Statistical Approaches To Gene X Environment Interactions For Complex Phenotypes
DOWNLOAD
Download Statistical Approaches To Gene X Environment Interactions For Complex Phenotypes PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Statistical Approaches To Gene X Environment Interactions For Complex Phenotypes book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Statistical Approaches To Gene X Environment Interactions For Complex Phenotypes
DOWNLOAD
Author : Michael Windle
language : en
Publisher: MIT Press
Release Date : 2016-07-08
Statistical Approaches To Gene X Environment Interactions For Complex Phenotypes written by Michael Windle and has been published by MIT Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-07-08 with Computers categories.
Findings from the Human Genome Project and from Genome-Wide Association (GWA) studies indicate that many diseases and traits manifest a more complex genomic pattern than previously assumed. These findings, and advances in high-throughput sequencing, suggest that there are many sources of influence-genetic, epigenetic, and environmental. This volume investigates the role of the interactions of genes and environment (G x E) in diseases and traits (referred to by the contributors as complex phenotypes) including depression, diabetes, obesity, and substance use.
Statistical Approaches To Gene Environment Interactions For Complex Phenotypes
DOWNLOAD
Author : Michael T. Windle
language : en
Publisher:
Release Date : 2016
Statistical Approaches To Gene Environment Interactions For Complex Phenotypes written by Michael T. Windle and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with SCIENCE categories.
Diverse methodological and statistical approaches for investigating the role of gene-environment interactions in a range of complex diseases and traits.
Assessing Gene Environment Interactions In Genome Wide Association Studies Statistical Approaches
DOWNLOAD
Author : Philip C. Cooley
language : en
Publisher: RTI Press
Release Date : 2014-05-14
Assessing Gene Environment Interactions In Genome Wide Association Studies Statistical Approaches written by Philip C. Cooley and has been published by RTI Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-05-14 with Science categories.
In this report, we address a scenario that uses synthetic genotype case-control data that is influenced by environmental factors in a genome-wide association study (GWAS) context. The precise way the environmental influence contributes to a given phenotype is typically unknown. Therefore, our study evaluates how to approach a GWAS that may have an environmental component. Specifically, we assess different statistical models in the context of a GWAS to make association predictions when the form of the environmental influence is questionable. We used a simulation approach to generate synthetic data corresponding to a variety of possible environmental-genetic models, including a “main effects only” model as well as a “main effects with interactions” model. Our method takes into account the strength of the association between phenotype and both genotype and environmental factors, but we focus on low-risk genetic and environmental risks that necessitate using large sample sizes (N = 10,000 and 200,000) to predict associations with high levels of confidence. We also simulated different Mendelian gene models, and we analyzed how the collection of factors influences statistical power in the context of a GWAS. Using simulated data provides a “truth set” of known outcomes such that the association-affecting factors can be unambiguously determined. We also test different statistical methods to determine their performance properties. Our results suggest that the chances of predicting an association in a GWAS is reduced if an environmental effect is present and the statistical model does not adjust for that effect. This is especially true if the environmental effect and genetic marker do not have an interaction effect. The functional form of the statistical model also matters. The more accurately the form of the environmental influence is portrayed by the statistical model, the more accurate the prediction will be. Finally, even with very large samples sizes, association predictions involving recessive markers with low risk can be poor
Phenotypic Plasticity Evolution
DOWNLOAD
Author : David W. Pfennig
language : en
Publisher: CRC Press
Release Date : 2021-05-31
Phenotypic Plasticity Evolution written by David W. Pfennig and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-05-31 with Science categories.
Phenotypic plasticity – the ability of an individual organism to alter its features in direct response to a change in its environment – is ubiquitous. Understanding how and why this phenomenon exists is crucial because it unites all levels of biological inquiry. This book brings together researchers who approach plasticity from diverse perspectives to explore new ideas and recent findings about the causes and consequences of plasticity. Contributors also discuss such controversial topics as how plasticity shapes ecological and evolutionary processes; whether specific plastic responses can be passed to offspring; and whether plasticity has left an important imprint on the history of life. Importantly, each chapter highlights key questions for future research. Drawing on numerous studies of plasticity in natural populations of plants and animals, this book aims to foster greater appreciation for this important, but frequently misunderstood phenomenon. Key Features Written in an accessible style with numerous illustrations, including many in color Reviews the history of the study of plasticity, including Darwin’s views Most chapters conclude with recommendations for future research
The Encyclopedia Of Clinical Psychology 5 Volume Set
DOWNLOAD
Author : Robin L. Cautin
language : en
Publisher: John Wiley & Sons
Release Date : 2015-01-20
The Encyclopedia Of Clinical Psychology 5 Volume Set written by Robin L. Cautin and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-01-20 with Psychology categories.
