Genes That Affect Development And Biological Timing In Caenorhabditis Elegans
DOWNLOAD
Download Genes That Affect Development And Biological Timing In Caenorhabditis Elegans PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Genes That Affect Development And Biological Timing In Caenorhabditis Elegans book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Genes That Affect Development And Biological Timing In Caenorhabditis Elegans
DOWNLOAD
Author : Yan Meng
language : en
Publisher:
Release Date : 2000
Genes That Affect Development And Biological Timing In Caenorhabditis Elegans written by Yan Meng and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Caenorhabditis elegans categories.
"In an effort to find new genes involved in development and the biological timing, I carried out a new screen for viable maternal-effect mutations similar in protocol to the previous screen in which 24 such genes have been identified. I screened 10,600 genomes and isolated 6 slow-growing mutations and 5 behavioral and morphological mutations. Another maternal-effect slow-growing mutation is isolated from a screen for both maternal-effect and non maternal-effect slow development mutations. Genetic mapping suggests that none of the seven slow growing mutations corresponds to previously identified genes, so seven new clk genes (clk-4, clk-5, clk-6, clk-7 clk-8, clk-9, clk-10) have been identified. Because most identified clk genes (clk-2, clk-4 to clk-10 and gro-1) are defined by single allele, we believe that these genes have not yet been saturated. Mutants of seven new clk genes have typical Clk phenotypes: a mean lengthening of embryonic development, postembryonic development, defecation cycle and life span. As the screening procedure did not involve any measure of life span, it is suggested that slow life is sufficient for long life. As expected, all seven mutations can be maternally rescued." --
Genes That Affect Development And Biological Timing In Caenorhabditis Elegans
DOWNLOAD
Author : Yan Meng
language : en
Publisher:
Release Date : 2000
Genes That Affect Development And Biological Timing In Caenorhabditis Elegans written by Yan Meng and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Caenorhabditis elegans categories.
"In an effort to find new genes involved in development and the biological timing, I carried out a new screen for viable maternal-effect mutations similar in protocol to the previous screen in which 24 such genes have been identified. I screened 10,600 genomes and isolated 6 slow-growing mutations and 5 behavioral and morphological mutations. Another maternal-effect slow-growing mutation is isolated from a screen for both maternal-effect and non maternal-effect slow development mutations. Genetic mapping suggests that none of the seven slow growing mutations corresponds to previously identified genes, so seven new clk genes (clk-4, clk-5, clk-6, clk-7 clk-8, clk-9, clk-10) have been identified. Because most identified clk genes (clk-2, clk-4 to clk-10 and gro-1) are defined by single allele, we believe that these genes have not yet been saturated. Mutants of seven new clk genes have typical Clk phenotypes: a mean lengthening of embryonic development, postembryonic development, defecation cycle and life span. As the screening procedure did not involve any measure of life span, it is suggested that slow life is sufficient for long life. As expected, all seven mutations can be maternally rescued." --
Unifying Mechanisms Of Developmental Timing
DOWNLOAD
Author : Gabriela Carolina Monsalve
language : en
Publisher:
Release Date : 2013
Unifying Mechanisms Of Developmental Timing written by Gabriela Carolina Monsalve and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with categories.
Chronobiologists focus on understanding at least two ways of regulating the time of life: biological clocks that anticipate environmental conditions, and temporal switches that regulate sequential events. Of the former, the best-characterized biological clocks regulate circadian rhythms in metazoans. These self sustaining oscillators involve transcriptional-translational feedback loops that affect the physiology of the organism. In contrast, progression through development requires the proper temporal coordination of factors that control sequential events. However, the timing mechanisms that coordinate both cyclical and successive events in development are not generally well understood. The molting cycle of C. elegans is an example of both a periodic and sequential developmental program. Molting of the exoskeleton involves the coordinated synthesis, secretion, and assembly of a new skeleton, as well as degradation of the old one. Quiescent behaviors also accompany the molting cycle. Worms molt four times, approximately once every eight hours when cultivated at room temperature. The molts are coordinated with successive transitions in the temporal fates of epidermal stem cells, which are programmed by genes in the heterochronic regulatory network. Every molt is a critical developmental transition and mis-coordination of the either the sequential or reiterative events can lead to larval arrest and death. This thesis describes how the C. elegans heterochronic gene lin-42a, homologous to the mammalian circadian clock protein PERIOD, is required for cyclical and sequential progression of development. The oscillatory expression of lin-42a in the epidermis peaks during the molts. Inactivation of lin-42a results in arrhythmic molts and continuously abnormal epidermal stem cell dynamics. In contrast, forced expression of lin-42a leads to anachronistic larval molts and lethargy in adults. These results suggest that rising and falling levels of LIN-42A allow the start and completion, respectively, of larval molts. Ancillary factors of the molting timer likely include the conserved nuclear hormone receptors NHR-23/ROR[alpha] and NHR-25/SF1, and the family of let-7 microRNAs. Thus, interconnected positive and negative regulatory interactions among LIN-42A, NHR-23 and -25, and let-7 may drive transitions through each molt. I propose that these factors regulate molting cycles in much the same way that PERIOD-based oscillators drive rhythmic behaviors and metabolic processes in mature mammals. The LIN-42-based timer may synchronize the periodic molts with fluctuations in external or internal conditions, in much the same way that circadian clocks synchronize rhythmic biological processes of higher metazoans with recurrent fluctuations in zeitgebers. To identify novel factors that regulate these molting cues, we designed a forward genetic screen to identify novel factors that regulate the timing of the molt. I identified that the LRP-2/Megalin receptor is required for the cessation of larval molting cycles. The lrp-2 transcripts are detected predominately in the anterior head neurons, suggesting that that major site of action of LRP-2 is in the nervous system. LRP-2 may function to sequester neuroendocrine cues from other tissues to control the terminal fate of larval molts. By analyzing the genetic and molecular mechanisms of that regulate the molting cycle, we anticipate the discovery of the broader mechanisms that couple biological periodicity and rapid development in higher organisms.
