Gap Junctions Molecular Basis Of Cell Communication In Health And Disease
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Gap Junctions Molecular Basis Of Cell Communication In Health And Disease
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Author :
language : en
Publisher: Academic Press
Release Date : 1999-12-22
Gap Junctions Molecular Basis Of Cell Communication In Health And Disease written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-12-22 with Science categories.
Since the first gap junction protein (connexin) was cloned over a decade ago, more than a dozen connexin genes have been cloned. Consequently, a wealth of information on the molecular basis of gap junctional communication has been accumulated. This book pays tribute to this exciting era in the history of cell communication research by documenting the great strides made in this field as a result of the merging of biophysics and molecular biology, two of the most powerful approaches to studying the molecular basis of membrane channel behavior. Twenty-eight comprehensive chapters, authored by internationally recognized leaders in the field, discuss the biophysical, physiological, and molecular characteristics of cell-to-cell communication via gap junctions. Key aspects of molecular structure, formation, gating, conductance, and permeability of vertebrate and invertebrate gap junction channels are highlighted. In addition, a number of chapters focus on recent discoveries that implicate connexin mutations and alterations of gap junctional communication in the pathogenesis of several diseases, including the X-linked Charcot Marie Tooth demyelinating disease, some forms of inherited sensorineural deafness, malignant transformation, cardiac malformations and arrhythmia, eye lens cataract, and Chagas' disease.
Gap Junction Mediated Intercellular Signalling In Health And Disease
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Author : Gail Cardew
language : en
Publisher: John Wiley & Sons
Release Date : 2008-04-30
Gap Junction Mediated Intercellular Signalling In Health And Disease written by Gail Cardew and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-04-30 with Science categories.
Gap junctions are key elements in communication between cells in multicellular organisms. It is clear that their activity is essential for normal embryonic development and normal function in adult organs, although the individual roles of the proteins that form the channels (connexins) are not yet fully understood. The last few years have seen considerable progress in this field and exciting new issues concerning gap junctional intercellular communication are being raised. Perturbed gap junction activity is beginning to be linked to certain pathologies, e.g. mutations in the major connexin of the heart have been found in human patients suffering from visceroatrial heterotaxia syndrome and mutations in the gene encoding another connexin have been found in patients with Charcot-Marie-Tooth disease. This book is the first to highlight the recent progress in understanding gap junction structure and to discuss the specific roles of individual connexins. It features contributions from an interdisciplinary group of experts who review the role of gap junctions in the heart, the retina and lens, the auditory system, the reproductive system, and in cell proliferation and cancer. The book will appeal to people interested in cell and molecular biology, embryonic development, neurobiology, cardiology, gynaecology and oncology.
Cell Intercommunication
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Author : Walmore C. De Mello
language : en
Publisher: CRC Press
Release Date : 2018-01-18
Cell Intercommunication written by Walmore C. De Mello and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-18 with Science categories.
This important publication addresses intercellular communication in health and disease. It includes recent advances in morphology and chemical organization of gap junctions. It discusses the possible role of intercellular channels in excitable and non-excitable tissues. The book presents modulation of junctional permeability, as well as the possible role of cell communication in embryonic development and growth. The text concludes with a synthetic view of the role of gap junctions and potential implications to cardiology, oncology, and other areas of pathology. This volume is important to professionals in pharmacology, physiology, biochemistry, biomedical science, pathobiology, pathology, molecular genetics, toxicology and human development.
Gap Junctions In Development And Disease
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Author : Elke Winterhager
language : en
Publisher: Springer Science & Business Media
Release Date : 2005-11-04
Gap Junctions In Development And Disease written by Elke Winterhager and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-11-04 with Science categories.
Communication between cells via intercellular channels – gap junctions – appears essential to certain developmental processes and appropriate organ function. Gap Junctions in Development and Disease aims to describe the molecular events underlying impaired development and disease. Beginning with a comprehensive review of various mouse and human genes encoding the channel-forming connexins, later chapters describe several connexin mutations associated with human diseases such as hereditary deafness and female infertility. Erroneous signaling mediated by the interaction of mutant connexins with other proteins, thought to be responsible for dysfunction of organs such as heart, muscle, brain, skin, lens, placenta, and endocrine tissue in both mice and men, is also addressed. Although the question of why some mutations in gap-junction proteins lead to specific phenotypes remains to be answered, the reviews in this book provide an intriguing insight into the future direction of this research field.
