Genes Environments And Interactions
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Genes Environments And Interactions
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Author : José M Álvarez-Castro
language : en
Publisher: Springer Nature
Release Date : 2024-01-18
Genes Environments And Interactions written by José M Álvarez-Castro and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-01-18 with Science categories.
Genetic effects are the core concepts from which quantitative genetics and the evolutionary synthesis emerged. The groundbreaking theory of genetic effects was first proposed over a century ago. This book revises that theory, both conceptually and mathematically, and brings it up-to-date. The theory here compiled is supplemented with non-previously-published developments covering the broadest spectrum of simultaneously multiallelic and multilocus architectures with autosomal and sex-linked loci Arbitrary interactions (dominance, gene-gene, gene-environment, gene-sex, and parent-of-origin interactions) are accounted for Both effects of allele substitutions from the reference of individual genotypes and in the context of populations are worked out Populations are considered regardless of any departures from equilibrium frequencies (including both departures from Hardy-Weinberg, departures from linkage equilibrium, and non-random associations between/among genes and environments) All developments are derived under the same mathematical framework, so that transformations of genetic effects between different contexts are easily allowed In brief, this book enables novel applications to current empirical paradigms (like gene-mapping and genomic prediction) while adhering to the classical conceptualization of genetic effects and variance decomposition that let quantitative genetics and the evolutionary synthesis flourish. All relevant concepts are carefully clarified and discussed from a historical perspective. The theoretical developments presented in the book are illustrated by built-in cases and applications with real data. Reassuringly, the adequacy of the theory here presented is corroborated based on the fundamentals of model development.
Gene Environment Interactions
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Author : Lucio G. Costa
language : en
Publisher: John Wiley & Sons
Release Date : 2005-12-16
Gene Environment Interactions written by Lucio G. Costa and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-12-16 with Science categories.
Understanding the play between heredity and environment, and relating it to disease causation, is the task of ecogenetics. Gene-Environment Interactions: Fundamentals of Ecogenetics presents the first comprehensive survey of this discipline, reflecting its relationship with toxicology, epidemiology, pharmacology, public health, and other medical and biological fields. Divided into four sections, the text elucidates key basic and advanced topics: * Section 1 covers fundamentals, including the history of the discipline, a discussion of the molecular laboratory tools currently available to assess genotypes, using such measurements in molecular epidemiology studies, and the statistical issues involved in their analysis. * Section 2 focuses on a number of key genetic polymorphisms relevant for ecogenetics, including enzymes of phase I and phase II metabolism, enzymes involved in DNA repair, as well as receptors and ion channels. This highlights characteristics of selected, widely studied genotypic/phenotypic differences, and allows discussion of how given genetic variations can influence responses to exogenous chemicals. * Section 3 examines gene-environment interactions through a disease-based approach, addressing how genetic polymorphisms can influence susceptibility to various diseases. Chapters cover important disease conditions such as various types of cancer, neurodegenerative diseases, cardiovascular disease, chronic pulmonary diseases, infectious diseases, diabetes, and obesity. * The final section discusses the ethical, legal, and social issues that arise when investigating and evaluating genetic polymorphisms in human populations, as well as the impact of ecogenetics on risk assessment, regulatory policies, and medicine and public health. Packed with clear examples illustrating concepts, as well as numerous tables and figures, Gene-Environment Interactions: Fundamentals of Ecogenetics is a unique resource for a wide range of physicians, students, and other specialists.
Gene Environment Interactions In Developmental Psychopathology
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Author : Kenneth A. Dodge
language : en
Publisher: Guilford Press
Release Date : 2011-09-01
Gene Environment Interactions In Developmental Psychopathology written by Kenneth A. Dodge and has been published by Guilford Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-01 with Psychology categories.
Bringing together foremost experts, this book reviews groundbreaking gene–environment research and explores implications for clinical practice, prevention, and public policy. Presented is cutting-edge work on the interplay of genetic factors and childhood experiences in the development of mental disorders such as depression, conduct disorder, and schizophrenia. Essential topics include what scientists currently know about "susceptibility genes"; the mechanisms by which maltreatment and other stressors interact with biological susceptibilities across development; and factors that make certain children more resilient than others. Future directions for personalizing treatment and prevention efforts, thus making them more effective, are discussed.
Gene Environment Transactions In Developmental Psychopathology
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Author : Patrick H. Tolan
language : en
Publisher: Springer
Release Date : 2017-04-29
Gene Environment Transactions In Developmental Psychopathology written by Patrick H. Tolan and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-04-29 with Psychology categories.
This book examines the current research in gene-environment transactions (GEX) and its potential use in developing interventions and applications tailored to individual genetic makeups. Key concepts underlying GEX studies in this area are defined, identifying fundamental challenges in devising informed research questions and conducting valid and useful experiments. Chapters analyze GEX models inspired by the present day genome-based frameworks, particularly in terms of advances in identifying and understanding complex environmental factors, using examples from common psychological conditions, such as antisocial behavior, chronic physical aggression, and chronic internalizing disorder. In addition, the book presents new and potential applications of the framework in the contexts of prevention science and intervention research. Topics featured in this book include: Epigenetics and the biology of gene x environment interactions. Gene by environment interactions and its potential use for intervention strategies in anxiety disorders. The challenges and potential for research on gene-environment interactions within autism spectrum disorder. Using genetically informed prevention trials to test gene x environment hypothese. Challenges for intervention research within the GEX framework. Gene-Environment Transactions in Developmental Psychopathology is a must-have resource for researchers/professors, clinicians, and related professionals as well as graduate students in developmental psychology, psychiatry, human genetics, and related disciplines.
