Multi Omics Strategies For Detecting Gene Environment Interactions

DOWNLOAD

Download Multi Omics Strategies For Detecting Gene Environment Interactions PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Multi Omics Strategies For Detecting Gene Environment Interactions book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page

Multi Omics Strategies For Detecting Gene Environment Interactions

DOWNLOAD
Author : Patrick Deelen
language : en
Publisher: Patrick Deelen
Release Date : 2019-05-06

Multi Omics Strategies For Detecting Gene Environment Interactions written by Patrick Deelen and has been published by Patrick Deelen this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-06 with Science categories.

Our DNA, 3 billion letters long, is the blueprint of life. People differ from each other in around 1% of these letters. However, it is largely unknown which of these differences cause disease, nor how exactly changes in DNA ultimately lead to disease. In my PhD research I contributed to the detection of these genetic risk factors and studied how these DNA changes actually disrupt the correct functioning of cells. Using the "Genome of the Netherlands" project results, in which the BBMRI-NL consortium fully mapped the DNA of 250 Dutch families, I was able to improve genetic research in other groups of people and thereby better detect genetic risk factors. I then looked at how these DNA changes disrupt individual cells in a large number of people participating in various Dutch bio-banks such as Lifelines. By looking at DNA, RNA, epigenetics and proteins at the same time, I was able to discover many genetic risk factors, which biological processes they disrupt, and which ones offer starting points for the development of new medicines that can repair these disrupted processes. In addition, through the large-scale re-use of RNA data, I was able to map how many genes relate together and to disease. With these big data analyses, I subsequently developed a new algorithm that is now being used to make a diagnosis more quickly in people with a serious illness. With my PhD research, I contributed to the immediate improvement of patient care and collected new knowledge that could help in the longer term with the development of new medicines.

Evolution Of Translational Omics

DOWNLOAD
Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 2012-09-13

Evolution Of Translational Omics written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-09-13 with Science categories.

Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials.

Multi Omics And Computational Biology In Horticultural Plants From Genotype To Phenotype Volume Ii

DOWNLOAD
Author : Yunpeng Cao
language : en
Publisher: Frontiers Media SA
Release Date : 2024-02-13

Multi Omics And Computational Biology In Horticultural Plants From Genotype To Phenotype Volume Ii written by Yunpeng Cao and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-02-13 with Science categories.

This Research Topic is part of the article collection series - Multi-omics and Computational Biology in Horticultural Plants: From Genotype to Phenotype. Horticultural plants play an important role for humans by providing herbal medicines, beverages, vegetables, fruits, and ornamentals. High-throughput technologies have revolutionised the time scale and power of detecting insights into physiological changes and biological mechanisms in plants. All sequencing data and tools have helped us better understand the evolutionary histories of horticultural plants and provide genotype and phenotype resources for molecular studies on economically important traits. The integration of these -omics technologies (e.g., genomics, transcriptomics, proteomics, metabolomics, lipidomics, ionomics, and redoxomics) is currently at the forefront of plant research. The genomes of horticultural plants are highly diverse and complex, often with a high degree of heterozygosity and polyploidy. Novel computational methods need to be developed to take advantage of state-of-the-art genomic technologies. As a result, the mining of multi-omics data and the development of new computational biology approaches for the reliable and efficient analysis of plant traits is necessary.

Multi Omics Approaches To Study Signaling Pathways

DOWNLOAD
Author : Jyoti Sharma
language : en
Publisher: Frontiers Media SA
Release Date : 2020-11-18

Multi Omics Approaches To Study Signaling Pathways written by Jyoti Sharma and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-18 with Science categories.

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Health Impacts Of Developmental Exposure To Environmental Chemicals

DOWNLOAD
Author : Reiko Kishi
language : en
Publisher: Springer Nature
Release Date : 2019-12-13

Health Impacts Of Developmental Exposure To Environmental Chemicals written by Reiko Kishi and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-12-13 with Medical categories.

This book provides concise and cutting-edge studies on threats resulting from exposure to environmental chemicals that can affect human health and development, with a particular emphasis on the DOHaD concept. The book is divided into five main parts, the first of which includes an introduction to the impacts of developmental exposure to environmental chemicals and historical perspectives, while the second focuses on how environmental chemicals can affect human organs, including neurodevelopment, immune functions, etc. In turn, the third part addresses the characteristics of specific chemicals and their effects on human health and development, while the fourth part provides a basis for future studies by highlighting the latest innovations in toxicology, remaining challenges, and promising strategies in children’s environmental health research, as well as ideas on how to bridge the gap between research evidence and practical policymaking. The fifth and last part outlines further research directions and related policymaking aspects. Health Impacts of Developmental Exposure to Environmental Chemicals will appeal to young and veteran researchers, students, and physicians (especially gynecologists and pediatricians) who are seeking comprehensive information on how children’s health can be affected by harmful chemicals and other environmental toxicants.