Developmental Timing
DOWNLOAD
Author :
language : en
Publisher: Academic Press
Release Date : 2013-09-04
Developmental Timing written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-09-04 with Science categories.
This new volume of Current Topics in Developmental Biology covers developmental timing, with contributions from an international board of authors. The chapters provide a comprehensive set of reviews covering such topics as the timing of developmental programs in Drosophila, temporal patterning of neural progenitors, and environmental modulation of developmental timing.
Caenorhabditis Elegans
DOWNLOAD
Author :
language : en
Publisher: Academic Press
Release Date : 2011-11-23
Caenorhabditis Elegans written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-11-23 with Technology & Engineering categories.
An updated edition of the classic Methods in Cell Biology volume 48, this book emphasizes diverse methods and technologies needed to investigate C. elegans, both as an integrated organism and as a model system for research inquiries in cell, developmental, and molecular biology, as well as in genetics and pharmacology. By directing its audience to tried-and-true and cutting-edge recipes for research, this comprehensive collection is intended to guide investigators of C. elegans for years to come. Diverse, up-to-date techniques covered will be useful to the broadening community of C. elegans researchers for years to come Chapters written by leaders in the field Tried and true methods deliver busy researchers a one-stop compendium of essential protocols
Molecular Biology Of The Cell
DOWNLOAD
Author : Bruce Alberts
language : en
Publisher:
Release Date : 2002
Molecular Biology Of The Cell written by Bruce Alberts and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Cytology categories.
C Elegans Ii
DOWNLOAD
Author : Donald L. Riddle
language : en
Publisher: Firefly Books
Release Date : 1997
C Elegans Ii written by Donald L. Riddle and has been published by Firefly Books this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Medical categories.
Defines the current status of research in the genetics, anatomy, and development of the nematode C. elegans, providing a detailed molecular explanation of how development is regulated and how the nervous system specifies varied aspects of behavior. Contains sections on the genome, development, neural networks and behavior, and life history and evolution. Appendices offer genetic nomenclature, a list of laboratory strain and allele designations, skeleton genetic maps, a list of characterized genes, a table of neurotransmitter assignments for specific neurons, and information on codon usage. Includes bandw photos. For researchers in worm studies, as well as the wider community of researchers in cell and molecular biology. Annotation copyrighted by Book News, Inc., Portland, OR
Lin 42 And Control Of Developmental Timing In Caenorhabditis Elegans
DOWNLOAD
Author : Heather Frances Gardner
language : en
Publisher:
Release Date : 2005
Lin 42 And Control Of Developmental Timing In Caenorhabditis Elegans written by Heather Frances Gardner and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with categories.
Lin 42 The C Elegans Homolog Of The Circadian Rhythm Gene Period Controls Developmental Timing And Dauer Formation
DOWNLOAD
Author : Jason Michael Tennessen
language : en
Publisher:
Release Date : 2007
Lin 42 The C Elegans Homolog Of The Circadian Rhythm Gene Period Controls Developmental Timing And Dauer Formation written by Jason Michael Tennessen and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Caenorhabditis elegans categories.
Scientific Frontiers In Developmental Toxicology And Risk Assessment
DOWNLOAD
Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 2000-12-21
Scientific Frontiers In Developmental Toxicology And Risk Assessment written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-12-21 with Nature categories.
Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.