Genetic Analysis Of Animal Models To Understand The Genomic Architecture Of Substance Use Disorders
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Genetic Analysis Of Animal Models To Understand The Genomic Architecture Of Substance Use Disorders
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Author : Gary T. Hardiman
language : en
Publisher: Frontiers Media SA
Release Date : 2022-11-03
Genetic Analysis Of Animal Models To Understand The Genomic Architecture Of Substance Use Disorders written by Gary T. Hardiman and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-03 with Medical categories.
Handbook Of Pharmacogenomics And Stratified Medicine
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Author : Sandosh Padmanabhan
language : en
Publisher: Academic Press
Release Date : 2014-04-28
Handbook Of Pharmacogenomics And Stratified Medicine written by Sandosh Padmanabhan and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-04-28 with Science categories.
Handbook of Pharmacogenomics and Stratified Medicine is a comprehensive resource to understand this rapidly advancing field aiming to deliver the right drug at the right dose to the right patient at the right time. It is designed to provide a detailed, but accessible review of the entire field from basic principles to applications in various diseases. The chapters are written by international experts to allow readers from a wide variety of backgrounds, clinical and non-clinical (basic geneticists, pharmacologists, clinicians, trialists, industry personnel, ethicists) to understand the principles underpinning the progress in this area, the successes, failures and the challenges ahead. To be accessible to the widest range of readers, the clinical application section introduces the disease process, existing therapies, followed by pharmacogenomics and stratified medicine details.Medicine is the cornerstone of modern therapeutics prescribed on the basis that its benefit should outweigh its risk. It is well known that people respond differently to medications and in many cases the risk-benefit ratio for a particular drug may be a gray area. The last decade has seen a revolution in genomics both in terms of technological innovation and discovering genetic markers associated with disease. In parallel there has been steady progress in trying to make medicines safer and tailored to the individual. This has occurred across the whole spectrum of medicine, some more than others. In addition there is burgeoning interest from the pharmaceutical industry to leverage pharmacogenomics for more effective and efficient clinical drug development. - Provides clinical and non-clinical researchers with practical information normally beyond their usual areas of research or expertise - Includes an basic principles section explaining concepts of basic genetics, genetic epidemiology, bioinformatics, pharmacokinetics and pharmacodynamics - Covers newer technologies– next generation sequencing, proteomics, metabolomics - Provides information on animal models, lymphoblastoid cell lines, stem cells - Provides detailed chapters on a wide range of disease conditions, implementation and regulatory issues - Includes chapters on the global implications of pharmacogenomics
Genomic Architecture Of Cardiovascular Diseases
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Author : Seitaro Nomura
language : en
Publisher: Frontiers Media SA
Release Date : 2022-06-21
Genomic Architecture Of Cardiovascular Diseases written by Seitaro Nomura and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-06-21 with Medical categories.
Animal Models For The Study Of Human Disease
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Author : P. Michael Conn
language : en
Publisher: Academic Press
Release Date : 2013-05-29
Animal Models For The Study Of Human Disease written by P. Michael Conn and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-29 with Science categories.
Animal Models for the Study of Human Disease identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease. The first section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine.The next sections of the work offers models for disease-oriented topics, including cardiac and pulmonary diseases, aging, infectious diseases, obesity, diabetes, neurological diseases, joint diseases, visual disorders, cancer, hypertension, genetic diseases, and diseases of abuse. - Organized by disease orientation for ease of searchability - Provides information on locating resources, animal alternatives and animal ethics - Covers a broad range of animal models used in research for human disease
Charney And Nestler S Neurobiology Of Mental Illness
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Author : Dennis Charney
language : en
Publisher: Oxford University Press
Release Date : 2025-01-03
Charney And Nestler S Neurobiology Of Mental Illness written by Dennis Charney and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-01-03 with Education categories.
"The genetic investigation into mental illnesses has progressed rapidly since the mapping of the human genome. Driven by advances in genomic profiling technology, massive genomic datasets are powering the discovery of genetic variation associated to complex traits including mental illness. From severe neurodevelopmental disorders to schizophrenia and depression, genetic variation plays some role in risk. Critically, most mental illnesses are complex, multifactorial and the consequence of a combination of genetic and environmental influences. This chapter will introduce the genome, its variation, and the methods used to identify what variants and genes matter for mental illnesses"--
The Oxford Handbook Of Substance Use And Substance Use Disorders
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Author : Kenneth J. Sher
language : en
Publisher:
Release Date : 2016
The Oxford Handbook Of Substance Use And Substance Use Disorders written by Kenneth J. Sher and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with Psychology categories.