Data Analysis For Omic Sciences Methods And Applications

DOWNLOAD
Author :
language : en
Publisher: Elsevier
Release Date : 2018-09-22

Data Analysis For Omic Sciences Methods And Applications written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-09-22 with Science categories.

Data Analysis for Omic Sciences: Methods and Applications, Volume 82, shows how these types of challenging datasets can be analyzed. Examples of applications in real environmental, clinical and food analysis cases help readers disseminate these approaches. Chapters of note include an Introduction to Data Analysis Relevance in the Omics Era, Omics Experimental Design and Data Acquisition, Microarrays Data, Analysis of High-Throughput RNA Sequencing Data, Analysis of High-Throughput DNA Bisulfite Sequencing Data, Data Quality Assessment in Untargeted LC-MS Metabolomic, Data Normalization and Scaling, Metabolomics Data Preprocessing, and more. Presents the best reference book for omics data analysis Provides a review of the latest trends in transcriptomics and metabolomics data analysis tools Includes examples of applications in research fields, such as environmental, biomedical and food analysis

Youmares 8 Oceans Across Boundaries Learning From Each Other

DOWNLOAD
Author : Simon Jungblut
language : en
Publisher: Springer
Release Date : 2018-08-29

Youmares 8 Oceans Across Boundaries Learning From Each Other written by Simon Jungblut and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-08-29 with Science categories.

This open access book presents the proceedings volume of the YOUMARES 8 conference, which took place in Kiel, Germany, in September 2017, supported by the German Association for Marine Sciences (DGM). The YOUMARES conference series is entirely bottom-up organized by and for YOUng MARine RESearchers. Qualified early career scientists moderated the scientific sessions during the conference and provided literature reviews on aspects of their research field. These reviews and the presenters’ conference abstracts are compiled here. Thus, this book discusses highly topical fields of marine research and aims to act as a source of knowledge and inspiration for further reading and research.

Multi Omics Strategies To Analyze Complex Agronomic Traits In Plants

DOWNLOAD
Author : Lin Chen
language : en
Publisher: Frontiers Media SA
Release Date : 2023-11-01

Multi Omics Strategies To Analyze Complex Agronomic Traits In Plants written by Lin Chen and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-11-01 with Science categories.

Omics For Personalized Medicine

DOWNLOAD
Author : Debmalya Barh
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-10-14

Omics For Personalized Medicine written by Debmalya Barh and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-14 with Medical categories.

“Omics for Personalized Medicine” will give to its prospective readers the insight of both the current developments and the future potential of personalized medicine. The book brings into light how the pharmacogenomics and omics technologies are bringing a revolution in transforming the medicine and the health care sector for the better. Students of biomedical research and medicine along with medical professionals will benefit tremendously from the book by gaining from the diverse fields of knowledge of new age personalized medicine presented in the highly detailed chapters of the book. The book chapters are divided into two sections for convenient reading with the first section covering the general aspects of pharmaocogenomic technology that includes latest research and development in omics technologies. The first section also highlights the role of omics in modern clinical trials and even discusses the ethical consideration in pharmocogenomics. The second section is focusing on the development of personalized medicine in several areas of human health. The topics covered range from metabolic and neurological disorders to non-communicable as well as infectious diseases, and even explores the role of pharmacogenomics in cell therapy and transplantation technology. Thirty-four chapters of the book cover several aspects of pharmacogenomics and personalized medicine and have taken into consideration the varied interest of the readers from different fields of biomedical research and medicine. Advent of pharmacogenomics is the future of modern medicine, which has resulted from culmination of decades of research and now is showing the way forward. The book is an honest endeavour of researchers from all over the world to disseminate the latest knowledge and knowhow in personalized medicine to the community health researchers in particular and the educated public in general.

Unsupervised Feature Extraction Applied To Bioinformatics

DOWNLOAD
Author : Y-h. Taguchi
language : en
Publisher: Springer Nature
Release Date : 2019-08-23

Unsupervised Feature Extraction Applied To Bioinformatics written by Y-h. Taguchi and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-23 with Technology & Engineering categories.

This book proposes applications of tensor decomposition to unsupervised feature extraction and feature selection. The author posits that although supervised methods including deep learning have become popular, unsupervised methods have their own advantages. He argues that this is the case because unsupervised methods are easy to learn since tensor decomposition is a conventional linear methodology. This book starts from very basic linear algebra and reaches the cutting edge methodologies applied to difficult situations when there are many features (variables) while only small number of samples are available. The author includes advanced descriptions about tensor decomposition including Tucker decomposition using high order singular value decomposition as well as higher order orthogonal iteration, and train tenor decomposition. The author concludes by showing unsupervised methods and their application to a wide range of topics. Allows readers to analyze data sets with small samples and many features; Provides a fast algorithm, based upon linear algebra, to analyze big data; Includes several applications to multi-view data analyses, with a focus on bioinformatics.