Gene Environment Interactions
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Gene Environment Interactions
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Author : Lucio G. Costa
language : en
Publisher: John Wiley & Sons
Release Date : 2005-12-16
Gene Environment Interactions written by Lucio G. Costa and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-12-16 with Science categories.
Understanding the play between heredity and environment, and relating it to disease causation, is the task of ecogenetics. Gene-Environment Interactions: Fundamentals of Ecogenetics presents the first comprehensive survey of this discipline, reflecting its relationship with toxicology, epidemiology, pharmacology, public health, and other medical and biological fields. Divided into four sections, the text elucidates key basic and advanced topics: * Section 1 covers fundamentals, including the history of the discipline, a discussion of the molecular laboratory tools currently available to assess genotypes, using such measurements in molecular epidemiology studies, and the statistical issues involved in their analysis. * Section 2 focuses on a number of key genetic polymorphisms relevant for ecogenetics, including enzymes of phase I and phase II metabolism, enzymes involved in DNA repair, as well as receptors and ion channels. This highlights characteristics of selected, widely studied genotypic/phenotypic differences, and allows discussion of how given genetic variations can influence responses to exogenous chemicals. * Section 3 examines gene-environment interactions through a disease-based approach, addressing how genetic polymorphisms can influence susceptibility to various diseases. Chapters cover important disease conditions such as various types of cancer, neurodegenerative diseases, cardiovascular disease, chronic pulmonary diseases, infectious diseases, diabetes, and obesity. * The final section discusses the ethical, legal, and social issues that arise when investigating and evaluating genetic polymorphisms in human populations, as well as the impact of ecogenetics on risk assessment, regulatory policies, and medicine and public health. Packed with clear examples illustrating concepts, as well as numerous tables and figures, Gene-Environment Interactions: Fundamentals of Ecogenetics is a unique resource for a wide range of physicians, students, and other specialists.
Cancer And The Environment
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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 2002-09-01
Cancer And The Environment written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-09-01 with Science categories.
The Roundtable on Environmental Health Sciences, Research, and Medicine wanted to address the link between environmental factors and the development of cancer in light of recent advances in genomics. They asked what research tools are needed, how new scientific information can be applied in a timely manner to reduce the burden of cancer, and how this can be flexible enough to treat the individual.
Gene Environment Interactions
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Author : Moyra Smith
language : en
Publisher: Academic Press
Release Date : 2020-01-24
Gene Environment Interactions written by Moyra Smith and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-24 with categories.
Gene Environment Interactions: Nature and Nurture in the Twenty-first Century offers a rare, synergistic view of ongoing revelations in gene environment interaction studies, drawing together key themes from epigenetics, microbiomics, disease etiology, and toxicology to illuminate pathways for clinical translation and the paradigm shift towards precision medicine. Across eleven chapters, Dr. Smith discusses interactions with the environment, human adaptations to environmental stimuli, pathogen encounters across the centuries, epigenetic modulation of gene expression, transgenerational inheritance, the microbiome's intrinsic effects on human health, and the gene-environment etiology of cardiovascular, metabolic, psychiatric, behavioral and monogenic disorders. Later chapters illuminate how our new understanding of gene environment interactions are driving advances in precision medicine and novel treatments. In addition, the book's author shares strategies to support clinical translation of these scientific findings to improve heath literacy among the general population. Offers a thorough, interdisciplinary discussion on recent revelations from gene environment interaction studies Illuminates environmental factors affecting disease-gene etiology and treatment Supports the clinical translation of gene environment interaction findings into novel therapeutics and precision medicine
Gene Environment Interactions In Developmental Psychopathology
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Author : Kenneth A. Dodge
language : en
Publisher: Guilford Press
Release Date : 2011-09-01
Gene Environment Interactions In Developmental Psychopathology written by Kenneth A. Dodge and has been published by Guilford Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-01 with Psychology categories.
Bringing together foremost experts, this book reviews groundbreaking gene–environment research and explores implications for clinical practice, prevention, and public policy. Presented is cutting-edge work on the interplay of genetic factors and childhood experiences in the development of mental disorders such as depression, conduct disorder, and schizophrenia. Essential topics include what scientists currently know about "susceptibility genes"; the mechanisms by which maltreatment and other stressors interact with biological susceptibilities across development; and factors that make certain children more resilient than others. Future directions for personalizing treatment and prevention efforts, thus making them more effective, are discussed.
Gene Environment Interactions In Psychiatry
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Author : Bart Ellenbroek
language : en
Publisher: Academic Press
Release Date : 2016-07-26
Gene Environment Interactions In Psychiatry written by Bart Ellenbroek and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-07-26 with Psychology categories.
Gene-Environment Interactions in Psychiatry: Nature, Nurture, Neuroscience begins with the basic aspects of gene–environment studies, such as basic genetics, principles of animals modeling, and the basic processes of how environmental factors affect brain and behavior, with part two describing the most important psychiatric disorders in detail. Each chapter has a similar structure that includes a general description of the disorder that is followed by an analysis of the role of genes and how they are affected by environmental factors. Each chapter ends with a description of the most relevant animal models, again focusing on gene–environment interactions. The book concludes with a critical evaluation of the current research and an outlook for the (possible) future, offering a vignette into the fascinating world of nature, nurture, and neuroscience. Written to provide in-depth basic knowledge on gene–environment interactions for graduate students, postgraduate students, clinicians, and scientists Includes descriptions of the major psychiatric disorders Provides detailed descriptions of animal models and basic genetic information Presents well-illustrated color figures to explain complex features in a simple manner
Gene Environment Interaction Analysis
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Author : Sumiko Anno
language : en
Publisher: CRC Press
Release Date : 2016-03-30
Gene Environment Interaction Analysis written by Sumiko Anno and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-03-30 with Mathematics categories.
