Gap Junction Mediated Intercellular Signalling In Health And Disease
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Gap Junction Mediated Intercellular Signalling In Health And Disease
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Author : Gail Cardew
language : en
Publisher: John Wiley & Sons
Release Date : 2008-04-30
Gap Junction Mediated Intercellular Signalling In Health And Disease written by Gail Cardew and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-04-30 with Science categories.
Gap junctions are key elements in communication between cells in multicellular organisms. It is clear that their activity is essential for normal embryonic development and normal function in adult organs, although the individual roles of the proteins that form the channels (connexins) are not yet fully understood. The last few years have seen considerable progress in this field and exciting new issues concerning gap junctional intercellular communication are being raised. Perturbed gap junction activity is beginning to be linked to certain pathologies, e.g. mutations in the major connexin of the heart have been found in human patients suffering from visceroatrial heterotaxia syndrome and mutations in the gene encoding another connexin have been found in patients with Charcot-Marie-Tooth disease. This book is the first to highlight the recent progress in understanding gap junction structure and to discuss the specific roles of individual connexins. It features contributions from an interdisciplinary group of experts who review the role of gap junctions in the heart, the retina and lens, the auditory system, the reproductive system, and in cell proliferation and cancer. The book will appeal to people interested in cell and molecular biology, embryonic development, neurobiology, cardiology, gynaecology and oncology.
Gap Junction Mediated Intracellular Signalling In Health And Disease
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Author : Gail; ed Cardew
language : en
Publisher:
Release Date : 1999
Gap Junction Mediated Intracellular Signalling In Health And Disease written by Gail; ed Cardew and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with categories.
Gap Junction Mediated Intercellular Signalling In Health And Disease
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Author : Novartis Foundation
language : en
Publisher: Wiley
Release Date : 1999-04-06
Gap Junction Mediated Intercellular Signalling In Health And Disease written by Novartis Foundation and has been published by Wiley this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-04-06 with Science categories.
Gap junctions are key elements in communication between cells in multicellular organisms. It is clear that their activity is essential for normal embryonic development and normal function in adult organs, although the individual roles of the proteins that form the channels (connexins) are not yet fully understood. The last few years have seen considerable progress in this field and exciting new issues concerning gap junctional intercellular communication are being raised. Perturbed gap junction activity is beginning to be linked to certain pathologies, e.g. mutations in the major connexin of the heart have been found in human patients suffering from visceroatrial heterotaxia syndrome and mutations in the gene encoding another connexin have been found in patients with Charcot-Marie-Tooth disease. This book is the first to highlight the recent progress in understanding gap junction structure and to discuss the specific roles of individual connexins. It features contributions from an interdisciplinary group of experts who review the role of gap junctions in the heart, the retina and lens, the auditory system, the reproductive system, and in cell proliferation and cancer. The book will appeal to people interested in cell and molecular biology, embryonic development, neurobiology, cardiology, gynaecology and oncology.
Gap Junctions In Development And Disease
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Author : Elke Winterhager
language : en
Publisher: Springer Science & Business Media
Release Date : 2005-11-04
Gap Junctions In Development And Disease written by Elke Winterhager and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-11-04 with Science categories.
Communication between cells via intercellular channels – gap junctions – appears essential to certain developmental processes and appropriate organ function. Gap Junctions in Development and Disease aims to describe the molecular events underlying impaired development and disease. Beginning with a comprehensive review of various mouse and human genes encoding the channel-forming connexins, later chapters describe several connexin mutations associated with human diseases such as hereditary deafness and female infertility. Erroneous signaling mediated by the interaction of mutant connexins with other proteins, thought to be responsible for dysfunction of organs such as heart, muscle, brain, skin, lens, placenta, and endocrine tissue in both mice and men, is also addressed. Although the question of why some mutations in gap-junction proteins lead to specific phenotypes remains to be answered, the reviews in this book provide an intriguing insight into the future direction of this research field.
