Gap Junction Mediated Intercellular Signalling In Health And Disease
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Gap Junction Mediated Intercellular Signalling In Health And Disease
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Author : Gail Cardew
language : en
Publisher: John Wiley & Sons
Release Date : 2008-04-30
Gap Junction Mediated Intercellular Signalling In Health And Disease written by Gail Cardew and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-04-30 with Science categories.
Gap junctions are key elements in communication between cells in multicellular organisms. It is clear that their activity is essential for normal embryonic development and normal function in adult organs, although the individual roles of the proteins that form the channels (connexins) are not yet fully understood. The last few years have seen considerable progress in this field and exciting new issues concerning gap junctional intercellular communication are being raised. Perturbed gap junction activity is beginning to be linked to certain pathologies, e.g. mutations in the major connexin of the heart have been found in human patients suffering from visceroatrial heterotaxia syndrome and mutations in the gene encoding another connexin have been found in patients with Charcot-Marie-Tooth disease. This book is the first to highlight the recent progress in understanding gap junction structure and to discuss the specific roles of individual connexins. It features contributions from an interdisciplinary group of experts who review the role of gap junctions in the heart, the retina and lens, the auditory system, the reproductive system, and in cell proliferation and cancer. The book will appeal to people interested in cell and molecular biology, embryonic development, neurobiology, cardiology, gynaecology and oncology.
Gap Junctions Molecular Basis Of Cell Communication In Health And Disease
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Author : Dale J. Benos
language : en
Publisher: Gulf Professional Publishing
Release Date : 1999-12-14
Gap Junctions Molecular Basis Of Cell Communication In Health And Disease written by Dale J. Benos and has been published by Gulf Professional Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-12-14 with Medical categories.
Since the first gap junction protein (connexin) was cloned over a decade ago, more than a dozen connexin genes have been cloned. Consequently, a wealth of information on the molecular basis of gap junctional communication has been accumulated. This book pays tribute to this exciting era in the history of cell communication research by documenting the great strides made in this field as a result of the merging of biophysics and molecular biology, two of the most powerful approaches to studying the molecular basis of membrane channel behavior. Twenty-eight comprehensive chapters, authored by internationally recognized leaders in the field, discuss the biophysical, physiological, and molecular characteristics of cell-to-cell communication via gap junctions. Key aspects of molecular structure, formation, gating, conductance, and permeability of vertebrate and invertebrate gap junction channels are highlighted. In addition, a number of chapters focus on recent discoveries that implicate connexin mutations and alterations of gap junctional communication in the pathogenesis of several diseases, including the X-linked Charcot-Marie-Tooth demyelinating disease, some forms of inherited sensorineural deafness, malignant transformation, cardiac malformations and arrhythmia, eye lens cataract, and Chagas disease.
Heart Cell Coupling And Impulse Propagation In Health And Disease
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Author : Walmor C. de Mello
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Heart Cell Coupling And Impulse Propagation In Health And Disease written by Walmor C. de Mello and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Heart Cell Coupling and Impulse Propagation in Health and Disease includes an up-to-date review on how heart cells communicate and impulse propagation under normal as well as under pathological conditions. The complexity of intercellular coupling and impulse propagation is discussed, providing the reader with a broad view of the importance of these processes and how they contribute to the generation of cardiac arrhythmias and heart failure. The different aspects and intricacies of heart cell communication is discussed by different authors, each one an expert in their own field. The present publication will be of interest to cardiologists, electrophysiologists, heart physiologists, cardiac pharmacologists, biophysicists, and cell or molecular biologists.
Cumulated Index Medicus
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Author :
language : en
Publisher:
Release Date : 1994
Cumulated Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with Medicine categories.
Scientific Report
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Author : Scripps Research Institute
language : en
Publisher:
Release Date : 1999
Scientific Report written by Scripps Research Institute and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Medicine categories.
Cardiovascular Signaling In Health And Disease
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Author : Narasimham L. Parinandi
language : en
Publisher: Springer Nature
Release Date : 2022-09-21
Cardiovascular Signaling In Health And Disease written by Narasimham L. Parinandi and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-21 with Sports & Recreation categories.
This contributed volume focuses on cardiovascular diseases (CVDs), and explores the ways in which signaling mechanisms at the biochemical, molecular, and cellular levels in the blood vessels (vascular) and heart contribute to the underlying causes of development and progression of the CVDs. This volume covers unique topics such as oxidant signaling in vascular and heart diseases and health, cytoskeletal signaling in vascular health and disease, phospholipase signaling in CVDs, lipid signaling in vascular and myocardial health and diseases, and drug discovery in cellular signaling for cardiovascular diseases. This book assembles the most important discoveries made by leaders on the cellular signaling mechanisms operating behind the development and progression of life-threatening CVDs. It is an extremely useful resource for the investigators in the field of CVDs, and opens the discussion for further discovery of efficient management and effective treatment of the CVDs.
