Jasper S Basic Mechanisms Of The Epilepsies
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Jasper S Basic Mechanisms Of The Epilepsies
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Author : Jeffrey Noebels
language : en
Publisher: Oxford University Press
Release Date : 2012-06-01
Jasper S Basic Mechanisms Of The Epilepsies written by Jeffrey Noebels and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-06-01 with Medical categories.
H.H. Jasper, A.A. Ward, A. Pope and H.H. Merritt, chair of the Public Health Service Advisory Committee on the Epilepsies, National Institutes of Health, published the first volume on Basic Mechanisms of the Epilepsies (BME) in 1969. Their ultimate goal was to search for a "better understanding of the epilepsies and seek more rational methods of their prevention and treatment." Since then, basic and clinical researchers in epilepsy have gathered together every decade and a half with these goals in mind -- assessing where epilepsy research has been, what it has accomplished, and where it should go. In 1999, the third volume of BME was named in honor of H.H. Jasper. In line with the enormous expansion in the understanding of basic epilepsy mechanisms over the past four decades, this fourth edition of Jasper's BME is the most ambitious yet. In 90 chapters, the book considers the role of interactions between neurons, synapses, and glia in the initiation, spread and arrest of seizures. It examines mechanisms of excitability, synchronization, seizure susceptibility, and ultimately epileptogenesis. It provides a framework for expanding the epilepsy genome and understanding the complex heredity responsible for common epilepsies as it explores disease mechanisms of ion channelopathies and developmental epilepsy genes. It considers the mechanisms of conditions of epilepsy comorbidities. And, for the first time, this 4th edition describes the current efforts to translate the discoveries in epilepsy disease mechanisms into new therapeutic strategies. This book, considered the 'bible' of basic epilepsy research, is essential for the student, the clinician scientist and all research scientists who conduct laboratory-based experimental epilepsy research using cellular, brain slice and animal models, as well as for those interested in related disciplines of neuronal oscillations, network plasticity, and signaling in brain strucutres that include the cortex, hippocampus, and thalamus. In keeping with the 1969 goals, the book is now of practical importance to the clinical neurologist and epileptologist as the progress of research in molecular genetics and modern efforts to design antiepileptic drugs, cures and repairs in the epilepsies converge and impact clinical care.
Jasper S Basic Mechanisms Of The Epilepsies
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Author : Jeffrey L. Noebels
language : en
Publisher:
Release Date : 2012
Jasper S Basic Mechanisms Of The Epilepsies written by Jeffrey L. Noebels and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Convulsions categories.
H.H. Jasper, A.A. Ward, A. Pope and H.H. Merritt, chair of the Public Health Service Advisory Committee on the Epilepsies, National Institutes of Health, published the first volume on Basic Mechanisms of the Epilepsies (BME) in 1969. Their ultimate goal was to search for a ""better understanding of the epilepsies and seek more rational methods of their prevention and treatment."" Since then, basic and clinical researchers in epilepsy have gathered together every decade and a half with these goals in mind -- assessing where epilepsy research has been, what it has accomplished, and where it shou.
Jasper S Basic Mechanisms Of The Epilepsies
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Author : Jeffrey L. Noebels
language : en
Publisher:
Release Date : 2023
Jasper S Basic Mechanisms Of The Epilepsies written by Jeffrey L. Noebels and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023 with categories.
Neurotransmitter Actions In The Vertebrate Nervous System
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Author : Michael Rogawski
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Neurotransmitter Actions In The Vertebrate Nervous System written by Michael Rogawski and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Intercellular communication via bioactive substances occurs in virtually all multicellular systems. Chemical neurotransmission in the vertebrate nervous system represents a form of signaling of this type. The biology of chemical neurotransmission is complex, involving transmitter synthesis, transport, and release by the presynaptic neuron; signal generation in the target tissue; and mechanisms for termination of the response. The focus of this book is on one aspect of this scheme: the diverse electrophysiological effects induced by different neurotransmitters on targets cells. In recent years, astonishing progress has been made in elucidating the specific physiological signals mediated by neurotransmitters in the verte brate nervous system, yet, in our view, this has not been adequately recog nized, perhaps because the new concepts have yet to filter into neuroscience textbooks. Nevertheless, the principles of neurotransmitter action are critical to advances in many areas of neuroscience, including molecular neurobiol ogy, neurochemistry, neuropharmacology, physiological psychology, and clinical neuroscience. It was the need for a sourcebook that prompted us to engage a group of neurophysiologists to prepare the chapters in this volume. However, there was an additional reason for this book: more and more it seemed that the field, if not yet having reached maturity, at least was ap proaching adolescence, with strengths in some areas and healthy conflicts in others. At this stage of development a textbook can help to define a field, clarify problems to be resolved, and identify areas for future investigation.