Gap Junctions Molecular Basis Of Cell Communication In Health And Disease
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Author :
language : en
Publisher: Academic Press
Release Date : 1999-12-22
Gap Junctions Molecular Basis Of Cell Communication In Health And Disease written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-12-22 with Science categories.
Since the first gap junction protein (connexin) was cloned over a decade ago, more than a dozen connexin genes have been cloned. Consequently, a wealth of information on the molecular basis of gap junctional communication has been accumulated. This book pays tribute to this exciting era in the history of cell communication research by documenting the great strides made in this field as a result of the merging of biophysics and molecular biology, two of the most powerful approaches to studying the molecular basis of membrane channel behavior. Twenty-eight comprehensive chapters, authored by internationally recognized leaders in the field, discuss the biophysical, physiological, and molecular characteristics of cell-to-cell communication via gap junctions. Key aspects of molecular structure, formation, gating, conductance, and permeability of vertebrate and invertebrate gap junction channels are highlighted. In addition, a number of chapters focus on recent discoveries that implicate connexin mutations and alterations of gap junctional communication in the pathogenesis of several diseases, including the X-linked Charcot Marie Tooth demyelinating disease, some forms of inherited sensorineural deafness, malignant transformation, cardiac malformations and arrhythmia, eye lens cataract, and Chagas' disease.
Molecular Biology Of The Cell
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Author : Bruce Alberts
language : en
Publisher:
Release Date : 2002
Molecular Biology Of The Cell written by Bruce Alberts and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Cytology categories.
Cell Cell Channels
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Author : František Baluška
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-08-28
Cell Cell Channels written by František Baluška and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-08-28 with Science categories.
This book covers cell-cell channels at all levels of biological organization. The purpose of this book is to document that cells are not physically separated and fully autonomous units of biological life as stated by the currently valid Cell Theory. If not the cell then some lower level unit must fulfill this role. The book deals also with the identity of this elusive unit of biological life.
Heart Cell Coupling And Impulse Propagation In Health And Disease
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Author : Walmor C. de Mello
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Heart Cell Coupling And Impulse Propagation In Health And Disease written by Walmor C. de Mello and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Heart Cell Coupling and Impulse Propagation in Health and Disease includes an up-to-date review on how heart cells communicate and impulse propagation under normal as well as under pathological conditions. The complexity of intercellular coupling and impulse propagation is discussed, providing the reader with a broad view of the importance of these processes and how they contribute to the generation of cardiac arrhythmias and heart failure. The different aspects and intricacies of heart cell communication is discussed by different authors, each one an expert in their own field. The present publication will be of interest to cardiologists, electrophysiologists, heart physiologists, cardiac pharmacologists, biophysicists, and cell or molecular biologists.
Gap Junctions In The Nervous System
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Author : David C. Spray
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
Gap Junctions In The Nervous System written by David C. Spray and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Medical categories.
This book deals with the types of gap junction proteins (connexins) and their distribution within the nervous system, the physiological properties of channels formed of each connexin, and the role of gap junction channels in functions of normal and pathological brain and peripheral nerve. Although glial tissue is emphasized, additional groups of chapters deal with neurons in the central nervous system and with the retina.
The Juxtaglomerular Apparatus
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Author : Roland Taugner
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-09
The Juxtaglomerular Apparatus written by Roland Taugner and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-09 with Medical categories.
Knowledge of the juxtaglomerular apparatus (JGA) of the kidney and of the synthesis and secretion of renin has increased to such an extent over the past few years that it is now appropriate to summarize this knowledge in a monograph on the JGA, the first of its kind. It was the authors' special concern to demonstrate the association between structure and function for renin secretion, not only within the juxtaglomerular region, but also in the region of the renal cortex beyond the JGA. The description of the pathology of the human JGA, studded with references to experimental findings but nevertheless fully self-contained, should help to make this monograph also useful for clinicians.