"Recommended. Undergraduates through faculty/researchers; professionals/practitioners;general readers." —Choice Includes well over 500 A-Z entries of between 500 and 7,500 words in length covering the main topics, key concepts, and influential figures in the field of clinical psychology Serves as a comprehensive reference with emphasis on philosophical and historical issues, cultural considerations, and conflicts Offers a historiographical overview of the ways in which research influences practice Cites the best and most up-to-date scientific evidence for each topic, encouraging readers to think critically 5 Volumes www.encyclopediaclinicalpsychology.com
Genetic Mapping And Marker Assisted Selection
DOWNLOAD
Author : N. Manikanda Boopathi
language : en
Publisher: Springer Nature
Release Date : 2020-04-07
Genetic Mapping And Marker Assisted Selection written by N. Manikanda Boopathi and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-07 with Medical categories.
The first edition of this book, Genetic Mapping and Marker Assisted Selection: Basics, Practice and Benefits, was widely appreciated as the first of its kind on this topic and has been listed as a reference work in several agricultural universities’ curricula. A great deal has happened over the last five years, making it high time to incorporate recent developments in genetic mapping and report on novel strategies in marker assisted selection in crop plants as a second edition. This book addresses a range of topics, including: new marker types and their genotyping methods based on high-throughput technologies, advances in genomics and their role in new marker development, improvements in genetic mapping strategies and software updates, developments in phenomics and their applications in QTL mapping, and how to incorporate these developments and advances in marker assisted selection in crop plants. Similar to the first edition, each technique and method is explained using a step-by-step method, allowing the book to serve as a self-study guide for scholars whose work involves the genetic improvement of crop plants for any trait of interest, particularly for biotic and abiotic stress resistance. In addition, the book offers a valuable guide for undergraduate and graduate students at agricultural universities and institutes that are interested and/or involved in the genetic improvement of crop plants using modern tools. In addition, the bibliography includes a list of suggested works for pursuing further research on the topics covered.
Recent Highlights In Molecular Medicine
DOWNLOAD
Author : Ignazio Castagliuolo
language : en
Publisher: Frontiers Media SA
Release Date : 2023-10-04
Recent Highlights In Molecular Medicine written by Ignazio Castagliuolo and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-04 with Science categories.
Genetics Primer For Exercise Science And Health
DOWNLOAD
Author : Stephen M. Roth
language : en
Publisher: Human Kinetics
Release Date : 2007
Genetics Primer For Exercise Science And Health written by Stephen M. Roth and has been published by Human Kinetics this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Health & Fitness categories.
The text maintains a practical focus while providing updates on current research findings and exploring how genetics may affect clinical practice and sport performance training.
The Genetic Basis Of Common Diseases
DOWNLOAD
Author : Richard A. King
language : en
Publisher: Oxford University Press
Release Date : 2002-10-17
The Genetic Basis Of Common Diseases written by Richard A. King and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-10-17 with Medical categories.
Since the first edition of this highly acclaimed text was published in 1992, much new knowledge has been gained about the role of genetic factors in common adult diseases, and we now have a better understanding of the molecular processes involved in genetic susceptibility and diseases mechanisms. The second edition fully incorporates these advances. The entire book has been updated and twelve new chapters have been added. Most of these chapters deal with diseases such as gallstones, osteoporosis, osteoarthritis, skin cancer, other common skin diseases, prostate cancer and migraine headaches that are seen by all physicians. Others address the genetic and molecular basis of spondylarthropathies, lupus, hemochromatosis, IgA deficiency, mental retardation, hearing loss, and the role of mitochondrial variation in adult diseases. Chapters on the evolution of human genetic disease and on animal models add important background on the omplexities of these diseases. Unique clinical applications of genetics to common diseases are covered in the additional new chapters on genetic counseling, pharmacogenetics, and the genetic consequences of modern therapeutics.
Our Canine Connection The History Benefits And Future Of Human Dog Interactions
DOWNLOAD
Author : Sandra McCune
language : en
Publisher: Frontiers Media SA
Release Date : 2022-04-11
Our Canine Connection The History Benefits And Future Of Human Dog Interactions written by Sandra McCune and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-11 with Science categories.