Gap Junction Mediated Intercellular Signalling In Health And Disease
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Author : Novartis Foundation
language : en
Publisher: Wiley
Release Date : 1999-04-06
Gap Junction Mediated Intercellular Signalling In Health And Disease written by Novartis Foundation and has been published by Wiley this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-04-06 with Science categories.
Gap junctions are key elements in communication between cells in multicellular organisms. It is clear that their activity is essential for normal embryonic development and normal function in adult organs, although the individual roles of the proteins that form the channels (connexins) are not yet fully understood. The last few years have seen considerable progress in this field and exciting new issues concerning gap junctional intercellular communication are being raised. Perturbed gap junction activity is beginning to be linked to certain pathologies, e.g. mutations in the major connexin of the heart have been found in human patients suffering from visceroatrial heterotaxia syndrome and mutations in the gene encoding another connexin have been found in patients with Charcot-Marie-Tooth disease. This book is the first to highlight the recent progress in understanding gap junction structure and to discuss the specific roles of individual connexins. It features contributions from an interdisciplinary group of experts who review the role of gap junctions in the heart, the retina and lens, the auditory system, the reproductive system, and in cell proliferation and cancer. The book will appeal to people interested in cell and molecular biology, embryonic development, neurobiology, cardiology, gynaecology and oncology.
Molecular Biology Of The Cell
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Author : Bruce Alberts
language : en
Publisher:
Release Date : 2002
Molecular Biology Of The Cell written by Bruce Alberts and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Cytology categories.
Heart Cell Coupling And Impulse Propagation In Health And Disease
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Author : Walmor C. de Mello
language : en
Publisher: Springer Science & Business Media
Release Date : 2002-10-31
Heart Cell Coupling And Impulse Propagation In Health And Disease written by Walmor C. de Mello and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-10-31 with Medical categories.
Heart Cell Coupling and Impulse Propagation in Health and Disease includes an up-to-date review on how heart cells communicate and impulse propagation under normal as well as under pathological conditions. The complexity of intercellular coupling and impulse propagation is discussed, providing the reader with a broad view of the importance of these processes and how they contribute to the generation of cardiac arrhythmias and heart failure. The different aspects and intricacies of heart cell communication is discussed by different authors, each one an expert in their own field. The present publication will be of interest to cardiologists, electrophysiologists, heart physiologists, cardiac pharmacologists, biophysicists, and cell or molecular biologists.
Cell Cell Channels
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Author : František Baluška
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-08-28
Cell Cell Channels written by František Baluška and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-08-28 with Science categories.
This book covers cell-cell channels at all levels of biological organization. The purpose of this book is to document that cells are not physically separated and fully autonomous units of biological life as stated by the currently valid Cell Theory. If not the cell then some lower level unit must fulfill this role. The book deals also with the identity of this elusive unit of biological life.
Molecular And Cellular Insights To Ion Channel Biology
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Author : Robert A. Maue
language : en
Publisher: Gulf Professional Publishing
Release Date : 2004
Molecular And Cellular Insights To Ion Channel Biology written by Robert A. Maue and has been published by Gulf Professional Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Calcium channels categories.
Annotation Contains fresh perspectives and up-to-date view points from international experts Illustrates the diverse array of techniques applied to ion channel research Represents a valuable resource to both the beginner and expert researcher, with over 2500 references and more than 100 figures and tables.
Gap Junction Structure And Chemical Regulation
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Author : Camillo Peracchia
language : en
Publisher: Academic Press
Release Date : 2019-02-16
Gap Junction Structure And Chemical Regulation written by Camillo Peracchia and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-02-16 with Science categories.
Gap Junction Structure and Chemical Regulation: Direct Calmodulin Role in Cell-to-Cell Channel Gating describes and discusses the findings of major studies conducted during the past century on the structure and chemical regulation of direct cell-to-cell communication via gap junction channels. Chapters bring together important findings on direct cell communication, from its history, to its structure and regulation. These channels are essential for normal organ function, and mutations in their protein (connexin) cause various diseases. The book is useful for established investigators who need a review on the field and young investigators who need a thorough resource for study and comprehension. Contains comprehensive, historical coverage on direct cell-to-cell communication Provides detailed coverage of gap junction channel structure and regulation, with extensive coverage of the direct role of calmodulin in channel gating Delivers a thorough description of models proposed for the chemical gating of gap junction channels