Jasper S Basic Mechanisms Of The Epilepsies
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Author : Antonio V. Delgado-Escueta
language : en
Publisher:
Release Date : 1999
Jasper S Basic Mechanisms Of The Epilepsies written by Antonio V. Delgado-Escueta and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Medical categories.
This volume brings together current research on the idiopathic and symptomatic epilepsies from all relevant basic science and clinical disciplines and identities promising areas of future investigation. Coverage represents advancing areas of biology that are being applied to epilepsy research, including developmental neurobiology, molecular biology and genetics, cellular and systems neurosciences, neurochemical pharmacology, and brain imaging. The book is organized into sections on neural development, genes, and the epilepsies; the idiopathic epilepsies; symptomatic lesional epilepsies; and frontiers in brain imaging and therapeutics. An editors' introduction to each section provides an overview of the fields of biology covered.
Astrocytes And Epilepsy
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Author : Jacqueline A. Hubbard
language : en
Publisher: Academic Press
Release Date : 2016-07-05
Astrocytes And Epilepsy written by Jacqueline A. Hubbard and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-07-05 with Medical categories.
Epilepsy is a devastating group of neurological disorders characterized by periodic and unpredictable seizure activity in the brain. There is a critical need for new drugs and approaches given than at least one-third of all epilepsy patients are not made free of seizures by existing medications and become "medically refractory". Much of epilepsy research has focused on neuronal therapeutic targets, but current antiepileptic drugs often cause severe cognitive, developmental, and behavioral side effects. Recent findings indicate a critical contribution of astrocytes, star-shaped glial cells in the brain, to neuronal and network excitability and seizure activity. Furthermore, many important cellular and molecular changes occur in astrocytes in epileptic tissue in both humans and animal models of epilepsy. The goal of Astrocytes and Epilepsy is to comprehensively review exciting findings linking changes in astrocytes to functional changes responsible for epilepsy for the first time in book format. These insights into astrocyte contribution to seizure susceptibility indicate that astrocytes may represent an important new therapeutic target in the control of epilepsy. Astrocytes and Epilepsy includes background explanatory text on astrocyte morphology and physiology, epilepsy models and syndromes, and evidence from both human tissue studies and animal models linking functional changes in astrocytes to epilepsy. Beautifully labelled diagrams are presented and relevant figures from the literature are reproduced to elucidate key findings and concepts in this rapidly emerging field. Astrocytes and Epilepsy is written for neuroscientists, epilepsy researchers, astrocyte investigators as well as neurologists and other specialists caring for patients with epilepsy. Presents the first comprehensive book to synthesize historical and recent research on astrocytes and epilepsy into one coherent volume Provides a great resource on the field of astrocyte biology and astrocyte-neuron interactions Details potential therapeutic targets, including chapters on gap junctions, water and potassium channels, glutamate and adenosine metabolism, and inflammation
Seizures And Epilepsy
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Author : Jerome Engel Jr
language : en
Publisher: Oxford University Press
Release Date : 2013-01-31
Seizures And Epilepsy written by Jerome Engel Jr and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-01-31 with Medical categories.
This second edition of 'Seizures and Epilepsy' is completely revised, due to tremendous advances in the understanding of the fundamental neuronal mechanisms underlying epileptic phenomena, as well as current diagnosis and treatment, which have been heavily influenced over the past several decades by seminal neuroscientific developments, particularly the introduction of molecular neurobiology, genetics, and modern neuroimaging. This resource covers a broad range of both basic and clinical epileptology.
Introduction To Epilepsy
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Author : Gonzalo Alarcón
language : en
Publisher: Cambridge University Press
Release Date : 2012-04-26
Introduction To Epilepsy written by Gonzalo Alarcón and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-04-26 with Medical categories.
Covers all aspects of epilepsy, from basic mechanisms to diagnosis and management, as well as legal and social considerations.
The Causes Of Epilepsy
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Author : Simon Shorvon
language : en
Publisher: Cambridge University Press
Release Date : 2019-05-02
The Causes Of Epilepsy written by Simon Shorvon and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-02 with Medical categories.
Expanded and revised, this unique book provides concise descriptions of the many causes of epilepsy, for use in clinical practice.
Epilepsy And Cerebral Localization
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Author : Wilder Penfield
language : en
Publisher: Springfield, Ill. : C.C. Thomas
Release Date : 1941
Epilepsy And Cerebral Localization written by Wilder Penfield and has been published by Springfield, Ill. : C.C. Thomas this book supported file pdf, txt, epub, kindle and other format this book has been release on 1941 with Brain categories.