God Science And Mind
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Author : Dennis Polis
language : en
Publisher: Lulu.com
Release Date : 2012-07-15
God Science And Mind written by Dennis Polis and has been published by Lulu.com this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-07-15 with Religion categories.
An exercise in Open Philosophy -- a worldview open to the full range of human experience including science, spirituality and traditional philosophy. Naturalism is exposed as a closed, a priori worldview. God is not an alternative to, but the completion of, scientific explanation. The foundations and data of evolution do not show randomness, but Mind in nature. Evolution aims at verifiable targets and develops means in advance of need. While God is proven deductively, the fine-tuning argument makes a strong case despite the anthropic principle. The rules of evidence are discussed critically before reviewing data on mind ranging from neuroscience, connectionism, & cybernetics to introspection, parapsychology, near death experiences & mysticism -- even I-Thou relationships. Current theories are inadequate to important data points. Traditional philosophy suggests a single substance, two-subsystem theory integrating a data processing brain and an intentional, immaterial soul to solve the mind-body problem.
Ion Channels And Transporters Of Epithelia In Health And Disease
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Author : Kirk L. Hamilton
language : en
Publisher: Springer
Release Date : 2015-12-14
Ion Channels And Transporters Of Epithelia In Health And Disease written by Kirk L. Hamilton and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-12-14 with Medical categories.
This book sheds new light on the physiology, molecular biology and pathophysiology of epithelial ion channels and transporters. It combines the basic cellular models and functions by means of a compelling clinical perspective, addressing aspects from the laboratory bench to the bedside. The individual chapters, written by leading scientists and clinicians, explore specific ion channels and transporters located in the epithelial tissues of the kidney, intestine, pancreas and respiratory tract, all of which play a crucial part in maintaining homeostasis. Further topics include the fundamentals of epithelial transport; mathematical modeling of ion transport; cell volume regulation; membrane protein folding and trafficking; transepithelial transport functions; and lastly, a discussion of transport proteins as potential pharmacological targets with a focus on the pharmacology of potassium channels.
Gap Junctions In Development And Disease
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Author : Elke Winterhager
language : en
Publisher: Springer Science & Business Media
Release Date : 2005-11-04
Gap Junctions In Development And Disease written by Elke Winterhager and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-11-04 with Science categories.
Communication between cells via intercellular channels – gap junctions – appears essential to certain developmental processes and appropriate organ function. Gap Junctions in Development and Disease aims to describe the molecular events underlying impaired development and disease. Beginning with a comprehensive review of various mouse and human genes encoding the channel-forming connexins, later chapters describe several connexin mutations associated with human diseases such as hereditary deafness and female infertility. Erroneous signaling mediated by the interaction of mutant connexins with other proteins, thought to be responsible for dysfunction of organs such as heart, muscle, brain, skin, lens, placenta, and endocrine tissue in both mice and men, is also addressed. Although the question of why some mutations in gap-junction proteins lead to specific phenotypes remains to be answered, the reviews in this book provide an intriguing insight into the future direction of this research field.
Extracellular Atp And Adenosine As Regulators Of Endothelial Cell Function
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Author : Evgenia Gerasimovskaya
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-04-26
Extracellular Atp And Adenosine As Regulators Of Endothelial Cell Function written by Evgenia Gerasimovskaya and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-04-26 with Science categories.
Extracellular purines and pyrimidines (ATP, ADP, UTP and adenosine) are released into the extracellular milieu in response to a variety of stress conditions and act as important regulators of vascular homeostasis. This new book is uniquely focused on the signaling actions of extracellular purines in endothelial cells and the crucial role of extracellular purines in regulation of angiogenesis, vascular tone, cell permeability, wound healing, inflammation and cell-to-cell communication. This book examines the responses of endothelial cells, originating from various tissues (such as cornea, pancreas and uterus), to extracellular nucleotides and adenosine under physiological and pathological conditions, i.e. pregnancy, hypoxia, hypertension, inflammation and diabetes. In the book’s 12 chapters, the role of purinergic signaling in endothelium-dependent tissue perfusion, regulation of endothelial barrier function, and angiogenesis are discussed. The mechanisms of ATP release and its role in intercellular communication are also presented. In addition, the book provides the most up to date mechanisms of extracellular nucleotide metabolism by purine-converting ecto-enzymes and their contribution to purinergic signaling in endothelial cells originating from various vascular beds. This book is a valuable resource for biomedical research scientists, clinical scientists, graduate students and health science professionals interested in the mechanisms of extracellular purine function in endothelial cells under physiologic and pathologic conditions.