Gene-environment (GE) interaction analysis is a statistical method for clarifying GE interactions applicable to a phenotype or a disease that is the result of interactions between genes and the environment. This book is the first to deal with the theme of GE interaction analysis. It compiles and details cutting-edge research in bioinformatics
Gene Environment Interactions In Birth Defects And Developmental Disorders
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Author :
language : en
Publisher: Elsevier
Release Date : 2023-02
Gene Environment Interactions In Birth Defects And Developmental Disorders written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-02 with Science categories.
Gene-Environment Interactions in Development and Disease, Volume 152 of the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Current Topics in Developmental Biology series Updated release includes the latest information on the Gene-Environment Interactions in Development and Disease
Gene Environment Transactions In Developmental Psychopathology
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Author : Patrick H. Tolan
language : en
Publisher: Springer
Release Date : 2017-04-29
Gene Environment Transactions In Developmental Psychopathology written by Patrick H. Tolan and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-04-29 with Psychology categories.
This book examines the current research in gene-environment transactions (GEX) and its potential use in developing interventions and applications tailored to individual genetic makeups. Key concepts underlying GEX studies in this area are defined, identifying fundamental challenges in devising informed research questions and conducting valid and useful experiments. Chapters analyze GEX models inspired by the present day genome-based frameworks, particularly in terms of advances in identifying and understanding complex environmental factors, using examples from common psychological conditions, such as antisocial behavior, chronic physical aggression, and chronic internalizing disorder. In addition, the book presents new and potential applications of the framework in the contexts of prevention science and intervention research. Topics featured in this book include: Epigenetics and the biology of gene x environment interactions. Gene by environment interactions and its potential use for intervention strategies in anxiety disorders. The challenges and potential for research on gene-environment interactions within autism spectrum disorder. Using genetically informed prevention trials to test gene x environment hypothese. Challenges for intervention research within the GEX framework. Gene-Environment Transactions in Developmental Psychopathology is a must-have resource for researchers/professors, clinicians, and related professionals as well as graduate students in developmental psychology, psychiatry, human genetics, and related disciplines.
Statistical Approaches To Gene X Environment Interactions For Complex Phenotypes
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Author : Michael Windle
language : en
Publisher: MIT Press
Release Date : 2016-07-08
Statistical Approaches To Gene X Environment Interactions For Complex Phenotypes written by Michael Windle and has been published by MIT Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-07-08 with Science categories.
Diverse methodological and statistical approaches for investigating the role of gene-environment interactions in a range of complex diseases and traits. Findings from the Human Genome Project and from Genome-Wide Association (GWA) studies indicate that many diseases and traits manifest a more complex genomic pattern than previously assumed. These findings, and advances in high-throughput sequencing, suggest that there are many sources of influence—genetic, epigenetic, and environmental. This volume investigates the role of the interactions of genes and environment (G × E) in diseases and traits (referred to by the contributors as complex phenotypes) including depression, diabetes, obesity, and substance use. The contributors first present different statistical approaches or strategies to address G × E and G × G interactions with high-throughput sequenced data, including two-stage procedures to identify G × E and G × G interactions, marker-set approaches to assessing interactions at the gene level, and the use of a partial-least square (PLS) approach. The contributors then turn to specific complex phenotypes, research designs, or combined methods that may advance the study of G × E interactions, considering such topics as randomized clinical trials in obesity research, longitudinal research designs and statistical models, and the development of polygenic scores to investigate G × E interactions. Contributors Fatima Umber Ahmed, Yin-Hsiu Chen, James Y. Dai, Caroline Y. Doyle, Zihuai He, Li Hsu, Shuo Jiao, Erin Loraine Kinnally, Yi-An Ko, Charles Kooperberg, Seunggeun Lee, Arnab Maity, Jeanne M. McCaffery, Bhramar Mukherjee, Sung Kyun Park, Duncan C. Thomas, Alexandre Todorov, Jung-Ying Tzeng, Tao Wang, Michael Windle, Min Zhang
Multi Omics Strategies For Detecting Gene Environment Interactions
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Author : Patrick Deelen
language : en
Publisher: Patrick Deelen
Release Date : 2019-05-06
Multi Omics Strategies For Detecting Gene Environment Interactions written by Patrick Deelen and has been published by Patrick Deelen this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-06 with Science categories.
Our DNA, 3 billion letters long, is the blueprint of life. People differ from each other in around 1% of these letters. However, it is largely unknown which of these differences cause disease, nor how exactly changes in DNA ultimately lead to disease. In my PhD research I contributed to the detection of these genetic risk factors and studied how these DNA changes actually disrupt the correct functioning of cells. Using the "Genome of the Netherlands" project results, in which the BBMRI-NL consortium fully mapped the DNA of 250 Dutch families, I was able to improve genetic research in other groups of people and thereby better detect genetic risk factors. I then looked at how these DNA changes disrupt individual cells in a large number of people participating in various Dutch bio-banks such as Lifelines. By looking at DNA, RNA, epigenetics and proteins at the same time, I was able to discover many genetic risk factors, which biological processes they disrupt, and which ones offer starting points for the development of new medicines that can repair these disrupted processes. In addition, through the large-scale re-use of RNA data, I was able to map how many genes relate together and to disease. With these big data analyses, I subsequently developed a new algorithm that is now being used to make a diagnosis more quickly in people with a serious illness. With my PhD research, I contributed to the immediate improvement of patient care and collected new knowledge that could help in the longer term with the development of new medicines.