with Science categories.

Jasper S Basic Mechanisms Of The Epilepsies

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Author : Jeffrey Noebels
language : en
Publisher: OUP USA
Release Date : 2012-06-29

Jasper S Basic Mechanisms Of The Epilepsies written by Jeffrey Noebels and has been published by OUP USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-06-29 with Medical categories.

Jasper's Basic Mechanisms, Fourth Edition, is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for "a better understanding of the epilepsies and rational methods of prevention and treatment.", the book represents an encyclopedic compendium neurobiological mechanisms of seizures, epileptogenesis, epilepsy genetics and comordid conditions. Of practical importance to the clinician, and new to this edition are disease mechanisms of genetic epilepsies and therapeutic approaches, ranging from novel antiepileptic drug targets to cell and gene therapies.

Gaba Signaling In Health And Disease

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Author : Yehezkel Ben-Ari
language : en
Publisher: Frontiers E-books
Release Date :

Gaba Signaling In Health And Disease written by Yehezkel Ben-Ari and has been published by Frontiers E-books this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.

GABAergic neurons provide most of the inhibitory drive of adult networks and play major roles in the integrative properties of brain networks. Alterations of GABAergic signals are associated with major neurological disorders and GABA mimetic drugs are widely used as comfort molecules and to treat several brain disorders. Thus, the inhibitory drive is altered in epilepsies, infantile developmentally related disorders but also Parkinson disease, and anoxo-ischemic insults to just name a few. From the developmental stand point, GABAergic neurons mature before principal neurons and provide an important source of early activities and are thus instrumental in activity dependent modulation of the construction of cortical functional units. The goal of this Research Topic is to bring together experts studying GABA signals at the molecular, cellular and network levels in physiological and pathological conditions and to examine the fate of GABA signals along transversal ideas linking these diverse domains. A particular emphasis is brain maturation as it is now clear that alteration of developmental sequences -notably of GABA signals- impairs brain development leading to life long deleterious neurological sequels. While this Frontiers Research Topic originated as a repository of work presented at CNCR Amsterdam, papers are invited from researchers continuing to work on this topic as the field expands.

Issues In Clinical Epileptology A View From The Bench

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Author : Helen E. Scharfman
language : en
Publisher: Springer
Release Date : 2014-07-10

Issues In Clinical Epileptology A View From The Bench written by Helen E. Scharfman and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-07-10 with Medical categories.

This book is dedicated to Dr. Philip A. Schwartzkroin. The book has a novel format because it is not intended to be a set of reviews. Instead, it is an effort to explore important topics in the epilepsy research field. Because articles are written by leaders in the field who have years of experience and individuals with diverse expertise, articles are likely to have a long-lasting impact and be relevant for both epileptologists and neuroscientists. Authors address topics that are important, unresolved questions in the field of epilepsy research, drawing on available data from both the bench and the clinic to support their points. A given topic is addressed by one or more authors, each writing from his/her own unique perspective. For all of the individuals who have been trained or worked with Philip Schwartzkroin in the past and/or have appreciated his contributions to the epilepsy field, this volume is an excellent way to celebrate his achievements and look to the ways they have moved the field forward and continue to stimulate its growth.

New Insights Into Adult Neurogenesis And Neurodegeneration Challenges For Brain Repair

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Author : Jose Angel Morales-Garcia
language : en
Publisher: Frontiers Media SA
Release Date : 2022-04-04

New Insights Into Adult Neurogenesis And Neurodegeneration Challenges For Brain Repair written by Jose Angel Morales-Garcia and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-04 with Science categories.

Gliomas Microenvironment New Drug Entities Mechanisms Of Action Molecular Biomarkers And Drug Delivery Strategies

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Author : Célia Cabral
language : en
Publisher: Frontiers Media SA
Release Date : 2024-07-26

Gliomas Microenvironment New Drug Entities Mechanisms Of Action Molecular Biomarkers And Drug Delivery Strategies written by Célia Cabral and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-07-26 with Science categories.

Gliomas are neoplasms originating in glial cells, the most malignant and frequent primary tumors of the Central Nervous System (CNS), representing approximately 40-50% of all intracranial tumors. Following the World Health Organization (WHO) guidelines, gliomas are classified into grades I-IV, regarding their malignancy degree. The latest report from WHO on CNS tumors considers that glioblastoma (GB), a grade IV adult-type diffuse glioma comprising isocitrate dehydrogenase (IDH)-wildtype tumors. Despite all efforts to improve patient survival and quality of life, the median survival remains lower due to the lack of effective diagnostic tools, poor prognosis, and limited therapeutic options. Regarding this, the design of novel treatment strategies is of the utmost importance. This can be by either the discovery of new medicines (for example synthetic compounds), repurposing known drugs or exploring novel strategies of drug delivery by nanotechnological platforms to improve treatment response and long-term survival of patients. Inter and intra-tumor heterogeneity mainly contribute to the poor prognosis and treatment efficacy. Therefore, exploiting tumor microenvironment (TME) and understanding GB’s cellular and molecular aspects are fundamental to developing more effective and better-tolerated personalized therapies. Thus, addressing physiological mechanisms involved in cancer development, progression and recurrence is crucial. Concerning this, our goal with this research topic is to share the latest advances in tumor-specific therapies for gliomas, especially GB, as well as to provide experimental validation of new bioactive molecules and their antitumor mechanism of action. Authors are invited to submit original research, review articles and systematic reviews covering, but not restricted to, the following topics: 1) Novel targeted therapies; 2) Mechanism of action and affected signaling pathways; 3) Repurposing drugs; 5) New chemical entities; 6) Pharmaceutical nanotechnology; 7) Drug delivery systems; 8) Preclinical and clinical studies of therapeutic molecules; 9) Potential molecular biomarkers to targeted therapies using proteomics or transcriptomics.