The Oxford Handbook of Substance Use and Substance Use Disorders provides comprehensive reviews of key areas of inquiry into the fundamental nature of substance use and SUDs, their features, causes, consequences, course, treatment, and prevention.
Index Medicus
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Author :
language : en
Publisher:
Release Date : 2004
Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Medicine categories.
Substance Use Disorders
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Author : Perry M. Duncan
language : en
Publisher: Cambridge University Press
Release Date : 2020-09-17
Substance Use Disorders written by Perry M. Duncan and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-17 with Medical categories.
Cognitive-behavioural principles are integrated with genetic and psychiatric factors to explain addiction's causes and consequences.
The Nonhuman Primate In Nonclinical Drug Development And Safety Assessment
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Author : Joerg Bluemel
language : en
Publisher: Academic Press
Release Date : 2015-03-13
The Nonhuman Primate In Nonclinical Drug Development And Safety Assessment written by Joerg Bluemel and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-03-13 with Medical categories.
The Nonhuman Primate in Drug Development and Safety Assessment is a valuable reference dedicated to compiling the latest research on nonhuman primate models in nonclinical safety assessment, regulatory toxicity testing and translational science. By covering important topics such as study planning and conduct, inter-species genetic drift, pathophysiology, animal welfare legislation, safety assessment of biologics and small molecules, immunotoxicology and much more, this book provides scientific and technical insights to help you safely and successfully use nonhuman primates in pharmaceutical toxicity testing. A comprehensive yet practical guide, this book is intended for new researchers or practicing toxicologists, toxicologic pathologists and pharmaceutical scientists working with nonhuman primates, as well as graduate students preparing for careers in this area. - Covers important topics such as species selection, study design, experimental methodologies, animal welfare and the 3Rs (Replace, Refine and Reduce), social housing, regulatory guidelines, comparative physiology, reproductive biology, genetic polymorphisms and more - Includes practical examples on techniques and methods to guide your daily practice - Offers a companion website with high-quality color illustrations, reference values for safety assessment and additional practical information such as study design considerations, techniques and procedures and dosing and sampling volumes
Charney Nestler S Neurobiology Of Mental Illness
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Author : Dennis S. Charney MD
language : en
Publisher: Oxford University Press
Release Date : 2017-11-29
Charney Nestler S Neurobiology Of Mental Illness written by Dennis S. Charney MD and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-29 with Medical categories.
In the years following publication of the DSM-5®, the field of psychiatry has seen vigorous debate between the DSM's more traditional, diagnosis-oriented approach and the NIMH's more biological, dimension-based RDoC (research domain criteria) approach. Charney & Nestler's Neurobiology of Mental Illness is an authoritative foundation for translating information from the laboratory to clinical treatment, and its fifth edition extends beyond this reference function to acknowledge and examine the controversies, different camps, and thoughts on the future of psychiatric diagnosis. In this wider context, this book provides information from numerous levels of analysis, including molecular biology and genetics, cellular physiology, neuroanatomy, neuropharmacology, epidemiology, and behavior. Sections and chapters are edited and authored by experts at the top of their fields. No other book distills the basic science and underpinnings of mental disorders-and highlights practical clinical significance-to the scope and breadth of this classic text. In this edition, Section 1, which reviews the methods used to examine the biological basis of mental illness in animal and cell models and in humans, has been expanded to reflect critically important technical advances in complex genetics (including powerful sequencing technologies and related bioinformatics), epigenetics, stem cell biology, optogenetics, neural circuit functioning, cognitive neuroscience, and brain imaging. This range of established and emerging methodologies offer groundbreaking advances in our ability to study the brain as well as unique opportunities for the translation of preclinical and clinical research into badly needed breakthroughs in our therapeutic toolkit. Sections 2 through 7 cover the neurobiology and genetics of major psychiatric disorders: psychoses (including bipolar disorder), mood disorders, anxiety disorders, substance use disorders, dementias, and disorders of childhood onset. Also covered within these sections is a summary of current therapeutic approaches for these illnesses as well as the ways in which research advances are now guiding the search for new treatments. Each of these parts has been augmented in several different areas as a reflection of research progress. The last section, Section 8, reconfigured in this new edition, now focuses on diagnostic schemes for mental illness. This includes an overview of the unique challenges that remain in diagnosing these disorders given our still limited knowledge of disease etiology and pathophysiology. The section then provides reviews of DSM-5®, which forms the basis of psychiatric diagnosis in the United States for all clinical work, and of RDoC, which provides an alternative perspective on diagnosis in heavy use in the research community. Also included are chapters on future efforts toward precision and computational psychiatry, which promise to someday align diagnosis with underlying biological abnormalities.