Cancer And The Environment
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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 2002-09-01
Cancer And The Environment written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-09-01 with Science categories.
The Roundtable on Environmental Health Sciences, Research, and Medicine wanted to address the link between environmental factors and the development of cancer in light of recent advances in genomics. They asked what research tools are needed, how new scientific information can be applied in a timely manner to reduce the burden of cancer, and how this can be flexible enough to treat the individual.
Genes Behavior And The Social Environment
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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 2006-12-07
Genes Behavior And The Social Environment written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-12-07 with Social Science categories.
Over the past century, we have made great strides in reducing rates of disease and enhancing people's general health. Public health measures such as sanitation, improved hygiene, and vaccines; reduced hazards in the workplace; new drugs and clinical procedures; and, more recently, a growing understanding of the human genome have each played a role in extending the duration and raising the quality of human life. But research conducted over the past few decades shows us that this progress, much of which was based on investigating one causative factor at a time—often, through a single discipline or by a narrow range of practitioners—can only go so far. Genes, Behavior, and the Social Environment examines a number of well-described gene-environment interactions, reviews the state of the science in researching such interactions, and recommends priorities not only for research itself but also for its workforce, resource, and infrastructural needs.
Genes Environments And Interactions
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Author : Danielle Marie Dick
language : en
Publisher:
Release Date : 2001
Genes Environments And Interactions written by Danielle Marie Dick and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with Alcoholism categories.
Behavior genetics has traditionally involved the partitioning of variance in behavior into latent sources of genetic and environmental influence. Results of that technique proved pivotal in raising awareness of the importance of genes at a time when environmental theories of behavior dominated. With widespread recognition that both genetic and environmental influences are important in the development of virtually all behavior, the new challenge is to move beyond latent sources of variance and to specify the genes and environments involved. This thesis has incorporated strategies from quantitative and molecular genetics to specify genes and environments involved in alcohol use and abuse, and to assess how these genes and environments act and interact. Using data from population-based, Finnish twin studies, a series of quantitative genetic analyses consecutively explore the influence of different environmental variables: socio-regional environment, home environment, and peer influences. Each of these environmental variables also illustrates a different way that the environment can interact with genetic factors. Socio-regional factors moderate influences on alcohol use, with the importance of genetic and environmental influences varying more than fivefold between environmental extremes. Parental monitoring and home atmosphere contribute additively to adolescent behavior problems, while peers' alcohol use exhibits a more complex, interactive relationship with self-reported adolescent alcohol use. A final chapter explores molecular analyses aimed at specifying genes involved in an alcohol-related phenotype. Thus, in a series of consecutive chapters, this dissertation explores (1) environments involved in alcohol use and abuse, (2) the manner in which these environments act and interact with genetic predispositions, and (3) genes involved in alcohol use and abuse.
Gene Environment Interaction Analysis
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Author : Sumiko Anno
language : en
Publisher: CRC Press
Release Date : 2016-03-30
Gene Environment Interaction Analysis written by Sumiko Anno and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-03-30 with Mathematics categories.
Gene-environment (GE) interaction analysis is a statistical method for clarifying GE interactions applicable to a phenotype or a disease that is the result of interactions between genes and the environment. This book is the first to deal with the theme of GE interaction analysis. It compiles and details cutting-edge research in bioinformatics
Gene Environment Interactions
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Author : Moyra Smith
language : en
Publisher: Academic Press
Release Date : 2020-01-24
Gene Environment Interactions written by Moyra Smith and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-24 with categories.
Gene Environment Interactions: Nature and Nurture in the Twenty-first Century offers a rare, synergistic view of ongoing revelations in gene environment interaction studies, drawing together key themes from epigenetics, microbiomics, disease etiology, and toxicology to illuminate pathways for clinical translation and the paradigm shift towards precision medicine. Across eleven chapters, Dr. Smith discusses interactions with the environment, human adaptations to environmental stimuli, pathogen encounters across the centuries, epigenetic modulation of gene expression, transgenerational inheritance, the microbiome's intrinsic effects on human health, and the gene-environment etiology of cardiovascular, metabolic, psychiatric, behavioral and monogenic disorders. Later chapters illuminate how our new understanding of gene environment interactions are driving advances in precision medicine and novel treatments. In addition, the book's author shares strategies to support clinical translation of these scientific findings to improve heath literacy among the general population. Offers a thorough, interdisciplinary discussion on recent revelations from gene environment interaction studies Illuminates environmental factors affecting disease-gene etiology and treatment Supports the clinical translation of gene environment interaction findings into novel therapeutics and precision medicine
Statistical Approaches To Gene Environment Interactions For Complex Phenotypes
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Author : Michael T. Windle
language : en
Publisher:
Release Date : 2016
Statistical Approaches To Gene Environment Interactions For Complex Phenotypes written by Michael T. Windle and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with SCIENCE categories.
Diverse methodological and statistical approaches for investigating the role of gene-environment interactions in a range of complex diseases and traits.